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239 Results Found

  • Article
  • Open Access
1 Citations
2,491 Views
15 Pages

1 January 2020

Acquired Immunodeficiency Syndrome (AIDS) is the most severe phase of Human Immunodeficiency Virus (HIV) infection. Living with HIV results in a weakened immune system, with AIDS being the final stage of HIV and puzzling the world. The current medica...

  • Review
  • Open Access
7 Citations
5,189 Views
20 Pages

Gut Microbiome Alteration in HIV/AIDS and the Role of Antiretroviral Therapy—A Scoping Review

  • Zsófia Gáspár,
  • Blin Nagavci,
  • Bálint Gergely Szabó and
  • Botond Lakatos

(1) Background: The gut microbiota plays a crucial role in chronic immune activation associated with human immunodeficiency virus (HIV) infection, acquired immune deficiency syndrome (AIDS) pathogenesis, non-AIDS-related comorbidities, and mortality...

  • Article
  • Open Access
15 Citations
4,851 Views
12 Pages

Despite a campaign of effective educational interventions targeting knowledge, attitudes, and prevention, Human Immunodeficiency-Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) continues to be a significant public health issue in India, with Miz...

  • Article
  • Open Access
9 Citations
3,200 Views
13 Pages

Factors Associated with Late Diagnosis of Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) in a University Hospital in Brazil: Challenges to Achieving the 2030 Target

  • Ligia Maria Nascimento Arantes,
  • Andrey Oeiras Pedroso,
  • Mayra Gonçalves Menegueti,
  • Elucir Gir,
  • Eliã Pinheiro Botelho,
  • Ana Cristina de Oliveira e Silva and
  • Renata Karina Reis

17 October 2023

Introduction: This study aimed to identify factors associated with late diagnosis and clinically monitor newly diagnosed HIV/AIDS patients. Method: Retrospective study, based on secondary data from a specialized unit at the Hospital das Clínic...

  • Review
  • Open Access
4,424 Views
23 Pages

The Role of Nutrition in HIV-Associated Neurocognitive Disorders: Mechanisms, Risks, and Interventions

  • Carlotta Siddi,
  • Jihane Balla,
  • Christy Agbey,
  • Paola Fadda and
  • Simona Dedoni

19 June 2025

HIV-associated neurocognitive disorders (HANDs) refer to a range of cognitive deficits that afflict people living with the Human Immunodeficiency Virus (HIV). The fundamental processes of HAND include persistent inflammation, immunological activation...

  • Article
  • Open Access
19 Citations
2,757 Views
23 Pages

Employing Fuzzy Logic to Analyze the Structure of Complex Biological and Epidemic Spreading Models

  • Nickie Lefevr,
  • Andreas Kanavos,
  • Vassilis C. Gerogiannis,
  • Lazaros Iliadis and
  • Panagiotis Pintelas

27 April 2021

Complex networks constitute a new field of scientific research that is derived from the observation and analysis of real-world networks, for example, biological, computer and social ones. An important subset of complex networks is the biological, whi...

  • Article
  • Open Access
5 Citations
5,024 Views
32 Pages

HIV vs. the Immune System: A Differential Game

  • Alessandra Buratto,
  • Rudy Cesaretto and
  • Rita Zamarchi

3 December 2015

A differential game is formulated in order to model the interaction between the immune system and the HIV virus. One player is represented by the immune system of a patient subject to a therapeutic treatment and the other player is the HIV virus. The...

  • Article
  • Open Access
7 Citations
16,397 Views
14 Pages

The Effects of Environmental Factors on Persons Living with HIV/AIDS

  • Lucersia Nichols,
  • Paul B. Tchounwou,
  • Leandro Mena and
  • Daniel Sarpong

In recent years, environmental awareness has received a great deal of public attention. However, little emphasis has been put on the influence of environmental factors (weather, personal attitudes, policies, physical structures, transportation, etc.)...

  • Article
  • Open Access
3 Citations
4,444 Views
10 Pages

With ten percent of the world’s children living with Human Immunodeficiency Virus (HIV/ AIDS) in India, achieving elimination of parent/mother to-child transmission (EPTCT/EMTCT) is far away. Timely initiation and optimal adherence to the preve...

