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Search Results (1,425)

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14 pages, 1971 KB  
Article
Experimental Study on the Growth Pattern and Flexural Strength Characteristics of Rafted Ice
by Ying Xu, Wei Li, Kuankuan Wu, Sichong Ma, Guojun Wang, Yuepeng Li and Dayong Zhang
Oceans 2025, 6(4), 62; https://doi.org/10.3390/oceans6040062 - 29 Sep 2025
Abstract
As a critical factor in ice load calculation for marine structures in cold regions, the growth mechanism and mechanical properties of rafted ice urgently require clarification. This study systematically investigated the growth patterns and flexural strength characteristics of rafted ice through laboratory-prepared specimens. [...] Read more.
As a critical factor in ice load calculation for marine structures in cold regions, the growth mechanism and mechanical properties of rafted ice urgently require clarification. This study systematically investigated the growth patterns and flexural strength characteristics of rafted ice through laboratory-prepared specimens. Experimental results indicate that the thickness of rafted ice exhibits a negative correlation with both ambient temperature and initial ice thickness during growth. Due to the higher porosity of its frozen layer, the density of rafted ice decreases by approximately 8% on average compared to single-layer ice. Three-point bending tests demonstrate that, under the combined effect of high tensile strength in the lower ice layer and energy absorption by the porosity of the frozen layer, the flexural strength of rafted ice ranges from 1.12 to 1.34 times that of single-layer ice. Full article
(This article belongs to the Special Issue Oceans in a Changing Climate)
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20 pages, 2125 KB  
Article
A New Continuous Bending and Straightening Curve Based on the High-Temperature Creep Property of a Low-Alloy Steel Continuous Casting Slab
by Yunhuan Sui, Haiqing Lu and Xingzhong Zhang
Metals 2025, 15(9), 1059; https://doi.org/10.3390/met15091059 - 22 Sep 2025
Viewed by 146
Abstract
The existing continuous caster layout curves cause plastic deformation of slabs during bending and straightening segments, while no effective deformation occurs in the basic arc segment, which tends to induce defects, such as cracks, and compromise slab quality. High-temperature creep deformation is generally [...] Read more.
The existing continuous caster layout curves cause plastic deformation of slabs during bending and straightening segments, while no effective deformation occurs in the basic arc segment, which tends to induce defects, such as cracks, and compromise slab quality. High-temperature creep deformation is generally regarded as detrimental to material performance. If the significant and inevitable creep deformation of a slab could be utilized to accomplish bending and straightening deformation during continuous casting, it would turn a potential harm into an advantage, ultimately enhancing both production efficiency and final product quality. Therefore, a new continuous bending and straightening curve based on the high-temperature creep property of a low-alloy steel slab was designed. The new curve cancelled the original basic arc segment and smoothly connected the bending and straightening segments, which not only substantially prolonged the effective bending and straightening deformation time but also extended the creep time. The locations within the slab corresponding to the temperature range of 1100 °C to 1200 °C were obtained from the simulated temperature field results. Comparing the calculated strain rates with the steady-state creep rates revealed that within the temperature range exhibiting favorable hot ductility, the bending and straightening deformation of the slab could be accomplished entirely through creep deformation. Full article
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17 pages, 4032 KB  
Article
Design and Fabrication of Posture Sensing and Damage Evaluating System for Underwater Pipelines
by Sheng-Chih Shen, Yung-Chao Huang, Chih-Chieh Chao, Ling Lin and Zhen-Yu Tu
Sensors 2025, 25(18), 5927; https://doi.org/10.3390/s25185927 - 22 Sep 2025
Viewed by 109
Abstract
This study constructed an integrated underwater pipeline monitoring system, which combines pipeline posture sensing modules and pipeline leakage detection modules. The proposed system can achieve the real-time monitoring of pipeline posture and the comprehensive assessment of pipeline damage. By deploying pipeline posture sensing [...] Read more.
