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Search Results (313)

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16 pages, 2800 KB  
Article
The Multimorbidity Knowledge Domain: A Bibliometric Analysis of Web of Science Literature from 2004 to 2024
by Xiao Zheng, Lingli Yang, Xinyi Zhang, Chengyu Chen, Ting Zheng, Yuyang Li, Xiyan Li, Yanan Wang, Lijun Ma and Chichen Zhang
Healthcare 2025, 13(21), 2687; https://doi.org/10.3390/healthcare13212687 - 23 Oct 2025
Viewed by 91
Abstract
Aim: With the intensification of population aging, the public health challenges posed by multimorbidity have become increasingly severe. This study employs bibliometric analysis to elucidate research hotspots and trends in the field of multimorbidity against the backdrop of global aging. The immediate aim [...] Read more.
Aim: With the intensification of population aging, the public health challenges posed by multimorbidity have become increasingly severe. This study employs bibliometric analysis to elucidate research hotspots and trends in the field of multimorbidity against the backdrop of global aging. The immediate aim is to systematically map the intellectual landscape and evolving patterns in multimorbidity research. The ultimate long-term aim is to provide a scientific basis for optimizing chronic disease prevention systems and guiding future research directions. Methods: The study adopted the descriptive research method and employed a bibliometric approach, analyzing 8129 publications related to multimorbidity from the Web of Science Core Collection. Using CiteSpace, we constructed and visualized several knowledge structures, including collaboration networks, keyword co-occurrence networks, burst detection maps, and co-citation networks within the multimorbidity research domain. Results: The analysis included 8129 articles from 2004 to 2024, published across 1042 journals, with contributions from 740 countries/regions, 33,931 institutions, and 40,788 authors. The five most frequently occurring keywords were prevalence, health, older adult, mortality, and risk. The top five contributing countries globally were the United States, the United Kingdom, Germany, China, and Spain. Five pivotal research trajectories delineate the intellectual architecture of this field: ① Evolution of Disease Cluster Management: Initial investigations (2013–2014) prioritized disease cluster coordination within general practice settings, particularly cardiovascular comorbidity management through primary care protocols and self-management strategies. ② Paradigm Shifts in Health Impact Assessment: Multimorbidity outcome research demonstrated sequential transitions—from physical disability evaluation (2013) to mental health consequences like depression (2016), culminating in current emphasis on holistic health indicators including frailty syndromes (2015–2019). ③ Expansion of Risk Factor Exploration: Analytical frameworks evolved from singular physical activity metrics (2014) toward comprehensive lifestyle-related determinants encompassing behavioral and environmental dimensions (2021). ④ Emergence of Polypharmacy Scholarship: Medication optimization studies emerged as a distinct research stream since 2016, addressing therapeutic complexities in multimorbidity management. ⑤ Frontier Investigations: Cutting-edge directions (2019–2021) feature cardiometabolic multimorbidity patterns and their dementia correlations, signaling novel interdisciplinary interfaces. Conclusions: The prevalence of multimorbidity is on the rise globally, particularly in older populations. Therefore, it is essential to prioritize the prevention of cardiometabolic conditions in older adults and to provide them with appropriate and effective health services, including disease risk monitoring and community-based chronic disease care. Full article
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37 pages, 7330 KB  
Article
A LoRa-Based Multi-Node System for Laboratory Safety Monitoring and Intelligent Early-Warning: Towards Multi-Source Sensing and Heterogeneous Networks
by Haiting Qin, Chuanshuang Jin, Ta Zhou and Wenjing Zhou
Sensors 2025, 25(21), 6516; https://doi.org/10.3390/s25216516 - 22 Oct 2025
Viewed by 357
Abstract
Laboratories are complex and dynamic environments where diverse hazards—including toxic gas leakage, volatile solvent combustion, and unexpected fire ignition—pose serious threats to personnel safety and property. Traditional monitoring systems relying on single-type sensors or manual inspections often fail to provide timely warnings or [...] Read more.
