Search Results (28)

Orphan nuclear receptor subfamily 4A (NR4A) are key regulators of inflammatory responses, largely by their interactions with NF-κB. Over the last decade, several NR4A modulators have been developed, and they are showing potential as therapeutics, although their widespread use in laboratory settings is limited. Here, we have examined, using myeloid cell line THP-1, whether the NR4A modulator 3-[(4-Chlorophenyl)-(1H-indol-3-yl)methyl]-1H-indole (C-DIM12) can alter the inflammatory outcome of six inflammatory ligands: lipopolysaccharide (LPS), tumour necrosis factor alpha (TNFα), interleukin-1 beta (IL-1β), flagellin (FL), lipoteichoic acid (LTA), and zymosan (ZY). We demonstrate that C-DIM12 (10 µM) selectively alters the secretion of inflammatory chemokine MCP-1 following exposure to distinct inflammatory ligands in a concentration-dependent manner. Furthermore, data obtained from THP-1 Lucia cell experiments show that 10 µM C-DIM12, and not 1 µM C-DIM12, can significantly attenuate the increased NF-κB transcriptional activity observed following the exposure to several inflammatory ligands (LPS, FL, TNFα, LTA, and ZY). Lastly, experimental analysis confirms that the cellular action(s) of C-DIM12 is independent of changes in metabolic parameters. Thus, these data contribute to the understanding of how the NR4A modulator C-DIM12 alters inflammatory responses in a myeloid cell following exposure to multiple ligands. Full article

Carotenoids are important pigments in pepper fruits. The colors of each pepper are mainly determined by the composition and content of carotenoid. The ‘ZY’ variety, which has yellow fruit, is a natural mutant derived from a branch mutant of ‘ZR’ with different colors. ZY and ZR exhibit obvious differences in fruit color, but no other obvious differences in other traits. To investigate the main reasons for the formation of different colored pepper fruits, transcriptome and metabolome analyses were performed in three developmental stages (S1–S3) in two cultivars. The results revealed that these structural genes (PSY1, CRTISO, CCD1, CYP97C1, VDE1, CCS, NCED1 and NCED2) related to carotenoid biosynthesis were expressed differentially in the two cultivars. Capsanthin and capsorubin mainly accumulated in ZR and were almost non-existent in ZY. S2 is the fruit color-changing stage; this may be a critical period for the development of different color formation of ZY and ZR. A combination of transcriptome and metabolome analyses indicated that CCS, NCED2, AAO4, VDE1 and CYP97C1 genes were key to the differences in the total carotenoid content. These new insights into pepper fruit coloration may help to improve fruit breeding strategies. Full article

This study aimed to develop a two-color pressure-sensitive paint (PSP) that has both high pressure sensitivity and high temperature sensitivity. Different nitrobenzoxadiazole (NBD) derivatives were used as the temperature probe. Among them, NBD-ZY37 demonstrated favorable stability against photodegradation, and its temperature sensitivity in an RTV118-based two-color PSP was −1.4%/°C. Moreover, temperature sensitivity was independent of pressure in the tested temperature range. PtTFPP was used, and its pressure sensitivity was measured to be 0.5% per kPa. The two-color PSP paint underwent further examination in jet impingement experiments. The experimental results indicated that the pressure fluctuation introduced by the shock waves occurred earlier at higher impingement angles. Specifically, when the pressure ratio was 2.38, increasing the impinging angle from 15° to 30° caused the location of the pressure wave to move from s/D at 0.8 to the exit of the nozzle. Simultaneously, the shape of the maximum pressure zone changed from a fan shape to a round shape. Additionally, the jet region expanded when the pressure ratio was increased. Full article

Blue oat mite species, including Penthaleus major and P. tectus, are pests widely distributed across China that cause damage to winter wheat. This study evaluated the genetic diversity of P. major and P. tectus on Triticum hosts collected from 23 geographic locations based on mitochondrial cytochrome c oxidase subunit I (COI) sequences. We identified nine haplotypes in 438 P. major individuals from 21 geographic locations and five haplotypes in 139 P. tectus individuals from 11 geographic locations. Meanwhile, P. major exhibits high values of haplotype diversity (Hd) and nucleotide diversity (Pi) (Hd = 0.534 > 0.5 and Pi = 0.012 > 0.005), representing a large stable population with a long evolutionary history. P. tectus shows low values of Hd and Pi (Hd = 0.112 < 0.5 and Pi = 0 < 0.005), which suggest recent founder events. Moreover, demographic analysis suggested that P. major and P. tectus have not undergone a recent population expansion. The lowest genetic variation was observed in Xiangzhou (XZ-HB), Zaoyang (ZY-HB), Siyang (SY-JS), and Rongxian (RX-SC), with only one species and one haplotype identified in over 30 individuals. Robust genetic differentiation was found in P. major compared to P. tectus, which provides a theoretical basis for the widespread distribution of P. major in China. Full article

