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29 pages, 868 KiB  
Article
Relationship Between Visual Acuity, Colour Vision, Contrast Sensitivity and Stereopsis, and Road Traffic Accidents: A Systematic Review and Meta-Analysis
by Diana García-Lozada, Fanny Rivera-Pinzón and Edgar Ibáñez-Pinilla
Safety 2025, 11(3), 71; https://doi.org/10.3390/safety11030071 - 28 Jul 2025
Viewed by 347
Abstract
The aim of this study was to evaluate the relationship between visual functions and road traffic accidents (RTAs) by meta-analysis of observational studies. The analysis included all drivers of motor vehicles, regardless of age, and those using private or public transport. Self-reported visual [...] Read more.
The aim of this study was to evaluate the relationship between visual functions and road traffic accidents (RTAs) by meta-analysis of observational studies. The analysis included all drivers of motor vehicles, regardless of age, and those using private or public transport. Self-reported visual outcomes were excluded. The risk of RTA in patients with reduced visual acuity was observed in commercial drivers in cross-sectional studies (PR 1.54, 95% CI 1.26–1.88), but not in private drivers in cohort (RR 1.04, 95% CI 0.74–1.46) or case–control studies (OR 1.04, 95% CI 0.78–1.40). A non-statistically significant association between colour vision defects and RTA was observed in cross-sectional studies (PR 1.50, 95% CI 0.91–2.45). No evidence was found for an increased risk of accidents in people with reduced stereopsis. In older adults with abnormal contrast sensitivity, a weak risk of RTA was observed in cohort studies. Evidence from low-quality cross-sectional studies suggests an increased risk of RTAs among commercial drivers with reduced visual acuity. The few case–control and cohort studies identified did not show an association between accident occurrence and visual function. Attention needs to be paid to this issue to facilitate the conduct of high-quality research that can support the development of road safety policies. Full article
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13 pages, 788 KiB  
Article
Advancing Kiwifruit Maturity Assessment: A Comparative Study of Non-Destructive Spectral Techniques and Predictive Models
by Michela Palumbo, Bernardo Pace, Antonia Corvino, Francesco Serio, Federico Carotenuto, Alice Cavaliere, Andrea Genangeli, Maria Cefola and Beniamino Gioli
Foods 2025, 14(15), 2581; https://doi.org/10.3390/foods14152581 - 23 Jul 2025
Viewed by 250
Abstract
Gold kiwifruits from two different farms, harvested at different times, were analysed using both non-destructive and destructive methods. A computer vision system (CVS) and a portable spectroradiometer were used to perform non-destructive measurements of firmness, titratable acidity, pH, soluble solids content, dry matter, [...] Read more.
Gold kiwifruits from two different farms, harvested at different times, were analysed using both non-destructive and destructive methods. A computer vision system (CVS) and a portable spectroradiometer were used to perform non-destructive measurements of firmness, titratable acidity, pH, soluble solids content, dry matter, and soluble sugars (glucose and fructose), with the goal of building predictive models for the maturity index. Hyperspectral data from the visible–near-infrared (VIS–NIR) and short-wave infrared (SWIR) ranges, collected via the spectroradiometer, along with colour features extracted by the CVS, were used as predictors. Three different regression methods—Partial Least Squares (PLS), Support Vector Regression (SVR), and Gaussian process regression (GPR)—were tested to assess their predictive accuracy. The results revealed a significant increase in sugar content across the different harvesting times in the season. Regardless of the regression method used, the CVS was not able to distinguish among the different harvests, since no significant skin colour changes were measured. Instead, hyperspectral measurements from the near-infrared (NIR) region and the initial part of the SWIR region proved useful in predicting soluble solids content, glucose, and fructose. The models built using these spectral regions achieved R2 average values between 0.55 and 0.60. Among the different regression models, the GPR-based model showed the best performance in predicting kiwifruit soluble solids content, glucose, and fructose. In conclusion, for the first time, the effectiveness of a fully portable spectroradiometer measuring surface reflectance until the full SWIR range for the rapid, contactless, and non-destructive estimation of the maturity index of kiwifruits was reported. The versatility of the portable spectroradiometer may allow for field applications that accurately identify the most suitable moment to carry out the harvesting. Full article
(This article belongs to the Section Food Quality and Safety)
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17 pages, 2942 KiB  
Article
Visual Perception and Fixation Patterns in an Individual with Ventral Simultanagnosia, Integrative Agnosia and Bilateral Visual Field Loss
by Isla Williams, Andrea Phillipou, Elsdon Storey, Peter Brotchie and Larry Abel
Neurol. Int. 2025, 17(7), 105; https://doi.org/10.3390/neurolint17070105 - 10 Jul 2025
Viewed by 248
Abstract
Background/Objectives: As high-acuity vision is limited to a very small visual angle, examination of a scene requires multiple fixations. Simultanagnosia, a disorder wherein elements of a scene can be perceived correctly but cannot be integrated into a coherent whole, has been parsed into [...] Read more.
