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28 pages, 579 KB  
Article
Measure for Measure in the Aqhat Epic: Retribution as a Poetic and Narrative Principle
by Shirly Natan-Yulzary
Religions 2026, 17(9), 998; https://doi.org/10.3390/rel17090998 (registering DOI) - 24 Aug 2026
Abstract
This study explores the poetic formulation of justice and retribution in the Aqhat Epic. ˀIlu, the supreme god of Ugarit, designates the goddess ˁAnatu “impious in heart,” yet he neither prevents her murder of ˀAqhatu nor punishes her overtly. The narrative contains [...] Read more.
This study explores the poetic formulation of justice and retribution in the Aqhat Epic. ˀIlu, the supreme god of Ugarit, designates the goddess ˁAnatu “impious in heart,” yet he neither prevents her murder of ˀAqhatu nor punishes her overtly. The narrative contains no judicial scene and no central governing deity who assumes the role of explicit divine adjudicator. Nevertheless, one may ask whether the story is shaped by a guiding mechanism of justice, comparable to certain biblical models of retribution, and what conception of retribution emerges from it, illuminating the relationship between gods and humans. The article highlights multiple instances showing that the narrative weaves a complex web linking transgression and consequence, in which acts of violence, desire, and rebellion give rise to corresponding consequences. These consequences manifest not only as visible punishments—such as the loss of the bow, the breaking of wings, and the curses upon implicated agents—but also in subtle reversals and ironic patterns accessible primarily to the audience. The moral order is neither absent nor declarative; rather, it is mediated through poetic formulations. Retribution unfolds on two interrelated levels: through overt narrative events and through a covert rhetorical structure that forges connections by means of repetition, key words, wordplay, and thematic symmetry. The study employs contextual close reading, supplemented by comments on the character roles. The conclusion reached is that the mechanism of measure-for-measure functions in the Aqhat Epic as a structuring narrative device, and that a sense of justice emerges through the convergence of human and divine agency. Full article
13 pages, 6356 KB  
Article
Application of the Hirshfeld Atom Refinement to Determine the Spin State of the Novel Fe(III) Schiff Base Complex
by Elena A. Buvaylo, Dmytro S. Nesterov, Evgeny Goreshnik and Oksana V. Nesterova
Compounds 2026, 6(3), 47; https://doi.org/10.3390/compounds6030047 - 5 Aug 2026
Viewed by 225
Abstract
The novel complex [FeIII(HL)(L)]·2dmf (1) was successfully synthesized by reacting iron chloride with dimethylformamide solution of the Schiff base ligand (H2L). The ligand was prepared in situ through the condensation of 5-bromo-salicylaldehyde and benzhydrazide. The compound 1 [...] Read more.
The novel complex [FeIII(HL)(L)]·2dmf (1) was successfully synthesized by reacting iron chloride with dimethylformamide solution of the Schiff base ligand (H2L). The ligand was prepared in situ through the condensation of 5-bromo-salicylaldehyde and benzhydrazide. The compound 1 was investigated by single crystal X-ray diffraction, IR spectroscopy, CASSCF/NEVPT2 and DFT theoretical calculations, revealing the high-spin (S = 5/2) state of Fe(III). The Hirshfeld Atom Refinement (HAR) of the crystal structure confirmed the sextet ground spin state of 1 through the comparison of R-factors and Hirshfeld deformation maps of the structures refined assuming high, indeterminate (S = 3/2) and low (S = 1/2) ground spin states. A series of basis sets and DFT functionals was screened, indicating that in most cases the combinations allow the correct determination of the ground state of 1. The def2-SVP double-zeta basis set combined with the GGA (Generalized Gradient Approximation) functional such as PBE or BP86 was found to be a sufficiently precise low-cost computational level. While further investigation is necessary, the results of the work tentatively suggest that the HAR could be successfully used for determination of the ground spin state of Fe(III) complexes even in the case of regular quality X-ray structures. Full article
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22 pages, 12850 KB  
Article
Lineage-Associated Genomic and Phenotypic Features of Bovine Mastitis-Associated Staphylococcus aureus from Northwestern China
by Ting Zhou, Xinying Tao, Zhiying Xue, Yongwang Huang, Yueqi Dong, Mohan Liu, Yilun Hu, Xin Wang and Yan Cui
Microorganisms 2026, 14(8), 1698; https://doi.org/10.3390/microorganisms14081698 - 2 Aug 2026
Viewed by 334
Abstract
Staphylococcus aureus is a major contagious pathogen causing bovine mastitis, with persistence and antimicrobial resistance posing ongoing challenges in dairy herds. From July 2022 to July 2023, 942 mastitis milk samples (267 clinical, 675 subclinical) from 10 farms in northwestern China yielded 98 [...] Read more.
