Search Results (803)

In this paper, we report a metal-driven structural tuning strategy with the L-histidine (His) ligand to modulate peroxidase-like nanozyme performance. Although the His coordinates with gold(III) ions to form an extended helical coordination polymer, its interaction with Cu(II) ions results in quantum-confined, ultrasmall nanoclusters. Based on the optical, structural, and surface analysis, the blue-emitting cores are stabilized by His ligands through imidazole nitrogen coordination, consistent with a Cu-centered coordination environment involved in the observed catalytic activity. According to the catalytic measurements, the His-Cu clusters outperformed the His-Au coordination polymer reference system. Steady-state kinetic modeling and 3D profiling revealed a pronounced shift in the pH optimum: low-valent Cu-containing His-Cu NCs enable efficient peroxide-dependent catalysis under nearly neutral conditions (pH 7.4), whereas His-Au CP exhibits its maximum activity under acidic conditions. Based on these findings, this work highlights nanoscale engineering for tailor-made biomimetic applications. Full article

Most active pharmaceutical ingredients (APIs) reach their target by passive systemic distribution, so the dose required for efficacy at the lesion is set by what healthy tissue can tolerate; conventional dosage forms consequently produce pharmacokinetic profiles that oscillate between toxic peaks and sub-therapeutic troughs. Nanoparticulate carriers (liposomes, lipid nanoparticles, polymeric and inorganic systems, and biomimetic carriers) and hydrogels (natural, synthetic, supramolecular, and microgel-assembled) have emerged as the dominant strategies to address this, increasingly combined as hybrid nanoparticle–hydrogel constructs in which the gel provides locoregional retention and the nanoparticles provide cargo protection, intracellular delivery and stimuli responsiveness. Stimuli-responsive chemistries (pH, redox, enzyme, ROS, hypoxia, temperature, light, magnetic, ultrasound, glucose, and multi-stimuli logic) translate the molecular signatures of a disease into spatiotemporally controlled cargo release. This narrative review consolidates the state of the art (prioritizing 2022–2026) and departs from the conventional carrier-type survey in one respect: the literature is read along an explicit chain—disease cue, sensing chemistry, carrier architecture, release mechanism and kinetics, administration route, and clinical readiness—which exposes a variable that classification by carrier type conceals. Across all three material classes, what governs release behavior is not primarily the carrier chemistry but the identity of the released species (dissolved drug, drug from an embedded nanoparticle, an intact nanoparticle, and a matrix fragment) and the transport step that limits it. This is why power-law exponent analysis developed for dissolved drug fits particulate release poorly, why statistical goodness-of-fit cannot by itself establish a release mechanism, and why carrier class predicts clinical readiness less well than administration route and regulatory product type. Translational hurdles—CMC complexity, regulatory fragmentation, anti-PEG immunogenicity, and the structural mismatch between preclinical promise and clinical efficacy—are critically appraised in light of previously reported <1% delivery efficiency analysis. This review identifies converging strategies that could move stimuli-responsive controlled release from an aspirational outcome to a routine clinical reality. Full article

Sinogram images represent projection-domain data acquired during digital breast tomosynthesis (DBT), preserving angular information prior to reconstruction. However, their low contrast and noise-related degradation limit their direct use in downstream tasks. This work proposes a budget-constrained hybrid biomimetic optimization framework for projection-domain contrast enhancement based on the integration of Particle Swarm Optimization (PSO) and the Nelder–Mead (NM) simplex method. The approach combines global exploration with local refinement under a fixed number of objective function evaluations (NFE), enabling fair and computationally efficient comparisons with standalone optimizers. Experiments were conducted on 222 labeled mammographic images (136 benign and 86 malignant), which were transformed into sinograms via the Radon transform. The proposed method achieves competitive performance in terms of PSNR, SSIM, and FSIM, while exhibiting faster convergence and reduced computational cost compared to several state-of-the-art swarm-based approaches. Additionally, the impact of the enhanced sinograms was evaluated through a downstream classification task using a Vision Transformer-based knowledge distillation scheme, demonstrating improved discrimination between benign and malignant cases. These results demonstrate that the proposed budget-constrained hybrid biomimetic strategy provides an effective and computationally efficient solution for contrast enhancement in projection-domain medical imaging. Full article

