Search Results (31)

Introduction: The global rise in antimicrobial resistance poses a growing threat to public health, particularly in low- and middle-income countries where diagnostic capacity and surveillance systems remain limited. In these settings, optimizing empiric antibiotic prescribing is critical, and syndromic antibiograms offer a promising approach to support evidence-based decision-making. This study examines anticipated barriers and facilitators to the adoption of syndromic antibiograms from the perspectives of pediatric clinicians and laboratory professionals at Maputo Central Hospital in Mozambique. Methods: Guided by the Dynamic Adaptation Process (DAP) framework, this qualitative study used semi-structured interviews with eighteen healthcare professionals to explore empiric antibiotic prescribing practices, perceptions of syndromic antibiograms, and system-level barriers and facilitators. Data were analyzed thematically using deductive codes derived from the DAP framework alongside inductive codes generated from participants’ narratives. Results: Barriers were identified at individual, organizational, and systems levels. Individual barriers included limited awareness, reliance on traditional practices, and resistance to change. Organizational barriers included weak leadership support, insufficient training, poor communication between clinicians and laboratory staff, suboptimal sample collection, heavy workloads, and staff shortages. Systems-level barriers comprised shortages of laboratory supplies and medicines, delays in laboratory results, and weak monitoring mechanisms. Facilitators included health worker motivation for evidence-based practice, organizational collaboration, peer and team support, and the presence of influential champions. Systems-level enablers included functional laboratory services, supportive institutional environments, alignment with clinical guidelines, and recognition of clinical utility. Conclusions: Successful implementation of syndromic antibiograms in LMIC will require addressing systemic and organizational barriers while fostering professional motivation, collaboration, and institutional support. Sustainable integration will depend on coordinated strategies—including resource strengthening, continuous training, supportive leadership, and structured monitoring—that collectively strengthen antimicrobial stewardship and inform health policy. Full article

We present a brief review of a nontraditional but significant application for a high-temperature charged plasma. The unorthodox proposition was made by Barry Ninham concerning a contribution from Casimir forces across high-temperature electron–positron plasma in nuclear interactions. The key message in this review is that high temperatures (about ${10}^{11}$ K) are found to be essential. Certainly, classical, semi-classical, and quantum considerations for the background media impact both the Casimir effect and the physics of stars and the Universe. Full article

The SIU wishes to extend its gratitude to the urologists who contributed their time to review abstract submissions for the 45th SIU Congress:Refaat Abusamra, Libya;Sanjai Addla, India;Kinju Adhikari, India;Neeraj Agarwal, United States;Madhu Agrawal, India;Sachin Agrawal, United Kingdom;Thomas Ahlering, United States;Shusuke Akamatsu, Japan;Peter Albers, Germany;Salah Albuheissi, United Kingdom;Naif Alhathal, Saudi Arabia;Bedeir Ali-El-Dein, Egypt;Murtadha Almusafer, Iraq;Anastasios Anastasiadis, Greece;Mohamed Arafa, Qatar;Amandeep Arora, India;Zeeshan Aslam, United Kingdom;Hammad Ather, Pakistan;Widi Atmoko, Indonesia;Melanie Aubé-Peterkin, QC;Riccardo Autorino, United States;Ben Ayres, United Kingdom;Puskal Kumar Bagchi, India;Ganesh Bakshi, India;Mevlana Derya Balbay, Turkey;Neil Barber, United Kingdom;John Barry, United States;Jens Bedke, Germany;Elisa Berdondini, Italy;Gajanan Bhat, India;Amit Bhattu, United States;Naeem Bhojani, Canada;N I Bhuiyan, Bangladesh;Marta Bizic, Serbia;Damien Bolton, Australia;Vincenzo Borgna, Chile;Muhammad Bulbul, Lebanon;Gian Maria Busetto, Italy;Ana Gabriela Caballero Garcia, Mexico;Adam Calaway, United States;Amparo Camacho, United States;Kevin Campbell, United States;Francesco Capelan, Switzerland;Manuel Castanheira de Oliveira, Portugal;Christine Joy Castillo, Philippines;David Castro-Diaz, Spain;Arun Chawla, India;Manohar ChikkaMoga Siddaiah, India;Archil Chkhotua, Georgia;Sung Yong Cho, Korea, Rep [...] Full article