Background/Objectives: As high-acuity vision is limited to a very small visual angle, examination of a scene requires multiple fixations. Simultanagnosia, a disorder wherein elements of a scene can be perceived correctly but cannot be integrated into a coherent whole, has been parsed into dorsal and ventral forms. In ventral simultanagnosia, limited visual integration is possible. This case study was the first to record gaze during the presentation of a series of visual stimuli, which required the processing of local and global elements. We hypothesised that gaze patterns would differ with successful processing and that feature integration could be disrupted by distractors. Methods: The patient received a neuropsychological assessment and underwent CT and MRI. Eye movements were recorded during the following tasks: (1) famous face identification, (2) facial emotion recognition, (3) identification of Ishihara colour plates, and (4) identification of both local and global letters in Navon composite letters, presented either alone or surrounded by filled black circles, which we hypothesised would impair global processing by disrupting fixation. Results: The patients identified no famous faces but scanned them qualitatively normally. The only emotion to be consistently recognised was happiness, whose scanpath differed from the other emotions. She identified none of the Ishihara plates, although her colour vision was normal on the FM-15, even mapping an unseen digit with fixations and tracing it with her finger. For plain Navon figures, she correctly identified 20/20 local and global letters; for the “dotted” figures, she was correct 19/20 times for local letters and 0/20 for global letters (chi-squared NS for local, p < 0.0001, global), with similar fixation of salient elements for both. Conclusions: Contrary to our hypothesis, gaze behaviour was largely independent of the ability to process global stimuli, showing for the first time that normal acquisition of visual information did not ensure its integration into a percept. The core defect lay in processing, not acquisition. In the novel Navon task, adding distractors abolished feature integration without affecting the fixation of the salient elements, confirming for the first time that distractors could disrupt the processing, not the acquisition, of visual information in this disorder. Full article
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24 pages, 10115 KiB  
Article
iSight: A Smart Clothing Management System to Empower Blind and Visually Impaired Individuals
by Daniel Rocha, Celina P. Leão, Filomena Soares and Vítor Carvalho
Information 2025, 16(5), 383; https://doi.org/10.3390/info16050383 - 3 May 2025
Viewed by 841
Abstract
Clothing management is a major challenge for blind and visually impaired individuals to perform independently. This research developed and validated the iSight, a mechatronic smart wardrobe prototype, integrating computer vision and artificial intelligence to identify clothing types, colours, and alterations. Tested with 15 [...] Read more.
Clothing management is a major challenge for blind and visually impaired individuals to perform independently. This research developed and validated the iSight, a mechatronic smart wardrobe prototype, integrating computer vision and artificial intelligence to identify clothing types, colours, and alterations. Tested with 15 participants, iSight achieved high user satisfaction, with 60% rating it as very accurate in clothing identification, 80% in colour detection, and 86.7% in near-field communication tag recognition. Statistical analyses confirmed its positive impact on confidence, independence, and well-being. Despite the fact that improvements in menu complexity and fabric information were suggested, iSight proves to be a robust, user-friendly assistive tool with the potential to enhance the daily living of blind and visually impaired individuals. Full article
(This article belongs to the Special Issue AI-Based Image Processing and Computer Vision)
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20 pages, 6149 KiB  
Article
Computer Vision and Transfer Learning for Grading of Egyptian Cotton Fibres
by Ahmed Rady, Oliver Fisher, Aly A. A. El-Banna, Haitham H. Emasih and Nicholas J. Watson
AgriEngineering 2025, 7(5), 127; https://doi.org/10.3390/agriengineering7050127 - 22 Apr 2025
Viewed by 925
Abstract
Egyptian cotton fibres have worldwide recognition due to their distinct quality and luxurious textile products known by the “Egyptian Cotton“ label. However, cotton fibre trading in Egypt still depends on human grading of cotton quality, which is resource-intensive and faces challenges in terms [...] Read more.
