Search Results (1,334)

This work presents the development of a wrist-worn wireless sensor system for high-accuracy indoor human zone tracking. The proposed system employs machine learning techniques to combine data from multiple sources, including a Received Signal Strength Indicator (RSSI) from wireless signals, three-axis acceleration, and three-axis angular velocity. A prototype wearable wireless sensor device was implemented using a SparkFun Thing Plus-XBee3 microcontroller supporting the Zigbee/IEEE 802.15.4 standard at 2.4 GHz, integrated with a six-degree-of-freedom IMU sensor (MPU-6050). Experiments using one wrist-worn sensor as a transmitter and one base station as a receiver were conducted in a two-story residential building environment covering three zones (i.e., staircase area, living room, and dining room) under static and dynamic test scenarios. Classification performances of 33 machine learning classifiers with different data feature groups and window sizes were evaluated. The results demonstrate the achievement of wrist-worn wireless sensor system development. The system exhibits high communication reliability with a packet delivery ratio (PDR) of 99.99% and can efficiently track data signals in real time. Results indicate that using only raw RSSI data achieves 75.0% accuracy in classifying human zones. However, when statistical RSSI features and accelerometer data fusion are applied, accuracies significantly increase to 98.7% (static scenario, wide neural network with a window size of 25) and 99.6% (dynamic scenario, Fine k-NN). These results demonstrate the system’s potential for indoor human tracking applications. Full article

Geiger-mode avalanche photodiode (GM-APD) array light detection and ranging (LiDAR) has significant advantages in low-light scenes due to its single-photon-level detection sensitivity. However, it is susceptible to noise, which leads to a decrease in target localization accuracy. Traditional methods rely on long-term accumulation to distinguish signal photons from noise photons, making it difficult to achieve efficient processing, especially in scenarios with sparse echo photons and low signal-to-noise ratio (SNR), where performance is limited. To quickly and accurately obtain three-dimensional (3D) information of the target under such extreme conditions, this paper proposes a method for target detection and temporal window depth estimation based on intensity information guidance. First, noise suppression is performed on the intensity image according to its statistical characteristics, and an outlier detection mechanism based on neighborhood sparsity is introduced to remove outliers, thereby completing the target detection. Next, by exploiting the spatial continuity and reflectivity similarity of the target, local fusion of photon data within the target neighborhood is performed to construct highly consistent “superpixels”. Finally, according to the distribution difference between signal photons and noise photons on the time axis, temporal window screening is applied to the superpixels to extract depth information, and empty pixels are filled using a convex segmentation method to achieve depth estimation of the target. The experimental results demonstrate that under conditions of low photon counts and strong noise, the proposed method significantly outperforms traditional and existing methods in target recovery and depth estimation by effectively integrating target intensity information. Furthermore, this method achieves faster reconstruction speed, enabling high-precision and high-efficiency 3D target reconstruction. Full article

Menopause represents a key transitional phase in women’s health, characterized by declining estrogen levels and increased risk for cardiometabolic, musculoskeletal, and urogenital disorders. Beyond its endocrine roots, emerging evidence highlights the gut microbiome as a critical modulator of systemic hormonal balance. This review synthesizes current understanding of the bidirectional relationship between estrogen and the gut microbiome and its implications for women’s health during menopause. Evidence from current studies reveals distinct findings across populations, reflecting the complexity of estrogen regulation in part by the gut microbiome (i.e., estrobolome). While no ideal gut microbial composition has been identified for women across stages of perimenopause, likely due to geographically unique gut microbiome profiles among healthy women, greater microbial diversity has been positively associated with improved estrogen regulation. Conversely, reduced diversity and altered Firmicutes/Bacteroidetes ratios have been linked to biomarkers of inflammation during perimenopause, which is a key driver across many perimenopausal symptoms. Although hormone replacement therapy remains the primary clinical intervention during perimenopause, we highlight emerging evidence on the adjuvant potential of diet, synbiotics, phytoestrogens, and strain-specific probiotics in modulating the estrogen–gut microbiome axis for improved health span trajectories and better symptom management. Future longitudinal studies integrating diet, gut microbiome profiles and symptom trajectories are essential to clarify these mechanisms across ethnicity and geography. Ultimately, understanding localized diet–microbiome interactions will enable the development of accessible, personalized, and non-hormonal strategies to complement and increase agency in proactive management during the perimenopausal transition. Full article