Laboratories are complex and dynamic environments where diverse hazards—including toxic gas leakage, volatile solvent combustion, and unexpected fire ignition—pose serious threats to personnel safety and property. Traditional monitoring systems relying on single-type sensors or manual inspections often fail to provide timely warnings or comprehensive hazard perception, resulting in delayed response and potential escalation of incidents. To address these limitations, this study proposes a multi-node laboratory safety monitoring and early warning system integrating multi-source sensing, heterogeneous communication, and cloud–edge collaboration. The system employs a LoRa-based star-topology network to connect distributed sensing and actuation nodes, ensuring long-range, low-power communication. A Raspberry Pi-based module performs real-time facial recognition for intelligent access control, while an OpenMV module conducts lightweight flame detection using color-space blob analysis for early fire identification. These edge-intelligent components are optimized for embedded operation under resource constraints. The cloud–edge–app collaborative architecture supports real-time data visualization, remote control, and adaptive threshold configuration, forming a closed-loop safety management cycle from perception to decision and execution. Experimental results show that the facial recognition module achieves 95.2% accuracy at the optimal threshold, and the flame detection algorithm attains the best balance of precision, recall, and F1-score at an area threshold of around 60. The LoRa network maintains stable communication up to 0.8 km, and the system’s emergency actuation latency ranges from 0.3 s to 5.5 s, meeting real-time safety requirements. Overall, the proposed system significantly enhances early fire warning, multi-source environmental monitoring, and rapid hazard response, demonstrating strong applicability and scalability in modern laboratory safety management. Full article
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24 pages, 2308 KB  
Review
Review on Application of Machine Vision-Based Intelligent Algorithms in Gear Defect Detection
by Dehai Zhang, Shengmao Zhou, Yujuan Zheng and Xiaoguang Xu
Processes 2025, 13(10), 3370; https://doi.org/10.3390/pr13103370 - 21 Oct 2025
Viewed by 419
Abstract
Gear defect detection directly affects the operational reliability of critical equipment in fields such as automotive and aerospace. Gear defect detection technology based on machine vision, leveraging the advantages of non-contact measurement, high efficiency, and cost-effectiveness, has become a key support for quality [...] Read more.
Gear defect detection directly affects the operational reliability of critical equipment in fields such as automotive and aerospace. Gear defect detection technology based on machine vision, leveraging the advantages of non-contact measurement, high efficiency, and cost-effectiveness, has become a key support for quality control in intelligent manufacturing. However, it still faces challenges including difficulties in semantic alignment of multimodal data, the imbalance between real-time detection requirements and computational resources, and poor model generalization in few-shot scenarios. This paper takes the paradigm evolution of gear defect detection technology as the main line, systematically reviews its development from traditional image processing to deep learning, and focuses on the innovative application of intelligent algorithms. A research framework of “technical bottleneck-breakthrough path-application verification” is constructed: for the problem of multimodal fusion, the cross-modal feature alignment mechanism based on Transformer network is deeply analyzed, clarifying its technical path of realizing joint embedding of visual and vibration signals by establishing global correlation mapping; for resource constraints, the performance of lightweight models such as MobileNet and ShuffleNet is quantitatively compared, verifying that these models reduce Parameters by 40–60% while maintaining the mean Average Precision essentially unchanged; for small-sample scenarios, few-shot generation models based on contrastive learning are systematically organized, confirming that their accuracy in the 10-shot scenario can reach 90% of that of fully supervised models, thus enhancing generalization ability. Future research can focus on the collaboration between few-shot generation and physical simulation, edge-cloud dynamic scheduling, defect evolution modeling driven by multiphysics fields, and standardization of explainable artificial intelligence. It aims to construct a gear detection system with autonomous perception capabilities, promoting the development of industrial quality inspection toward high-precision, high-robustness, and low-cost intelligence. Full article
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25 pages, 2474 KB  
Article
Data Augmentation-Enhanced Myocardial Infarction Classification and Localization Using a ResNet-Transformer Cascaded Network
by Yunfan Chen, Qi Gao, Jinxing Ye, Yuting Li and Xiangkui Wan
Biology 2025, 14(10), 1425; https://doi.org/10.3390/biology14101425 - 16 Oct 2025
Viewed by 295
Abstract
Accurate diagnosis of myocardial infarction (MI) holds significant clinical importance for public health systems. Deep learning-based ECG, classification and localization methods can automatically extract features, thereby overcoming the dependence on manual feature extraction in traditional methods. However, these methods still face challenges such [...] Read more.
