Search Results (11,365)

Endometriosis is characterized by enhanced cellular proliferation, migration, and resistance to apoptosis, contributing to lesion persistence and progression. Targeting cellular plasticity and mesenchymal-associated functions may therefore represent a promising therapeutic strategy. Here, we investigated the effects of Pelargonium graveolens essential oil (PGEO) on proliferation, apoptosis, migration, cytoskeletal organization, transcriptional regulation, and metabolic alterations in human endometriotic 12Z cells. PGEO treatment suppressed proliferative capacity in a concentration-dependent manner and significantly impaired cell migration, accompanied by reduced β-tubulin expression and decreased levels of mesenchymal-associated markers CD73 and CD105. Increased GRP78 expression together with ultrastructural alterations, including cytoplasmic vacuolization and mitochondrial and endoplasmic reticulum changes, indicated activation of cellular stress responses. Although transcriptional analysis revealed increased CCND1 and PIK3CA mRNA levels, these changes did not parallel the observed suppression of proliferation, suggesting compensatory regulatory responses. Untargeted metabolomic profiling revealed alterations in energy metabolism characterized by increased levels of glycolysis-related metabolites, reduced levels of several amino acids including glutamine and histidine, and changes in lipid-associated metabolites. Collectively, these findings demonstrate that PGEO suppresses proliferative and migratory behavior in endometriotic cells while modulating cytoskeletal, transcriptional, and metabolic pathways, highlighting its potential as a candidate for further investigation in endometriosis-targeted therapeutic strategies. Full article

Background/Objectives: Circadian rhythm disruption is linked to cognitive decline, yet it remains unclear how behavioral and physiological rhythm markers are differently associated with cognition in amnestic mild cognitive impairment (aMCI). The primary aim of this study was to compare sleep–wake timing, rest–activity rhythm (RAR), and dim light melatonin onset (DLMO) between patients with aMCI and cognitively normal controls. Exploratory analyses further examined their associations with domain-specific cognitive performance. Methods: Eighteen aMCI patients and 21 cognitively normal controls (NC) enrolled. Cognitive function was assessed using the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Battery (CERAD-K). Participants underwent 5-day actigraphy to assess sleep–wake timing and non-parametric RAR variables, including interdaily stability (IS), intradaily variability (IV), and relative amplitude (RA). DLMO was determined from hourly salivary melatonin samples collected over five hours before sleep onset under dim-light conditions. Group comparisons of circadian markers were conducted as the primary analyses, and generalized linear models were used for exploratory analyses of associations between circadian markers and cognitive outcomes. Results: Groups did not significantly differ in sleep–wake timing, RAR parameters and DLMO. Sleep–wake timing variables and DLMO were not significantly associated with cognitive performance. Higher IS was associated with better visuospatial memory and executive function, whereas higher RA was associated with poorer verbal memory among aMCI patients. Conclusions: Although sleep–wake timing and melatonin phase did not differ between groups nor predict cognitive performance, higher daily rhythm stability was linked to better non-verbal memory and executive functioning. In contrast, high RA may relate to poorer verbal memory in aMCI, suggesting that elevated RA may not reflect true circadian robustness required for optimal cognition. Full article

Fibers in vortex turbulence fields involve complex gas–solid coupling effects, significantly influencing the spinning process within vortex nozzles. This paper utilizes the Discrete Element Method (DEM) to refine the existing rigid bead–elastic rod model describing fiber constitutive behavior. This improved model is used to numerically simulate the dynamic behavior of a single flexible fiber within the vortex field of the nozzle. Based on elastic mechanics, this study establishes mapping functions converting relative displacement and angular displacement between beads into internal forces and torques within the beads. A contact model is also developed to handle fiber–wall interactions. The effects of different nozzle structures on fiber motion are investigated. The improved model successfully simulates the entire motion process of a single fiber during spinning. Its reliability is validated by comparing with experimentally collected fiber motion data. The study reveals that a twist chamber diameter of 6 mm, a conical cavity angle of 55 degrees, and a distance of 1.05 mm between the jet orifice and the hollow spindle yield optimal fiber twist count and wrapping density. This research provides effective insights for developing textile equipment that relies on airflow to drive fiber spinning and contributes to establishing a comprehensive twisting mechanism. Full article