  • Review
  • Open Access
5 Citations
5,170 Views
18 Pages

Microbicides for Topical HIV Immunoprophylaxis: Current Status and Future Prospects

  • Yury V. Zhernov,
  • Vladislava O. Petrova,
  • Mark Y. Simanduyev,
  • Denis V. Shcherbakov,
  • Roman V. Polibin,
  • Oleg V. Mitrokhin,
  • Artem A. Basov,
  • Nadezhda N. Zabroda,
  • Sonya O. Vysochanskaya and
  • Narmina Yu. Feyziyeva
  • + 2 authors

Microbicides, which are classified as topical antiseptic agents, are a revolutionary advancement in HIV prevention aimed to prevent the entry of infectious agents into the human body, thus stopping the sexual transmission of HIV and other sexually tr...

  • Article
  • Open Access
3 Citations
3,335 Views
17 Pages

In-Vitro Subtype-Specific Modulation of HIV-1 Trans-Activator of Transcription (Tat) on RNAi Silencing Suppressor Activity and Cell Death

  • Larance Ronsard,
  • Ashraf S. Yousif,
  • Janani Ramesh,
  • N. Sumi,
  • Matthew Gorman,
  • Vishnampettai G. Ramachandran and
  • Akhil C. Banerjea

23 October 2019

Human immunodeficiency virus (HIV) is a global health concern affecting millions of individuals with a wide variety of currently circulating subtypes affecting various regions of the globe. HIV relies on multiple regulatory proteins to modify the hos...

  • Case Report
  • Open Access
2 Citations
3,812 Views
10 Pages

Histoplasmosis is an uncommon opportunistic infection in human immunodeficiency virus (HIV) positive children. The most common form is primary disseminated histoplasmosis, characterized by persistent fever and failure to thrive. A 10-year-old HIV pos...

  • Article
  • Open Access
8 Citations
4,481 Views
10 Pages

Prevalence and Determinants of Medication Adherence among Patients with HIV/AIDS in Southern Vietnam

  • Phuong M. Nguyen,
  • Anh N. Thach,
  • Xuan D. Pham,
  • Anh N. Lam,
  • Thao N. P. Nguyen,
  • Chu X. Duong,
  • Lam V. Nguyen,
  • Thao H. Nguyen,
  • Suol T. Pham and
  • Thang Nguyen
  • + 1 author

5 February 2021

This study was conducted to determine the prevalence and determinants of medication adherence among patients with HIV/AIDS in southern Vietnam. Methods: A cross-sectional study was conducted in a hospital in southern Vietnam from June to December 201...

  • Article
  • Open Access
7 Citations
3,381 Views
11 Pages

Impact of Antiretroviral Therapy on the Risk of Recurrence in HIV-1 Infected Patients with Kaposi Sarcoma: A Multicenter Cohort Experience

  • Manuela Colafigli,
  • Arturo Ciccullo,
  • Alberto Borghetti,
  • Iuri Fanti,
  • Federico Melis,
  • Sara Modica,
  • Ilaria Uccella,
  • Antonio Bonadies,
  • Virginia Ferraresi and
  • Alessandra Latini
  • + 8 authors

23 November 2019

Kaposi sarcoma (KS) remains a relevant malignancy in human immunodeficiency virus (HIV)-infected patients with a non-standardized management; despite past suggestions that ritonavir-boosted protease inhibitor (bPI)-based regimens could be preferable,...

  • Commentary
  • Open Access
6 Citations
2,649 Views
4 Pages

28 August 2024

Despite over four decades of unremitting efforts since the discovery of acquired immunodeficiency syndrome (AIDS)/human immunodeficiency virus (HIV), there remains no cure for HIV nor a vaccine for its prevention [...]