Periodontitis and dental caries remain among the most prevalent chronic diseases, and their local treatment is limited less by the choice of active agent than by the difficulty of sustaining therapeutic concentrations against salivary and crevicular clearance, the mucosal barrier and the biofilm matrix. This narrative review (PubMed/MEDLINE, Scopus, Web of Science; 2010–2026; 118 sources) maps five mechanistic classes—mucoadhesive, in situ gelling, stimuli-responsive, nano-/microparticulate and biomimetic—alongside marketed sustained-release products onto the specific barrier each addresses and onto an explicit translational gradient. The barriers are quantified rather than described: a pocket of ≈0.5 µL perfused at ≈20 µL/h turns over some 40 times hourly, giving an intra-crevicular half-life of about one minute, and the inflamed pocket is neutral-to-alkaline (pH 7.4–8.5), so acid-triggered release is a cariogenic and not a periodontal strategy, whereas alkaline-triggered release remains an open design space. A dose calculation from these figures identifies payload potency and deliverable mass, not carrier retention, as the binding constraint on phytocompound delivery. Because no single class overcomes all barriers, hybrid nano-in-macro architectures are analysed as the structural solution. Measured against a marketed benchmark of ≈0.3 mm additional probing-depth reduction, progress now depends on consolidation rather than on novelty. Full article

Myocardial infarction remains a leading cause of heart failure because current reperfusion therapies cannot prevent adverse ventricular remodeling or restore lost cardiomyocytes. Regenerative strategies based on stem cells and extracellular vesicles (EVs) have emerged as promising approaches; however, their clinical efficacy is limited by poor retention, rapid clearance, and the hostile post-infarction microenvironment. This narrative review critically examines the role of biomaterial-assisted delivery systems in enhancing stem cell and EV-based cardiac regeneration, with particular emphasis on the distinction between biomimetic and bioactive biomaterials, mechanisms of action, preclinical and clinical evidence, translational barriers, and emerging regenerative technologies. Current evidence demonstrates that injectable hydrogels, extracellular matrix-derived scaffolds, cardiac patches, conductive biomaterials, and multifunctional delivery platforms improve therapeutic retention, prolong paracrine signaling, and actively modulate inflammation, angiogenesis, fibrosis, and extracellular matrix remodeling, resulting in superior functional recovery compared with conventional delivery approaches in preclinical models. Nevertheless, robust clinical evidence remains limited because few biomaterial-assisted strategies have advanced beyond early-phase studies. Future progress will depend on integrating smart biomaterials with engineered extracellular vesicles, gene editing, and personalized regenerative approaches, together with standardized manufacturing, harmonized regulatory frameworks, and adequately powered clinical trials. Full article

Biomimetic surface texturing provides a promising strategy for regulating the vibration behavior of rolling bearings under starved lubrication. In this study, vein-like, elliptical, semi-elliptical, and composite textures inspired by Monstera deliciosa leaves were fabricated on the shaft-washer raceways of thrust cylindrical roller bearings at depths of 4 μm, 8 μm, and 12 μm. Tangential and normal vibration signals were analyzed using time-domain parameters, frequency spectra, power spectral density, and time–frequency maps. The results showed that both texture morphology and depth strongly affected vibration stability. Most textured bearings exhibited lower vibration responses than the smooth bearing after prolonged operation. Among the tested depths, 8 μm produced the most stable response, characterized by lower peak values, smoother root mean square curves, reduced power spectral density levels, and more uniform time–frequency energy distributions. The 8 μm semi-elliptical texture exhibited the best overall performance by suppressing transient impacts and high-frequency energy concentration. These findings indicate that vibration regulation in textured rolling bearings depends primarily on the synergistic matching between texture morphology and depth rather than texture complexity alone. Full article

Conventional oral and injectable drug administration still struggles with unstable plasma levels, weak targeting, and considerable systemic toxicity, problems that become especially acute in chronic disease management. Implantable and wearable biomedical devices offer one path around these limits, yet device-only platforms continue to fall short on drug loading, release control, and protection of fragile therapeutics. Integrating nanoparticle-based biomaterials into such devices has therefore moved from a research curiosity to a serious clinical strategy. As a result, understanding the design principles, translational challenges, and clinical potential of these hybrid platforms has become increasingly important. This review provides a comprehensive assessment of four major nanoparticle families—polymeric carriers (PLGA, chitosan, and micelles), lipid-based vehicles (liposomes, SLNs, and NLCs), inorganic systems (gold, mesoporous silica, iron oxide, and calcium phosphate), and hybrid composites—focusing on how their physicochemical properties govern drug encapsulation, release behavior, and tissue compatibility. These classes are then linked to specific implantable formats such as drug-eluting stents, nano-enabled scaffolds, and reservoir depots, and to wearable formats including transdermal patches, microneedle arrays, biosensor-coupled patches, and patient-actuated devices. A dedicated section addresses stimuli-responsive release driven by pH, enzymes, temperature, and electrical or magnetic fields, alongside closed-loop platforms that pair real-time biosensing with on-demand dosing. Surface engineering strategies, ligand targeting, antifouling coatings, antimicrobial layers, and immune-modulating chemistries are also discussed, together with the central translational hurdles: long-term stability, foreign body response, scale-up, sterilization, and regulatory classification of combination products. Finally, the review outlines near-term directions, including AI-driven dosing, 4D bioprinting, biomimetic nanocarriers, gene therapy delivery, and bioresorbable electronics, that together suggest where these hybrid platforms are likely to mature next. Full article

