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26 Results Found

  • Review
  • Open Access
86 Citations
13,047 Views
18 Pages

An Overview of Diabetic Foot Ulcers and Associated Problems with Special Emphasis on Treatments with Antimicrobials

  • Mirza Shahed Baig,
  • Ahmadi Banu,
  • Mehrukh Zehravi,
  • Ritesh Rana,
  • Sushil S. Burle,
  • Sharuk L. Khan,
  • Fahadul Islam,
  • Falak A. Siddiqui,
  • Ehab El Sayed Massoud and
  • Simona Cavalu
  • + 1 author

14 July 2022

One of the most significant challenges of diabetes health care is diabetic foot ulcers (DFU). DFUs are more challenging to cure, and this is particularly true for people who already have a compromised immune system. Pathogenic bacteria and fungi are...

  • Article
  • Open Access
68 Citations
23,174 Views
15 Pages

Classifications of impacted teeth allow defining the type and degree of retention, as well as assessing the degree of difficulty of the procedure. The aim of this study was to conduct retrospective analysis of the degree of retention and difficulty i...

(This article belongs to the Section Oral Health)
  • Article
  • Open Access
4 Citations
4,182 Views
14 Pages

6 February 2025

Background and Objectives: The primary objective of this study was to determine the predictive factors of limb salvage and wound healing in patients presenting with diabetic foot ulcers (DFUs) following successful below-the-knee endovascular angiopla...

(This article belongs to the Section Surgery)
  • Article
  • Open Access
35 Citations
442 Views
13 Pages

Microbial Profile, Antimicrobial Resistance, and Molecular Characterization of Diabetic Foot Infections in a University Hospital

  • Azza A. Ismail,
  • Marwa A. Meheissen,
  • Talaat A. Abd Elaaty,
  • Nermine E. Abd-Allatif and
  • Heba S. Kassab

15 March 2021

Introduction: Diabetic foot infections (DFIs) are among the most severe complications of diabetes. The aim of this study was to determine the etiological pathogens of DFIs in different Wagner’s and IDSA/IWGDF grades, and to assess their antimicrobial...

  • Article
  • Open Access
3 Citations
1,424 Views
17 Pages

10 December 2025

Objective: To establish a reliable machine-learning-based model for predicting the risk of lower limb amputation in patients with diabetic foot ulcers and to provide quantitative evidence for clinical decision-making and individualized prevention str...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
1 Citations
1,528 Views
11 Pages

DC Voltage Induces Quadratic Optical Nonlinearity in Ion-Exchanged Glasses at Room Temperature

  • Sergey Scherbak,
  • Gennadiy Kan,
  • Dmitry Tagantsev and
  • Andrey Lipovskii

9 March 2024

We demonstrate that applying DC voltage at room temperature to an ion-exchanged glass induces quadratic optical nonlinearity in a subsurface region of the glass. We associate this with the EFISH (Electric-Field-Induced Second Harmonic) effect due to...

(This article belongs to the Section Optics and Lasers)
  • Article
  • Open Access
8 Citations
2,851 Views
10 Pages

Diabetic foot infections (DFIs) are a severe complication of diabetes and are increasing in prevalence globally. The microbiology of DFIs exhibits significant regional variation, with Acinetobacter baumannii frequently emerging as the predominant pat...

  • Article
  • Open Access
27 Citations
8,441 Views
9 Pages

The Effects of Silver-Releasing Foam Dressings on Diabetic Foot Ulcer Healing

  • Yu-Chi Wang,
  • Hsiao-Chen Lee,
  • Chien-Lin Chen,
  • Ming-Chun Kuo,
  • Savitha Ramachandran,
  • Rong-Fu Chen and
  • Yur-Ren Kuo

3 April 2021

Diabetic foot ulcers (DFUs) are a serious complication in diabetic patients and lead to high morbidity and mortality. Numerous dressings have been developed to facilitate wound healing of DFUs. This study investigated the wound healing efficacy of si...