Egyptian cotton fibres have worldwide recognition due to their distinct quality and luxurious textile products known by the “Egyptian Cotton“ label. However, cotton fibre trading in Egypt still depends on human grading of cotton quality, which is resource-intensive and faces challenges in terms of subjectivity and expertise requirements. This study investigates colour vision and transfer learning to classify the grade of five long (Giza 86, Giza 90, and Giza 94) and extra-long (Giza 87 and Giza 96) staple cotton cultivars. Five Convolutional Neural networks (CNNs)—AlexNet, GoogleNet, SqueezeNet, VGG16, and VGG19—were fine-tuned, optimised, and tested on independent datasets. The highest classifications were 75.7%, 85.0%, 80.0%, 77.1%, and 90.0% for Giza 86, Giza 87, Giza 90, Giza 94, and Giza 96, respectively, with F1-Scores ranging from 51.9–100%, 66.7–100%, 42.9–100%, 40.0–100%, and 80.0–100%. Among the CNNs, AlexNet, GoogleNet, and VGG19 outperformed the others. Fused CNN models further improved classification accuracy by up to 7.2% for all cultivars except Giza 87. These results demonstrate the feasibility of developing a fast, low-cost, and low-skilled vision system that overcomes the inconsistencies and limitations of manual grading in the early stages of cotton fibre trading in Egypt. Full article
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14 pages, 5362 KiB  
Communication
Comparison of Colour Measurement Methods in the Food Industry
by Hanna Boruczkowska, Tomasz Boruczkowski, Monika Bronkowska, Maja Prajzner and Elżbieta Rytel
Processes 2025, 13(5), 1268; https://doi.org/10.3390/pr13051268 - 22 Apr 2025
Viewed by 1327
Abstract
Colour is a key parameter in the evaluation of food products. Accurate colour measurement enables us to maintain their consistent quality. The aim of this study was to compare three colour measurement methods. The food products used for the study were French fries, [...] Read more.
Colour is a key parameter in the evaluation of food products. Accurate colour measurement enables us to maintain their consistent quality. The aim of this study was to compare three colour measurement methods. The food products used for the study were French fries, the colour of which was checked after defined frying times. Their colour was measured using a professional Minolta C-5 spectrophotometer (Konica Minolta Sensing Europe B.V., Nieuwegein, The Netherlands) as well as a low-cost SparkFun SEN-15050 spectrophotometer (SparkFun Electronics, Niwot, CO, USA) and a readily available HP SkanJet 4850 scanner (Hewlett Packard, Palo Alto, CA, USA). The images obtained were analysed using free ImageJ software ver. 1.54. The results indicate that low-cost spectrophotometers used in the Internet of Things (IoT) systems and colour measurement methods based on vision techniques are suitable for less precise but fast measurements and, in such cases, can successfully replace the expensive and often bulky devices. Full article
(This article belongs to the Section Food Process Engineering)
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25 pages, 3802 KiB  
Article
Computer Vision in Monitoring Fruit Browning: Neural Networks vs. Stochastic Modelling
by Maria Kondoyanni, Dimitrios Loukatos, Charalampos Templalexis, Diamanto Lentzou, Georgios Xanthopoulos and Konstantinos G. Arvanitis
Sensors 2025, 25(8), 2482; https://doi.org/10.3390/s25082482 - 15 Apr 2025
Cited by 2 | Viewed by 634
Abstract
As human labour is limited and therefore expensive, computer vision has emerged as a solution with encouraging results for monitoring and sorting tasks in the agrifood sector, where conventional methods for inspecting fruit browning that are generally subjective, time-consuming, and costly. Thus, this [...] Read more.