This study constructed an integrated underwater pipeline monitoring system, which combines pipeline posture sensing modules and pipeline leakage detection modules. The proposed system can achieve the real-time monitoring of pipeline posture and the comprehensive assessment of pipeline damage. By deploying pipeline posture sensing and leakage detection modules in array configurations along an underwater pipeline, information related to pipeline posture and flow variations is continuously collected. An array of inertial sensor nodes that form the pipeline posture sensing system is used for real-time pipeline posture monitoring. The system measures underwater motion signals and obtains bending and buckling postures using posture algorithms. Pipeline leakage is evaluated using flow and water temperature data from Hall sensors deployed at each node, assessing pipeline health while estimating the location and area of pipeline damage based on the flow values along the nodes. The human–machine interface designed in this study for underwater pipelines supports automated monitoring and alert functions, so as to provide early warnings for pipeline postures and the analysis of damage locations before water supply abnormalities occur in the pipelines. Underwater experiments validated that this system can precisely capture real-time postures and damage locations of pipelines using sensing modules. By taking flow changes at these locations into consideration, the damage area with an error margin was estimated. In the experiments, the damage areas were 8.04 cm2 to 25.96 cm2, the estimated results were close to the actual area trends (R2 = 0.9425), and the area error was within 5.16 cm2 (with an error percentage ranging from −20% to 26%). The findings of this study contribute to the management efficiency of underwater pipelines, enabling more timely maintenance while effectively reducing the risk of water supply interruption due to pipeline damage. Full article
(This article belongs to the Topic Innovation, Communication and Engineering)
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11 pages, 2881 KB  
Article
Experimental Investigation of Very High Cycle Fatigue and Fatigue Crack Growth Behaviors of X17CrNi15-2 Stainless Steel
by Ran Li, Fengcai Liu, Mengyu Wu, Wenshu Wei, Yuehua Lai, Hao Liu, Jian Ye, Tianze Cao, Jianfeng Li and Wenbo Li
Processes 2025, 13(9), 3004; https://doi.org/10.3390/pr13093004 - 20 Sep 2025
Viewed by 206
Abstract
Understanding the fatigue behavior of materials is essential for designing components capable of enduring prolonged use under varying stress conditions. This study investigates the high-cycle fatigue and fatigue crack growth characteristics of X17CrNi15-2 stainless steel. Very high-cycle fatigue (VHCF) and fatigue crack growth [...] Read more.
Understanding the fatigue behavior of materials is essential for designing components capable of enduring prolonged use under varying stress conditions. This study investigates the high-cycle fatigue and fatigue crack growth characteristics of X17CrNi15-2 stainless steel. Very high-cycle fatigue (VHCF) and fatigue crack growth tests were conducted on conventional fatigue and compact tension (CT) specimens fabricated from X17CrNi15-2 stainless steel. The fatigue crack growth behavior of the CT specimens was analyzed using Paris’ law. A revised version of Paris’ law was suggested based on the fatigue crack growth rate plotted against the stress intensity factor range, expanding on prior research utilizing three-point single-edge notch bend specimens. Scanning electron microscopy (SEM) was employed to examine the fracture mechanisms of both fatigue specimen types. The results indicated that the fatigue specimens failed in the VHCF regime under stress amplitudes ranging from 100 to 450 MPa. A power law correlation between stress amplitude and fatigue life was established, with material constants of 7670.3954 and −0.1663. These findings offer valuable insights into the material’s performance and are crucial for enhancing its suitability in engineering applications where high-cycle fatigue is a critical factor. Full article
(This article belongs to the Section Manufacturing Processes and Systems)
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17 pages, 4830 KB  
Article
Experimental and Numerical Studies of Two- and Three-Layer Corrugated Boards in Bending Test
by Gabriela Kmita-Fudalej and Leszek Czechowski
Materials 2025, 18(18), 4351; https://doi.org/10.3390/ma18184351 - 17 Sep 2025
Viewed by 229
Abstract
This paper deals with the analysis of four-point bending two- and three-layer corrugated boards along the direction perpendicular to the machine direction. The taken segments of paperboard were examined to determine the bending stiffness for three different configurations. The investigations were carried out [...] Read more.
