Search Results (94)

This paper provides experimental and numerical evidence supporting the occurrence of liposome congregation at the floors of meteor craters on Early Earth. This work builds on our earlier research, which demonstrated that liposomes submerged in a shallow Archean pond are protected from harmful UV radiation. This protection enables them to survive sufficiently long for autocatalytic amphiphile replication and for the mutation and selection of assemblies that enhance membrane stability. For liposomes to fuse, grow, exchange contents and membrane components, and divide, they must establish a population, i.e., form a dense conglomerate that enables close physical contact. The study demonstrates that such a congregation is feasible in bowl-shaped meteor craters on Early Earth, especially under periodic seismic disturbances. Full article

Between 1959 and 1962, Alvin Scodel, J. Sayer Minas, and colleagues conducted some of the earliest laboratory studies of strategic interaction using non-zero-sum games. Working at the margins of economics in the Journal of Conflict Resolution, they documented a striking pattern: subjects frequently chose options that reduced an opponent’s payoff by more than their own, even when mutual cooperation was both individually and collectively optimal. These results—especially the behavior observed in their so-called Game H4, a Harmony Game in which cooperation strictly dominated defection—anticipate a central insight of evolutionary game theory: what matters for adaptation is relative payoff, not absolute gain. This essay reinterprets the Scodel–Minas experiments through a Darwinian lens, arguing that they provide an early empirical challenge to Nash-equilibrium reasoning and to models that evaluate strategies solely in terms of absolute utility. By reconstructing the H4 payoff structure and embedding it within a simple evolutionary framework, I show how small levels of “competitive” behavior can destabilize cooperative equilibria that appear self-evident under standard assumptions. I then revisit three later “puzzles” in the evolution of cooperation—altruistic punishment, the fragility of “win–win” treaties, and rejections in ultimatum bargaining—to ask how differently they might have been framed had the Scodel–Minas findings been part of the canonical experimental literature. Rather than treating these phenomena as surprising anomalies, a historically informed, relative-payoff perspective suggests that they could have been recognized much earlier as natural expressions of an already documented pattern. Full article

This paper proposes a novel scheme for the origin of RNA replicase based on the replication-first stable complex evolution (SCE) model, also known as the stable complex encoding (SCE) model, and attempts to derive this scheme from the metabolism-first graded autocatalysis replication domain (GARD) model, thereby theoretically integrating the two hypotheses of the origin of life: replication-first and metabolism-first. Currently, although the replication-first model has made some progress in the artificial selection of RNA replicase, it has yet to achieve a true breakthrough. Meanwhile, metabolism-first models such as the CAS (Collectively Autocatalytic Set) and its graph version RAF (Reflexively Autocatalytic and Food-generated) models, have conducted in-depth research into the origin of metabolic networks but have failed to address the critical transformation issue from metabolism to RNA replication. This paper argues that these two hypotheses should mutually support each other. By introducing oligonucleotide assemblies and expanding the concept of composomes in the GARD model, this paper attempts to understand the general evolutionary mechanism of enzymes, thereby addressing the long-standing neglect of enzymatic catalysis in metabolism-first theories. This integrated scheme not only provides new theoretical support for the evolution of RNA replicase but also offers important insights into solving the key transition problem from chemical evolution to biological evolution. Full article

This paper will respond to James Sterba’s paper “An Ethics without God That is Compatible with Darwinian Evolution”. In his paper, Sterba argues that God cannot be the source of morality. Sterba maintains this position because he believes that his problem of extreme suffering entails that God cannot exist. Furthermore, Sterba argues that divine command theory has a number of serious problems confronting it. Alternatively, Sterba maintains that one can account for objective morality without appealing to God’s nature and/or commands. In response, this paper grants that Sterba presents a logically consistent account of objective morality without appealing to God’s nature and/or commands. However, this paper also cites a couple of reasons why one might think that God is still the better explanation for objective morality. This paper furthermore argues that Sterba’s objections do not demonstrate that divine command theory is false. The main thrust of this paper, though, focuses on Sterba’s argument about horrendous suffering. This paper argues that Sterba’s argument on horrendous suffering (while challenging) does not prove that a morally perfect God could not exist. Full article

