Search Results (191)

This study evaluates the influence of general anesthesia (GA) and spinal anesthesia (SA) on physiological and oxidative stress in parturients undergoing elective cesarean section, one of the most frequently performed surgical procedures worldwide. A total of 101 pregnant women were included, categorized into GA (n = 51) and SA (n = 50) groups. Blood samples were collected at three time points: one hour before surgery (Measurement 1), at umbilical cord clamping (Measurement 2), and two hours post-surgery (Measurement 3). Biomarkers of oxidative stress, complete blood count, and levels of biochemical parameters were measured. In second and/or third measurement, biochemical blood analysis showed increased prolactin and cortisol levels, followed by spike of glucose and insulin in the GA group. However, levels of tri-iodothyronine were reduced in both groups in the third measurement. Glutathione S-transferase (GST) activity was increased in both groups in third measurement. The results showed increased concentrations of total SH groups and decreased concentrations of non-protein SH groups in the GA group during Measurement 2. Lymphocyte count was found to be predictor of GST levels. The results indicate more a pronounced endocrine response in GA group and speak in favor of spinal anesthesia. Both kinds of anesthesia are equally safe in terms of the oxidative status of the tissue. Full article

Salinity stress is a major environmental challenge that adversely impacts the physiological and biochemical processes of pasture, consequently resulting in reduced yields and compromised quality. Biochar amendment has recently emerged as a promising strategy to alleviate the deleterious effects of salinity stress. However, the interactive influences of salinity stress and wheat straw biochar on the physiological, biochemical, and growth characteristics of alfalfa (Medicago sativa L.) remain underexplored. A factorial experiment was conducted using a randomized complete design with five salinity levels (0, 25, 50, 75, and 100 mM NaCl) and three application rates of biochar (0, 25, and 50 g kg⁻¹) to evaluate wheat straw biochar’s potential in alleviating salinity stress in alfalfa. Results showed that salinity stress increased oxidative stress (hydrogen peroxide and malondialdehyde) and reduced chlorophyll fluorescence (maximum quantum efficiency of photosystem II by 1–27%), leading to decreasing photosynthetic parameters, thereby constraining biomass accumulation by 9–77%. Wheat straw biochar amendment under the highest salinity stress, particularly at 25 g kg⁻¹, mitigated oxidative stress by reducing H₂O₂ and MDA levels by 35% and 33%, respectively, while decreasing the antioxidant enzymes activities of CAT, POD, and SOD by 47%, 42%, and 39%, respectively, compared to the control (non-biochar addition). Concurrently, biochar restored the osmoregulatory substance concentrations of proline and soluble sugar by 59% and 33%, respectively, compared to the control. Furthermore, wheat straw biochar amendment increased the net CO₂ assimilation rate by 98%, thereby increasing biomass by 63%. Our study demonstrates that wheat straw biochar can contribute to protecting alfalfa against salinity stress by modulating physiological and biochemical responses. These findings demonstrate that the 25 g kg⁻¹ wheat straw biochar application had the best performance, suggesting this amendment could be a viable strategy for improving alfalfa productivity in salt-affected soils. Future research should explore long-term field applications and the underlying mechanisms of biochar–plant–soil–plant interactions under diverse saline-alkali environments. Full article

Purpose/Objectives: Salvage radiotherapy (SRT) after a radical prostatectomy is a curative approach for patients with biochemical recurrence (BR). However, outcomes are often less favorable when imaging reveals macroscopic local recurrence. In such cases, dose escalation through stereotactic salvage radiotherapy (SSRT) may offer improved disease control. The STARR trial (NCT05455736) is a prospective, multicenter study evaluating the efficacy and safety of SSRT in patients with macroscopic prostate bed recurrence. This interim analysis reports early findings from the initial patient cohort. Materials and Methods: Patients with BR (PSA > 0.2 ng/mL) post-prostatectomy and PET-confirmed macroscopic recurrence (PSMA or Choline PET, confirmed by MRI) were eligible. Treatment involved CyberKnife^®-based SSRT delivering 35 Gy in five fractions to the visible lesion. Androgen deprivation therapy (ADT) was not permitted. Complete biochemical response (CBR) was defined as PSA < 0.2 ng/mL, and biochemical response (BR) as a ≥50% PSA reduction. Additional outcomes included biochemical, radiological, and ADT-free survival (bPFS, rPFS, aPFS). Results: As of analysis, 51 patients were enrolled, with a median follow-up of 16 months (95% CI: 16–22). CBR and BR were achieved in 45.1% and 80.4% of patients, respectively. Events affecting bPFS, rPFS, and aPFS occurred in 12, 5, and 6 patients, with median values not yet reached. Toxicity was minimal, with two cases each of acute grade 2 GI and GU events, and one late grade 2 GI event. No grade ≥ 3 toxicities were reported. Conclusion: Early data support SSRT as a safe and a promising option for macroscopic local recurrence, with encouraging response rates and minimal toxicity. Full article