This paper deals with the analysis of four-point bending two- and three-layer corrugated boards along the direction perpendicular to the machine direction. The taken segments of paperboard were examined to determine the bending stiffness for three different configurations. The investigations were carried out experimentally and numerically. The tests of bending were analysed only in the elastic range of the material. Each configuration of paperboard was modelled as an orthotropic material. The numerical analysis was based on the finite element method by applying Ansys® software. Several material properties and the thicknesses of papers were assumed to determine the general stiffness in bending. In the analysis, two different discrete models based on geometries of the paperboard were elaborated to adjust the results to the experimental ones. The results of analyses for some configurations showed good agreement with the experiment. This paper indicates some differences in stiffness between two- and three-layer paperboards. Full article
(This article belongs to the Section Materials Simulation and Design)
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17 pages, 5016 KB  
Article
Compositional Effects on Mechanical Performance of Zirconia–Magnesia–Alumina Ceramics
by Rafael Shakirzyanov, Sofiya Maznykh, Yuriy Garanin and Malik Kaliyekperov
Ceramics 2025, 8(3), 114; https://doi.org/10.3390/ceramics8030114 - 17 Sep 2025
Viewed by 183
Abstract
The study of the relationship between the composition and mechanical properties of structural ceramics based on zirconium, magnesium and aluminum oxides is an important scientific and technological task. In this study, ceramics of the composition x·ZrO2-(90−x)·MgO-10·Al2O3 (x [...] Read more.
The study of the relationship between the composition and mechanical properties of structural ceramics based on zirconium, magnesium and aluminum oxides is an important scientific and technological task. In this study, ceramics of the composition x·ZrO2-(90−x)·MgO-10·Al2O3 (x = 10–80 wt.%) were obtained using standard ceramic technology. XRD, SEM, Vickers hardness and biaxial flexural strength measurements were performed to determine the effect of concentration x on the phase composition, microstructure and mechanical characteristics of the sintered samples. The results show that with an increase in the starting concentration x in experimental samples, the fraction of the stabilized ZrO2 phase grows, and the grain size decreases. These two factors determine the values of microhardness and biaxial bending strength. Experimental investigation on the ternary oxide ceramics shows that for ceramics sintered at 1500 °C, the microhardness values varied within the range of 815–1300 HV1 and the biaxial bending strength of 110–250 MPa. Full article
(This article belongs to the Special Issue Mechanical Behavior and Reliability of Engineering Ceramics)
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24 pages, 3590 KB  
Article
Flexural Behavior and Composite Action of Structural Concrete Insulated Panels as Floor Slabs: Effects of Reinforcement Placement and Spacing
by Samreen Gul, Sarmad Shakeel, Hammad Anis Khan and Muhammad Usman
Buildings 2025, 15(18), 3347; https://doi.org/10.3390/buildings15183347 - 16 Sep 2025
Viewed by 314
Abstract
Structural Concrete Insulated Panels (SCIPs) offer a precast, lightweight, and off-site option for several types of construction including residential, commercial, and industrial structures. This study addresses a critical gap in the existing literature by investigating the flexural behavior of Structural Concrete Insulated Panels [...] Read more.