As human labour is limited and therefore expensive, computer vision has emerged as a solution with encouraging results for monitoring and sorting tasks in the agrifood sector, where conventional methods for inspecting fruit browning that are generally subjective, time-consuming, and costly. Thus, this study investigated the application of computer vision techniques and various RGB cameras in the detection and classification of enzymatic browning in cut pears, comparing convolutional neural networks (CNNs) with stochastic modelling. More specifically, light is shed on the potential of CNN-based approaches for high-throughput and easily adapted applications and the potential of stochastic methods for precise, quantitative analyses. In particular, the developed CNN model was easily trained and achieved an accuracy of 96.6% and an F1-score greater than 0.96 during testing with real pear slices. On the other hand, stochastic modelling provided quantitative indices (i.e., the Browning Index (BI) and Yellowing Index (YI)) derived from the CIE Lab* colour model, thus offering accurate monitoring of enzymatic browning and related optical changes but it was less versatile as it required human expertise for implementation and tuning. Using both the BI and YI as input vectors in the NN Bayesian classifier increased the correct classification rate of control samples to 82.85% (4.6% increase) and to 89.81% (15% increase) for treated samples. Finally, a future need for a hybrid approach combining the strengths of both methods was identified, with improved robustness and practicality of image analysis systems in agricultural quality control to enable higher levels of automation in this area. Full article
(This article belongs to the Section Physical Sensors)
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42 pages, 7133 KiB  
Article
Advanced Diagnostics of Aircraft Structures Using Automated Non-Invasive Imaging Techniques: A Comprehensive Review
by Kostas Bardis, Nicolas P. Avdelidis, Clemente Ibarra-Castanedo, Xavier P. V. Maldague and Henrique Fernandes
Appl. Sci. 2025, 15(7), 3584; https://doi.org/10.3390/app15073584 - 25 Mar 2025
Cited by 3 | Viewed by 1758
Abstract
The aviation industry currently faces several challenges in inspecting and diagnosing aircraft structures. Current aircraft inspection methods still need to be fully automated, making early detection and precise sizing of defects difficult. Researchers have expressed concerns about current aircraft inspections, citing safety, maintenance [...] Read more.
The aviation industry currently faces several challenges in inspecting and diagnosing aircraft structures. Current aircraft inspection methods still need to be fully automated, making early detection and precise sizing of defects difficult. Researchers have expressed concerns about current aircraft inspections, citing safety, maintenance costs, and reliability issues. The next generation of aircraft inspection leverages semi-autonomous and fully autonomous systems integrating robotic technologies with advanced Non-Destructive Testing (NDT) methods. Active Thermography (AT) is an example of an NDT method widely used for non-invasive aircraft inspection to detect surface and near-surface defects, such as delamination, debonding, corrosion, impact damage, and cracks. It is suitable for both metallic and non-metallic materials and does not require a coupling agent or direct contact with the test piece, minimising contamination. Visual inspection using an RGB camera is another well-known non-contact NDT method capable of detecting surface defects. A newer option for NDT in aircraft maintenance is 3D scanning, which uses laser or LiDAR (Light Detection and Ranging) technologies. This method offers several advantages, including non-contact operation, high accuracy, and rapid data collection. It is effective across various materials and shapes, enabling the creation of detailed 3D models. An alternative approach to laser and LiDAR technologies is photogrammetry. Photogrammetry is cost-effective in comparison with laser and LiDAR technologies. It can acquire high-resolution texture and colour information, which is especially important in the field of maintenance inspection. In this proposed approach, an automated vision-based damage evaluation system will be developed capable of detecting and characterising defects in metallic and composite aircraft specimens by analysing 3D data acquired using an RGB camera and a IRT camera through photogrammetry. Such a combined approach is expected to improve defect detection accuracy, reduce aircraft downtime and operational costs, improve reliability and safety and minimise human error. Full article
(This article belongs to the Special Issue Non-destructive Testing of Materials and Structures - Volume II)
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12 pages, 863 KiB  
Article
The Exon-Based Transcriptomic Analysis of Parkinson’s Disease
by Sulev Kõks
Biomolecules 2025, 15(3), 440; https://doi.org/10.3390/biom15030440 - 19 Mar 2025
Cited by 1 | Viewed by 549
Abstract
Parkinson’s disease (PD) is a neurodegenerative disease with a complicated pathophysiology and diagnostics. Blood-based whole transcriptome analysis of the longitudinal PPMI cohort was performed with a focus on the change in the expression of exons to find potential RNA-based biomarkers. At the moment [...] Read more.