Staphylococcus aureus is a major contagious pathogen causing bovine mastitis, with persistence and antimicrobial resistance posing ongoing challenges in dairy herds. From July 2022 to July 2023, 942 mastitis milk samples (267 clinical, 675 subclinical) from 10 farms in northwestern China yielded 98 S. aureus isolates (10.4%), which were characterized by whole-genome sequencing, antimicrobial susceptibility testing, biofilm assays, and virulence profiling. Ten sequence types, seven clonal complexes, and 16 spa types were identified, dominated by ST1 (42.9%) and ST97 (24.5%). ST1 was mainly associated with subclinical mastitis, whereas ST97 was enriched in clinical cases; a novel ST9955 (13.3%) was exclusively detected in subclinical isolates. No methicillin-resistant S. aureus was detected. Resistance was most frequently observed to penicillin (42.9%), erythromycin (28.6%), clindamycin (22.4%), and tetracycline (10.2%), with higher rates in clinical isolates. 65.3% of isolates exhibited strong biofilm-forming ability, which was significantly more frequent in subclinical cases (70.3% vs. 55.9%, p < 0.05). Virulence genes showed conserved adhesion/biofilm determinants but lineage-dependent distribution of immune evasion and toxin genes, with stable co-occurrence among capsule, biofilm, T7SS, iron acquisition, and immune evasion loci. Overall, the population was diverse but strongly lineage-structured, dominated by a few successful clones, highlighting the value of lineage-resolved surveillance for understanding and controlling bovine mastitis. Full article
(This article belongs to the Section Veterinary Microbiology)
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32 pages, 1616 KB  
Review
From the Cosmos to the Cell: The Central Role of Iron in the Chemistry and Evolution of Life
by Paolo Arosio and Fadi Bou-Abdallah
Int. J. Mol. Sci. 2026, 27(15), 6651; https://doi.org/10.3390/ijms27156651 - 25 Jul 2026
Viewed by 520
Abstract
Iron, with the unique stability of its nucleus, occupies an unusual position among the elements: its abundance on Earth is not simply a geological accident but a direct consequence of nuclear reactions that happened inside stars billions of years ago. Formed at the [...] Read more.
Iron, with the unique stability of its nucleus, occupies an unusual position among the elements: its abundance on Earth is not simply a geological accident but a direct consequence of nuclear reactions that happened inside stars billions of years ago. Formed at the final stages of fusion in stars, iron spread through space by supernova explosions and became part of the material that formed Earth, eventually becoming the dominant component of the planet’s core. At the surface, iron’s redox chemistry shaped the early atmosphere and oceans, and its availability as a soluble ferrous ion in the anaerobic Archean ocean made it a natural cofactor for the first enzymatic reactions. That same redox flexibility and the ability of iron to shuttle between Fe2+ and Fe3+ across a wide range of electrochemical potentials explain why virtually every major metabolic pathway in biology depends on iron in one form or another. Yet iron is also dangerous: free and chelated iron can catalyze the production of toxic hydroxyl radicals through Fenton chemistry, the reactivity of which depends strongly on the nature of the chelating ligand, and every living system must balance its need for iron against the oxidative damage that uncontrolled iron causes. This tension between catalytic necessity and chemical toxicity has driven much of the regulatory complexity we observe in modern iron metabolism. In this review, we first outline iron’s journey from its formation in stars to its role in shaping Earth’s structure and the emergence of early iron-dependent biology. We then discuss in detail how fundamental physical and chemical factors continue to influence living systems. Full article
(This article belongs to the Collection Latest Review Papers in Endocrinology and Metabolism)
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30 pages, 5107 KB  
Review
Pyrometallurgical Processing of Iron Manganese Ores: A Review with Emphasis on Kazakhstan’s Mineral Resources and Technological Prospects
by Yerlan Zhumagaliyev, Yerbol Shabanov, Bauyrzhan Orynbayev, Maulen Jundibayev, Ablay Zhunusov, Akgul Jundibayeva, Karlyga Almuratova and Erbolat Kobegen
Appl. Sci. 2026, 16(14), 7326; https://doi.org/10.3390/app16147326 - 22 Jul 2026
Viewed by 548
Abstract
The depletion of high-grade manganese ore reserves, accompanied by the progressive decline in ore quality, has intensified concerns regarding the supply of suitable manganese raw materials for Kazakhstan’s ferroalloy industry. Under these conditions, the development of efficient processing technologies for iron manganese ores [...] Read more.