This research examines the impact of Entrepreneurial Orientation and Market Orientation on Dynamic Capabilities and investigates how these capabilities influence Firm Performance in the wine tourism industry. Drawing on the Dynamic Capabilities View, the research addresses a gap in the literature by clarifying the relationships between strategic orientations (Entrepreneurial and Market) and performance outcomes in a rapidly evolving tourism context. Data were collected through a structured questionnaire administered to 171 entrepreneurs operating visitable wineries, using a five-point Likert scale. Structural Equation Modeling was employed to test the proposed relationships. The results indicate that both Entrepreneurial Orientation and Market Orientation significantly contribute to the development of Dynamic Capabilities, which in turn positively affect Firm Performance. The findings confirm the mediating role of Dynamic Capabilities in the relationship between strategic orientations and performance, offering new theoretical insights into how entrepreneurial and market-oriented behaviors translate into improved organizational outcomes. From a practical perspective, the research provides implications for wine tourism firms seeking to enhance innovation, adaptability, and market responsiveness, thereby strengthening long-term competitiveness in an increasingly dynamic and competitive environment. Full article

Those who serve in the armed forces are shaped not only by incentives and opportunity structures but also by institutions that cultivate norms of duty, authority, and collective obligation. This study argues that religious institutions function as such socializing agents and play a measurable role in military enlistment in the United States. Complementing existing research that focuses on denomination or belief as key indicators, we introduce an institutional framework that emphasizes participation in religious communities. The focus is not on the affiliation but instead on the socialization offered and conducted in those institutions. Religious communities cultivate behavioral dispositions, such as discipline, hierarchy, and collective orientation, that align with the demands of military service. As such, they are associated with an increased likelihood of enlistment. Using data from the 2024 Cooperative Election Study (CES), we employ logistic regression models to distinguish between religious identity, institutional engagement, and individual religiosity. The results show that, per our sample, religious identity and evangelical affiliation are not significant predictors of enlistment. Instead, regular participation in religious institutions is strongly and consistently associated with a higher likelihood of military service. These findings suggest that institutional socialization can be an important factor in explaining the relationship between religion and military service. Full article

This study examines how Saudi consumers evaluate the commodification of cultural symbols in fashion amid intensified heritage branding and symbolic market expansion. It addresses a gap in the literature on internal cultural commodification, where tensions surrounding authenticity, legitimacy, and commercialization emerge within the same cultural community rather than across clearly separate cultural groups. Drawing on a culturally grounded application of the Theory of Planned Behavior and related literature on consumer ethnocentrism and moral evaluation, the study investigates how perceived authenticity, perceived cultural appropriation, ethical sense, and consumer ethnocentrism shape attitudes toward cultural commodification and purchase intention in the Saudi fashion context. Data were collected through an Arabic-language questionnaire-based survey of Saudi consumers (N = 552) using a non-probability purposive sampling approach. The measurement model employed reflective scales adapted from prior literature and was assessed for reliability and validity. To strengthen methodological rigor, the analysis also considered common method bias diagnostics. The proposed relationships were tested using partial least squares structural equation modeling (PLS-SEM) with bootstrapping. The findings indicate that perceived authenticity is positively associated with attitudes toward cultural commodification and relates to purchase intention primarily through attitudes. Perceived cultural appropriation is negatively associated with both attitudes and purchase intention, suggesting both a direct deterrent effect and an indirect pathway via attitudes. Consumer ethnocentrism shows a negative association with purchase intention and a weaker negative association with attitudes, while its moderating role appears statistically significant but limited in magnitude. Ethical sense displays a more complex pattern, combining negative indirect effects through evaluative pathways with a positive direct association with intention, consistent with qualified rather than purely restrictive participation in symbolic consumption. The study contributes to the literature by clarifying how consumer responses to heritage-based fashion commercialization are shaped by representational, ethical, and normative evaluations in a non-Western setting. Practically, it suggests that fashion brands operating in Saudi heritage markets should manage authenticity claims, symbolic legitimacy, and appropriation risk with greater cultural and ethical sensitivity. Full article