Accurate diagnosis of myocardial infarction (MI) holds significant clinical importance for public health systems. Deep learning-based ECG, classification and localization methods can automatically extract features, thereby overcoming the dependence on manual feature extraction in traditional methods. However, these methods still face challenges such as insufficient utilization of dynamic information in cardiac cycles, inadequate ability to capture both global and local features, and data imbalance. To address these issues, this paper proposes a ResNet-Transformer cascaded network (RTCN) to process time frequency features of ECG signals generated by the S-transform. First, the S-transform is applied to adaptively extract global time frequency features from the time frequency domain of ECG signals. Its scalable Gaussian window and high phase resolution can effectively capture the dynamic changes in cardiac cycles that traditional methods often fail to extract. Then, we develop an architecture that combines the Transformer attention mechanism with ResNet to extract multi-scale local features and global temporal dependencies collaboratively. This compensates for the existing deep learning models’ insufficient ability to capture both global and local features simultaneously. To address the data imbalance problem, the Denoising Diffusion Probabilistic Model (DDPM) is applied to synthesize high-quality ECG samples for minority classes, increasing the inter-patient accuracy from 61.66% to 68.39%. Gradient-weighted Class Activation Mapping (Grad-CAM) visualization confirms that the model’s attention areas are highly consistent with pathological features, verifying its clinical interpretability. Full article
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29 pages, 2376 KB  
Systematic Review
Manufacturing Supply Chain Resilience Amid Global Value Chain Reconfiguration: An Enhanced Bibliometric–Systematic Literature Review
by Yan Li, Xinxin Xia, Cong Wang and Qingbo Huang
Systems 2025, 13(10), 873; https://doi.org/10.3390/systems13100873 - 5 Oct 2025
Viewed by 775
Abstract
Global Value Chains (GVCs) have driven the worldwide dispersion of manufacturing but remain highly vulnerable to macro-level shocks, including financial crises, geopolitical tensions, and the COVID-19 pandemic. These shocks expose manufacturing supply chains (MSCs) to systemic risks, but limited research has explored how [...] Read more.
Global Value Chains (GVCs) have driven the worldwide dispersion of manufacturing but remain highly vulnerable to macro-level shocks, including financial crises, geopolitical tensions, and the COVID-19 pandemic. These shocks expose manufacturing supply chains (MSCs) to systemic risks, but limited research has explored how GVC reconfiguration mediates their impact on manufacturing supply chain resilience (MSCR). To address this gap, this study conducts an enhanced bibliometric–systematic literature review (B-SLR) of 120 peer-reviewed articles. The findings reveal that macro-level shocks induce GVC reconfigurations along geographical, value, and governance dimensions, which in turn trigger MSCR through node- and link-level mechanisms. MSCR represents a manufacturer-centered capability that enables MSCs to preserve, realign, and enhance value amid shocks. Building on these insights, this research proposes a multi-tier strategy encompassing firm-level practices, inter-firm collaborations, and policy interventions. This study outlines three key contributions. First, at the theoretical level, it embeds MSCR within a GVC framework, clarifying how GVC reconfiguration mediates SCR under macro-level shocks. Second, at the methodological level, it ensures corpus completeness through snowballing and refines bibliometric mapping with multi-dimensional visualization. Third, at the managerial level, it provides actionable guidance for firms, industry alliances, and policymakers to align MSCR strategies with the dynamics of global production networks. Full article
(This article belongs to the Section Supply Chain Management)
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18 pages, 2035 KB  
Review
Streptomyces as Biofactories: A Bibliometric Analysis of Antibiotic Production Against Staphylococcus aureus
by Pablício Pereira Cardoso, Kamila Brielle Pantoja Vasconcelos, Sámia Rocha Pereira, Rafael Silva Cardoso, Ramillys Carvalho de Souza, Lucas Francisco da Silva Nogueira, Suelen Fabrícia dos Santos Bentes, Vivaldo Gemaque de Almeida and Silvia Katrine Rabelo da Silva
Antibiotics 2025, 14(10), 983; https://doi.org/10.3390/antibiotics14100983 - 30 Sep 2025
Viewed by 611
Abstract
Infections caused by Staphylococcus aureus pose significant public health challenges, particularly due to antibiotic-resistant strains like MRSA. In this context, Streptomyces, a genus known for producing natural antibiotics, emerges as a promising source for novel therapeutic agents. In this study, a bibliometric [...] Read more.