The depletion of high-grade manganese ore reserves, accompanied by the progressive decline in ore quality, has intensified concerns regarding the supply of suitable manganese raw materials for Kazakhstan’s ferroalloy industry. Under these conditions, the development of efficient processing technologies for iron manganese ores characterized by low Mn/Fe ratios and complex mineralogical compositions has become increasingly important. This review examines current pyrometallurgical approaches for the processing of iron manganese ores, including carbothermic reduction roasting followed by magnetic separation, reduction smelting for the production of rich manganese slag, and hydrogen-based selective reduction followed by magnetic separation. Particular attention is given to the mineralogical and chemical characteristics of Kazakhstan’s iron manganese ores, which significantly limit their direct utilization in conventional ferromanganese production processes. The advantages and limitations of these technologies are critically evaluated in terms of metal recovery, Mn/Fe upgrading efficiency, energy requirements, environmental performance, and industrial applicability. The comparative analysis identifies reduction smelting as the most suitable route for Kazakhstan’s iron manganese ores under current technological conditions. This conclusion is primarily supported by the low Mn/Fe ratios, elevated iron contents, and complex mineralogical associations characteristic of the major Kazakhstan deposits, which limit the efficiency of solid-state reduction followed by magnetic separation. During smelting, the original mineral structure is destroyed, and iron and manganese are separated directly between the liquid metal and slag phases. Published studies report iron recoveries exceeding 95%, MnO recovery to the slag of approximately 94.6%, and Mn/Fe ratios above 15 in the resulting rich manganese slag. In addition, the process produces two potentially marketable products-cast iron and rich manganese slag-and can be integrated more readily into Kazakhstan’s existing ferroalloy production infrastructure. Therefore, reduction smelting currently represents the most technologically mature and practically feasible route for the comprehensive utilization of Kazakhstan’s iron manganese resources. Full article
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18 pages, 9664 KB  
Article
Structure–Function Relationships in Polysaccharide–Iron Complexes: Molecular Characterization, Acid-Stress Release Stability, and Gastrointestinal Tolerability
by Xiangqiu Qi, Hongwei Zhu, Xin Yan, Xi Kang, Dandan Xiao and Xianyi Sha
Pharmaceutics 2026, 18(7), 896; https://doi.org/10.3390/pharmaceutics18070896 - 21 Jul 2026
Viewed by 355
Abstract
Background: Polysaccharide–iron complexes (PICs) are widely used oral iron supplements, but their gastrointestinal tolerability varies and remains incompletely understood. As typical non-biological complex drugs (NBCDs), PICs exhibit structural heterogeneity, and their functional performance may be linked to higher-order structural attributes. Methods: [...] Read more.