Objective: Neurosurgical interventions for medically refractory hypertonia (MRH) benefit both patients and their caregivers. Concurrent severe rotatory scoliosis and fusion constructs can make traditional microsurgical rhizotomy and navigated radiofrequency ablation (RFA) peripheral rhizotomy technically infeasible. We report the first case series of lumbosacral endoscopic ventral–dorsal rhizotomy (eVDR) in patients with MRH, and highlight this novel, minimally invasive, safe, and effective technique. Material and Methods: We retrospectively reviewed our single institution series of four patients with advanced hypertonia, gross motor function classification scale (GMFCS) 5, and severe rotatory scoliosis who underwent an eVDR using a flexible endoscope. We report demographics, operative characteristics, and outcomes. Results: Four patients underwent bilateral L1-S1 eVDR. Two patients had spastic quadriplegia and two had mixed spastic and dystonic hypertonia. Mean operative time was 225 ± 11 min and mean estimated blood loss (EBL) was 28.8 ± 26.2 mLs. Average length of stay was 2.75 days (range = 1–5 days), and average follow-up was 5.75 months (range = 3–9 months). All patients had significant decrease in bilateral lower extremity modified Ashworth Scale (mAS) scores (median decrease = 3, interquartile range [IQR] = 1; Wilcoxon rank-sum test z = −2.3, p = 0.02). The median decrease in Barry–Albright Dystonia Scale (BADS) scores for both patients with dystonia was 8 (IQR = 0). Two patients had minor perioperative events; none required additional surgery. All parents reported improvement in caregiving metrics. Conclusions: eVDR offers a safe and effective approach for tone reduction in patients with MRH and severe rotatory scoliosis and/or fusion hardware, which disallows traditional approaches. Full article

This study explores the different techniques used to manufacture porous clay-based ceramics, examining their properties such as porosity, strength, permeability and filtration efficiency. Different techniques are discussed in this review, with additive manufacturing being one of the most innovative techniques for manufacturing porous ceramics. Porous ceramics have their applications in numerous domains. Such ceramic filters have the advantages of retaining heavy materials, suspended particles, bacteria, viruses and, water turbidity. Thus, the choice of the technique and propriety is a crucial step in obtaining a porous ceramic with the best performance. Barry et al. prepared porous phyllosilicate-based ceramics by freeze-tape casting on four samples and obtained porosity values in the range of 67–79% and diametrical compressive strength in the range of 3–7 MPa. Manni et al. prepared porous red ceramics from Moroccan clay and coffee waste (10, 20 and 30 wt.%) via uniaxial pressing and sintering at 1150 °C. They obtained porosities ranging from 30.2 to 63.8% and flexural strength values from 1.8 to 19.5 MPa. Medri et al. prepared ZrB2-based porous bodies with the use of sponges and polyurethane foams as templates via the replica method and obtained high porosity over 80% and compressive strength up to 4.8 MPa. The use of clay and peanut shell mixtures was used in preparing porous silicate ceramics after unidirectional pressing and sintering at 1100 °C. These samples included 25 mass% of peanut shells, and exhibited porosity in the range of 40 to 60% and diametrical compressive strength in the range of 1–6 MPa. Such properties are suitable for domestic use of these types of clay-based ceramic filters. Moreover, the permeability values and removal of some pollutants, like arsenic, have been satisfactory for the first set of samples. Full article

Thirteen porcelains assigned to Sèvres factory productions and a few references to the other contemporary factories (Chantilly, Limoges, and Venice) have been studied on-site with a portable X-ray fluorescence (pXRF) spectrometer in order to control the provenance attribution. Characteristic XRF signals of major elements (Si, Ca, K, Pb) and minor/trace (Au, Bi, As, Ti, Co, Cu, Zn, Ni, Y, Zr, Rb, and Sr) elements are compared for the paste, blue mark, various glazed (colored) areas, and gilding. The comparison of peak intensities clearly distinguishes different types of hard- and soft-paste porcelain, made from either similar or distinct raw materials. The analysis of transition elements associated with cobalt identifies three types of cobalt blue and reveals that du Barry-style decoration on certain artifacts was typical of 19th-century production. On-site comprehensive studies of the two famous Etruscan-style breast bowls from Rambouillet Castle dairy, using pXRF and Raman spectroscopy, confirm the use of soft-paste porcelain for the cup and hard-paste for its support, providing detailed information on the use of gold nanoparticles in the burgundy-colored decoration. Full article

This article considers religion in extractive zones by focusing on a religious practice in an extractive zone, namely, an Afro-Brazilian Irmandade (Catholic lay religious association) devoted to Our Lady of Mercy in Diamantina, Minas Gerais, Brazil. It adopts approaches from history and cultural studies to examine art, architecture, archives, and material culture, and brings these methodologies into conversation with Mary Louis Pratt’s notion of contact zones, Charles Long’s connection between these zones and new religious practices, Eduardo Gudynas’ definition of extraction, and Macarena Gómez-Barris’ decolonial methodologies for approaching the study of extractive zones. This study is contextualized in the history of mining in Brazil, the connection between mining and enslavement of Africans in the Americas, and the enduring legacy of lay religious associations in Brazil. The article then examines the association’s church, focusing on its late 18th and early 19th century façade and the statues at its main altar, and its 19th and 20th century maintenance records. It suggests that the Irmandades are engaged in a unique religious practice that arises within an extractive region because of specific historical, political, and social reasons, and that they give their members a place within the existing structures even as they challenge them. Full article