English oak (Quercus robur) hosts over 200 species of galls formed by insect larvae, most notably the oak gall wasp (Cynips quercusfolii). These galls result from the abnormal growth of plant tissue in response to oviposition, acting as a shelter and nutrient source for the larvae. In addition, the galls trigger oxidative stress in the host plant, resulting in the increased production of reactive oxygen species (ROS). This stress response promotes the biosynthesis of antioxidant compounds, including phenolic acids, flavonoids, and tannins. To our knowledge, this is the first study to monitor seasonal changes in phenolic acids, flavonoids, and tannins in relation to C. quercusfolii infestation over a complete vegetation cycle using integrated UPLC profiling and statistical modeling PCA. For the first time, the contents of phenolic acids, flavonoids, and tannins were assessed throughout the vegetation cycle—from flowering to acorn fall. Results showed that galls affect the biochemical profile of the whole plant, suggesting a systemic response to local infection. The results provide new insights into oak defense responses and suggest that gall formation may be associated with systemic metabolic shifts potentially involved in stress mitigation. Furthermore, the study supports the further investigation of oak galls as a valuable source of polyphenols for pharmacological and industrial applications. Full article

Background/Objectives: Postpartum depression (PPD), the most common and prevalent psychiatric disorder after birth, is a prevalent yet underdiagnosed psychiatric condition that remains insufficiently understood, particularly in terms of its biological basis. While epidemiological data are extensive, few studies have systematically investigated their underlying biological mechanisms. The purpose of this study was to explore the potential links between blood biomarker levels and postpartum depressive symptoms, contributing to the development of a unified biological model of PPD. Methods: We conducted a cross-sectional study between 2023 and 2025 at a tertiary academic hospital in Timisoara, Romania, involving 860 postpartum women recruited at hospital discharge (1–2 weeks after childbirth). The participants completed the Edinburgh Postnatal Depression Scale (EPDS) and provided peripheral blood samples, which were analyzed using standardized protocols. The blood levels of pregnancy-related hormones (estrogen and progesterone), vitamin D, biochemical markers of inflammatory response (white blood cell count, C-reactive protein, fibrinogen, neutrophil count, lymphocyte count, and ferritin), anemia indicators (hemoglobin, red blood cell count, hematocrit, and ferritin), thyroid hormones (TSH, FT3, and FT4) and markers of coagulation abnormalities (D-dimer, platelets, fibrinogen, APTT, and INR) were evaluated. The data were analyzed with JASP v0.19.3. The statistical methods included multivariate linear regression, the Kruskal–Wallis and Mann–Whitney U tests, and Spearman correlation, with significance set at p < 0.05. Results: The analysis revealed that postpartum depression (PPD) is associated with distinct biological profiles, reflecting the unique hormonal and physiological changes in the peripartum period. Significant associations were identified between EPDS scores and the levels of estrogen, progesterone, thyroid hormones (TSH, FT3, and FT4), inflammatory markers (CRP and ferritin), vitamin D, and coagulation parameters (APTT and INR). These findings support the notion that PPD has a multifactorial biological basis and highlight the potential of these biomarkers as early predictors of risk. Conclusions: Integrating biochemical assessments into postpartum care may enhance early identification and inform targeted preventive interventions, such as hormone monitoring, vitamin D and iron supplementation, or thyroid function correction. Full article