Background: Polysaccharide–iron complexes (PICs) are widely used oral iron supplements, but their gastrointestinal tolerability varies and remains incompletely understood. As typical non-biological complex drugs (NBCDs), PICs exhibit structural heterogeneity, and their functional performance may be linked to higher-order structural attributes. Methods: In this study, two commercial PIC preparations (test samples A and B) were comparatively investigated to explore their structure–function relationship using a multi-dimensional approach. Structural properties were characterized by gel permeation chromatography (GPC), mass spectrometry (MS), Fourier-transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) spectroscopy, along with monosaccharide composition analysis. Functional behaviors and physiological relevance were further evaluated through in vitro acid-stress release studies and in vivo rat gastrointestinal tolerability assessments. Results: The results revealed that test sample A exhibited a glucose-only detectable monosaccharide profile but a higher and broader apparent molecular-weight distribution, indicating monosaccharide compositional uniformity together with macromolecular heterogeneity. In contrast, test sample B showed detectable glucose and mannose, a lower and narrower apparent molecular-weight distribution, higher measured free iron, and greater iron release under the tested acidic conditions. An exploratory 7-day rat gastrointestinal tolerability study (n = 4 per group) indicated that these distinct profiles may impact mucosal tolerability. Structurally stable test sample A allowed intestinal iron accumulation while maintaining mucosal integrity. Conversely, the rapid dissociation of test sample B induced observable mucosal injury, despite lower local iron retention. Conclusions: These findings suggest that the gastrointestinal tolerability of PICs may be associated with their structural attributes and release behavior, rather than total iron content alone. Overall, this exploratory study highlights a potential relationship between multi-dimensional PIC structure and functional performance, emphasizing the need for broader, structure-informed frameworks in the quality evaluation of complex iron therapies. Full article
(This article belongs to the Section Drug Delivery and Controlled Release)
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19 pages, 4693 KB  
Article
Molecular Docking and Energetic Analysis of Deferoxamine in Uropathogenic Escherichia coli in an Experimental Model
by Mayane Cristina Pereira Marques, Flávia Danyelle Oliveira Nunes, Camila Evangelista Carnib Nascimento, José Lima Pereira-Filho, Israel Viegas Moreira, Ana Beatriz Santos Sousa, Aline Santana Figueredo, Roseane Lustosa de Santana Lima, Gabriel Moreira Pereira, Raysa Lins Caldas, Antônio Silva Machado, Rosilda Silva Dias, Jaiza Sousa Penha, Bruna Caroline Silva Falcão, Phelipe Austríaco Teixeira, Marliete Carvalho da Costa, Joicy Cortez de Sá Sousa, Caio Pavão Tavares, Valério Monteiro-Neto, Eduardo Martins de Sousa and Rafael Cardoso Carvalhoadd Show full author list remove Hide full author list
Microorganisms 2026, 14(7), 1590; https://doi.org/10.3390/microorganisms14071590 - 21 Jul 2026
Viewed by 399
Abstract
Neurogenic bladder is a condition associated with impaired voiding, leading to urinary stasis and increased susceptibility to urinary tract infections, predominantly caused by Escherichia coli. In this context, bacterial iron acquisition systems represent attractive targets for alternative antimicrobial strategies. This study aimed [...] Read more.
Neurogenic bladder is a condition associated with impaired voiding, leading to urinary stasis and increased susceptibility to urinary tract infections, predominantly caused by Escherichia coli. In this context, bacterial iron acquisition systems represent attractive targets for alternative antimicrobial strategies. This study aimed to investigate the interactions of deferoxamine with E. coli iron acquisition proteins, combining an experimental model of neurogenic bladder with molecular analyses. The experimental model of neurogenic bladder was induced by complete spinal cord transection in rats, followed by urine collection by cystocentesis and microbiological characterization of uropathogens. Subsequently, molecular docking and energetic analyses were performed to evaluate the binding of deferoxamine and its Fe-DFO complex to the FhuE receptor of the ferric hydroxamate uptake pathway, with FhuA and FhuD prepared as correlated targets of the same pathway for structural context. The animals presented urinary retention and bacterial colonization, with E. coli identified as the pathogen. The results of the molecular docking revealed geometrically plausible accommodation of Fe-DFO within siderophore recognition pockets, involving residues associated with siderophore recognition and transport, as well as binding affinity scores consistent with weak-to-moderate structural complementarity compared to reference ligands. It is concluded that the neurogenic bladder model provides a biologically relevant framework for the study of urinary tract infections and that deferoxamine exhibits molecular interactions consistent with the ferric hydroxamate uptake system of E. coli. Because the present analysis was restricted to the Fhu pathway, these findings cannot be extrapolated to overall bacterial iron homeostasis, which involves multiple parallel acquisition systems. The current work is explicitly positioned as a proof-of-concept investigation; in vivo administration of DFO in the neurogenic bladder model, functional assays of iron uptake, transporter specificity experiments, and molecular dynamics analyses are identified as priority directions for future work. Full article
(This article belongs to the Section Medical Microbiology)
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16 pages, 2853 KB  
Article
Chiral Behavior and Racemization of Salen-Type Ligands and Their Iron Complexes: An X-Ray Crystal Structure Study
by Marika Iwatani, Daisuke Nakane and Takashiro Akitsu
Crystals 2026, 16(7), 465; https://doi.org/10.3390/cryst16070465 - 18 Jul 2026
Viewed by 352
Abstract
Chiral salen-type metal complexes are promising for diverse applications, yet their crystals often exhibit complicated chiral behavior. We investigated the crystal structures of chlorine-substituted salen-type ligands incorporating a 1,2-diphenylethylenediamine moiety and their iron complexes, which revealed varied chiral phenomena. Synthesis of the ligands [...] Read more.