Structural Concrete Insulated Panels (SCIPs) offer a precast, lightweight, and off-site option for several types of construction including residential, commercial, and industrial structures. This study addresses a critical gap in the existing literature by investigating the flexural behavior of Structural Concrete Insulated Panels (SCIPs) under pinned-ended conditions—unlike prior research that focused primarily on fixed-ended configurations. It further introduces original variations in reinforcement placement and spacing, offering a novel perspective on enhancing composite action and deflection performance in floor slab applications. By experimentally evaluating four distinct SCIP configurations using four-point bending tests, the research contributes new empirical data to inform optimized structural design. The findings reveal ultimate moment capacities ranging from 2.84 to 5.70 kN m, and degrees of composite action between 6.5% and 28.2%. Notably, SCIP-2 and SCIP-3 satisfied ACI 318-19 deflection criteria, demonstrating their viability for structural flooring systems. The findings emphasize the capacity of SCIPs to transform the building sector by providing practical and sustainable solutions for floor systems. Full article
(This article belongs to the Special Issue Seismic Prevention and Response Analysis of Buildings)
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13 pages, 3916 KB  
Article
Experimental and Numerical Insights into the Semi-Circular Bend (SCB) Test for Tensile Strength Estimation in Rock-like Materials
by Rashid Hajivand Dastgerdi and Agnieszka A. Malinowska
Materials 2025, 18(18), 4285; https://doi.org/10.3390/ma18184285 - 12 Sep 2025
Viewed by 317
Abstract
The uncracked semi-circular bend (SCB) test has recently gained attention as a simple and material-efficient method for determining the tensile strength of brittle geomaterials. However, as reported in the literature and confirmed by our experiments, localized damage at the roller supports remains a [...] Read more.
The uncracked semi-circular bend (SCB) test has recently gained attention as a simple and material-efficient method for determining the tensile strength of brittle geomaterials. However, as reported in the literature and confirmed by our experiments, localized damage at the roller supports remains a critical limitation that may compromise measurement accuracy and test validity. This study addresses this limitation through experimental testing on red and gray sandstone, complemented by numerical simulations to provide deeper insight into stress distribution and fracture mechanisms in the SCB test. Experimental results showed that six out of twelve specimens experienced local damage, ranging from slight crushing and surficial cracking at the base roller zones in red sandstone to rock chipping in gray sandstone. The stiffer sandstone exhibited more severe local damage due to its limited deformability. These damages were attributed to minor geometric imperfections introduced during sample preparation. Nevertheless, all tests yielded valid tensile strength values, with SCB results showing good agreement with Brazilian test outcomes and demonstrating significantly lower coefficients of variation. Finite element simulations confirmed that crack initiation consistently occurred at the middle of the flat edge under pure tensile stress, indicating a mode I fracture mechanism. Numerical analyses further revealed pronounced stress concentrations, particularly compressive stresses, at the roller contact zones, induced by the specimen’s low span-to-depth ratio, which increased the fracture load required for failure. Full article
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27 pages, 3530 KB  
Article
Damage Identification and Safety Threshold During the Construction and Operation Phases of Cast-in-Place Continuous Rigid Frame Bridges
by Xuefeng Ye, Na Yang, Huina Chen, Manman Yang and Tingyao Wu
Buildings 2025, 15(18), 3282; https://doi.org/10.3390/buildings15183282 - 11 Sep 2025
Viewed by 290
Abstract
This paper presents an analysis of the mechanical characteristics of bridge structures during both construction and operation phases, with a focus on stress distribution patterns and the impact of vehicle loads on structural safety. The monitoring during the construction phase indicates that the [...] Read more.
This paper presents an analysis of the mechanical characteristics of bridge structures during both construction and operation phases, with a focus on stress distribution patterns and the impact of vehicle loads on structural safety. The monitoring during the construction phase indicates that the compressive stress of the main beam segments is mainly controlled by prestress, and the maximum compressive stress meets the specification requirements; the maximum tensile stress of the main beam occurs in the stage when the tension reinforcement of the top pier is under stress, and the tensile stress value is within the allowable range of the specification. Under the negative bending moment of the pier top, the tensile stress at the upper edge reaches the peak simultaneously with the pre-pressurization stress. In contrast, the tensile stress at the mid-span joint transfers to the lower edge, and the corresponding bending moment significantly decreases. Based on the maximum tensile stress theory, when the stress of the structure caused by the earthquake wave reaches the ultimate tensile strength of the concrete, it is prone to cause structural damage. Therefore, it is necessary to limit the vehicle weight and driving speed to reduce the vibration impact. According to the “Regulations on the Management of Over-limit Transport Vehicles on Highways” issued by the Ministry of Transport (the total designed load shall not exceed 55 tons), after calculation, it is known that the maximum allowable driving speed of a 60-ton vehicle is 81.4 km per hour, which exceeds the safety limit of the specification. The research shows that in actual operation, the driving speed needs to be dynamically controlled according to the vehicle weight to ensure the long-term safety and durability of the bridge structure. Full article
(This article belongs to the Section Building Structures)
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17 pages, 2298 KB  
Article
Influence of the Process-Related Surface Structure of L-PBF Manufactured Components on Residual Stress Measurement Using the Incremental Hole Drilling Method
by Sebastian Gersch, Ulf Noster, Carsten Schulz and Jörg Bagdahn
Appl. Sci. 2025, 15(18), 9861; https://doi.org/10.3390/app15189861 - 9 Sep 2025
Viewed by 365
Abstract
Laser Powder Bed Fusion (L-PBF) parts combine geometric freedom with process-induced rough surfaces that challenge residual-stress metrology. We evaluated the accuracy of the incremental hole-drilling (IHD) method with electronic speckle pattern interferometry (ESPI) by applying defined stresses via four-point bending to stress-relieved AlSi10Mg [...] Read more.