Staphylococcus aureus is a significant bacterial pathogen responsible for a wide range of diseases in both humans and animals. This study aimed to investigate nucleotide sequence variations, gene expression patterns, and serum biomarkers, including acute phase proteins (APPs), hormonal fluctuations, and iron profile parameters in sheep affected by pneumonia. Additionally, the study focused on the isolation and characterization of S. aureus from pneumonic sheep, with particular emphasis on the prevalence of methicillin-resistant S. aureus (MRSA) strains. Blood samples were collected from both healthy and pneumonic sheep for gene expression and biochemical analyses, while nasal swabs from pneumonic sheep were used for bacterial isolation and identification. Out of 100 nasal swabs analyzed, 44% tested positive for Staphylococcus spp., and 61.4% of these were confirmed as S. aureus by PCR. The mecA gene, a key marker of methicillin resistance, was identified in 17 isolates (38.6% of the S. aureus-positive samples). MRSA isolates showed complete resistance to amoxicillin, cloxacillin, and erythromycin, and high resistance to penicillin, amoxicillin, and tetracycline; however, all MRSA strains remained fully susceptible to vancomycin. Gene expression analysis revealed that TLR2, CLEC4E, PTX3, CXCL8, and IL15RA were significantly upregulated (p < 0.05) in pneumonic ewes, while SOCS3 expression was markedly downregulated. Sequence analysis of immune-related genes revealed notable nucleotide differences between healthy and affected animals. Furthermore, the pneumonic group exhibited significantly elevated levels of APPs, cortisol, and growth hormone, along with reduced levels of insulin, T3, and T4. These findings underscore the zoonotic risk posed by MRSA and emphasize the need for robust surveillance and antibiotic stewardship to control its spread. The study also highlights the importance of molecular diagnostics in accurately identifying MRSA and elucidating resistance mechanisms, thereby facilitating targeted treatment and informed management strategies. Full article

Acute pancreatitis (AP) is one of the gastrointestinal pathologies that most frequently requires hospital admission; about half of all deaths occur within the first two weeks and are caused by multi-organ failure. Predicting the degree of severity of AP before 48 h is a challenge. Background/Objectives: Having an early marker, before 48 h after admission, could be useful to avoid or diagnose early complications such as organ failure (OF). A few sentences could place the question addressed in a broader context and highlight the purpose of the study. Methods: A retrospective study conducted in a third-level hospital, during the period from August 2019 to June 2021. Patients aged >18 years, with a diagnosis of PA, who had a complete clinical history and complete biochemical and imaging data were included. The scores of the APACHE II, BISAP, revised Atlanta classification, and modified Marshall scales were recorded. Results: Of the 103 patients included, 60% were women, the mean age was 47.76 years, and the hospital stay was 8 days (IQR 6–12); the most frequent etiology was biliary in 46 (44.7%) patients; the most frequent BMI was overweight with 34 (33%) patients; and 38 (36.9%) patients had a systemic inflammatory response at admission. Hypoalbuminemia was observed in 34 (33%) of the 103 patients at admission; of these, 42 (40.8%) had an APACHE II score > 8 points, 17 (16.3%) a BISAP score > 2, 57 (54.8%) patients were classified as moderate AP according to the revised Atlanta classification, and 54 patients had a score according to the modified Marshall score > 2. A statistically significant difference in the development of death was observed between patients with hypoalbuminemia versus those with normal serum albumin levels. Conclusions: In this study, we show the usefulness of hipoalbuminemia (<3.5 g/dL) at hospital admission in patients with AP, as a severity and mortality indicator. With the results obtained, we conclude that low albumin levels are a good predictor of severity and are useful for establishing timely treatment and close follow-up. Full article

This study investigates the effectiveness of organic compost as a sustainable alternative to chemical fertilizers for improving soil health and enhancing crop productivity under greenhouse conditions. The experiment focused on sweet basil (Ocimum basilicum L.), an aromatic herb highly sensitive to soil fertility and structure, cultivated in sandy loam soil—a prevalent substrate in arid and semi-arid regions, often limited by poor water and nutrient retention. Using a randomized complete block design with six compost application rates, this study evaluated the physicochemical, biochemical, and agronomic responses of both soil and plants. The results demonstrated significant improvements across all parameters (p < 0.05), with the 30 t/ha compost treatment yielding the most notable enhancements in soil structure, nutrient content, and plant performance while maintaining acceptable levels of heavy metals. Soil organic matter (SOM) increased to 13.71%, while shoot length (SL), essential oil content (EOC), and the 100-seed weight improved to 42 cm, 0.83%, and 0.32 g, respectively, compared to the control. These finding underscore the benefits of high compost application rates in boosting greenhouse horticultural productivity while promoting sustainable agriculture. Moreover, this study supports the reduction in chemical fertilizer dependency and encourages the adoption of circular economy principles (CEPs) through organic waste recycling. Full article