Infections caused by Staphylococcus aureus pose significant public health challenges, particularly due to antibiotic-resistant strains like MRSA. In this context, Streptomyces, a genus known for producing natural antibiotics, emerges as a promising source for novel therapeutic agents. In this study, a bibliometric analysis of the scientific literature (2015–2024) on Streptomyces as antibiotic biofactories against S. aureus was performed, aiming to identify publication trends, collaborative networks, and emerging research areas. Using the Web of Science database, searches were performed with descriptors (“Streptomyces” AND “Staphylococcus aureus”), including original articles and reviews in English. Data were analyzed with VOSviewer and Biblioshiny to visualize collaborative networks, keyword co-occurrences, and trends. A total of 755 articles from 3705 authors were analyzed, highlighting significant collaboration (98.7%). Publications showed marked growth, particularly in Microbiology (21.7%), Pharmacology and Pharmacy (16.8%), and Biotechnology and Applied Microbiology (16.1%). China and India led in publication volume, whereas the United States exhibited the highest citation impact. Key emerging research topics include biosynthesis and metabolic optimization, antimicrobial activity and bioprospecting, mechanisms of antibiotic action and bacterial resistance, and genomic analyses. Research on Streptomyces for antibiotic production against S. aureus demonstrates continuous expansion and global interest, emphasizing the importance of international collaboration and multidisciplinary approaches. Future studies should intensify exploration of biodiverse environments, genetic engineering applications, and combinatorial strategies to effectively address antimicrobial resistance. Full article
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26 pages, 9360 KB  
Article
Multi-Agent Hierarchical Reinforcement Learning for PTZ Camera Control and Visual Enhancement
by Zhonglin Yang, Huanyu Liu, Hao Fang, Junbao Li and Yutong Jiang
Electronics 2025, 14(19), 3825; https://doi.org/10.3390/electronics14193825 - 26 Sep 2025
Viewed by 496
Abstract
Border surveillance, as a critical component of national security, places increasingly stringent demands on the target perception capabilities of video monitoring systems, especially in wide-area and complex environments. To address the limitations of existing systems in low-confidence target detection and multi-camera collaboration, this [...] Read more.
Border surveillance, as a critical component of national security, places increasingly stringent demands on the target perception capabilities of video monitoring systems, especially in wide-area and complex environments. To address the limitations of existing systems in low-confidence target detection and multi-camera collaboration, this paper proposes a novel visual enhancement method for cooperative control of multiple PTZ (Pan–Tilt–Zoom) cameras based on hierarchical reinforcement learning. The proposed approach establishes a hierarchical framework composed of a Global Planner Agent (GPA) and multiple Local Executor Agents (LEAs). The GPA is responsible for global target assignment, while the LEAs perform fine-grained visual enhancement operations based on the assigned targets. To effectively model the spatial relationships among multiple targets and the perceptual topology of the cameras, a graph-based joint state space is constructed. Furthermore, a graph neural network is employed to extract high-level features, enabling efficient information sharing and collaborative decision-making among cameras. Experimental results in simulation environments demonstrate the superiority of the proposed method in terms of target coverage and visual enhancement performance. Hardware experiments further validate the feasibility and robustness of the approach in real-world scenarios. This study provides an effective solution for multi-camera cooperative surveillance in complex environments. Full article
(This article belongs to the Section Artificial Intelligence)
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17 pages, 20573 KB  
Article
Digital Twin-Based Intelligent Monitoring System for Robotic Wiring Process
by Jinhua Cai, Hongchang Ding, Ping Wang, Xiaoqiang Guo, Han Hou, Tao Jiang and Xiaoli Qiao
Sensors 2025, 25(19), 5978; https://doi.org/10.3390/s25195978 - 26 Sep 2025
Viewed by 661
Abstract
In response to the growing demand for automation in aerospace harness manufacturing, this study proposes a digital twin-based intelligent monitoring system for robotic wiring operations. The system integrates a seven-degree-of-freedom robotic platform with an adaptive servo gripper and employs a five-dimensional digital twin [...] Read more.