The rise in the West of religious unbelief and its sometimes companions, relativism and nihilism, has been widely noted. Dostoyevsky’s famous dictum, “Without God, everything is permissible,” has in many quarters been taken as more recommendation than warning. The causes behind this trend are surely complex, but a key accelerant appears to have been the triumph of Darwin’s theory of evolution, in its original and now updated forms. Taken to its logical conclusions, the theory, together with part of its methodological apparatus (methodological naturalism), would seem to drain physical reality of meaning and humans of free will, significance, and higher purpose. Atheist philosopher Daniel Dennett called it a “universal acid.” The subject is one that could fill many books. One manageable way of rendering the subject manageable in a single paper is by considering key narratives that buttress Darwinian theory and by tracing the theory’s impact on the narrative arts of literature and film. How have Christians in the academy responded to modern evolutionary theory’s impact on the culture? One response has been to graft it onto Christianity in the hopes of neutralizing the theory’s more pernicious cultural implications. In practice, such attempts have tended to fundamentally alter either modern evolutionary theory or Christianity or both. Before attempting any such union, we would do well to revisit the foundations of the theory. Full article

This essay is a response to James Sterba’s “An Ethics without God That Is Compatible with Darwinian Evolution.” As an atheist philosopher I show that atheist morality is essentially and thoroughly a secular morality, and that the most reasonable ethics are secular systems in that they do not require a God, gods, or goddesses. I go on to defend an atheist morality based on polls showing that countries with atheist populations are healthier than religious ones. Then I point out the sources of human morality, arguing that there is a common neighborly morality that matters, based on facts about who we are as a species, which includes the pre-human sources in the animal world. Finally, I mention how that Sterbaian Ethics, as it should henceforth be called, can succeed. Full article

Background: Evolutionary game theory (EGT), originating from Darwinian competition studies, offers a powerful framework for understanding complex healthcare interactions where multiple stakeholders with conflicting interests evolve strategies over time. Unlike traditional game theory, EGT accounts for bounded rationality and strategic evolution through imitation and selection. Aims and objectives: In our study, we use Synthetic Knowledge Synthesis (SKS) that integrates descriptive bibliometrics and bibliometric mapping to systematically analyze the application of EGT in healthcare. The SKS aimed to identify prolific research topics, suitable publishing venues, and productive institutions/countries for collaboration and funding. Data was harvested from the Scopus bibliographic database, encompassing 539 publications from 2000 to June 2025, Results: Production dynamics is revealing an exponential growth in scholarly output since 2019, with peak productivity in 2024. Descriptive bibliometrics showed China as the most prolific country (376 publications), followed by the United States and the United Kingdom. Key institutions are predominantly Chinese, and top journals include PLoS One and Frontiers in Public Health. Funding is primarily from Chinese entities like the National Natural Science Foundation of China. Bibliometric mapping identified five key research themes: game theory in cancer research, evolution game-based simulation of supply management, evolutionary game theory in epidemics, evolutionary games in trustworthy connected public health, and evolutionary games in collaborative governance. Conclusions: Despite EGT’s utility, significant research gaps exist in methodological robustness, data availability, contextual modelling, and interdisciplinary translation. Future research should focus on integrating machine learning, longitudinal data, and explicit ethical frameworks to enhance EGT’s practical application in adaptive, patient-centred healthcare systems. Full article