  • Review
  • Open Access
17 Citations
5,713 Views
19 Pages

Advances in SIV/SHIV Non-Human Primate Models of NeuroAIDS

  • Sonia Moretti,
  • Sara Virtuoso,
  • Leonardo Sernicola,
  • Stefania Farcomeni,
  • Maria Teresa Maggiorella and
  • Alessandra Borsetti

12 August 2021

Non-human primates (NHPs) are the most relevant model of Acquired Immunodeficiency Syndrome (AIDS) and neuroAIDS, being of great importance in explaining the pathogenesis of HIV-induced nervous system damage. Simian Immunodeficiency Virus (SIV)/ Simi...

  • Review
  • Open Access
8 Citations
7,399 Views
15 Pages

The Role of Glutathione in the Management of Cell-Mediated Immune Responses in Individuals with HIV

  • Nicole Lin,
  • Thomas Erdos,
  • Carson Louie,
  • Raina Desai,
  • Naomi Lin,
  • Gregory Ayzenberg and
  • Vishwanath Venketaraman

Human immunodeficiency virus (HIV) is a major cause of death worldwide. Without appropriate antiretroviral therapy, the infection can develop into acquired immunodeficiency syndrome (AIDS). AIDS leads to the dysregulation of cell-mediated immunity re...

  • Article
  • Open Access
2 Citations
3,269 Views
12 Pages

Optimization of Public Health Education Parameters for Controlling the Spread of HIV/AIDS Infection

  • Mohammad Hossein Ostadzad,
  • Salman Baroumand and
  • Mohammad Reza Mahmoudi

22 April 2020

Due to the prevalence of Human Immuno-deficiency Virus/Acquired Immuno-Deficiency Syndrome (HIV/AIDS) infection in society and the importance of preventing the spread of this disease, a mathematical model for sexual transmission of HIV/AIDS epidemic...

  • Review
  • Open Access
11 Citations
5,097 Views
16 Pages

4 September 2020

HIV-1 is the causative agent of acquired immunodeficiency syndrome (AIDS). It affects millions of people worldwide and the pandemic persists despite the implementation of highly active antiretroviral therapy. A wide spectrum of techniques has been im...

  • Review
  • Open Access
11 Citations
5,868 Views
27 Pages

HIV-1-Mediated Acceleration of Oncovirus-Related Non-AIDS-Defining Cancers

  • Jessica Proulx,
  • Maria Ghaly,
  • In-Woo Park and
  • Kathleen Borgmann

With the advent of combination antiretroviral therapy (cART), overall survival has been improved, and the incidence of acquired immunodeficiency syndrome (AIDS)-defining cancers has also been remarkably reduced. However, non-AIDS-defining cancers amo...

  • Review
  • Open Access
71 Citations
17,285 Views
27 Pages

30 March 2010

Since the human immunodeficiency virus (HIV) was discovered as the etiological agent of acquired immunodeficiency syndrome (AIDS), it has encouraged much research into antiviral compounds. The reverse transcriptase (RT) of HIV has been a main target...

  • Review
  • Open Access
13 Citations
5,154 Views
13 Pages

Thyroid Diseases and Thyroid Asymptomatic Dysfunction in People Living With HIV

  • Cristina Micali,
  • Ylenia Russotto,
  • Benedetto Maurizio Celesia,
  • Laura Santoro,
  • Andrea Marino,
  • Giovanni Francesco Pellicanò,
  • Giuseppe Nunnari and
  • Emmanuele Venanzi Rullo

1 September 2022

Thyroid diseases (TDs) and thyroid asymptomatic dysfunctions (TADs) are correlated with Human Immunodeficiency virus (HIV) infection and Acquired ImmunoDeficiency Syndrome (AIDS) as well as many endocrine dysfunctions and dysregulation of hormonal ax...

  • Article
  • Open Access
31 Citations
4,856 Views
18 Pages

Human immunodeficiency virus (HIV) is a retrovirus that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS). It can be spread and transmitted through two fundamental modes, one by virus-to-cell infection, and the other by dir...