Chiral salen-type metal complexes are promising for diverse applications, yet their crystals often exhibit complicated chiral behavior. We investigated the crystal structures of chlorine-substituted salen-type ligands incorporating a 1,2-diphenylethylenediamine moiety and their iron complexes, which revealed varied chiral phenomena. Synthesis of the ligands using (1S,2S)-, (1R,2R)-, and racemic starting amines exclusively produced racemic ligands. A similar racemization of the ligand was observed during the formation of a dinuclear oxidized Fe(III)-O-Fe(III) complex from FeSO4·6H2O (1). Conversely, complexation with FeCl3 maintained the optically active (1S,2S)-configuration even in the iron(III) complex (2). To elucidate these structural features, intermolecular interactions were quantified via Hirshfeld surface analysis. Additionally, generative AI (Gemini, Google) was employed for data interpretation to discuss the correlation between the structural characteristics of chirality and Hirshfeld surface analysis. Full article
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24 pages, 3680 KB  
Review
TPEN—Advanced Metal Chelator: From Characterization to Biomedical Applications
by Katarzyna Rydel-Ciszek
Molecules 2026, 31(14), 2482; https://doi.org/10.3390/molecules31142482 - 16 Jul 2026
Viewed by 539
Abstract
TPEN (N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine) is a ligand containing six nitrogen donors. It is characterized by high structural flexibility, enabling the coordination of metals with various ionic radii and coordination numbers. It is an advanced metal chelator that [...] Read more.
TPEN (N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine) is a ligand containing six nitrogen donors. It is characterized by high structural flexibility, enabling the coordination of metals with various ionic radii and coordination numbers. It is an advanced metal chelator that demonstrates high selectivity, particularly towards “soft” and “medium” metal ions, and has a wide range of applications, from coordination chemistry, materials engineering, and nuclear energy to innovations in medicine. TPEN can cross cell membranes freely, which is important in cell biology. However, its presence is not neutral for healthy cells and can lead to apoptosis by depleting essential metals such as zinc, iron, and copper. Targeted delivery systems are therefore essential. This can be achieved, for example, by using nanoparticles that release TPEN upon ultrasound. This review systematizes the understanding of TPEN complexes. Methods for the coordination of various d-, p-, and f-block metals are presented, as well as the properties of these complexes, which are crucial to understanding the mechanisms of reaction with TPEN. This ligand may find applications both as a diagnostic tool (in sensors) and as a therapeutic tool (by inducing cancer cell death). This work also demonstrates the need to design new and more effective TPEN analogs that overcome problems with solubility and stability in acids. Full article
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42 pages, 2657 KB  
Review
Biotechnological Modulation of Legumes via Fermentation: Impacts on Nutrient Bioaccessibility, Glycemic Index, and Antinutrients—A Scoping Review
by Carolina Noma, Carlos Henrique Pagno, Julio Cesar Colivet Briceno, Priscila Zaczuk Bassinello and Juliana Aparecida Correia Bento
Foods 2026, 15(14), 2483; https://doi.org/10.3390/foods15142483 - 13 Jul 2026
Cited by 1 | Viewed by 827
Abstract
The global transition toward plant-based diets has driven the inclusion and legumes as primary sources of proteins and micronutrients. However, the raw whole seed hosts complex matrices of antinutritional factors and crystalline starch arrangements that limit proteolytic digestibility, chelate essential minerals, and induce [...] Read more.