In response to the growing demand for automation in aerospace harness manufacturing, this study proposes a digital twin-based intelligent monitoring system for robotic wiring operations. The system integrates a seven-degree-of-freedom robotic platform with an adaptive servo gripper and employs a five-dimensional digital twin framework to synchronize physical and virtual entities. Key innovations include a coordinated motion model for minimizing joint displacement, a particle-swarm-optimized backpropagation neural network (PSO-BPNN) for adaptive gripping based on wire characteristics, and a virtual–physical closed-loop interaction strategy covering the entire wiring process. Methodologically, the system enables motion planning, quality prediction, and remote monitoring through Unity3D visualization, SQL-driven data processing, and real-time mapping. The experimental results demonstrate that the system can stably and efficiently complete complex wiring tasks with 1:1 trajectory reproduction. Moreover, the PSO-BPNN model significantly reduces prediction error compared to standard BPNN methods. The results confirm the system’s capability to ensure precise wire placement, enhance operational efficiency, and reduce error risks. This work offers a practical and intelligent solution for aerospace harness production and shows strong potential for extension to multi-robot collaboration and full production line scheduling. Full article
(This article belongs to the Section Sensors and Robotics)
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19 pages, 4231 KB  
Article
Deep Feature Decoupling Network for Ball Mill Load Signals
by Xiaoyan Luo, Wei Huang, Saisai He, Wencong Xiao and Zhihong Jiang
Machines 2025, 13(10), 881; https://doi.org/10.3390/machines13100881 - 24 Sep 2025
Viewed by 331
Abstract
Accurately identifying the load status of a ball mill is critical for optimizing grinding efficiency and ensuring operational stability. However, the one-dimensional vibration signals collected from ball mills exhibit strong non-stationarity and a high degree of entanglement between multi-scale local transient features and [...] Read more.
Accurately identifying the load status of a ball mill is critical for optimizing grinding efficiency and ensuring operational stability. However, the one-dimensional vibration signals collected from ball mills exhibit strong non-stationarity and a high degree of entanglement between multi-scale local transient features and long-range temporal evolution patterns. To address this, rather than relying on a purely black-box approach, this paper introduces a novel Deep Multi-scale Spatial–Temporal Feature Decoupling Network (DMSTFD-Net) guided by a clear feature decoupling philosophy to enhance model interpretability. The core of DMSTFD-Net lies in its hierarchical collaborative feature refinement mechanism. It first utilizes a one-dimensional residual network (ResNet) to adaptively capture and preliminarily decouple multi-scale spatial characteristics from the raw signal. Subsequently, the extracted high-level feature sequences are fed into a bidirectional gated recurrent unit (Bi-GRU) to decouple high-order temporal dynamic patterns. Experiments on a multi-condition dataset demonstrate that the proposed network achieves a state-of-the-art accuracy of 97.65%. Furthermore, dedicated cross-condition experiments and t-SNE visualizations validate the framework’s effectiveness. The results confirm that DMSTFD-Net provides a powerful, robust, and more interpretable solution for ball mill load identification. Full article
(This article belongs to the Section Advanced Manufacturing)
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28 pages, 14783 KB  
Article
HSSTN: A Hybrid Spectral–Structural Transformer Network for High-Fidelity Pansharpening
by Weijie Kang, Yuan Feng, Yao Ding, Hongbo Xiang, Xiaobo Liu and Yaoming Cai
Remote Sens. 2025, 17(19), 3271; https://doi.org/10.3390/rs17193271 - 23 Sep 2025
Viewed by 546
Abstract
Pansharpening fuses multispectral (MS) and panchromatic (PAN) remote sensing images to generate outputs with high spatial resolution and spectral fidelity. Nevertheless, conventional methods relying primarily on convolutional neural networks or unimodal fusion strategies frequently fail to bridge the sensor modality gap between MS [...] Read more.