Laser Powder Bed Fusion (L-PBF) parts combine geometric freedom with process-induced rough surfaces that challenge residual-stress metrology. We evaluated the accuracy of the incremental hole-drilling (IHD) method with electronic speckle pattern interferometry (ESPI) by applying defined stresses via four-point bending to stress-relieved AlSi10Mg coupons, rather than measuring unknown process stresses. Flat specimens (2 mm, thin per ASTM E837) were analyzed on up-skin, side-skin, and CNC-milled surfaces; thin-specimen calibration coefficients were used. After a preliminary inter-specimen check (three specimens per surface; spread < 8 MPa), one representative specimen per surface was tested with three drill sites to assess intra-specimen uniformity. Measured IHD–ESPI stresses agreed best at 70 MPa: deviations were ~4.1% (up-skin), 6.0% (side-skin), and 6.24% (CNC-milled). At 10 MPa the relative errors increased (23.6%, 18.4%, and 1.40%), consistent with reduced ESPI signal-to-noise and fixture compliance in the low-stress regime. At 140 MPa, deviations rose again (21.1%, 14.3%, and 13.1%), reflecting operation near the ~60% Rp0.2 elastic limit of hole-drilling and potential local plasticity. Surface-dependent artifacts also mattered as follows: the side-skin required no coating and performed comparably to CNC-milled, whereas the up-skin’s roughness plus matting spray introduced fringe distortions and chip/coating debris near the hole. This controlled study indicates that IHD–ESPI can provide reliable results on L-PBF AlSi10Mg in the mid-stress range when surface preparation, coating, and rig compliance are carefully managed. Limitations include excluding down-skin surfaces and testing only one specimen per condition; thus, results should be generalized cautiously. Full article
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19 pages, 2667 KB  
Article
Theoretical Aspects of Topology and Successful Applications to Glasses and Proteins
by Punit Boolchand, James Charles Phillips, Matthieu Micoulaut and Aaron Welton
Int. J. Topol. 2025, 2(3), 14; https://doi.org/10.3390/ijt2030014 - 9 Sep 2025
Viewed by 525
Abstract
The origin of glass formation has been one of the greatest mysteries of science. The first clues emerged in GexSe1-x glasses, where the bond-stretching and bond angle-bending constraints are countable, and it was found that the most favorable compositions for [...] Read more.