Vertical axis wind turbines (VAWTs) suffer from dynamic stall (DS) at low tip-speed ratios (λ), where cyclic variations in angle of attack (α) dominate the blade aerodynamics, severely undermining aerodynamic performance and power extraction. The coupled influence of airfoil parameters on DS remains unexplored. To address this gap, a fully coupled parametric study using 126 incompressible URANS simulations is conducted, examining three geometric parameters of symmetric airfoils: maximum thickness (t/c), chordwise position of maximum thickness (x_t/c), and leading-edge (LE) radius index (I). The results show that coupled geometric modification fundamentally alters the stall mechanism, shifting it from abrupt, LE-driven separation toward a gradual, trailing-edge (TE)-controlled process as airfoils transition from thin, forward-x_t/c profiles to thicker configurations with aft x_t/c and reduced I. This transition enhances boundary-layer (BL) stability, delays DS onset, weakens dynamic stall vortex (DSV) formation, and mitigates unsteady aerodynamic loading. Within the investigated design space, the best-performing configuration (NACA0024–4.5/3.5) achieves a 73% increase in turbine power coefficient (C_P) relative to the baseline airfoil (NACA0018–6.0/3.0), mainly through passive control of BL separation and vortex development. These findings highlight the limitations of single-parameter optimization and establish a physics-based, coupled-design framework for mitigating DS-induced performance losses in VAWTs. Full article

The use of olive by-products in livestock farming is a valuable resource, given their high levels of bioactive compounds with antioxidant and health-promoting properties. This preliminary study adopted an integrated approach to evaluate the influence of dietary Olea europaea L. polyphenols on animal welfare, physiological stress response, intestinal morphofunctional traits, and meat quality in Neroametà finishing pigs, a novel Casertana × Large White genetic line (Neroametà). Thirty pigs reared under extensive farming conditions were randomly allocated to two groups (n = 15): a control group fed a standard diet (C) and a treatment group (OL) supplemented with 300 mg/head/day of olive polyphenolic extract for 90 days. The study focused on the systemic correlation between host health and product quality. Meat composition, rheological properties, meat antioxidant activity, stress parameters, and fatty acid profiles of the longissimus lumborum and psoas major muscles were analyzed. Results showed that the OL diet significantly modulated the HPA axis, as evidenced by a marked reduction in plasma ACTH and cortisol levels, alongside improved antioxidant status. These physiological changes were positively associated with a trophic effect on the intestinal mucosa, characterized by increased villus height and a more favorable villus/crypt ratio. Regarding meat quality, the OL group exhibited superior oxidative stability, optimized pH decline, and an improved intramuscular fatty acid profile (increased MUFA and n-3 PUFA, reduced SFA). Despite the pilot scale of 30 animals, these findings provide a solid foundation for characterizing the Neroametà breed. In conclusion, Olea europaea L. polyphenols act as a multi-level modulator, enhancing physiological resilience and meat quality, offering a sustainable strategy for high-quality pork production in line with circular economy and One Health principles. Full article

Motor vehicle encroachment into non-motorized lanes is a common but hard-to-verify violation in urban intersections, especially when monitored from unmanned aerial vehicles (UAVs) or high-mounted overhead views. Existing rule-based solutions built on horizontal bounding boxes and center-point/line-crossing criteria are sensitive to perspective distortion, occlusion, and frame-to-frame jitter, resulting in unstable decisions and low evidential value. This paper presents a cascaded UAV-view system that closes the loop from perception to evidence output through detection–segmentation–recognition–decision. First, we adopt a two-stage detection cascade: a lightweight vehicle detector localizes vehicles using axis-aligned bounding boxes, and a dedicated YOLOv5n-based oriented bounding box (OBB) license plate detector, constructed via architecture grafting and weight transfer, is then applied within each vehicle region of interest (ROI) to localize rotated license plates under large pose variation and small-target conditions. Second, a U-Net lane region segmentation module provides pixel-level spatial constraints to define an enforceable lane occupancy region. Third, a perspective rectification step is integrated with the PP-OCRv4 optical character recognition (OCR) framework to improve license plate recognition reliability for tilted plates. Finally, an area ratio criterion and an N-frame temporal counter are used to suppress transient misdetections and stabilize alarms. On a representative 100-sample controlled encroachment benchmark, the proposed system improves detection accuracy from 67.0% to 92.0% and reduces the false positive rate from 32.35% to 5.88% compared with a baseline horizontal bounding box (HBB)-based rule. The system outputs both violation alarms and license plate evidence, supporting practical deployment for multi-view traffic governance. Full article