Peripheral nerve injury disrupts the function of the peripheral nervous system, leading to sensory, motor, and autonomic deficits. While peripheral nerves possess an intrinsic regenerative capacity, complete sensory and motor recovery remains challenging due to the unpredictable nature of the healing process, which is influenced by the extent of the injury, age, and timely intervention. Recent advances in microsurgical techniques, imaging technologies, and a deeper understanding of nerve microanatomy have enhanced functional outcomes in nerve repair. Nerve injury initiates complex pathophysiological responses, including Wallerian degeneration, macrophage activation, Schwann cell dedifferentiation, and axonal sprouting. Complete nerve disruptions require surgical intervention to restore nerve continuity and function. Direct nerve repair is the gold standard for clean transections with minimal nerve gaps. However, in cases with larger nerve gaps or when direct repair is not feasible, alternatives such as autologous nerve grafting, vascularized nerve grafts, nerve conduits, allografts, and nerve transfers may be employed. Autologous nerve grafts provide excellent biocompatibility but are limited by donor site morbidity and availability. Vascularized grafts are used for large nerve gaps and poorly vascularized recipient beds, while nerve conduits serve as a promising solution for smaller gaps. Nerve transfers are utilized when neither direct repair nor grafting is possible, often involving re-routing intact regional nerves to restore function. Nerve conduits play a pivotal role in nerve regeneration by bridging nerve gaps, with significant advancements made in material composition and design. Emerging trends in nerve regeneration include the use of 3D bioprinting for personalized conduits, gene therapy for targeted growth factor delivery, and nanotechnology for nanofiber-based conduits and stem cell therapy. Advancements in molecular sciences have provided critical insights into the cellular and biochemical mechanisms underlying nerve repair, leading to targeted therapies that enhance axonal regeneration, remyelination, and functional recovery in peripheral nerve injuries. This review explores the current strategies for the therapeutic management of peripheral nerve injuries, highlighting their indications, benefits, and limitations, while emphasizing the need for tailored approaches based on injury severity and patient factors. Full article

Lateral flow tests (LFTs) had a pivotal role in combating the spread of the SARS-CoV-2 virus throughout the COVID-19 pandemic thanks to their affordability and ease of use. Most of LFT devices were based on nitrocellulose membrane strips whose industrial upscaling to billions of devices has already been extensively demonstrated. Nevertheless, the assay option in an LFT format is largely restricted to qualitative detection of the target antigens. In this research, we surveyed the potential of UV nanoimprint lithography (UV-NIL) and extrusion coating (EC) for the high-throughput production of disposable capillary-driven, foil-based tests that allow multistep assays to be implemented for quantitative readout to address the inherent lack of on-demand fluid control and sensitivity of paper-based devices. Both manufacturing technologies operate on the principle of imprinting that enables high-volume, continuous structuring of microfluidic patterns in a roll-to-roll (R2R) production scheme. To demonstrate the feasibility of R2R-fabricated foil chips in a point-of-care biosensing application, we adapted a commercial chemiluminescence multiplex test for COVID-19 antibody detection originally developed for a capillary-driven microfluidic chip manufactured with injection molding (IM). In an effort to build a complete ecosystem for the R2R manufacturing of foil chips, we also recruited additional processes to streamline chip production: R2R biofunctionalization and R2R lamination. Compared to conventional fabrication techniques for microfluidic devices, the R2R techniques highlighted in this work offer unparalleled advantages concerning improved scalability, dexterity of seamless handling, and significant cost reduction. Our preliminary evaluation indicated that the foil chips exhibited comparable performance characteristics to the original IM-fabricated devices. This early success in assay translation highlights the promise of implementing biochemical assays on R2R-manufactured foil chips. Most importantly, it underscores the potential utilization of UV-NIL and EC as an alternative to conventional technologies for the future development in vitro diagnostics (IVD) in response to emerging point-of-care testing demands. Full article