The origin of glass formation has been one of the greatest mysteries of science. The first clues emerged in GexSe1-x glasses, where the bond-stretching and bond angle-bending constraints are countable, and it was found that the most favorable compositions for glass formation involved matching constraints with the degrees of freedom. Modulated-Differential Scanning Calorimetric (MDSC) studies on GexSe1-x chalcogenide glasses revealed two elastic phase transitions—a stiffness transition at x = 0.20 and a stress transition at x = 0.26—leading to the observation of three topological phases: a flexible phase at x < 0.20, an intermediate phase in the 0.20 < x < 0.26 range, and a stressed–rigid phase for compositions x > 0.26. The three topological phases (TPs) have now been generically observed in more than two dozen chalcogenides and modified oxide glasses. In proteins, the transition from the unfolded (flexible) to the folded (isostatically rigid intermediate) phase represents the stiffness transition. Self-organization causes proteins to display a dynamic reversibility of the folding process. The evolutions of protein dynamics may also exhibit stiffness phase transitions similar to those seen in glasses. Full article
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13 pages, 4881 KB  
Article
Optimisation of Fibre-Reinforced Hybrid Composites Under Combined Loading
by Chensong Dong and Joseph Abel Philip Vaidyan
J. Compos. Sci. 2025, 9(9), 486; https://doi.org/10.3390/jcs9090486 - 8 Sep 2025
Viewed by 337
Abstract
Fibre-reinforced hybrid composites offer an effective balance between strength, weight, and cost by combining multiple fibre types within a single matrix. This study focuses on optimising the design of carbon/glass fibre-reinforced hybrid composites under combined bending and torsional loading using finite element analysis [...] Read more.
Fibre-reinforced hybrid composites offer an effective balance between strength, weight, and cost by combining multiple fibre types within a single matrix. This study focuses on optimising the design of carbon/glass fibre-reinforced hybrid composites under combined bending and torsional loading using finite element analysis (FEA) and response surface methodology. Twelve different layup configurations, including sandwich and non-sandwich hybrid designs, were analysed to identify the optimal ply angles and fibre volume fractions that maximise failure load while minimising material cost and density. The results reveal that sandwich-type layups, such as [C3G]S, [C2G2]S, and [CG3]S, demonstrate superior strength-to-weight performance, achieving failure loads exceeding 300 N. The study also confirms that optimal ply angles range from 12° to 30°, depending on the layup configuration, and that increasing the carbon fibre volume fraction generally enhances failure load, though an optimal balance with glass fibres must be maintained. The findings provide valuable design guidelines for engineers seeking to tailor hybrid composites for aerospace, automotive, and structural applications. Future work should focus on experimental validation and extending the analysis to additional loading conditions, such as impact and fatigue, to further improve the robustness of hybrid composite structures. Full article
(This article belongs to the Special Issue Recent Progress in Hybrid Composites)
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21 pages, 4203 KB  
Article
An Optimal Control Strategy Considering Fatigue Load Suppression for Wind Turbines with Soft Switch Multiple Model Predictive Control Based on Membership Functions
by Shuhao Cheng, Yixiao Gao, Jia Liu, Changhao Guo, Fang Xu and Lei Fu
Energies 2025, 18(17), 4695; https://doi.org/10.3390/en18174695 - 4 Sep 2025
Viewed by 703
Abstract
Model predictive control (MPC) has been proven effective in terms of cooperative control for wind turbines (WTs). Previous work was limited to segmented linearization at a specific operating point, which significantly affected the robustness of the MPC performance. Moreover, due to nonlinearity, frequent [...] Read more.
Model predictive control (MPC) has been proven effective in terms of cooperative control for wind turbines (WTs). Previous work was limited to segmented linearization at a specific operating point, which significantly affected the robustness of the MPC performance. Moreover, due to nonlinearity, frequent control switching would result in the instability and fluctuation of the closed-loop control system. To address these issues, this paper proposes a novel cooperative control strategy considering fatigue load suppression for wind turbines, which is named soft switch multiple model predictive control (SSMMPC). Firstly, based on the gap metric, a model bank is constructed to divide the nonlinear WT model into several linear segments. Then, the multiple MPC is designed in a wide range of operating points. To settle the control signal oscillation problem, a soft-switching rule based on the triangular–trapezoidal hybrid membership function is proposed during controller selection. Several simulations are performed to verify the effectiveness and flexibility of SSMMPC in the partial-load region and full-load region. The results confirm that the proposed SSMMPC exhibits excellent performance in both reference operating point tracking and fatigue load mitigation, especially for the main shaft torque and tower bending load. Full article
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19 pages, 5270 KB  
Article
Design Theory and Experimental Study of Strengthening Reinforced Concrete Beams Using Prestressed Carbon Fiber Sheets
by Zejun Zhang, Yu Qin, Guanxu Long, Yao Ran, Yanhua Guan, Yan Wang, Renjuan Sun and Yuanshun Qian
Buildings 2025, 15(17), 3126; https://doi.org/10.3390/buildings15173126 - 1 Sep 2025
Viewed by 457
Abstract
To improve the design theory of prestressed carbon fiber sheet reinforcement and enrich its practical application, a corresponding theoretical analysis and experimental study were carried out. According to the ductile failure condition of reinforced concrete (RC) beams and the plane cross-section assumption, the [...] Read more.