  • Review
  • Open Access
9 Citations
3,885 Views
29 Pages

Therapeutic Potential of Marine Bioactive Peptides against Human Immunodeficiency Virus: Recent Evidence, Challenges, and Future Trends

  • Jameel Mohammed Al-Khayri,
  • Waqas Asghar,
  • Sipper Khan,
  • Aqsa Akhtar,
  • Haris Ayub,
  • Nauman Khalid,
  • Fatima Mohammed Alessa,
  • Muneera Qassim Al-Mssallem,
  • Adel Abdel-Sabour Rezk and
  • Wael Fathi Shehata

25 July 2022

Acquired immunodeficiency syndrome (AIDS) is a chronic and potentially fatal ailment caused by the human immunodeficiency virus (HIV) and remains a major health problem worldwide. In recent years, the research focus has shifted to a greater emphasis...

  • Case Report
  • Open Access
5 Citations
85 Views

2 June 2014

Genitourinary tuberculosis (TB) is infrequently reported in the United States, but is a common form of extrapulmonary TB that often goes unnoticed due to its insidious and sometimes asymptomatic presentation. Prostate involvement and the development...

  • Article
  • Open Access
6 Citations
4,759 Views
14 Pages

28 June 2019

Faith-based programs have been long regarded as influential social approaches to form positive attitudes to human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) within the last few decades. However, recent scholars argue that...

  • Review
  • Open Access
28 Citations
11,827 Views
26 Pages

Applications of the FIV Model to Study HIV Pathogenesis

  • Craig Miller,
  • Zaid Abdo,
  • Aaron Ericsson,
  • John Elder and
  • Sue VandeWoude

20 April 2018

Feline immunodeficiency virus (FIV) is a naturally-occurring retrovirus that infects domestic and non-domestic feline species, producing progressive immune depletion that results in an acquired immunodeficiency syndrome (AIDS). Much has been learned...

  • Article
  • Open Access
3 Citations
11,270 Views
10 Pages

The Human Immunodeficiency Virus / Acquired Immunodeficiency syndrome (HIV/AIDS) is spreading rapidly in all regions of the world. But in India it is only 20 years old. Within this short period it has emerged as one of the most serious public health...

  • Review
  • Open Access
22 Citations
5,850 Views
18 Pages

Cryptococcal Immune Reconstitution Inflammatory Syndrome: From Blood and Cerebrospinal Fluid Biomarkers to Treatment Approaches

  • Vânia Maria Sabadoto Brienze,
  • Júlio César André,
  • Elisabete Liso and
  • Irina Vlasova-St. Louis

27 January 2021

Immune reconstitution inflammatory syndrome (IRIS) presents as an exaggerated immune reaction that occurs during dysregulated immune restoration in immunocompromised patients in late-stage human immunodeficiency virus (HIV) infection who have commenc...

  • Brief Report
  • Open Access
1 Views
2 Pages

18 January 2012

In India, acquired immunodeficiency syndrome (AIDS) is a growing epidemic involving all sections of the society. Health care personnel are at increased risk of acquiring blood borne diseases like AIDS, hepatitis, etc. We aimed to assess the level of...

  • Review
  • Open Access
13 Citations
10,863 Views
14 Pages

Aptamer Technology: Adjunct Therapy for Malaria

  • Nik Abdul Aziz Nik Kamarudin,
  • Nurul Adila Mohammed and
  • Khairul Mohd Fadzli Mustaffa

Malaria is a life-threatening parasitic infection occurring in the endemic areas, primarily in children under the age of five, pregnant women, and patients with human immunodeficiency virus and acquired immunodeficiency syndrome (HIV)/(AIDS) as well...

  • Review
  • Open Access
11 Citations
2,763 Views
12 Pages

Impaired Mitochondrial Function in T-Lymphocytes as a Result of Exposure to HIV and ART

  • Alexander V. Blagov,
  • Vasily N. Sukhorukov,
  • Shuzhen Guo,
  • Dongwei Zhang,
  • Mikhail A. Popov and
  • Alexander N. Orekhov

2 April 2023

Mitochondrial dysfunction is a described phenomenon for a number of chronic and infectious diseases. At the same time, the question remains open: is this condition a consequence or a cause of the progression of the disease? In this review, we conside...