A set of Y-type zeolites with Si/Al atomic ratios between 7–45 were studied as catalysts in the aminocyclization reaction between acrolein and ammonia to produce pyridine and 3-picoline. The catalytic activity tests at 360 °C revealed that the acrolein conversion increased in the order Z45 < ZY34 < ZY7 < ZY17, in agreement with the increase of the total acidity per gram of catalyst. In all cases, pyridine bases and cracking products (acetaldehyde and formaldehyde) were detected in the outflow from the reactor. The total yield of pyridines was inversely proportional to the total acidity for the catalysts, which presented large surface areas and micro- and mesoporosity. The selectivity towards 3-picoline was favored when using catalysts with a Brønsted/Lewis acid sites ratio close to 1. The formation of pyridine occurred more selectively over Lewis acid sites than Brønsted acid sites. The deactivation tests showed that the time on stream of the catalysts depended on the textural properties of zeolites, i.e., large pore volume and large BET area, as evidenced by the deactivation rate constants and the characterization of the spent catalysts. The physicochemical properties of the catalysts were determined by XRD, UV-vis, and Raman spectroscopies, infrared spectroscopy with adsorbed pyridine, N₂ physisorption, and SEM-EDXS. After the reaction, the spent catalysts were characterized by XRD, Raman spectroscopy, TGA, and SEM-EDXS, indicating that the uniform deposition of polyaromatic species on the catalyst surface and within the porous system resulted in the loss of activity. Full article

In this study, we examine the effect of integrating different carbon nanostructures (carbon nanotubes, CNTs, graphene nanoplatelets, GNPs) into Ni- and Ni-W-based bi-functional catalysts for hydrocracking of heptane performed at 400 °C. The effect of varying the SiO₂/Al₂O₃ ratio of the zeolite Y support (between 5 and 30) on the heptane conversion is also studied. The results show that the activity, in terms of heptane conversion, followed the order CNT/Ni-ZY5 (92%) > GNP/Ni-ZY5 (89%) > CNT/Ni-W-ZY30 (86%) > GNP/Ni-W-ZY30 (85%) > CNT/Ni-ZY30 (84%) > GNP/Ni-ZY30 (83%). Thus, the CNT-based catalysts exhibited slightly higher heptane conversion as compared to the GNP-based ones. Furthermore, bimetallic (Ni-W) catalysts possessed higher BET surface areas (725 m²/g for CNT/Ni-W-ZY30 and 612 m²/g for CNT/Ni-ZY30) and exhibited enhanced hydrocracking activity as compared to the monometallic (Ni) catalyst with the same zeolite support and type of carbon structure. It was also shown that CNT-based catalysts possessed higher regeneration capability than their GNP-based counterparts due to the slightly higher thermal stability of the CVD-grown CNTs. Full article

In this paper, we propose an interface layer using the coplanar waveguide (CPW) between an array antenna and transmitting receiver modules (TRMs) for X-band military ship radar systems. To improve transmission characteristics, the interface layer with the CPW has three transition parts: Transition part A is between the sub miniature push-on (SMP) connector and the interface layer. Transition part B is the CPW in which the thickness gradually increases. Transition part C is for connecting the interface layer and the antenna. The measured reflection and transmission coefficients of the fabricated interface layer are −22.4 dB and −0.82 dB, respectively. To verify the proposed interface layer, we then apply the layer to a 2 × 2 X-band array antenna and measure the array antenna characteristics, such as reflection coefficients, array antenna gain, and half-power beam widths (HPBWs). The measured reflection coefficient is under −10 dB from 8.6 GHz to 10.2 GHz, and the bore-sight array gain of the 2 × 2 array antenna is 10.5 dBi at 9.5 GHz. In addition, the measured HPBWs under the same conditions are 47.8° and 39.1° in the zx- and zy-planes, respectively. The results demonstrate that the proposed interface layer using the CPW is suitable for X-band radar systems. Full article