Biomimetic perception systems integrate heterogeneous cues selectively rather than treating all available information as equally reliable. Inspired by this principle, this study proposes QGFace-LLaVA, a multimodal large language model (MLLM)-centered framework for robust face analysis under imperfect metadata. A pretrained MLLM serves as the shared prompt-conditioned visual–language reasoning backbone, while structured side information, including age, gender, confidence cues, and availability indicators, is regulated through task-aware quality estimation, reliability-guided metadata calibration, gated residual correction, and counterfactual metadata reliability regularization (CMRR). Experiments on FER2013, CelebA-40, and UTKFace cover facial expression recognition, facial attribute recognition, and age estimation under clean, noisy, missing, shuffled, naturally erroneous, and counterfactual metadata conditions. The results show that metadata utility depends jointly on task relevance, metadata reliability, and fusion strategy, and that clean-setting gains do not necessarily imply robustness. QGFace-LLaVA reduces harmful dependence on unreliable metadata, while CMRR provides additional stability under corruption and mismatch. Overall, the framework transfers biomimetic selective cue integration into MLLM-based face analysis by treating metadata as reliability-controlled auxiliary evidence rather than a uniformly beneficial input. Full article

Background: Hepatocellular carcinoma (HCC) remains challenging to treat because of the limited therapeutic efficacy and insufficient selectivity of conventional therapies. To overcome these limitations, multifunctional nanoplatforms integrating biomimetic strategies and combination therapy have attracted increasing attention. Single-modality therapies are often limited by insufficient therapeutic efficacy and restricted mechanisms of action, highlighting the need for biomimetic nanoplatforms that integrate combination therapeutic strategies for enhanced antitumor performance. Methods: Herein, a biomimetic strategy-based nanoplatform (DI-ZM) was constructed via a combination of ZIF-8 biomineralization, physical adsorption of dihydroartemisinin (DHA) and indocyanine green (ICG), followed by HepG2 cell membrane coating to achieve homologous interaction. This design enables integrated chemotherapy, photothermal therapy (PTT), and photodynamic therapy (PDT) within a single system. Results: The resulting DI-ZM nanoparticles exhibited a hydrodynamic diameter of approximately ~200 nm with good colloidal stability and high drug-loading capacity. Under 808 nm laser irradiation, DI-ZM achieved a temperature elevation to ~66 °C within 5 min, together with efficient ROS generation. Compared with uncoated nanoparticles, the biomimetic membrane coating significantly enhanced cellular uptake and homologous targeting ability, as confirmed by CLSM and flow cytometry analysis. Benefiting from the biomimetic membrane coating, DI-ZM further exhibited improved homologous targeting and cellular uptake, which contributed to enhanced intracellular ROS generation. This was accompanied by significant mitochondrial membrane depolarization and apoptosis rates exceeding 80% in HepG2 cells under laser irradiation, ultimately resulting in markedly enhanced cytotoxicity. In addition, the biomimetic membrane coating also enabled efficient penetration of DI-ZM into multicellular tumor spheroids, indicating its improved tumor-penetration capability. In vivo antitumor studies further revealed effective tumor suppression with a tumor inhibition rate of approximately 97%, along with acceptable systemic tolerance in HepG2 tumor-bearing mice. Conclusion: The biomimetic membrane-coated ZIF-8 nanoplatform integrating chemotherapy with ICG-mediated phototherapy (photothermal and photodynamic therapy) provides an effective strategy for the combination therapy against HCC. Full article