Cyflumetofen (CYF) and its main metabolite, trifluoromethyl benzoic acid (B-1), both of which contain a trifluoromethyl group, are increasingly used in agriculture due to their high stability and efficacy. Structurally, these molecules share several physicochemical features with per- and polyfluoroalkyl substances (PFASs), including endocrine disruption and reproductive toxicity. This study aims to evaluate the reproductive toxicity effects of CYF and its metabolites using adult zebrafish as a model organism. The results indicate that exposure to CYF and B-1 at environmentally relevant concentrations for 21 days causes hormonal disruption and abnormal gonadal development in fish; moreover, as the concentrations increase, CYF and B-1 significantly impair the reproductive capacity of zebrafish and lead to developmental abnormalities in their offspring. Based on the ratio of E2/T and the alteration of key genes in the HPG axis, such as cyp17a2 and cyp11c1, it is hypothesized that CYF and B-1 disrupt hormonal homeostasis via the HPG axis. Notably, male fish were more susceptible when exposed to CYF or B-1, exhibiting sex-specific differences. RNA-seq analysis revealed that CYF/B-1 promotes Ca²⁺ release from the zebrafish brain and induces steroid hormone dysregulation based on the HPG axis via genes such as hsd17a and gnrh. In summary, this study provides key insights into the reproductive toxicity of CYF and its major metabolite, highlighting their risks to the environment and human health. Full article

To investigate the mechanism of texture formation during the cold rolling of Ti-3Al-2.5V tubes for aerospace hydraulic systems, this study examines the microstructure at various locations of two deformation cones with ‘Q’ ratios of 1.055 and 1.300, respectively, in a single cold-rolling pass, revealing their continuous texture evolution. The results indicate that the cold-rolling texture primarily forms during the sinking section. A higher ‘Q’ ratio leads to a stronger tendency for the c-axis of grains to align parallel to the radial direction of the tube, resulting in enhanced radial texture intensity. Beyond influencing texture through dislocation slip, a higher ‘Q’ ratio also elevates the Schmid factor for {10$\stackrel{\mathrm{-}}{1}$2} twinning. This twinning mechanism primarily forms the radial texture by altering the stress state. Consequently, this change not only facilitates twin activation but also modifies the rotation direction of grains during the twinning process. Compared to the cone with a ‘Q’ ratio of 1.055, the deformation cone with a ‘Q’ ratio of 1.300 contains a greater number of twins oriented along <0001>//RD, leading to a stronger radial texture in the tube. Full article

Background: Lipomas are common benign subcutaneous neoplasms treated surgically for cosmetic or symptomatic reasons. The minimal one-third incision and four-step (MOTIF) technique provides reliable excision with minimal scarring, but smaller proportional incisions remain unstudied. This study evaluates the minimal one-quarter incision and four-step (MOQIF) technique. Methods: Retrospective review of 82 patients undergoing MOQIF excision of histologically confirmed subcutaneous lipomas by a single surgeon from July 2024–December 2025 was done. Lipomas were stratified by maximum diameter: small-intermediate (<5 cm) and large (≥5 cm). MOQIF used a one-quarter incision of the lipoma’s long axis determined by preoperative ultrasound measurement and palpation with four steps: hydro dissection preserving superficial subcutaneous tissue, superficial dissection, staged deep dissection with selective cautery of fibrovascular septa, and intact mass delivery. Outcomes included excision length, postoperative complications, Vancouver Scar Scale (VSS) scores, recurrence, and subjective treatment satisfaction of patients. Results: Mean lipoma size was 6.8 ± 2.0 cm (75.6% ≥5 cm). All lipomas were completely excised through 1.69 ± 0.49 cm incisions (ratio 0.25). Complications were low: seroma 10.98% (16.7% vs. 9.4%, p = 0.404), hematoma 7.3% (11.1% vs. 6.3%, p = 0.608), with no infections, nerve injuries, or recurrences at a mean 8.9-month follow-up. VSS scores were equivalent between groups (0.83 vs. 1.06; p = 0.438) and overall patient satisfaction was high (3.54 ± 0.53 (2–4)). Conclusions: MOQIF achieves complete lipoma excision through one-quarter incisions with safety and cosmetic outcomes across lipoma sizes, demonstrating feasibility through standardized technique refinement and careful case selection. Full article