Harrison has argued that ethics requires a god and, thus, keeps ethical norms from being threatened by evolutionary debunking. This paper argues that consensus is a better guarantee for ethics than gods, and ethics compatible with evolution is necessary for us to achieve consensus. To reduce the divide between theists and atheists and to prevent us from losing our pursuit of the common good, I start from the key consensus already achieved by Sterba and Harrison, that is, ethics does not specifically require God. It follows that ethics does not require gods and is our own affair. The Darwinian evolutionary theory shows that, when we are adapting to the environment, we develop different behaviors. This provides a common ground for understanding our differences and motivates us to adapt to a new environment where we, who are vastly different, have to live together. Finally, I take Confucian ethics as an example to show how ethics that begins with blood relations has given rise to our golden rule. Thus, the Darwinian evolutionary theory should not be seen as a threat. Full article

This paper engages with James Sterba’s arguments from an Islamic theological perspective, particularly drawing on the Mu‘tazilite tradition. It focuses on three central themes: (1) the position of God in the face of horrendous evils, (2) the relationship between divine command theory and moral objectivity, and (3) the compatibility of Darwinian evolution with objective morality. First, I challenge Sterba’s claim that the existence of a wholly good and powerful God is logically incompatible with horrendous evils by proposing a “theistic structuralist” framework inspired by the Mu‘tazilite scholar Qadi Abd al-Jabbar. Second, while largely agreeing with Sterba’s critique of divine command theory, I incorporate a Mu‘tazilite view that grounds moral objectivity in God’s inherently good nature. Third, I support Sterba’s argument—against Sharon Street—that Darwinian evolution does not undermine moral objectivity, but I further argue that a consistent defense of this view ultimately requires the existence of God. Full article

This essay explores the question: can we have an objective ethics without God? This question is raised by James Sterba, who argues in the affirmative. As an atheistic ethicist, Sterba is motivated to maintain an objective morality that is not based in theism and that can withstand the problems with Darwinism. Sterba examines what he sees as one of the most popular theistic attempts to ground human morality, viz., divine command theory. In rejecting both divine command theory and theism, Sterba offers what he believes can offer objective morality: a basic moral norm that all people should adhere to. This article examines Sterba’s criticism of divine command theory along with his own efforts at establishing an objective morality in what he considers a universal abstract principle. In the end, this article argues that Sterba’s axiomatic principle is unclear as to its ontological foundation as well as its causal efficacy in attempting to obligate objective human ethics. It will be argued that Sterba is correct about human nature being the locus of morality, but that atheism fails at providing human teleology to account for such morality. Full article

There is much confusion about the apparent opposition between Darwinian evolution and the second law of thermodynamics. Both entropy and entropy production play more fundamental roles in the origin of life and Darwinian evolution than is generally recognized. I argue that Darwinian evolution can be understood as a tendency for entropy production to increase. Since the second law is about the increase in entropy, this hypothesis goes beyond the second law because it is about the increase in entropy production. This hypothesis can explain some aspects of biology that Darwinism struggles with, such as the origin of life, the origin of Darwinism, ecological successions, and an apparent general trend towards biological complexity. Gould proposed a wall of minimal complexity to explain this apparent increase in biological complexity. I argue that the apparent increase in biological complexity can be understood as a tendency for biological entropy production to increase through a broader range of free energy transduction mechanisms. In the context of a simple universe-in-a-cup-of-coffee model, entropy production is proposed as a more quantifiable replacement for the notion of complexity. Finally, I sketch the cosmic history of entropy production, which suggests that increases and decreases of free energy availability constrain the tendency for entropy production to increase. Full article