The global transition toward plant-based diets has driven the inclusion and legumes as primary sources of proteins and micronutrients. However, the raw whole seed hosts complex matrices of antinutritional factors and crystalline starch arrangements that limit proteolytic digestibility, chelate essential minerals, and induce accelerated postprandial glycemic responses. Conventional culinary and thermal treatments applied in isolation are frequently insufficient to disrupt the physicochemical matrix of the seeds, leaving critical gaps regarding how to sustainably optimize mineral bioaccessibility and convert water-soluble starches into stable slowly digestible fractions. This scoping review synthesizes analytical evidence demonstrating that targeted fermentative bioprocessing acts as a microstructural modulator. However, these biochemical outcomes are not unidirectional; the expansion of nutritional value is strictly governed by a complex interplay of substrate properties, process moisture, pH adjustments, and thermal pretreatments in plant defense frameworks and spatially reorganizing starch polymers. Microbial organic acid production and the mechanical penetration of fungal hyphae promote a 90–100% degradation and elimination of phytates and condensed tannins, eliminating non-digestible galacto-oligosaccharides and inactivating trypsin inhibitors. These mechanisms optimize phytate-to-mineral molar ratios, doubling the bioaccessibility of iron, zinc, and calcium in the digestive aqueous phases, while microbial beta-glucosidase expression bioconverts conjugated glycosides into free aglycones with high antioxidant activity. Simultaneously, the induction of molecular retrogradation drives continuous increases in the resistant starch fraction, inducing significant reductions in the hydrolysis index and lowering the predictive glycemic index to low thresholds. These findings consolidate controlled fermentation as a viable biotechnological intervention, providing structural guidelines for the rational design of functional foods, biofortified baked goods, and vegan beverages with high digestive tolerance. Full article
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37 pages, 1770 KB  
Article
Low-Complexity Residual-Corrected Loss-Minimization Current-Reference Generation for PMSM Drives
by Su-Min Kim and Han Ho Choi
Electronics 2026, 15(14), 3000; https://doi.org/10.3390/electronics15143000 - 8 Jul 2026
Cited by 1 | Viewed by 309
Abstract
This paper proposes a low-complexity residual-corrected loss-minimization current-reference generation method for permanent magnet synchronous motor (PMSM) drives. Existing loss-minimization control (LMC) methods often rely on lookup tables, numerical optimization, high-order algebraic equations, or explicit approximations based on maximum torque per ampere (MTPA) and [...] Read more.
This paper proposes a low-complexity residual-corrected loss-minimization current-reference generation method for permanent magnet synchronous motor (PMSM) drives. Existing loss-minimization control (LMC) methods often rely on lookup tables, numerical optimization, high-order algebraic equations, or explicit approximations based on maximum torque per ampere (MTPA) and maximum torque per voltage (MTPV) references. While effective, these simplified approximations often introduce residual errors relative to the true loss-optimal conditions. To address this, this paper adopts a more consistent iron-loss equivalent-circuit objective and analytically eliminates the torque equality constraint, reducing the LMC problem to a one-dimensional scalar minimization problem of the d-axis current. This paper demonstrates that this reduced objective is strictly convex over the admissible scalar domain, allowing for an exact benchmark solution via a scalar convex solver. The proposed method constructs a resistance-aware initial reference from explicit MTPA and MTPV approximations and then applies a one-step scalar Newton-type residual correction using the gradient and Hessian of the reduced loss objective. The initial reference reproduces the known exact surface-mounted PMSM (SPMSM) LMC solution in the SPMSM limit. The correction direction is proved to be a strict descent direction, and a safeguarded step-size ensures loss reduction compared to the initial approximation. The main novelty is the use of the scalar LMC optimality residual as a fixed-cost correction layer for explicit LMC references. The numerical validation is interpreted as steady-state current-reference mapping accuracy and model-based controllable loss-objective verification against the exact scalar optimum, not as hardware drive-efficiency validation. Tests including the no-MTPV case show reduced current-reference and loss-objective gaps while retaining a fixed-cost structure that may support future embedded implementation after validation; hardware transient and efficiency validation under inverter nonlinearity, temperature variation, saturation, and PWM effects remains for future work. Full article
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20 pages, 351 KB  
Article
The Comic Mask of Socrates: Irony, Initiation, and the Pedagogy of Laughter in Plato’s Symposium
by Shlomy Mualem
Humanities 2026, 15(7), 89; https://doi.org/10.3390/h15070089 - 6 Jul 2026
Viewed by 305
Abstract
Nietzsche claimed, in The Birth of Tragedy, that the Platonic dialogues are the lifeboat on which Socrates rescues older poetry, only to finish off comedy. This article contests that claim. Distinguishing comedy (a mode organized around to geloion, whose object Plato [...] Read more.