Personalized transdermal drug delivery systems (TDDS) represent a transformative approach in precision medicine by enabling patient-specific, non-invasive, and controlled therapeutic administration. Conventional transdermal patches are limited by fixed dosing, passive diffusion, and interindividual variability in skin permeability and metabolism, often leading to suboptimal therapeutic outcomes. Recent advances in materials science, nanotechnology, microneedle engineering, and digital health have enabled the development of next-generation personalized TDDS capable of programmable, adaptive, and feedback-controlled drug release. Smart wearable patches integrating biosensors, microfluidics, microneedles, and wireless connectivity allow real-time monitoring of physiological and biochemical parameters, enabling closed-loop drug delivery tailored to individual metabolic profiles. Nanocarriers such as lipid nanoparticles, polymeric nanoparticles, and stimuli-responsive hydrogels further enhance drug stability, penetration, and controlled release, while 3D-printing technologies facilitate patient-specific customization of patch geometry, drug loading, and release kinetics. Artificial intelligence (AI) and machine learning tools are increasingly being employed to predict drug permeation behavior, optimize enhancer combinations, and personalize dosing regimens based on pharmacogenomic and pharmacokinetic data. Despite these advances, regulatory complexity, manufacturing standardization, long-term biocompatibility, and cybersecurity considerations remain critical challenges for clinical translation. This review highlights recent innovations in personalized TDDS, discusses their clinical potential, and examines regulatory and technological barriers. Collectively, these emerging smart transdermal platforms offer a promising pathway toward adaptive, patient-centered therapeutics that can significantly improve treatment efficacy, safety, and compliance. Future research should focus on integrating multimodal biosensing, advanced biomaterials, scalable manufacturing strategies, and robust regulatory frameworks to enable clinically validated, fully autonomous transdermal systems that can dynamically adapt to real-time patient needs in diverse therapeutic settings. Full article

Industrial drying of spunlace nonwovens (fibrous materials produced by hydroentanglement using high-pressure water jets) represents one of the most energy-intensive stages of production due to the high water content remaining after the hydroentanglement process and the large thermal energy required for water evaporation. Understanding the relationship between material structure, production parameters, and water removal intensity is therefore essential for improving process efficiency. This study investigates the drying behavior of viscose–polyester spunlace nonwovens using an integrated mass balance and statistical modeling approach based on industrial production data. Process parameters were collected from an industrial SCADA (Supervisory Control and Data Acquisition) monitoring system and combined with laboratory measurements of nonwoven mass per unit area. Experimental results show that 926–1840 kg/h of water can be removed during drying at temperatures below 100 °C, depending primarily on production speed and structural parameters of the material. A multivariate exponential regression model was developed to describe the nonlinear relationship between drying temperature, production parameters, and water removal intensity. The model demonstrated high predictive accuracy when validated with independent test data. The results indicate that mass throughput and structural characteristics dominate the drying process, while temperature variations remain limited by technological constraints. The proposed modeling framework enables predictive control of industrial drying conditions and provides a practical tool for improving energy efficiency in industrial nonwoven manufacturing. Full article

Background/Objectives: Cardiovascular disease (CVD) is the leading cause of death in China. While obesity and dietary patterns are well-established factors, the independent association between overall dietary quality and CVD prevalence—specifically whether this link persists regardless of Body Mass Index (BMI)—requires further clarification. Furthermore, the behavioral and cognitive correlates that drive dietary quality, such as health literacy, remain insufficiently explored. This study evaluated the association of dietary quality with self-reported CVD among Chinese adults, independent of BMI, and identified the key behavioral and cognitive factors associated with dietary adherence in this population. Methods: This cross-sectional study surveyed 975 Chinese adults through anonymous questionnaires and collected self-reported data on CVD, BMI, dietary quality, and health literacy. One-way analysis of variance (ANOVA) and the chi-square test were used to compare the characteristics between groups, and multivariate Logistic regression was used to analyze the association between dietary quality and the odds of CVD, sequentially adjusting for variables such as BMI, physical activity. Results: Higher dietary quality was independently associated with lower odds of CVD (Model 3: OR = 0.879, 95% CI: 0.845–0.915, p < 0.001). Notably, this inverse association remained significant after adjusting for BMI, which itself showed no significant association with CVD prevalence in the multivariable model. Regarding population profiling, poor dietary quality was significantly related to regular smoking (p < 0.05), whereas age, gender, residence, employment status, and BMI showed no significant associations with dietary quality categories. Furthermore, health literacy (p < 0.05) and physical activity (p < 0.05) showed positive associations with superior dietary quality. Conclusions: Dietary quality is a significant independent factor inversely associated with CVD prevalence, regardless of obesity status. Suboptimal dietary habits cluster among smokers and individuals with lower health literacy and physical activity levels, showing a stronger association with cognitive and behavioral factors than with demographic or occupational characteristics. Interventions should prioritize enhancing health literacy and addressing the clustering of unhealthy behaviors to effectively address the cardiovascular burden in the Chinese population. Full article