Conventional buckling-restrained braces (BRBs) with rectangular steel tube confinement suffer from stress concentration and inefficient material utilization, limiting their seismic performance. To address these limitations, this study proposes a novel non-rectangular concrete-filled steel tube BRB system incorporating elliptical and corrugated cross-sections. Comprehensive finite element simulations using ABAQUS are conducted to systematically investigate the influence of key geometric parameters—wall thickness (1–14 mm), corner radius (40–55 mm), and corrugation angle (30–75°)—on hysteretic behavior, load-bearing capacity, and failure modes. The results demonstrate that optimized non-rectangular sections achieve load-bearing capacity comparable to conventional rectangular designs (e.g., elliptical section with 12 mm wall thickness reaches 10.02 MN, a 75% increase over 1 mm thickness) while significantly improving material efficiency. Corrugated sections exhibit enhanced weak-axis performance, with equivalent viscous damping ratios exceeding the NIST-recommended threshold of 0.25. Parametric analyses reveal that wall thickness above 12 mm yields diminishing returns; corner radius reduction to 40 mm triggers local buckling yet increases peak capacity; and corrugation angles exceeding 50° induce instability. All non-buckling models satisfy AISC compression strength adjustment factor requirements (β ≤ 1.3). This study systematically evaluates non-rectangular BRB geometries, filling a critical gap in the literature and providing design guidelines that leverage shape optimization to enhance both seismic resilience and material economy. Full article

Background: Type 2 diabetes mellitus (T2DM) is characterized by chronic low-grade inflammation that contributes to cardiometabolic complications. While diabetes duration reflects cumulative metabolic exposure, its relationship with systemic inflammatory burden remains insufficiently defined. We aimed to investigate inflammatory patterns across diabetes duration and to explore their metabolic and cardio–renal correlates. Methods: This real-world cross-sectional study included 250 adults with T2DM. Diabetes duration was analyzed both continuously and across four predefined strata (0–4, 5–9, 10–14, and ≥15 years). Inflammatory burden was assessed using C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Given the skewed distribution of CRP, log-transformed CRP was used in regression analyses. Nonlinear associations were evaluated using quadratic regression models. This approach was selected because preliminary descriptive analyses suggested a non-monotonic relationship between diabetes duration and CRP levels. Inclusion of a quadratic term allowed formal testing of a potential curvilinear association between diabetes duration and inflammatory burden. Spearman correlations were performed to assess associations with metabolic, renal, and cardiovascular variables. Results: CRP showed a nonlinear cross-sectional association across diabetes duration strata. Median CRP values were higher in early (0–4 years: 0.62 mg/L) and long-standing diabetes (≥15 years: 0.77 mg/L) compared with intermediate-duration groups (p = 0.063). Quadratic regression confirmed a U-shaped relationship (adjusted β_duration = −0.079, p < 0.001; β_duration² = 0.0027, p < 0.001; R² = 0.326). ESR differed significantly across duration strata (p = 0.002), with the highest levels observed in long-standing diabetes. CRP correlated positively with BMI (ρ = 0.151; p = 0.017) and triglyceride-to-HDL ratio (ρ = 0.215; p < 0.001), but not with HbA1c. Both CRP and ESR were more strongly associated with functional CKD (ρ = 0.350 and 0.429, respectively; p < 0.001) than with ASCVD. Conclusions: Inflammatory burden in T2DM shows a nonlinear cross-sectional pattern across diabetes duration, characterized by elevated levels in early and long-standing disease. Systemic inflammation appears more closely linked to renal dysfunction than to established cardiovascular disease. These findings support a cardio–renal–inflammatory axis in which prolonged diabetes exposure contributes to renal decline, which in turn amplifies systemic inflammatory activation. Full article

Background/Objectives: Metabolic dysfunction-associated steatohepatitis (MASLD) represents a prevalent liver disease worldwide. It is crucial to maintain the stability of the gut–liver axis in order to inhibit the advancement of MASLD. Broccoli-derived exosome-like nanoparticles (BDENs) can alleviate constipation and improve colitis. This study investigated whether BDENs possess therapeutic potential for improving induced MASLD by the gut–liver axis. Methods: BDENs were fractionated from fresh broccoli using differential centrifugation, and the microRNAs were identified and analyzed. 24 male C57BL/6J mice (6 weeks old) were randomized into the control group, HFD group, and BDENs group, with 8 mice per group. After 8 weeks of high-fat diet modeling, the BDENs group accepted BDENs daily oral gavage of 100 mg/kg (B.W.), while the control and HFD groups accepted 1 × PBS. Four weeks after BDENs intervention, analysis was conducted on liver injury markers, liver tissue pathology, intestinal barrier, cecal content metabolomics and fecal 16S rRNA, serum inflammatory factors, and hepatic inflammation. Results: BDENs identified 1659 miRNAs associated with physiological processes such as immunity, antioxidant defense, and fatty acid biosynthesis. BDENs significantly reduced weight and ALT/AST ratio (p < 0.05). Furthermore, BDENs attenuated hepatic histopathological damage and lipid accumulation. For the gut–liver axis, BDENs maintained intestinal barrier, regulated intestinal bile acid metabolism and restored the gut microbiota. Additionally, BDENs reduced serum LPS level (p < 0.01) and suppressed hepatic inflammation, including F4/80 and IL-6, IL-1β (p < 0.0001). Conclusions: Oral BDENs therapy demonstrates potential for ameliorating MASLD. Full article