Rare earth elements (REEs) are critical for advanced manufacturing and clean energy, yet their separation remains extremely challenging due to the nearly identical ionic radii of adjacent lanthanides. Conventional solvent extraction, ion exchange, and precipitation methods are limited by their high reagent consumption, slow kinetics, poor selectivity, and environmental burdens. Nanofiltration (NF) offers a green and efficient alternative—operating in the aqueous phase with low energy demand and continuous high throughput. This review systematically summarizes NF-based REE separation. We first elucidate the fundamental mechanisms (size exclusion, Donnan exclusion, dielectric exclusion, and complexation enhancement), and discuss how lanthanide hydration chemistry underpins these synergistic effects. Membrane materials, from commercial to biomimetic, are critically surveyed, with an emphasis on strategies to overcome the trade-off between permeability and selectivity. The impacts of operating conditions and solution chemistry are analyzed, and NF applications ranging from single REE systems to real leachates are assessed. A comparative evaluation positions NF against conventional technologies. Key challenges remain: poor adjacent REE selectivity, membrane fouling, performance loss at high salinity, chemical instability, and a gap between model and real feeds. Future directions include designing high-selectivity membranes, integrating machine learning optimization, establishing standardized protocols, and realizing closed-loop process integration. Full article

Scaffold architecture shapes tissue regeneration through the mechanical, topographical, and biochemical cues it presents to cells, yet geometrically elaborate scaffolds do not reliably produce more organized tissues, while comparatively simple architectures can exert strong organizational effects. We argue that scaffold performance is better understood by distinguishing geometric complexity from effective informational dimensionality: a relational property of the scaffold–cell system, defined as the number of independently manipulated architectural directions that produce distinguishable, above-noise changes in a jointly measured mechanotransductive response. Unlike structural entropy, fractal dimension, or feature-counting metrics, this construct depends on cellular accessibility, cue persistence, and non-redundancy. Mechanotransduction supplies its biological basis, integrating scaffold-derived cues through focal adhesions, cytoskeletal organization, nuclear deformation, and YAP/TAZ signaling, and we distinguish early resolvability from later organizational stabilization. We outline an operational strategy for estimating both from factorial scaffold libraries, common readout panels, and rank-based analysis of the response mapping, illustrated with selected experimental precedents rather than a systematic evidence sample. Positioned relative to biomimetic, mechanobiology-guided, and morphospace approaches, it yields testable predictions on dimensional compression, redundancy, and the resolvability–stability dissociation. Scaffold design is thus reframed from maximizing complexity or native resemblance toward engineering stable, cell-readable dimensions of organization. Full article

Inadequate cleaning of flexible endoscope channels remains a major cause of healthcare-associated infections despite established reprocessing protocols. We developed biomimetic carbon balls inspired by mustard seed surface features as a brush-free adjunct for endoscope channel cleaning, combining mild mechanical action with adsorption-based removal of organic debris. Activated carbon (AC) balls and carbon fiber (CF) balls with diameters of 1.8–3.0 mm were fabricated to fit 2.5–3.5 mm working channels and characterized by TGA, BET, SEM, and EDS. Cleaning performance was evaluated using tomato powder residue and microbiological validation, and computational fluid dynamics was used to assess flow behavior in a 2.7 mm channel containing a 2.6 mm ball under suction. CF balls showed more uniform thermal degradation (8.9% residual mass at 1000 °C) and a ribbed fibrous morphology. In contrast, AC balls exhibited porous, irregular structures with strong adsorption capacity, characterized by high thermal stability (86.4–89.3% residual mass) and pore volumes of 0.087–0.108 cm³/g and BET surface areas of 63.00 m²/g and 21.65 m²/g. After residue exposure, AC surfaces retained more particulate matter, while CF surfaces remained cleaner and promoted more pronounced wall interaction. Microbiological testing showed effective decontamination, with bacterial counts reduced below the detection limit. CFD analysis demonstrated pressure-driven gap flow, elevated local velocity, and vortex-induced wall shear stress sufficient to enhance debris removal without apparent channel damage. These results suggest that mustard seed-inspired carbon balls provide a promising brush-free strategy for endoscope reprocessing by integrating adsorption, hydrodynamic agitation, and gentle scouring to improve cleaning safety and efficacy. Full article