Pansharpening fuses multispectral (MS) and panchromatic (PAN) remote sensing images to generate outputs with high spatial resolution and spectral fidelity. Nevertheless, conventional methods relying primarily on convolutional neural networks or unimodal fusion strategies frequently fail to bridge the sensor modality gap between MS and PAN data. Consequently, spectral distortion and spatial degradation often occur, limiting high-precision downstream applications. To address these issues, this work proposes a Hybrid Spectral–Structural Transformer Network (HSSTN) that enhances multi-level collaboration through comprehensive modelling of spectral–structural feature complementarity. Specifically, the HSSTN implements a three-tier fusion framework. First, an asymmetric dual-stream feature extractor employs a residual block with channel attention (RBCA) in the MS branch to strengthen spectral representation, while a Transformer architecture in the PAN branch extracts high-frequency spatial details, thereby reducing modality discrepancy at the input stage. Subsequently, a target-driven hierarchical fusion network utilises progressive crossmodal attention across scales, ranging from local textures to multi-scale structures, to enable efficient spectral–structural aggregation. Finally, a novel collaborative optimisation loss function preserves spectral integrity while enhancing structural details. Comprehensive experiments conducted on QuickBird, GaoFen-2, and WorldView-3 datasets demonstrate that HSSTN outperforms existing methods in both quantitative metrics and visual quality. Consequently, the resulting images exhibit sharper details and fewer spectral artefacts, showcasing significant advantages in high-fidelity remote sensing image fusion. Full article
(This article belongs to the Special Issue Artificial Intelligence in Hyperspectral Remote Sensing Data Analysis)
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22 pages, 2910 KB  
Review
Global Research Trends in Catalysis for Green Hydrogen Production from Wastewater: A Bibliometric Study (2010–2024)
by Motasem Y. D. Alazaiza, Al-Anoud Al-Yazeedi, Talal Al Wahaibi, Farouk Mjalli, Abdulkareem Abubakar, Mohammed Abd El Hameed and Mohammed Javeed Siddique
Catalysts 2025, 15(9), 915; https://doi.org/10.3390/catal15090915 - 22 Sep 2025
Cited by 1 | Viewed by 757
Abstract
By turning a waste stream into a clean energy source, green hydrogen generation from wastewater provides a dual solution to energy and environmental problems. This study presents a thorough bibliometric analysis of research trends in the field of green hydrogen generation from wastewater [...] Read more.
By turning a waste stream into a clean energy source, green hydrogen generation from wastewater provides a dual solution to energy and environmental problems. This study presents a thorough bibliometric analysis of research trends in the field of green hydrogen generation from wastewater between 2010 and 2024. A total of 221 publications were extracted from Scopus database, and VOSviewer (1.6.20) was used as a visualization tool to identify influential authors, institutions, collaborations, and thematic focus areas. The analysis revealed a significant increase in research output, with a peak of 122 publications in 2024, with a total of 705 citations. China had the most contributions with 60 publications, followed by India (30) and South Korea (26), indicating substantial regional involvement in Asia. Keyword co-occurrence and coauthorship network mapping revealed 779 distinct keywords grouped around key themes like electrolysis, hydrogen evolution reactions, and wastewater treatment. Significantly, this work was supported by contributions from 115 publication venues, with the International Journal of Hydrogen Energy emerging as the most active and cited source (40 articles, 539 citations). The multidisciplinary aspect of the area was highlighted by keyword co-occurrence analysis, which identified recurring themes including electrolysis, wastewater treatment, and hydrogen evolution processes. Interestingly, the most-cited study garnered 131 citations and discussed the availability of unconventional water sources for electrolysis. Although there is growing interest in the field, it is still in its initial phases, indicating a need for additional research, particularly in developing countries. This work offers a basic overview for researchers and policymakers who are focused on promoting the sustainable generation of green hydrogen from wastewater. Full article
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30 pages, 4224 KB  
Article
Tracing Five Decades of Psoriasis Pharmacotherapy: A Large-Scale Bibliometric Investigation with AI-Guided Terminology Normalization
by Ada Radu, Andrei-Flavius Radu, Gabriela S. Bungau, Delia Mirela Tit and Paul Andrei Negru
Pharmaceuticals 2025, 18(9), 1422; https://doi.org/10.3390/ph18091422 - 21 Sep 2025
Viewed by 714
Abstract
Background/Objectives: Large-scale bibliometric assessments of psoriasis pharmacotherapy research remain limited despite significant research output in this rapidly evolving field. This study aimed to map the evolution of systemic psoriasis therapy research over five decades and demonstrate how systematic analysis of research trajectories [...] Read more.