From the late 1960s onwards, the groups of Barry Ninham and Adrian Parsegian, and their many collaborators, made a number of essential contributions to theory and experiment of intermolecular forces. In particular, they explored the semi-classical theory: Maxwell’s equations and Planck quantization of light leads to Lifshitz and Casimir interactions. We discuss some selected thought-provoking results from Ninham and his group. Some of the results have been conceived as controversial but, we would say, never uninteresting. Full article

The discovery of Helicobacter pylori (H. pylori) in the early 1980s by Nobel Prize winners in medicine Robin Warren and Barry Marshall led to a revolution in physiopathology and consequently in the treatment of peptic ulcer disease. Subsequently, H. pylori has also been linked to non-gastrointestinal diseases, such as autoimmune thrombocytopenia, acne rosacea, and Raynaud’s syndrome. In addition, several studies have shown an association with cardiovascular disease and atherosclerosis. Our narrative review aims to investigate the connection between H. pylori infection, gut microbiota, and extra-gastric diseases, with a particular emphasis on atherosclerosis. We conducted an extensive search on PubMed, Google Scholar, and Scopus, using the keywords “H. pylori”, “dysbiosis”, “microbiota”, “atherosclerosis”, “cardiovascular disease” in the last ten years. Atherosclerosis is a complex condition in which the arteries thicken or harden due to plaque deposits in the inner lining of an artery and is associated with several cardiovascular diseases. Recent research has highlighted the role of the microbiota in the pathogenesis of this group of diseases. H. pylori is able to both directly influence the onset of atherosclerosis and negatively modulate the microbiota. H. pylori is an important factor in promoting atherosclerosis. Progress is being made in understanding the underlying mechanisms, which could open the way to interesting new therapeutic perspectives. Full article

Barry Turner’s 1978 Man-made Disasters and Charles Perrow’s 1984 Normal Accidents were seminal books but a detailed comparison has yet to be undertaken. Doing so is important to establish content and priority of key ideas underpinning contemporary safety science. Turner’s research found socio-technical and systemic patterns that meant that major organisational disasters could be foreseen and were preventable. Perrow’s macro-structuralist industry focus was on technologically deterministic but unpredictable and unpreventable “system” accidents, particularly rare catastrophes. Andrew Hopkins and Nick Pidgeon respectively suggested that some prominent writers who wrote after Turner may not have been aware of, or did not properly acknowledge, Turner’s work. Using a methodology involving systematic reading and historical, biographical and thematic theory analysis, a detailed review of Turner’s and Perrow’s backgrounds and publications sheds new light on Turner’s priority and accomplishment, highlighting substantial similarities as well as clear differences. Normal Accidents did not cite Turner in 1984 or when republished with major additions in 1999. Turner became better known after a 1997 second edition of Man-made Disasters but under-acknowledgment issues by Perrow and others continued. Ethical citation and potential reasons for under-acknowledgment are discussed together with lessons applicable more broadly. It is concluded that Turner’s foundational importance for safety science should be better recognised. Full article

To assess the performance and scalability of the Unified Forecast System (UFS) Short-Range Weather (SRW) application, case studies are chosen to cover a wide variety of forecast applications. Here, model forecasts of Hurricane Barry (July 2019) are examined and analyzed. Several versions of the Global Forecast System (GFS) and Rapid Refresh Forecast System (RRFS) physics suites are run in the UFS-SRW at grid spacings of 25 km, 13 km, and 3 km. All model configurations produce significant track errors of up to 350 km at landfall. The track errors are investigated, and several commonalities are seen between model configurations. A westerly bias in the environmental steering flow surrounding the tropical cyclone (TC) is seen across forecasts, and this bias is coincident with a warm sea surface temperature (SST) bias and overactive convection on the eastern side of the forecasted TC. Positive feedback between the surface winds, latent heating, moisture, convection, and TC intensification is initiated by this SST bias. The asymmetric divergent flow induced by the excess convection results in all model TC tracks being diverted to the east as compared to the track derived from reanalysis. The large differences between runs using the same physics packages at different grid spacing suggest a deficiency in the scalability of these packages with respect to hurricane forecasting in vertical wind shear. Full article

This paper explores the development of two theories of human behavior as they relate to work systems. Both Murray Bowen and Barry Oshry formulated theories of how people operate in groups. Bowen developed his theory through observation of families and extended his thinking to apply more broadly. Oshry observed work systems in his lab and thought what he saw there could also be true in families and society at large. Practitioners have applied both theories in their work with groups. However, neither theory has received much attention in terms of the theoretical concepts they contain or the processes the theoreticians used to generate them. The purpose of this paper is to examine the methods these two theorists use to create their frameworks, compare and contrast the theories they posited as a result, and consider the possible future development for them. Full article