  • Article
  • Open Access
12 Citations
5,485 Views
14 Pages

Dynamics of HIV-TB Co-Infection Model

  • Nita H Shah,
  • Nisha Sheoran and
  • Yash Shah

11 March 2020

According to World Health Organization (WHO), the population suffering from human immunodeficiency virus (HIV) infection over a period of time may suffer from TB infection which increases the death rate. There is no cure for acquired immunodeficiency...

  • Review
  • Open Access
11 Citations
5,557 Views
36 Pages

Human immunodeficiency virus (HIV) causes one of the most dangerous diseases—acquired immunodeficiency syndrome (AIDS). An estimated about 40 million people are currently living with HIV worldwide, most of whom are already on antiretroviral the...

  • Brief Report
  • Open Access
3 Citations
9,972 Views
8 Pages

5 November 2021

In January 2018, the Minister of Health, Labour and Welfare, Japan, released an amended Guideline on the Prevention of Specified Infectious Diseases on Acquired Immunodeficiency Syndrome (AIDS) to propose measures to control the human immunodeficienc...

  • Review
  • Open Access
55 Citations
4,876 Views
18 Pages

Pyrroles as Privileged Scaffolds in the Search for New Potential HIV Inhibitors

  • Maria da Conceição Avelino Dias Bianco,
  • Debora Inacio Leite Firmino Marinho,
  • Lucas Villas Boas Hoelz,
  • Monica Macedo Bastos and
  • Nubia Boechat

2 September 2021

Acquired immunodeficiency syndrome (AIDS) is caused by human immunodeficiency virus (HIV) and remains a global health problem four decades after the report of its first case. Despite success in viral load suppression and the increase in patient survi...

  • Review
  • Open Access
32 Citations
8,519 Views
14 Pages

HIV Vaccination: A Roadmap among Advancements and Concerns

  • Maria Trovato,
  • Luciana D’Apice,
  • Antonella Prisco and
  • Piergiuseppe De Berardinis

Since the identification of the Human Immunodeficiency Virus type 1 (HIV-1) as the etiologic agent of AIDS (Acquired Immunodeficiency Syndrome), many efforts have been made to stop the AIDS pandemic. A major success of medical research has been the d...

  • Article
  • Open Access
13 Citations
6,084 Views
22 Pages

Towards the De Novo Design of HIV-1 Protease Inhibitors Based on Natural Products

  • Ana L. Chávez-Hernández,
  • K. Eurídice Juárez-Mercado,
  • Fernanda I. Saldívar-González and
  • José L. Medina-Franco

1 December 2021

Acquired immunodeficiency syndrome (AIDS) caused by the human immunodeficiency virus (HIV) continues to be a public health problem. In 2020, 680,000 people died from HIV-related causes, and 1.5 million people were infected. Antiretrovirals are a way...

  • Article
  • Open Access
4 Citations
3,476 Views
9 Pages

Spanish Nursing Students’ Attitudes toward People Living with HIV/AIDS: A Cross-Sectional Survey

  • María Adelaida Álvarez-Serrano,
  • Encarnación Martínez-García,
  • Adelina Martín-Salvador,
  • María Gázquez-López,
  • María Dolores Pozo-Cano,
  • Rafael A. Caparrós-González and
  • María Ángeles Pérez-Morente

Human immunodeficiency virus (HIV) infection is still a public health issue. Human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) creates, in society, stigmatizing attitudes, fear, and discrimination against infected people; ev...

  • Communication
  • Open Access
1 Citations
3,173 Views
12 Pages

Harnessing Natural Mosaics: Antibody-Instructed, Multi-Envelope HIV-1 Vaccine Design

  • Robert E. Sealy,
  • Barry Dayton,
  • David Finkelstein and
  • Julia L. Hurwitz

11 May 2021

The year 2021 marks the 40th anniversary since physicians recognized symptoms of the acquired immunodeficiency syndrome (AIDS), a disease that has since caused more than 30 million deaths worldwide. Despite the passing of four decades, there remains...