Promoting the effective use of abandoned farmland has become a key policy priority for strengthening food security in China. However, disentangling the decision-making processes among diverse participating actors is a foundational prerequisite for addressing the governance challenge of abandoned farmland utilization. Building on this, the present study employs a four-actor evolutionary game model and sensitivity analysis of key parameters to systematically examine the interactions among four key actors—local governments, village collectives, family farms, and farmers—and to identify the corresponding evolutionarily stable strategies (ESSs) across different stages of abandoned farmland utilization. The results show that: (1) Multi-actor strategic interactions in abandoned farmland utilization exhibit a multi-stage evolutionary trajectory, in which all actors gradually shift their strategic choices under changing cost–benefit structures, regulatory intensity, and coordination conditions, leading to different evolutionary stable equilibria across governance stages. (2) The configuration in which local governments adopt loose regulation, the village collective plays an active coordinating role, family farms pursue long-term operations, and farmers choose recultivation is a key condition for achieving a Pareto-optimal equilibrium. (3) Although farmers’ production willingness and behavioral choices form the basis for the utilization of abandoned farmland, spontaneous individual action alone is insufficient to address the structural contradictions currently facing abandoned farmland utilization in China. To effectively promote the evolution of abandoned farmland governance toward a stable collaborative equilibrium and ultimately realize sustainable utilization, it is necessary to further optimize governmental administrative control models and incentive mechanisms, strengthen the organizational and coordinating functions of village collectives, and improve long-term operational support systems for family farms. This study systematically elucidates the underlying logic of China’s abandoned farmland utilization from the perspective of multi-actor behavioral decision-making, providing policy-referential insights for optimizing policy design, reducing coordination costs, and improving the efficiency of abandoned farmland utilization. Full article

The integration of rapidly renewable biomass into insect production systems has been proposed as a strategy to improve resource-use efficiency in insect production. This study evaluated the graded inclusion levels of dried watermeal (Wolffia globosa) in diets of two-spotted crickets (Gryllus bimaculatus) and assessed voluntary nutrient regulation under free-choice feeding. Four fixed-inclusion diets (0%, 25%, 35%, and 45% watermeal) and one self-selection treatment were tested over 28 days. Growth performance, feed conversion ratio (FCR), survival rate (Surv), production index (PI), and whole-body composition were determined. Repeated-measures analysis using linear mixed-effects models indicated that treatment, week, and their interaction were statistically significant (p ≤ 0.024). However, partial R² analysis showed that the independent contributions of treatment and week were negligible, whereas the treatment × week interaction explained measurable variance, indicating that dietary effects were primarily expressed through time-dependent responses. Segmented regression identified a breakpoint at 35% watermeal inclusion (95% CI: 24.93–45.07), indicating that PI was the highest within a moderate supplementation range under the present fixed-diet conditions rather than at a precise single optimum. Inclusion levels beyond this threshold reduced performance. Under free-choice conditions, crickets progressively increased watermeal intake with age and maintained stable nitrogen-free extract (NFE):crude protein (CP) and gross energy (GE):CP intake ratios, selecting an average of 25–35% watermeal over the experimental period. This supplementation range improved feed efficiency and protein deposition while limiting lipid accumulation, suggesting improved energy–protein balance and nutrient partitioning. The self-selection result is interpreted as evidence of behavioral intake regulation under choice conditions and not as direct validation of the segmented-regression breakpoint. Collectively, these findings provide complementary statistical and behavioral evidence supporting a biologically relevant moderate inclusion range (approximately 30–35%) of dried watermeal. Full article

The paper utilizes the synergy of vibration and hot air flow to form a composite force field, and low-quality fine coal with viscous moisture is subjected to ash removal. The vibration signals of the bed surface at different positions are collected online using an accelerometer, and the dominant force affecting the vibration behavior of the bed is analyzed using signal time-domain analysis. By examining the impact of the synergy between vibration and airflow on the ash removal effect of low-quality, viscous moisture coal, the response of the drying and sorting behavior of low-quality fine coal to this synergy is elucidated. Based on the study of the experimental results of dehydration and ash removal of −6 + 1 mm fine coal, under the synergy of temperature and load force field, when the air flow temperature is 90 °C, v = 0.65 m/s, and f = 20 Hz, the collision force range between particles is 120 nN–370 N, which is different from that between particles. The liquid bridge force is large, which can achieve the fracture of liquid bridges between particles and strengthen the loose fluidization of particles. In addition, based on the study of the vibration characteristics of the bed surface at different positions, the vibration along the y-axis direction plays a dominant role in the density segregation behavior of the bed particles. With the increase in gas velocity and vibration frequency, the ash content of the selected clean coal exhibits a trend of first decreasing and then increasing. At the same time, the ash segregation degree initially increases and then decreases. Moreover, under the conditions of v = 0.65 m/s and f = 20 Hz, the separation effect of fine coal is the best. The separation accuracy E values of 1–6 mm without fine particles are 0.06 g/cm³, and the ash content of the clean coal is 12.55%. Full article