Antimicrobial resistance (AMR) is considered a global healthcare emergency in the 21st century. Although the evolution of microorganisms through Darwinian mechanisms and antibiotic misuse are established drivers, the structural socioeconomic factors of AMR remain insufficiently explored. This review takes on an analytical perspective, drawing upon a wide spectrum of evidence to examine the extent to which socioeconomic factors contribute to the global proliferation of AMR, with an emphasis on low- and middle-income countries (LMICs). The analytical review at hand was carried out through a search for relevant articles and reviews on PubMed, Google Scholar, the Centers for Disease Control and Prevention, and the World Health Organization database using combinations of the keywords “antimicrobial resistance,” “socioeconomic factors,” “low- and middle-income countries,” “surveillance,” “healthcare access,” and “agriculture.” Preference was given to systematic reviews, high-impact primary studies, and policy documents published in peer-reviewed journals or by reputable global health organizations. Our analysis identifies a complex interplay of systemic vulnerabilities that accelerate AMR in resource-limited settings. A lack of regulatory frameworks regarding non-prescription antibiotic use enables the proliferation of multi-drug-resistant microorganisms. Low sewer connectivity facilitates the environmental dissemination of resistance genes. Proper antibiotic selection is hindered by subpar healthcare systems and limited diagnostic capabilities to deliver appropriate treatment. Additionally, gender disparities, forced migration, and climate-driven zoonotic transmission compound the burden. During the COVID-19 pandemic, antimicrobial misuse surged, further amplifying resistance trends. AMR is not solely a biological phenomenon, but a manifestation of global inequity. Mitigation requires a transformation of policy directed toward a “One Health” strategy that incorporates socioeconomic, environmental, and health system reforms. Strengthening surveillance, investing in infrastructure, regulating pharmaceutical practices, and promoting health equity are essential to curb the rising tide of resistance. Full article

Functional divergences of coding genes can be caused by divergences in their coding sequences and expression. However, whether and how expression divergences and coding sequence divergences coevolve is not clear. Gene expression divergences in differentiated cells and tissues recapitulate developmental models within a species, while gene expression divergences between analogous cells and tissues resemble traditional phylogenies in different species, suggesting that gene expression divergences are molecular traits that can be used for evolutionary studies. Using transcriptomes and evolutionary proxies to study gene expression divergences among differentiated cells and tissues in Arabidopsis, expression divergences of coding genes are shown to be strongly anti-correlated with phylostrata (gene ages), indicators of selective constraint Ka/Ks (nonsynonymous replacement rate/synonymous substitution rate) and indicators of positive selection (frequency of loci with Ka/Ks > 1), but only weakly or not correlated with indicators of neutral selection (Ks). Our results thus suggest that expression divergences largely coevolve with coding sequence divergences, suggesting that expression divergences of coding genes are selectively fixed by natural selection but not neutral selection, which provides a molecular framework for trait diversification, functional adaptation and speciation. Our findings therefore support that positive selection rather than negative or neutral selection is a major driver for the origin and evolution of Arabidopsis genes, supporting the Darwinian theory at molecular levels. Full article

Since Darwin, evolutionary population dynamics has captivated scientists and has applications beyond biology, such as in game theory where economists use it to explore evolution in new ways. This approach has renewed interest in dynamic evolutionary systems. In this paper, we propose an information-theoretic method to estimate trait parameters in a Darwinian model for species with single or multiple traits. Using Fisher information, we assess estimation errors and demonstrate the method through simulations. Full article

This study articulates how naming and family trees can become epic texts upon which intended or unintended meanings, identities and narratives can be decoded, including mutations in families, as basic units of society. Many studies in African anthroponym have articulated names and naming from differing perspectives, but have tended to ignore the diachronic and synchronic significance of looking at family trees which are woven in time and space through naming. Within the framework of Darwinian Theory of Evolution, we used in-depth interviews with a purposive sample of respondents from the Bette people of the Obudu local government area, to enable us to build family trees which were subtextually analyzed for meaning and mutations through six generations. Our findings enabled us to develop deeper insights into how a longitudinal articulation of naming and family trees can enhance our understanding of the synchronic realities, increased cultural aliteracy, dislocation of homesteads due to occupational shifts, changing ideas of kinship, patriarchal attitudes towards women and challenge of new technologies like DNA testing and new media within the Bette traditional kinship tradition. Significantly, naming and family trees, beyond dynastic delineations for identity, inclusivity and otherness, can become signifiers of a people’s epic progression and mutation, and, as it were, a tapestry of significant narratives of micro and macro family history. Full article