Background/Objectives: Large-scale bibliometric assessments of psoriasis pharmacotherapy research remain limited despite significant research output in this rapidly evolving field. This study aimed to map the evolution of systemic psoriasis therapy research over five decades and demonstrate how systematic analysis of research trajectories can illuminate the transformation of specialized medical fields into central components of precision medicine. Methods: A comprehensive bibliometric analysis was conducted using Web of Science Core Collection as the single data source, examining 19,284 publications spanning 1975–2025. The methodology employed AI-enhanced terminology normalization for standardizing pharmaceutical nomenclature, VOSviewer version 1.6.20 for network visualization, and Bibliometrix package for temporal trend analysis and thematic evolution mapping. International collaboration networks, thematic evolution across three distinct periods (1975–2000, 2001–2010, 2011–2025), and citation impact patterns were systematically analyzed. Results: Four distinct developmental phases were identified, with publications growing from 9 articles in 1975 to 1638 in 2024. The United States dominated research output with 5959 documents, while Canada achieved the highest citation efficiency at 62.65 citations per document. Global collaboration encompassed 70 countries organized into four regional clusters, with a 28-nation Asia–Pacific–Africa–Middle East alliance representing the largest collaborative group. Citation impact peaked during 2001–2008, coinciding with revolutionary biological therapy introduction. Thematic evolution demonstrated systematic transformation from two foundational themes to nine specialized domains, ultimately consolidating into four core areas focused on targeted therapeutics and evidence-based methodologies. Keyword analysis demonstrated progression from basic immunological studies to sophisticated targeted interventions, evolving from tumor necrosis factor alpha inhibitors to contemporary interleukin-17/interleukin-23 pathway targeting and Janus kinase inhibitors. Conclusions: Over five decades, psoriasis therapeutics research has shifted from a niche dermatological discipline to a central model for innovation in immune-mediated diseases. This evolution illustrates how bibliometric approaches can capture the dynamics of scientific transformation, offering strategic insights for guiding pharmaceutical innovation, shaping research priorities, and informing precision medicine strategies across inflammatory conditions. Full article
(This article belongs to the Section Pharmacology)
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20 pages, 39725 KB  
Article
TFP-YOLO: Obstacle and Traffic Sign Detection for Assisting Visually Impaired Pedestrians
by Zhiwei Zheng, Jin Cheng and Fanghua Jin
Sensors 2025, 25(18), 5879; https://doi.org/10.3390/s25185879 - 19 Sep 2025
Viewed by 546
Abstract
With the increasing demand for intelligent mobility assistance among the visually impaired, machine guide dogs based on computer vision have emerged as an effective alternative to traditional guide dogs, owing to their flexible deployment and scalability. To enhance their visual perception capabilities in [...] Read more.
With the increasing demand for intelligent mobility assistance among the visually impaired, machine guide dogs based on computer vision have emerged as an effective alternative to traditional guide dogs, owing to their flexible deployment and scalability. To enhance their visual perception capabilities in complex urban environments, this paper proposes an improved YOLOv8-based detection algorithm, termed TFP-YOLO, designed to recognize traffic signs such as traffic lights and crosswalks, as well as small obstacle objects including pedestrians and bicycles, thereby improving the target detection performance of machine guide dogs in complex road scenarios. The proposed algorithm incorporates a Triplet Attention mechanism into the backbone network to strengthen the perception of key regions, and integrates a Triple Feature Encoding (TFE) module to achieve collaborative extraction of both local and global features. Additionally, a P2 detection head is introduced to improve the accuracy of small object detection, particularly for traffic lights. Furthermore, the WIoU loss function is adopted to enhance training stability and the model’s generalization capability. Experimental results demonstrate that the proposed algorithm achieves a detection accuracy of 93.9% and a precision of 90.2%, while reducing the number of parameters by 17.2%. These improvements significantly enhance the perception performance of machine guide dogs in identifying traffic information and obstacles, providing strong technical support for subsequent path planning and embedded deployment, and demonstrating considerable practical application value. Full article
(This article belongs to the Section Intelligent Sensors)
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18 pages, 81615 KB  
Article
Experiments of Network Literacy for Urban Designers: Bridging Information Design and Spatial Morphology
by Dario Rodighiero
Land 2025, 14(9), 1901; https://doi.org/10.3390/land14091901 - 17 Sep 2025
Viewed by 611
Abstract
Urban morphology has long been studied through typologies, spatial configurations, and historical change, yet cities are not static artifacts but dynamic environments continually reshaped by people, infrastructures, and politics. This article brings Actor–Network Theory (ANT) into dialogue with Aldo Rossi’s notion of the [...] Read more.