Background/Objectives: Energy drinks (EDs) are widely consumed by adolescents despite increasing evidence of adverse health effects. This study aimed to assess ED consumption patterns, risk perception, and associated factors among adolescents in the Principality of Asturias, Spain. Methods: A cross-sectional descriptive study was conducted between January and March 2025 in a sample of 1250 adolescents aged 13–18 years. Data were collected using an anonymous questionnaire assessing frequency and age at initiation of ED consumption, motives and contexts of use, perception of adverse effects, and co-occurrence with other risk behaviors. Descriptive analyses and linear regression models were performed to identify predictors of ED consumption. Results: Overall, 29.6% of participants reported occasional or habitual ED consumption. Consumption was significantly higher among upper secondary school students, particularly in social settings and during study-related activities (p < 0.001). ED consumption was significantly associated with other risk behaviors, including alcohol and tobacco use (p < 0.001). Additionally, 8.6% of adolescents reported that EDs have no adverse health effects. Male sex, alcohol consumption, and tobacco use were the main predictors of ED consumption. Conclusions: A substantial proportion of adolescents consume EDs, with early initiation and increasing consumption with age and educational level. Although some adverse effects are recognized, risk perception remains low. These findings underscore the need for preventive, educational, and regulatory strategies to reduce ED consumption and its normalization among adolescents. Full article

Introduction: Childhood and adolescent obesity is a growing global health challenge associated with early metabolic and cardiovascular complications. This study aims to compare questionnaire-assessed physical activity patterns and lifestyle characteristics among children and adolescents with obesity and normal-weight peers and to explore their associations with clinical measurements and cardiometabolic risk. Assessing resting metabolic rate (RMR) by indirect calorimetry may provide additional insight into metabolic status beyond conventional anthropometric indicators. Methods: This prospective cross-sectional study included 58 children and adolescents aged 5–18 years with obesity and 30 normal-weight controls evaluated in Sfânta Maria Emergency Children’s Hospital Iași, Romania. Clinical data included anthropometric measurements and available biochemical parameters. RMR was assessed through indirect calorimetry (Fitmate Pro, Cosmed, Rome, Italy). Parents completed a structured lifestyle questionnaire adapted from validated international instruments, collecting information on physical activity, sedentary behavior, and wearable device use. Data analysis was conducted using SPSS 22.0, applying descriptive statistics and Pearson correlation analysis. Results: Children with obesity reported higher body mass index (BMI) (30.48 ± 5.31 kg/m²), higher RMR values, lower physical activity levels and greater sedentary time than controls. RMR correlated positively with BMI, central adiposity, blood pressure, waist-to-height, hepatic steatosis and exercise tolerance. Although electronic devices for monitoring physical activity were more frequently used in the obesity group, this was not associated with higher activity levels. Conclusions: Children and adolescents with obesity exhibited a clustered cardiometabolic risk profile and reduced physical activity. RMR measured by indirect calorimetry may contribute to a more comprehensive metabolic assessment in pediatric obesity. Full article

Alzheimer’s disease (AD) is a neurodegenerative disorder for which no effective treatments are currently available. PANoptosis is a coordinated cell death pathway involving pyroptosis, apoptosis, and necroptosis. Astragaloside IV (AS-IV) is a bioactive saponin derived from Astragalus membranaceus. Behavioral performance was evaluated using the Morris water maze and open field tests, while neuronal damage was assessed by Nissl staining. The expression levels of Aβ, IL-18, and PANoptosis-related proteins were analyzed by Western blot. Immunofluorescence was performed to assess the co-localization of PANoptosis-associated proteins with neurons in the hippocampal region. In addition, the effects of AS-IV on the expression of PANoptosis-related proteins were examined in Aβ-induced HT22 cells. AS-IV improved spatial memory performance and alleviated anxiety-like behaviors in AD mice. Furthermore, AS-IV treatment significantly reduced Aβ protein levels and attenuated neuronal loss in the hippocampus. Key markers of PANoptosis were downregulated following AS-IV treatment. Immunofluorescence revealed strong co-localization between PANoptosis-associated proteins and neurons. In vitro, AS-IV also inhibited the Aβ-induced upregulation of PANoptosis-related proteins in HT22 cells. Collectively, these results indicate that AS-IV exerts neuroprotective effects in AD models, which may be associated with reduced Aβ protein deposition, attenuated neuronal loss, and the regulation of PANoptosis-related proteins in the hippocampus. Full article