Nietzsche claimed, in The Birth of Tragedy, that the Platonic dialogues are the lifeboat on which Socrates rescues older poetry, only to finish off comedy. This article contests that claim. Distinguishing comedy (a mode organized around to geloion, whose object Plato himself defines in the Philebus as self-ignorance) from irony (a two-level device of meaning), it argues that Socratic irony in Plato is comic in a precise threefold sense: genealogically, as the inheritance of the eirōn-mask from the Aristophanic Clouds; structurally, wherever the dialogues frame it for staged laughter; and thematically, as the instrument of the laughing exposure of doxosophia. Drawing on Kierkegaard’s reading of the Socratic maieutic as ‘indirect communication’ and Vlastos’s concept of ‘complex irony,’ the article offers a close reading of Alcibiades’ speech in the Symposium within the generic frame Plato himself names at 222d: the satyr-play, ‘tragedy at play,’ in which tragic material is held inside a laughing form. The speech’s mythological imagery (Silenus, Marsyas, Corybants, Sirens) carries a coordinated dark sub-text that reverses its overt meaning—the satyric signature, not a departure from the comic. Against Vlastos, who locates pedagogical failure in Alcibiades’ self-deception, and Lane, who finds complex irony’s deliberate indeterminacy ethically indefensible, the article proposes a meta-ironic resolution: Plato stages both positions simultaneously, performing at the authorial level the very pharmakon-logic the speech describes—a seriocomic philosophical method grounded in the mythological ambivalence of the theatre of Dionysus. Full article
(This article belongs to the Special Issue Comedy and Platonic Interpretation)
22 pages, 2402 KB  
Review
Deactivation and Regeneration of Iron-Based Fischer–Tropsch Catalysts in Coal-to-Liquids: A Critical Review
by Yongping Ding, Shuzhuang Sun, Meng Wu and Yusheng Qiu
Catalysts 2026, 16(7), 609; https://doi.org/10.3390/catal16070609 - 2 Jul 2026
Viewed by 463
Abstract
Iron-based Fischer–Tropsch synthesis (Fe-FTS) catalysts are central to coal-to-liquid (CTL) processes but suffer from rapid and complex deactivation under industrial conditions. This review critically examines the key deactivation mechanisms, including carbon/wax deposition, hydrothermal sintering, chemical poisoning (S, Cl, As), and mechanical attrition, and [...] Read more.
Iron-based Fischer–Tropsch synthesis (Fe-FTS) catalysts are central to coal-to-liquid (CTL) processes but suffer from rapid and complex deactivation under industrial conditions. This review critically examines the key deactivation mechanisms, including carbon/wax deposition, hydrothermal sintering, chemical poisoning (S, Cl, As), and mechanical attrition, and evaluates modern regeneration strategies. These strategies include supercritical fluid extraction for wax removal, controlled oxidative decoking, reductive reconstruction of active iron carbides (χ-Fe5C2), chemical de-poisoning, and structural upcycling. We also discuss emerging techniques such as non-thermal plasma and supercritical fluid-assisted reactivation. Finally, we highlight challenges in irreversible phase transformation, in -situ regeneration engineering, and economic feasibility, and outline future directions toward regeneration-friendly catalyst design and advanced syngas purification for a circular CTL economy. Full article
(This article belongs to the Special Issue Advanced Catalysts for Energy Conversion and Environmental Protection)
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14 pages, 3046 KB  
Article
Influence of Thermally Grown Steel Oxides on Hydrogen Permeation Flux
by Mattia Pelucchi, Luca Gritti, Brigida Alfano, Raphael Rosa and Marina Cabrini
Corros. Mater. Degrad. 2026, 7(3), 42; https://doi.org/10.3390/cmd7030042 - 2 Jul 2026
Viewed by 476
Abstract
Hydrogen–steel interactions remain a critical concern for the safe deployment of hydrogen–natural gas mixtures in pipeline infrastructures. Thermally grown iron oxides may be a good barrier to hydrogen ingress into the crystalline lattice of pipeline steels, but their actual effectiveness depends strongly on [...] Read more.