Tree species recognition is important for remote–sensing mapping and dynamic monitoring of forest resource. However, the complex phenological cycle poses a challenge to remote–sensing recognition of deciduous tree species in mountainous areas, and the selection of temporal phase is particularly important to improve recognition accuracy. Multispectral images of Ziyuan–1 02C (ZY–1 02C) and Ziyuan–3 (ZY–3) at three phenological phases of spring, autumn and winter (12 May, 29 September and 7 December, recorded as T_5–12, T_9–29 and T_12–7) are selected to optimize sensitive spectral indices. Support vector machine (SVM) and maximum likelihood model (MLE) are constructed to explore the optimum phase of recognizing on Quercus acutissima (O. acutissima ) and Robinia pseudoacacia (R. pseudoacacia) in Mount Tai. The results showed the average spectral reflection intensity of O. acutissima was higher than that of R. pseudoacacia Compared to other phenological periods, the most significant spectral differences between O. acutissima and R. pseudoacacia were found in the spring (12 May), which was identified as the optimum phenological phase. Band 4 is the most sensitive band in all the three phases for the tree species recognition. Moreover, the overall recognition accuracy of deciduous tree species on 12 May reached 89.25%, which was significantly higher than the other two phases. On 12 May, the recognition accuracies of SVM based on sensitive spectral indices of up to 93.59% for O. acutissima and 85.44% for R. pseudoacacia, were higher overall than that of the MLE. Sensitive spectral indices introduced were shown to significantly improve the recognition accuracy for tree species over a single sensitive band. The study is expected to facilitate the precise recognition and forestry management on Mount Tai. Full article

Lodging is one of the main reasons for the reduction in seed yield and is the limitation of mechanized harvesting in B. napus. The dissection of the regulatory mechanism of lodging resistance is an important goal in B. napus. In this study, the lodging resistant B. napus line, YG689, derived from the hybridization between B. napus cv. Zhongyou 821 (ZY821) and Capsella bursa-pastoris, was used to dissect the regulation mechanism of hard stem formation by integrating anatomical structure, transcriptome and metabolome analyses. It was shown that the lignocellulose content of YG689 is higher than that of ZY821, and some differentially expressed genes (DEGs) involved in the lignocellulose synthesis pathway were revealed by transcriptome analyses. Meanwhile, GC–TOF–MS and UPLC–QTOF–MS identified 40, 54, and 31 differential metabolites in the bolting stage, first flower stage, and the final flower stage. The differential accumulation of these metabolites might be associated with the lignocellulose biosynthesis in B. napus. Finally, some important genes that regulate the metabolic pathway of lignocellulose biosynthesis, such as BnaA02g18920D, BnaA10g15590D, BnaC05g48040D, and NewGene_216 were identified in B. napus through the combination of transcriptomics and metabolomics data. The present results explored the potential regulatory mechanism of lignocellulose biosynthesis, which provided a new clue for the breeding of B. napus with lodging resistance in the future. Full article