Biomaterial-associated infection remains a persistent challenge for implantable devices, catheters, wound dressings, and tissue-engineering scaffolds. This structured narrative review critically evaluates biomimetic superwetting polysaccharide-based composite hydrogel interfaces based on chitosan, alginate, hyaluronic acid, cellulose/nanocellulose, bacterial cellulose, and dextran. The analysis links polymer network design and cross-linking strategy to pore architecture, swelling, mechanical properties, hydration-layer stabilization, protein adsorption, bacterial adhesion, biofilm development, and cytocompatibility. Stable interfacial hydration can increase the energetic penalty for protein and bacterial approach, but high water uptake alone is insufficient: excessive swelling, low network density, poorly controlled pore interconnectivity, and weak wet-state fixation can compromise durability or provide protected sites for bacterial retention. Study-level comparisons therefore emphasize reported values for network structure, swelling, mechanics, wettability or hydration, and antibacterial/antibiofilm performance, with unreported parameters identified as such. Notably, interactions among biomaterials, bacteria, and host tissues exhibit synergistic and co-evolutionary characteristics, forming a dynamically evolving microecological balance. This eco-synergistic perspective provides a useful conceptual framework for proposing antifouling strategies that aim to regulate rather than eradicate bacterial colonization. Future work should prioritize eco-synergistic design, durable hydration, mechanically stable and porous-yet-cleanable networks, selective interfacial regulation, dynamic characterization, standardized testing, and manufacturable formulations with the minimum necessary active components. Full article

Breast cancer treatment still faces challenges including local recurrence, systemic toxicity, tumor heterogeneity, drug resistance, and immunosuppression. Conventional systemic administration provides limited exposure at the tumor site and exhibits significant toxicity. Injectable hydrogels, combining the properties of minimally invasive administration, in situ gelation, local retention, and sustained release, have become a key platform for local precision drug delivery. Compared with nanomedicines or free drugs, hydrogels can both prolong drug retention time and achieve on-demand release through the modulation of crosslinking density, degradation rate, and responsive chemical bonds. This review is organized around the material logic of such systems. Injectable hydrogels are first classified into natural, synthetic, hybrid, supramolecular, nanocomposite, and self-healing systems, the in situ gelation chemistries available to each are compared, and network parameters such as crosslinking density, mesh size, swelling, porosity, modulus, and rheology are related to release kinetics and intratumoral retention. Current research is primarily advancing along two directions: one is the construction of pH-, enzyme-, redox/ROS-, hypoxia-, ATP-, glucose-or thermo-responsive hydrogels; the other is achieving active targeting by integrating functionalized hydrogels with targets such as CD44, folate receptor, integrins, EGFR, transferrin receptor, and HER2 or with biomimetic cell-membrane coatings. On this basis, hydrogels have been extended to cancer vaccines, immune checkpoint modulation, local delivery of CAR-T/CAR-NK, as well as combination therapies involving chemotherapy, photothermal therapy, photodynamic therapy, chemodynamic therapy, sonodynamic therapy, radiosensitization, gene therapy, and theranostics. The constraints imposed on hydrogel design by different payload classes, including small molecules, natural products, proteins and peptides, nucleic acids, antibodies, exosomes, and gene-editing machinery, are further examined, and imaging-integrated theranostic gels are discussed together with the emerging role of machine learning and digital fabrication in hydrogel optimization. Based on the biological foundations of breast cancer, this review summarizes advances in the material design, microenvironment-responsive release, targeting strategies, immunomodulation, and combination therapy of hydrogels, critically evaluates the limitations of each strategy, and aims to provide a reference for the design of mechanistically well-defined and translatable hydrogel delivery systems for breast cancer. Full article

The twentieth (20th) century represents a radical transformation in architectural history. Unlike previous centuries, characterized by gradual stylistic continuity, it witnessed a succession of theoretical ruptures, technological innovations, material discoveries, and experimental design paradigms. Each movement emerged by questioning the assumptions of its predecessors, generating an experimentation laboratory that transformed the relationship between buildings, resources, climate, and society. Despite this exceptional intellectual and technological legacy, 20th-century architecture is still predominantly interpreted through its technological shortcomings, while the historical evolution of its contributions to environmental sustainability and energy efficiency is still lacking. This study reconstructs the historical genealogy of environmental sustainability and energy efficiency across the principal architectural movements of the 20th century. Through a comparative analysis of design theories and architectural principles, it identifies environmental and energy paradigms, drawbacks, and design lessons. Environmental sustainability evolved around material durability, adaptability, resource optimization, contextual integration, and life cycle thinking, whereas energy efficiency developed through passive climatic strategies, building morphology, envelope performance, daylight, natural ventilation, and environmental control. The study demonstrates that many of the principles underpinning contemporary sustainable and energy-efficient architecture originated during the 20th century. Approaches such as Parametricism, Computational Design, Biomimetic Architecture, Climate-Responsive Design, Circular Architecture, and Regenerative Design extend these concepts through new scientific understanding, digital technologies, and environmental performance objectives. Full article