  • Review
  • Open Access
9 Citations
7,089 Views
43 Pages

New Therapies and Strategies to Curb HIV Infections with a Focus on Macrophages and Reservoirs

  • Maria Marra,
  • Alessia Catalano,
  • Maria Stefania Sinicropi,
  • Jessica Ceramella,
  • Domenico Iacopetta,
  • Romina Salpini,
  • Valentina Svicher,
  • Stefania Marsico,
  • Stefano Aquaro and
  • Michele Pellegrino

18 September 2024

More than 80 million people worldwide have been infected with the human immunodeficiency virus (HIV). There are now approximately 39 million individuals living with HIV/acquired immunodeficiency syndrome (AIDS). Although treatments against HIV infect...

  • Review
  • Open Access
72 Citations
12,074 Views
15 Pages

New Challenges of HIV-1 Infection: How HIV-1 Attacks and Resides in the Central Nervous System

  • Victoria Rojas-Celis,
  • Fernando Valiente-Echeverría,
  • Ricardo Soto-Rifo and
  • Daniela Toro-Ascuy

13 October 2019

Acquired immunodeficiency syndrome (AIDS) has become one of the most devastating pandemics in recorded history. The main causal agent of AIDS is the human immunodeficiency virus (HIV), which infects various cell types of the immune system that expres...

  • Review
  • Open Access
18 Citations
5,513 Views
18 Pages

The Role of RNA Modification in HIV-1 Infection

  • Shuqi Wang,
  • Huanxiang Li,
  • Zhengxing Lian and
  • Shoulong Deng

RNA plays an important role in biology, and more than 170 RNA modifications have been identified so far. Post-transcriptional modification of RNA in cells plays a crucial role in the regulation of its stability, transport, processing, and gene expres...

  • Article
  • Open Access
32 Citations
12,421 Views
13 Pages

The Environmental and Social Influences of HIV/AIDS in Sub-Saharan Africa: A Focus on Rural Communities

  • Christine U. Oramasionwu,
  • Kelly R. Daniels,
  • Matthew J. Labreche and
  • Christopher R. Frei

The Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) pandemic has caused far-reaching effects in sub-Saharan Africa. The pandemic has effectively diminished the workforce, increased poverty rates, reduced agricultural produc...

  • Article
  • Open Access
81 Citations
10,951 Views
19 Pages

Understanding Global HIV Stigma and Discrimination: Are Contextual Factors Sufficiently Studied? (GAPRESEARCH)

  • Bach Xuan Tran,
  • Hai Thanh Phan,
  • Carl A. Latkin,
  • Huong Lan Thi Nguyen,
  • Chi Linh Hoang,
  • Cyrus S.H. Ho and
  • Roger C.M. Ho

Stigma and discrimination are among the greatest challenges that people living with human immunodeficiency virus (HIV) face, and both are known to negatively affect quality of life as well as treatment outcomes. We analyzed the growing research and c...

  • Article
  • Open Access
10 Citations
4,279 Views
17 Pages

Analysis of HIV/AIDS Epidemic and Socioeconomic Factors in Sub-Saharan Africa

  • Shuman Sun,
  • Zhiming Li,
  • Huiguo Zhang,
  • Haijun Jiang and
  • Xijian Hu

29 October 2020

Sub-Saharan Africa has been the epicenter of the outbreak since the spread of acquired immunodeficiency syndrome (AIDS) began to be prevalent. This article proposes several regression models to investigate the relationships between the HIV/AIDS epide...

  • Case Report
  • Open Access
7 Citations
118 Views

2 September 2019

Introduction: The eustachian valve is a normal remnant of the right valve of the sinus venosus, which directs blood in the embryo life from the inferior vena cava into the left atrium through the foramen ovale. Case report: We report a case of eustac...

  • Review
  • Open Access
17 Citations
4,224 Views
14 Pages

15 December 2023

In the last three decades, there has been a considerable improvement in human immunodeficiency virus (HIV) therapy. Acquired immunodeficiency syndrome (AIDS) is no longer a common cause of death for people living with HIV (PLWH) in developed countrie...

  • Review
  • Open Access
23 Citations
12,760 Views
23 Pages

13 September 2018

The structure and function of exocrine glands are negatively affected by human immunodeficiency virus (HIV) infection and its co-morbidities, including innate and adaptive immune responses. At the same time, exocrine function may also be influenced b...

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