Parkinson’s disease (PD) is a neurodegenerative disease with a complicated pathophysiology and diagnostics. Blood-based whole transcriptome analysis of the longitudinal PPMI cohort was performed with a focus on the change in the expression of exons to find potential RNA-based biomarkers. At the moment of diagnosis, the expression of exons was very similar in both control and PD patients. The exon-based analysis identified 27 differentially expressed exons in PD patients three years after the diagnosis compared to the health controls. Moreover, thirteen exons were differentially expressed during the three-year progression of the PD. At the same time, control subjects had only minimal changes that can mostly be attributed to being related to aging. Differentially regulated exons we identified in the PD cohort were mostly related to different aspects of the pathophysiology of PD, such as an innate immune response or lysosomal activity. We also observed a decline in the expression of the OPN1MW3 gene that is related to colour vision, which suggests that colour vision analysis could be a practical biomarker to monitor the progression of PD. Full article
(This article belongs to the Section Molecular Medicine)
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13 pages, 1107 KiB  
Article
Colour Preference of Post Hatchling Hawksbill (Eretmochelys imbricata) and Green (Chelonia mydas) Sea Turtles in Captivity
by Jordan Drake, Mohammed F. Khayat, Rhondda Jones and Ellen Ariel
Animals 2025, 15(5), 628; https://doi.org/10.3390/ani15050628 - 21 Feb 2025
Viewed by 1200
Abstract
Variations in the ecological roles of sea turtle species may lead to differentiations in ocular design and visual sensitivity to the colour spectrum. Behavioural colour preference studies in air and in water on hatchling and post-hatchling green turtles found evidence of a blue [...] Read more.
Variations in the ecological roles of sea turtle species may lead to differentiations in ocular design and visual sensitivity to the colour spectrum. Behavioural colour preference studies in air and in water on hatchling and post-hatchling green turtles found evidence of a blue hue attractiveness when given a choice between blue, red, and yellow. This paper assessed and compared the colour preferences to singular colours via the behavioural responses of eleven hawksbill turtles and twelve green turtles at 15 months of age and at 22 months of age. Turtles were presented with one coloured water balloon per day (purple (400–450 nm), dark blue (450–490 nm), cyan (490–520 nm), green (520–560 nm), yellow (560–590 nm), orange (590–635 nm), and red (635–700 nm)). Time to contact balloons with beak and behaviours exhibited by turtles were recorded. Hawksbill turtles had the greatest level of interactions across both phases to shorter wavelengths with hue preference being between 450 and 490 nm. Green turtles consistently had the greatest level of interaction to longer wavelengths with a yellow (560–590 nm) hue preference. The results of this study support behavioural differences between two co-occurring turtle species that may reflect an adaptive preference for colour wavelengths associated with the optimal foraging niche for each. Full article
(This article belongs to the Section Herpetology)
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24 pages, 2264 KiB  
Review
Transforming Architectural Digitisation: Advancements in AI-Driven 3D Reality-Based Modelling
by Kai Zhang and Francesco Fassi
Heritage 2025, 8(2), 81; https://doi.org/10.3390/heritage8020081 - 18 Feb 2025
Cited by 1 | Viewed by 1349
Abstract
The capture of 3D reality has demonstrated increased efficiency and consistently accurate outcomes in architectural digitisation. Nevertheless, despite advancements in data collection, 3D reality-based modelling still lacks full automation, especially in the post-processing and modelling phase. Artificial intelligence (AI) has been a significant [...] Read more.