Background/Objectives: Osteosarcoma treatment options remain limited due to tumor metastasis and the toxicity of conventional chemotherapy, warranting new therapeutic strategies. A well-founded strategy is the use of flavonoids, a class of phytochemicals possessing pharmaceutical properties that contribute to anticancer effects, including antioxidant and anti-inflammatory properties. This study aimed to evaluate the anticancer potential of flavonoids in osteosarcoma and investigate their interaction with doxorubicin. Methods: In this study, five flavonoids were screened for cytotoxicity and selectivity across four osteosarcoma cell lines and healthy fibroblasts (MRC-5). The interaction between myricetin and doxorubicin was assessed using a fixed-ratio combination approach. Cell migration and invasion were evaluated using cell exclusion/wound healing and 2D co-culture assays. EMT-related gene expressions were assessed by RT-qPCR. Antitumor activity was evaluated in vivo using a chick chorioallantoic membrane (CAM) xenograft model. Results: Myricetin emerged as the most selective compound, exhibiting cytotoxicity against osteosarcoma cells while sparing MRC-5 fibroblasts. Notably, myricetin synergized with doxorubicin (ratio 69:1), enhancing its cytotoxicity and significantly reducing osteosarcoma cell migration in vitro. Myricetin downregulated SNAI1 and MMP9, suggesting modulation of epithelial–mesenchymal transition (EMT)-related pathways. Complementarily, in the CAM xenograft model, myricetin reduced xenograft tumor size, confirming its anticancer activity in vivo. Conclusions: Collectively, these findings emphasize the anticancer potential of myricetin in osteosarcoma through inhibition of the SNAI1/MMP-9 signaling axis. Full article

The influence of impact configuration and block shape on rockfall rebound behavior has been highlighted in numerous experimental studies. To further investigate these effects, an experimental campaign was conducted using rigid elliptical-disk blocks, allowing the simultaneous examination of block geometry and impact configuration under controlled conditions. The experimental setup was inspired by existing analytical approaches that employ elliptical geometries to describe rebound mechanics and to provide a more detailed interpretation of the parameters governing impact response. The results show that coefficients of restitution exhibit substantial scatter and do not display systematic trends with respect to the geometric aspect ratio of the elliptical disks (a/b ≈ 1.25–2.0), within the testing range of this experiment. Instead, rebound behavior is primarily controlled by impact configuration, as described by the orientation of the major axis and the impact angle. The following two distinct impact types were identified: instantaneous and rolling, associated with different responses. The experimental data were further used to assess existing analytical models, revealing limited quantitative agreement due to the idealized assumptions in their formulation. Overall, the study demonstrates that rebound response in rockfall processes is strongly configuration-dependent, emphasizing the need for modeling approaches that explicitly account for impact configuration and contact geometry. Full article

The combined control method of dimples and Gurney flaps has proven effective in enhancing the power coefficient of Vertical Axis Wind Turbines (VAWTs). However, the adaptability of this combined control structure to different airfoil geometries remains unclear. This paper investigates the aerodynamic characteristics of the Toward-Outside Dimple-Gurney Flap (TO-DGF) on three typical airfoils: NACA0021, NACA0012, and S1046. A dynamic flow field prediction model was established using the Lattice Boltzmann Method (LBM) combined with Wall-Modeled Large Eddy Simulation (WMLES). The Taguchi experimental design was employed to analyze the sensitivity of aerodynamic performance to airfoil type, Gurney flap position, and Gurney flap height. The results indicate that the airfoil type is the most critical factor affecting the power coefficient $C_P$, contributing significantly to the performance variance. Specifically, the NACA0021 airfoil demonstrated optimal performance in suppressing dynamic stall. Furthermore, the optimal DGF position varies with the tip speed ratio (TSR): placing the structure at 0.05C and 0.15C from the trailing edge yields the best aerodynamic performance for low (TSR = 1.5) and medium (TSR = 2.4) TSRs, respectively. This study provides a valuable reference for the structural design of high-efficiency VAWT blades within the investigated TSR range. Full article