Urban morphology has long been studied through typologies, spatial configurations, and historical change, yet cities are not static artifacts but dynamic environments continually reshaped by people, infrastructures, and politics. This article brings Actor–Network Theory (ANT) into dialogue with Aldo Rossi’s notion of the locus to rethink urban design as both enduring form and relational process. Building on Manuel Lima’s taxonomy, the study develops a methodological workflow that translates street networks into visualizations, pairing embeddings with topographic maps to highlight structural patterns. Applied to a comparative set of cities, the analysis distinguishes three broad morphological tendencies—archetypal, geometrical, and relational—each reflecting different logics of urban organization. The results show how scale and connectivity condition the interpretability of embeddings, revealing both alignments and divergences between cartographic and topological representations. Beyond empirical findings, the article frames network literacy as a meeting ground for design theory, science and technology studies, and information visualization. It concludes by proposing that advancing urban morphology today requires not only new computational tools but also sustained interdisciplinary collaboration across design, urban studies, and data science. Full article
(This article belongs to the Special Issue Urban Morphology: A Perspective from Space (Second Edition))
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24 pages, 11507 KB  
Review
A Review on Ecological and Environmental Impacts of Pumped Hydro Storage Based on CiteSpace Analysis
by Hailong Yin, Xuhong Zhao, Meixuan Chen, Zeding Fu, Yingchun Fang, Hui Wang, Meifang Li, Jiahao Luo, Peiyang Tan and Xiaohua Fu
Water 2025, 17(18), 2752; https://doi.org/10.3390/w17182752 - 17 Sep 2025
Viewed by 1051
Abstract
This study conducted a systematic review of 222 research articles (2014–2024) from the Web of Science Core Collection database to investigate the ecological and environmental impacts of pumped hydro storage (PHS). Utilizing CiteSpace 6.1R software for visual analysis, the research hotspots and evolutionary [...] Read more.
This study conducted a systematic review of 222 research articles (2014–2024) from the Web of Science Core Collection database to investigate the ecological and environmental impacts of pumped hydro storage (PHS). Utilizing CiteSpace 6.1R software for visual analysis, the research hotspots and evolutionary trends over the past decade were comprehensively examined. Key findings include the following: (1) Annual publication output exhibited sustained growth, with China contributing 29.7% of total publications, ranking first globally. (2) Research institutions demonstrated broad geographical distribution but weak collaborative networks, as the top 10 institutions accounted for only 21.6% of total publications, highlighting untapped potential for cross-regional cooperation. (3) Current research focuses on three domains: ecological–environmental benefit assessment, renewable energy synergistic integration, and power grid regulation optimization. Emerging trends emphasize multi-objective planning (e.g., economic–ecological trade-offs) and hybrid system design (e.g., solar–wind–PHS coordinated dispatch), providing critical support for green energy transitions. (4) Post-2020 research has witnessed novel thematic directions, including deepened studies on wind–PHS coupling and life-cycle assessment (LCA). Policy-driven renewable energy integration research entered an explosive growth phase, with PHS–photovoltaic–wind complementary technologies emerging as a core innovation pathway. Future research should prioritize strengthening institutional collaboration networks, exploring region-specific ecological impact mechanisms, and advancing policy–technology–environment multi-dimensional frameworks for practical applications. Full article
(This article belongs to the Section Hydraulics and Hydrodynamics)
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