The capture of 3D reality has demonstrated increased efficiency and consistently accurate outcomes in architectural digitisation. Nevertheless, despite advancements in data collection, 3D reality-based modelling still lacks full automation, especially in the post-processing and modelling phase. Artificial intelligence (AI) has been a significant focus, especially in computer vision, and tasks such as image classification and object recognition might be beneficial for the digitisation process and its subsequent utilisation. This study aims to examine the potential outcomes of integrating AI technology into the field of 3D reality-based modelling, with a particular focus on its use in architecture and cultural-heritage scenarios. The main methods used for data collection are laser scanning (static or mobile) and photogrammetry. As a result, image data, including RGB-D data (files containing both RGB colours and depth information) and point clouds, have become the most common raw datasets available for object mapping. This study comprehensively analyses the current use of 2D and 3D deep learning techniques in documentation tasks, particularly downstream applications. It also highlights the ongoing research efforts in developing real-time applications with the ultimate objective of achieving generalisation and improved accuracy. Full article
(This article belongs to the Section Architectural Heritage)
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15 pages, 3163 KiB  
Article
Colour Vision Deficits in Children with Amblyopia: Impact of Angular Size of Stimuli on Detection
by Kristine Kalnica-Dorosenko, Anzelika Litavnieka, Renars Truksa, Aiga Svede and Sandra Valeina
Vision 2025, 9(1), 3; https://doi.org/10.3390/vision9010003 - 10 Jan 2025
Viewed by 1098
Abstract
This study investigates colour vision deficits in children with amblyopia by employing a computerized colour vision test with varying stimulus sizes (1°, 2°, and 3°). The aim is to delineate the impact of amblyopia on colour discrimination in children and to determine the [...] Read more.
This study investigates colour vision deficits in children with amblyopia by employing a computerized colour vision test with varying stimulus sizes (1°, 2°, and 3°). The aim is to delineate the impact of amblyopia on colour discrimination in children and to determine the effectiveness of the computerized colour vision test in detecting these deficits. The study involved 40 participants, divided into 20 children with amblyopia and 20 without amblyopia (control group). Our findings reveal that, during binocular viewing, children with amblyopia exhibit significant impairments in colour vision both for red–green and blue–yellow axes, primarily for 1° chromatic stimuli, but not for larger stimuli (2° and 3°). These findings offer valuable insight into the functional visual limitations in pediatric amblyopia, potentially guiding more targeted clinical assessments and interventions. Full article
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25 pages, 15537 KiB  
Article
The Periodic Feeding Frequency of the Juvenile Tropical Rock Lobster (Panulirus ornatus) in the Examination of Chemo-Attract Diet Performance and Colour-Contrast Preference
by Christopher Peters, Sandra Infante Villamil and Leo Nankervis
Animals 2024, 14(20), 2971; https://doi.org/10.3390/ani14202971 - 15 Oct 2024
Cited by 1 | Viewed by 1788
Abstract
Significant research investment into tropical rock lobster (TRL) aquaculture production methods has led to a rapidly developing industry in Vietnam and, more recently, in Australia. The need for an effective formulated feed has been highlighted for both industries; however, feed intake has been [...] Read more.
Significant research investment into tropical rock lobster (TRL) aquaculture production methods has led to a rapidly developing industry in Vietnam and, more recently, in Australia. The need for an effective formulated feed has been highlighted for both industries; however, feed intake has been a consistent limitation. Visual and chemical cues regulating feed recognition and consumption are expected to yield valuable data, leading to increased feed intake. Lobsters were placed in white- and grey-coloured enclosures to examine the effect of background colour on their feeding behaviour in terms of feeding occurrence and response time. The impact of background colour on TRL feeding behaviour found no statistically significant differences between TRL in white and grey enclosures, suggesting grayscale contrast does not directly affect feeding behaviour. Experiment 2 studied the effects of coloured feeding zones on feeding response in white enclosures. Yellow feeding zones led to a decreased feeding time (473 ± 443 s) and increased time spent feeding (168 ± 1832 s) compared to other colours, possibly due to the yellow-blue chromaticity (b*) contrast. Experiment 3 examined chemo-attractants (glycine, taurine and inositol) and their influence on the feeding behaviour of TRL, but no increased responses were observed. Experiments two and three assessed TRL feeding activity in morning and evening periods, highlighting their nocturnal behaviour, with more feeding occurring in the evening. This project enhances our understanding of photoreceptive and chemoreceptive factors affecting TRL feeding behaviour with formulated feed. It also reveals the potential for background colour changes to enhance marketable colours in commercial settings. Additionally, the study confirmed the effective use of animal tracking software (EthoVision XT) for lobster species tracking in future behavioural trials. Full article
(This article belongs to the Special Issue Factors Affecting Fish Food Intake)
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13 pages, 1746 KiB  
Review
Gene Therapy for Achromatopsia
by Megan F. Baxter and Grace A. Borchert
Int. J. Mol. Sci. 2024, 25(17), 9739; https://doi.org/10.3390/ijms25179739 - 9 Sep 2024
Cited by 3 | Viewed by 3988
Abstract
Achromatopsia is the most common cone dysfunction syndrome, affecting 1 in 30,000 people. It is an autosomal recessive disorder with a heterogeneous genetic background with variants reported in CNGA3, CNGB3, GNAT2, PDE6C, PDE6H, and ATF6. Up to 90% [...] Read more.