It is highly necessary to apply unmanned aerial vehicle (UAV) remote sensing technology to forest health assessment. To prove the feasibility of quantitative inversion of photosynthetic pigment content (PPC) in Populus euphratica Oliv. individual tree canopy (PeITC) by using multispectral UAV images, in this study, Parrot Sequoia+ multispectral UAV system was manipulated to collect the images of Populus euphratica (Populus euphratica Oliv.) sample plots in Daliyabuyi Oasis from 2019 to 2020, and the canopy PPCs of five Populus euphratica sample trees per plot were determined in six plots. The Populus euphratica crown regions were extracted by grey wolf optimizer-OTSU (GWO-OTSU) multithreshold segmentation algorithm from the normalized difference vegetation index (NDVI) images of Populus euphratica sample plots obtained after preprocessing, and the PeITCs were segmented by multiresolution segmentation algorithm. The mean values of 27 spectral indices in the PeITCs were calculated in each plot, and the optimal model was constructed for quantitative estimation of the PPCs in the PeITCs, then the inversion results were compared and verified based on GF-6 and ZY1-02D satellite imageries respectively. The results were as follows. (1) The average value of canopy chlorophyll content (Chl) was 2.007 mg/g, the mean value of canopy carotenoid content (Car) was 0.703 mg/g. The coefficient of variation (C.V) of both were basically the same and they were both of strong variability. The measured PPCs of the PeITCs in Daliyabuyi Oasis was generally low. The average contents of chlorophyll and carotenoid in PeITC in June were more than twice those in August, while the mean ratio between them was significantly lower in June than in August. The measured PPCs had no obvious spatial distribution law. However, that could prove the rationality of sample selection in this study. (2) NDVI had the best effect of highlighting vegetation among all quadrats in the study area. Based on the GWO-OTSU multithreshold segmentation method, the canopy area of Populus euphratica could be quickly and effectively extracted from the quadrat NDVI map. The best segmentation effect of PeITCs was obtained based on a multiresolution segmentation method when the segmentation scale was 120, the shape index was 0.7, and the compactness index was 0.5. Compared with manual vectorization method of visual interpretation, the root mean square error (RMSE) and Pearson correlation coefficient (R) values of the mean NDVI values in PeITCs obtained by these two methods were 0.038 and 0.951. (3) Only 12 of the 27 spectral indices were significantly correlated with Chl and Car at the significance level of 0.02. Characteristics of the calibration set and validation set were basically consistent with those of the entire set. The classification and regression tree-decision tree (CART-DT) model performed best in the estimation of the PPCs in the PeITCs, in which, when estimating the Car, the calibration coefficient of determination (R²_C) was 0.843, the calibration root mean square error (RMSE_C) was 0.084, the calibration residual prediction deviation (RPD_C) was 2.525, the validation coefficient of determination (R²_V) was 0.670, the validation root mean square error (RMSE_V) was 0.251, the validation residual prediction deviation (RPD_V) was 1.741. (4) Qualitative comparison of spectral reflectance and NDVI values between GF-6 multispectral imagery and Parrot Sequoia+ multispectral image on the 172 PeITCs can show the reliability of Parrot Sequoia+ multispectral image. The comparison results of five PeITCs relative health degree judged by field vision judgment, measured SPAD value, predicted value of Chl (Chl_pre), the red edge value calculated by ZY1-02D (ZY1-02D_red edge) and the Carotenoid Reflection Index 2 (CRI2) value calculated by ZY1-02D (ZY1-02D_CRI2) can further prove the scientificity of inversion results to a certain extent. These results indicate that multispectral UAV images can be applied for quantitative inversion of PPC in PeITC, which could provide an indicator for the construction of a Populus euphratica individual tree health evaluation indicator system based on UAV remote sensing technology in the next step. Full article

The fuel cladding is one of the most important structural components for maintaining the integrity of a fuel channel and for safely exploitation of a nuclear power plant. The corrosion behavior of a fuel cladding material, Zy-4, under high pressure and temperatures conditions, was analyzed in a static isothermal autoclave under simulated primary water conditions—a LiOH solution at 310 °C and 10 MPa for up to 3024 h. After this, the oxides grown on the Zy-4 sample surface were characterized using electrochemical measurements, gravimetric analysis, metallographic analysis, SEM and XPS. The maximum oxide thicknesses evaluated by gravimetric and SEM measurements were in good agreement; both values were around 1.2 µm. The optical light microscopy (OLM) investigations identified the presence of small hydrides uniformly distributed horizontally across the alloy. EIS impedance spectra showed an increase in the oxide impedance for the samples oxidized for a long time. EIS plots has the best fit with an equivalent circuit which illustrated an oxide model that has two oxide layers: an inner oxide layer and outer layer. The EIS results showed that the inner layer was a barrier layer, and the outer layer was a porous layer. Potentiodynamic polarization results demonstrated superior corrosion resistance of the samples tested for longer periods of time. By XPS measurements we identified all five oxidation states of zirconium: Zr⁰ located at 178.5 eV; Zr⁴⁺ at 182.8 eV; and the three suboxides, Zr⁺, Zr²⁺ and Zr³⁺ at 179.7, 180.8 and 181.8 eV, respectively. The determination of Vickers microhardness completed the investigation. Full article

Zircaloy-4 has an important role in the construction of generation III nuclear reactors. An important application is the fuel element sheath, which must have excellent corrosion resistance in the working environment, adequate mechanical characteristics and very good heat transfer properties from the combustible element to the coolant. The corrosion processes at high temperatures, the accidents that lead to significant increases in temperature and the structural transformations associated with them affect the heat transfer process. The paper presents research on the influence of high temperatures on the microstructure and thermal diffusivity of the zy-4 alloy. The samples were treated in air, at temperatures between 850 and 1050 °C for 60 min. The corrosion layers were characterized microstructurally and chemically. Furthermore, the transformations produced in the base material under the corrosion layer were analyzed. The values of thermal diffusivity were determined and correlated with the structural transformations. Considering the state of research on the materials appropriate to be used for new generation reactors, the current importance of third-generation reactors for energy systems and the fact that they will operate in the coming years, we consider that the study offers useful outcomes in the field of nuclear energy. Full article