Hydrogen–steel interactions remain a critical concern for the safe deployment of hydrogen–natural gas mixtures in pipeline infrastructures. Thermally grown iron oxides may be a good barrier to hydrogen ingress into the crystalline lattice of pipeline steels, but their actual effectiveness depends strongly on their composition and stability under service conditions. Several experimental approaches have been proposed to investigate the correlation between thermally grown oxides and hydrogen permeation. Among these, electrochemical permeation testing offers a more complex but safer methodology compared to pressurized hydrogen gas tests. However, when the oxide is directly exposed to the charging side (cathodic charging conditions), permeation behaviour often appears comparable to that of bare steel, and rapid oxide degradation occurs. This study introduces an alternative permeation testing configuration that enables direct assessment of thin thermally grown oxides while preserving their structural integrity. By deliberately placing the oxide on the anodic detection side, mechanical removal during hydrogen evolution is suppressed, allowing the intrinsic resistance of the oxide to hydrogen transport to be evaluated. Carbon steel samples were thermally oxidized at 250 °C for controlled exposure times, and the resulting oxide scales were characterized by Raman spectroscopy, revealing variations in hematite and magnetite fractions. Hydrogen permeation was evaluated using a Devanathan–Stachurski cell by positioning the oxidized surface either on the cathodic charging side or on the anodic detection side. Under these conditions, significant variations in apparent steady-state permeation current density were observed as a function of oxidation time and oxide composition. Full article
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19 pages, 12376 KB  
Article
Microwave-Synthesized Iron Oxides as Adsorbents for Cd(II) Removal from Water
by Fabrizio Ruggieri, Milena Casalena, Mariacristina Di Pelino and Selene Fiori
Sustain. Chem. 2026, 7(3), 30; https://doi.org/10.3390/suschem7030030 - 1 Jul 2026
Viewed by 365
Abstract
The contamination of aquatic environments by cadmium and other toxic heavy metals represents a major environmental concern requiring efficient and operationally sustainable remediation strategies. In this work, iron oxide materials were synthesized through a microwave-assisted hydrothermal method and evaluated for Cd(II) removal from [...] Read more.
The contamination of aquatic environments by cadmium and other toxic heavy metals represents a major environmental concern requiring efficient and operationally sustainable remediation strategies. In this work, iron oxide materials were synthesized through a microwave-assisted hydrothermal method and evaluated for Cd(II) removal from aqueous systems. Different precursor compositions and organic additives were initially screened in order to identify the most suitable adsorbent formulation. The selected Fe-Tart material was characterized by FTIR, SEM-EDS, and XRD analyses, revealing hydroxylated and poorly crystalline iron oxide structures with heterogeneous surface organization. Batch adsorption experiments were performed under controlled conditions to investigate the influence of pH and equilibrium adsorption behavior, while adsorption data were analyzed using Langmuir and Freundlich isotherm models. Cd(II) uptake showed strong pH dependence, with adsorption progressively increasing from acidic to near-neutral conditions and reaching approximately 80% removal at pH 7–8. The Langmuir model provided the best fitting results (R2 = 0.988), suggesting preferential occupation of energetically comparable surface sites with a maximum adsorption capacity of 6.51 mg g−1. The adsorption behavior was interpreted within a pH-dependent surface complexation framework involving hydroxylated iron oxide surfaces. Although the adsorption capacity remained lower than that reported for some highly engineered adsorbents, the results indicate that microwave-assisted synthesis may provide a relatively simple and rapid route for preparing iron oxide-based materials potentially applicable to water remediation systems. Full article
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