Soil salinity stress inhibits the growth of most beneficial soil fungi, thereby adversely affecting crop growth, though the underlying mechanisms remain poorly understood. Our study revealed that the beneficial fungus Trichoderma guizhouense NJAU4742 exhibited limited salt tolerance, with its growth being significantly suppressed under elevated salinity. To investigate the physiological, biochemical, and molecular responses of NJAU4742 to salt stress and its subsequent effects on tomato growth, we subjected NJAU4742 to X-ray irradiation, aiming to obtain mutants with altered salt tolerance. A forward mutant strain (designated M15) displaying near-complete loss of salt tolerance was successfully isolated. Comparative transcriptomic analysis between the wild type (wt) and M15 identified gene Tgmfs, a salt stress-responsive gene belonging to the major facilitator superfamily. By constructing Tgmfs knockout (Tgmfs-KO) and overexpression (Tgmfs-OE) strains, we observed that Tgmfs deletion caused intracellular Na⁺ accumulation in NJAU4742, prompting compensatory upregulation of Na⁺/K⁺-ATPase activity to maintain ion homeostasis. Concurrently, salt stress induced reactive oxygen species accumulation and oxidative stress in fungal cells, which was counteracted by enhanced superoxide dismutase activity and an elevated NAD⁺/NADH ratio, collectively boosting antioxidant defenses. Pot experiments demonstrated that the application of Tgmfs-OE or wt spore suspensions markedly improved tomato salt tolerance, with Tgmfs-OE treatment showing superior efficacy. This study advances our understanding of filamentous fungal salt adaptation mechanisms and their synergistic effects on plant resilience. Full article

Buprenorphine and methadone are widely used as medication for addiction treatment (MAT) in patients with opioid use disorders. However, there is no compelling evidence of their impact on the immune–endocrine response. Therefore, the aim of this study was to examine the effects of the aforementioned medications on craving and on biomarkers of inflammation and cortisol, approaching the dose issue concurrently. Sixty-six patients (thirty-four under methadone and thirty-two under buprenorphine) who had just entered a MAT program and were stabilized with the suitable administered doses after a two-week process were divided into four groups based on medication dose (i.e., methadone high dose, buprenorphine high dose, methadone medium dose, and buprenorphine medium dose). The heroin craving questionnaire for craving assessment was completed, and the blood biomarkers were measured on Days 1 and 180. According to the results, high doses of both medications were accompanied by low levels of craving, cortisol, and inflammation on Day 1, and no alterations were observed on Day 180. On the contrary, medium doses reduced the tested psychosocial and biochemical parameters in terms of time, indicating a positive action for the patients. Concludingly, modifications in MAT doses are needed soon after the stabilization process to prevent inflammation and avoid relapse, thus helping opioid-addicted patients toward rehabilitation. Full article

Investigating the impact of oxygen-enriched water combined with LED light on lettuce growth for two consecutive cycles is essential for advancing greenhouse cultivation in Mediterranean climates, where summer heat poses significant challenges. This study investigates the combined impact of oxygen-enriched water (O₂EW) and LED lighting on physiological, biochemical, and growth responses of two lettuce cultivars across two cultivation cycles in a controlled environment. The two lettuce types, Lactuca sativa var. ‘Lollo Bionda’ (Lugano) and Lactuca sativa var. ‘Lollo Rosso’ (Carmesi), were cultivated employing the Nutrient Film Technique (NFT) method within a regulated greenhouse setting. A randomized complete block design (RCBD) evaluated lettuce growth in an NFT system under three treatments: natural water (NW), oxygen-enriched water (O₂EW), and O₂EW with LED light (380–840 nm) (LED + O₂EW). The plants were exposed to natural oxygen levels (NW) of 6.2–7.4 mg L⁻¹ in the first and 7.4–8.1 mg L⁻¹ in the second period. Under O₂EW, levels reached 8.0–8.6 mg L⁻¹ and 8.7–9.2 mg L⁻¹, respectively, while LED + O₂EW concentrations were 8.4–8.5 mg L⁻¹ in the first and 8.8–8.4 mg L⁻¹ in the second period. The PPFD for ‘Lugano’ ranged from 426 to 486 µmol m⁻² s⁻¹ in the first cycle and 437–511 µmol m⁻² s⁻¹ in the second, averaging 448.66 and 460.65 µmol m⁻² s⁻¹, respectively. For ‘Carmesi’, it ranged from 421 to 468 and 441 to 492.3 µmol m⁻² s⁻¹, with averages of 438.66 and 457.1 µmol m⁻² s⁻¹. Statistical analysis was performed using two-way ANOVA and Tukey’s HSD test (p < 0.05) in IBM SPSS Statistics (version 29.0.2.0). The applied treatments significantly influenced the plants’ physiological parameters, including the photosynthetic rate, stomatal conductance, transpiration rate, and antioxidant activity. These treatments also significantly (p < 0.05) affected plant growth metrics such as the height, diameter, mass, number of leaves, root length, root mass, as well as biochemical components like chlorophyll, nitrate, and glucose content. The applied treatments significantly enhanced plant growth, biochemical components, and physiological parameters. Via comparative analysis, we concluded that the overall physiological performance of the plants in the second cycle was approximately 21.18% higher compared to the first cycle when combining all attributes. ‘Lugano’ showed stronger growth in height, mass, and root traits, while ‘Carmesi’ excelled in antioxidant activity, especially under LED + O₂EW treatment. Oxygen treatments boosted photosynthesis and transpiration in both varieties, with ‘Carmesi’ showing higher rates and ‘Lugano’ demonstrating greater growth, especially in the second cycle. In conclusion, O₂EW and LED treatments significantly enhance lettuce growth and resilience, particularly under warmer conditions, highlighting their potential to support sustainable year-round greenhouse cultivation. Full article