To improve the design theory of prestressed carbon fiber sheet reinforcement and enrich its practical application, a corresponding theoretical analysis and experimental study were carried out. According to the ductile failure condition of reinforced concrete (RC) beams and the plane cross-section assumption, the initial tensile strain control range of carbon fiber sheets with different reinforcement layers was analyzed. Based on the requirement of improving the flexural capacity of beams, a calculation method for reinforcement layers and the initial tensile strain of carbon fiber sheets was proposed. According to the requirements of the practice of prestressed carbon fiber sheet reinforcement, a design process for strengthening RC beams with prestressed carbon fiber sheets was proposed. Through the proposed design method and design process, the design and practice of prestressed carbon fiber sheet reinforcement of RC beams were carried out, and a four-point bending test was carried out on a reinforced beam. The results showed that the failure mode of RC beams after reinforcement was plastic failure, which met the designed bearing capacity requirement. Full article
(This article belongs to the Section Building Structures)
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22 pages, 3886 KB  
Article
Targeted Development of an Optimised Formulation for 3D-Printing of a Sertraline Hydrochloride-Containing Drug Delivery System with Immediate-Release Characteristics Utilising a Mixture Design
by Mirco Bienhaus, Leif Neumann, Charlotte Müller and Frank E. Runkel
Pharmaceutics 2025, 17(9), 1137; https://doi.org/10.3390/pharmaceutics17091137 - 30 Aug 2025
Viewed by 737
Abstract
Objectives: Although 3D-printing has been identified as a promising technique for personalised medicine manufacturing, developing complex formulations that are suitable for the process can be challenging. This study evaluates the use of a mixture design for the targeted development of an optimised formulation [...] Read more.
Objectives: Although 3D-printing has been identified as a promising technique for personalised medicine manufacturing, developing complex formulations that are suitable for the process can be challenging. This study evaluates the use of a mixture design for the targeted development of an optimised formulation designed for the 3D-printing of oral dosage forms containing the drug sertraline hydrochloride featuring immediate-release drug dissolution. Methods: The polymers Eudragit E PO, Kollidon 17 PF and hydroxypropyl cellulose were compared in simple screening experiments regarding their extrudability, printability and disintegration. A combination of Eudragit E PO and Kollidon 17 PF proved superior and therefore served as the basis for the mixture design. The resulting blends were processed via hot melt extrusion to produce filaments, which were then measured for bending stress using a 3-point-bending-test, and 3D-printed sample plates were used to determine the crystallinity index of sertraline hydrochloride using X-ray diffraction in a previously identified range with low interference from the other components. The formulation was optimised using statistically based models with the aim of minimising the bending stress to obtain flexible, process-robust filaments and simultaneously minimising the crystallinity index with the intention of improving the solubility of the drug by maximising its amorphous content. Results: The filaments made from the optimised formulation could be reliably printed, and the amorphous state of the active ingredient therein was confirmed. The oral dosage forms produced from these showed immediate release characteristics in an acidic medium. Conclusions: This study demonstrates the advantages of a mixture design for optimising complex formulations in a time- and resource-efficient way and could serve as a basis for other research groups to develop innovative, customisable drug delivery systems more effectively. Full article
(This article belongs to the Section Physical Pharmacy and Formulation)
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