The computer-aided design/computer-aided manufacturing (CAD/CAM) fabrication technique has become one of the hottest topics in the dental field. This technology can be applied to fixed partial dentures, removable dentures, and implant prostheses. This study aimed to evaluate the feasibility of NaCaPO₄-blended zirconia as a new CAD/CAM material. Eleven different proportional samples of zirconia and NaCaPO₄ (xZyN) were prepared and characterized by X-ray diffractometry (XRD) and Vickers microhardness, and the milling property of these new samples was tested via a digital optical microscope. After calcination at 950 °C for 4 h, XRD results showed that the intensity of tetragonal ZrO₂ gradually decreased with an increase in the content of NaCaPO₄. Furthermore, with the increase in NaCaPO₄ content, the sintering became more obvious, which improved the densification of the sintered body and reduced its porosity. Specimens went through milling by a computer numerical control (CNC) machine, and the marginal integrity revealed that being sintered at 1350 °C was better than being sintered at 950 °C. Moreover, 7Z3N showed better marginal fit than that of 6Z4N among thirty-six samples when sintered at 1350 °C (p < 0.05). The milling test results revealed that 7Z3N could be a new CAD/CAM material for dental restoration use in the future. Full article

Changes to the redox environment of seawater in the Late Ordovician affect the process of organic matter enrichment and biological evolution. However, the evolution of redox and its underlying causes remain unclear. This paper analyzed the vertical variability of main, trace elements and δ³⁴Spy from a drill core section (well ZY5) in the Upper Yangtze Platform, and described the redox conditions, paleoproductivity and paleoclimate variability recorded in shale deposits of the P. pacificus zone and M. extraordinarius zone that accumulated during Wufeng Formation. The results showed that shale from well ZY5 in Late Ordovician was deposited under oxidized water environment, and there are more strongly reducing bottom water conditions of the M. extraordinarius zone compared with the P. pacificus zone. Excess silica (SiO_2(exc)) and substitution index of paleoproductivity (Y) indicated that the P. pacificus zone had higher paleoproductivity whereas the M. extraordinarius zone was lower. The high productivity level controlled O₂ release in the shallow water area as well as the oxidation degree of the P. pacificus zone. The decrease of productivity and the relatively stagnant water mass of the inner Yangtze Sea controlled the formation of relatively reduced water conditions in the M. extraordinarius zone. The chemical index of alteration (CIA) results suggested that palaeoclimatic conditions changed from warm and humid to cold and dry climate from the P. pacificus to the M. extraordinarius zones in the study area. A comparative analysis of the published Fe-S-C data for the Xiushan Datianba section showed that in the P. pacificus zone of the inner Yangtze Sea, warm and humid climate conditions drove high productivity, sulphate flux and low reactive iron flux, which promoted the expansion of oxic ocean-surface waters and mid-depth euxinic waters. In the M. extraordinarius zone, the cold and dry climate with significant uplift of the Xiang’e Submarine High led to the relative sea level decline, resulting in low productivity, sulfate flux and high reactive iron flux, which promoted the expansion of the mid-depth ferruginous waters and the shrinkage of oxic ocean-surface waters. The results offered new insights into the co-evolution of continents and oceans, and explained the role of continental weathering and uplift of the Xiang’e Submarine High in the exchange of sulfate flux and nutrients in the redox environment change of inner Yangtze Sea during the Late Ordovician. Full article

Hybrid architectures integrating a processor with an SRAM-based FPGA fabric—for example, Xilinx ZynQ SoC—are increasingly being used as a single-chip solution in several market segments to replace multi-chip designs. These devices not only provide advantages in terms of logic density, cost and integration, but also provide run-time in-field reconfiguration capabilities. However, the current reconfiguration capabilities provided by vendor tools are limited to the module level. Therefore, incremental run-time configuration memory changes require a lengthy compilation time for off-line bitstream generation along with storage and reconfiguration time overheads with traditional vendor methodologies. In this paper, an internal configuration access port (ICAP) controller that provides a versatile fine-grain resource-level incremental reconfiguration of the programmable logic (PL) resources in ZynQ SoC is presented. The proposed controller implemented in PL, called VR-ZyCAP, can reconfigure look-up tables (LUTs) and Flip-Flops (FF). The run-time reconfiguration of FF is achieved through a reset after reconfiguration (RAR)-featured partial bitstream to avoid the unintended state corruption of other memory elements. Along with versatility, our proposed controller improves the reconfiguration time by 30 times for FFs compared to state-of-the-art works while achieving a nearly 400-fold increase in speed for LUTs when compared to vendor-supported software approaches. In addition, it achieves competitive resource utilization when compared to existing approaches. Full article