Identifying and selecting almond cultivars with drought tolerance traits is crucial for developing more resilient cultivars, especially in regions prone to water scarcity or facing changing climate conditions. In this study, the physiological and biochemical responses of different almond cultivars to water stress were evaluated using a randomized complete block design (RCBD) with three replications at the Agricultural and Natural Resources Research Center of Chaharmahal and Bakhtiari Province, Shahrekord, Iran, during the 2020 and 2021 growing seasons. During each season, the drought stress treatments were applied for four months prior to the collection of leaf tissue and assessment of the physiological and biochemical traits of the treated trees. In general, significant differences were observed for the different effects considered in the fitted model (years, repetitions, cultivars, drought treatments). The relative water content, as well as the chlorophyll a and b contents in the leaves of the evaluated cultivars, significantly decreased with increasing stress intensity. However, the total phenol content and the activities of antioxidant enzymes increased in response to drought stress. There were considerable differences in the studied cultivars’ responses to increasing drought intensity. According to the results, cultivars “Shahrood 8”, “Garnem”, and “Shahrood 12” demonstrated a high antioxidant capacity and the highest resistance, as observed through a smaller reduction in the relative water content under severe drought stress compared with the other cultivars. These results provide valuable insights that contribute to the development of more resilient almond cultivars and rootstocks, particularly in regions susceptible to water scarcity or those experiencing changing climatic conditions. Full article

The metabolic response to a maximal exercise test in physically inactive adults remains poorly understood, particularly regarding the role of adiponectin, an adipokine with insulin-sensitizing and anti-inflammatory properties. Adiponectin circulates in three isoforms—low (LMW), medium (MMW), and high-molecular-weight (HMW)—with differing bioactivities. While exercise is known to influence adiponectin levels, evidence is conflicting, and few studies have explored isoform-specific changes. This study aimed to evaluate the effects of a single maximal exercise session on circulating adiponectin isoforms and their associations with metabolic and kidney function markers in physically inactive young adults. In this quasi-experimental study, twenty-one physically inactive participants (mean age 24.6 ± 2.1 years, 85.7% women) completed a progressive cycle ergometer test. Circulating levels of LMW and MMW adiponectin, metabolic outcomes (e.g., cholesterol, triglycerides, fibroblast growth factor 21 (FGF21)), and kidney function markers (e.g., creatinine, proteinuria) were assessed before and after exercise using biochemical assays and Western blotting. Comparisons between pre- and post-exercise values were made with the Wilcoxon test. Exercise increased lipid metabolism markers (total cholesterol, triglycerides, HDL) and kidney stress indicators (albuminuria, proteinuria) (p < 0.05). LMW and MMW adiponectin levels showed no significant overall changes, but LMW adiponectin positively correlated with changes in total cholesterol and FGF21, while MMW adiponectin negatively correlated with creatinine and proteinuria (p < 0.05). HMW adiponectin was undetectable by our methods. A single maximal exercise session revealed isoform-specific associations between adiponectin and metabolic or kidney stress markers, emphasizing the complex role of adiponectin in exercise-induced metabolic responses. Future research should explore mechanisms underlying these differential associations to optimize exercise interventions for metabolic health improvement. Full article