Achromatopsia is the most common cone dysfunction syndrome, affecting 1 in 30,000 people. It is an autosomal recessive disorder with a heterogeneous genetic background with variants reported in CNGA3, CNGB3, GNAT2, PDE6C, PDE6H, and ATF6. Up to 90% of achromatopsia patients harbour mutations in CNGA3 or CNB3, which encode for the alpha and beta subunits of the cone cyclic nucleotide-gated (CNG) channel in cone-specific phototransduction. The condition presents at birth or early infancy with poor visual acuity, nystagmus, photophobia, and colour vision loss in all axes. Multimodal retinal imaging has provided insightful information to characterise achromatopsia patients based on their genotype. There is no FDA-approved treatment for achromatopsia; however, studies have reported several preclinical gene therapies with anatomical and functional improvements reported in vivo. There are currently five gene therapy clinical trials registered for human patients at the phase I/II stage and for CNGA3 or CNGB3 causing achromatopsia. This review aims to discuss the genetics of achromatopsia, genotypic and phenotypic correlations in multimodal retinal imaging, and the developments and challenges in gene therapy clinical trials. Full article
(This article belongs to the Special Issue Advances in Gene and Cell Therapy—2nd Edition)
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11 pages, 1897 KiB  
Article
Colour Vision Changes across Lifespan: Insights from FM100 and CAD Tests
by Renārs Trukša, Sergejs Fomins, Zane Jansone-Langina and Laura Tenisa
Vision 2024, 8(3), 53; https://doi.org/10.3390/vision8030053 - 6 Sep 2024
Cited by 2 | Viewed by 2916
Abstract
(1) Background: in this research study, colour vision was evaluated in individuals aged 19 to 70 years with and without red–green colour vision disorders. (2) Methods: study participant colour vision was assessed with anomaloscope, HRR, FM100 hue, and CAD tests. (3) Results: No [...] Read more.
(1) Background: in this research study, colour vision was evaluated in individuals aged 19 to 70 years with and without red–green colour vision disorders. (2) Methods: study participant colour vision was assessed with anomaloscope, HRR, FM100 hue, and CAD tests. (3) Results: No significant correlation was found between participant age and chromatic sensitivity of the red–green colour opponent channel. However, a decrease in blue–yellow colour opponent channel chromatic sensitivity was confirmed with the FM100 hue test and CAD test. Analysis of FM100 hue test error scores across age groups revealed a decline in chromatic sensitivity in the short-wave region of visible light with increasing age. Comparison of the colour-deficient individual results of the CAD and anomaloscope tests confirmed that CAD test sensitivity and specificity reaches 100%. However, some individuals with deutan-type deficits were misclassified as having protan-type deficits. This study confirmed the effectiveness of the FM100 test in identifying individuals with moderate to severe colour vision deficits, with sensitivity and specificity rates of 81.25% and 95.38%. (4) Conclusions: It was found that the FM100 hue test effectively identifies individuals with moderate and severe red–green colour vision deficiencies. On the other hand, individuals with mild colour vision deficiencies may go undetected with the FM100 hue test. Full article
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