(This article belongs to the Section Dermatology)
  • Case Report
  • Open Access
1 Citations
9,015 Views
8 Pages

20 July 2022

The management of diabetic foot ulcers (DFUs) presents challenges to even the most experienced wound-care providers. Because of the chronic, non-healing nature of many DFUs, advances in the treatment and care of this disease process are particularly...

  • Article
  • Open Access
82 Citations
11,647 Views
14 Pages

18 September 2020

Background: This study reviews the mortality of patients with diabetic foot ulcers (DFU) from the first consultation with a Multidisciplinary Diabetic Foot Team (MDFT) and analyzes the main cause of death, as well as the relevant clinical factors ass...

(This article belongs to the Special Issue Diabetic Foot Complications: Current Challenges and Future Prospects-Part I)
  • Article
  • Open Access
441 Views
18 Pages

DFU-MambaKAN: A Lightweight Hybrid Mamba-KAN Architecture for Diabetic Foot Ulcer Screening and Severity Grading

  • Md Nafis Azad Nobel,
  • Sazid Rahman Kazi,
  • Tajul Islam Rafi,
  • Mainuddin Adel Rafi,
  • Umer Aqeel,
  • Md Ranu Hossen,
  • Md Al Ridwan and
  • Roise Uddin

Diabetic foot ulcers (DFUs) are a major cause of lower-extremity amputation, and image-based decision support may assist screening and preliminary triage where specialist access is limited. We propose DFU-MambaKAN, a hybrid architecture combining a p...

(This article belongs to the Topic Artificial Intelligence and Big Data in Biomedical Engineering)
  • Article
  • Open Access
3,000 Views
18 Pages

Background: Diabetic foot ulcer (DFU) is a major complication of type 2 diabetes (T2D), frequently resulting in disability, lower-limb amputation, and substantial healthcare burden. Early identification of patients at high risk of progressing to seve...

  • Article
  • Open Access
41 Citations
131 Views

Acute Phase Reactants Predict the Risk of Amputation in Diabetic Foot Infection

  • Baris Akinci,
  • Serkan Yener,
  • Sena Yesil,
  • Nur Yapar,
  • Yasin Kucukyavas and
  • Firat Bayraktar

Background: Prediction of amputation would aid clinicians in the management of diabetic foot infections. We aimed to assess the predictive value of baseline and posttreatment levels of acute phase reactants in the outcome of patients with diabetic fo...

  • Article
  • Open Access
29 Citations
168 Views

Efficacy of Intralesional Platelet-Rich Plasma in Diabetic Foot Ulcer

  • Ajay Gupta,
  • Chethan Channaveera,
  • Satyaranjan Sethi,
  • Sunil Ranga and
  • Vijender Anand

Background: Diabetic foot ulcer (DFU) is well managed by infection control, euglycemic state, and debridement of the ulcer followed by appropriate dressing and off-loading of the foot. Studies show that approximately 90% of DFUs that are properly off...

  • Case Report
  • Open Access
1,321 Views
12 Pages

Multidisciplinary Management of Diabetic Foot Ulcers Impacted by Social Determinants of Health: A Review and Case Report

  • Kara Turner,
  • Denise Levy,
  • Jairo L. Arce-Morales,
  • Manasa Kanneganti,
  • Johanna P. Daily and
  • Alyson K. Myers

Introduction: Diabetic foot ulcers (DFUs) are a debilitating complication of diabetes, and management by multidisciplinary foot teams has been shown to reduce serious sequelae, such as amputations. There are stark racial and ethnic disparities in mor...

(This article belongs to the Section Complications and Comorbidities of Diabetes)
  • Article
  • Open Access
1,055 Views
17 Pages

Plantar load distribution and postural stability are key functional domains in diabetic foot assessment, yet their association in early-stage disease remains poorly characterized. This study aimed to investigate the association between static plantar...

  • Article
  • Open Access
1 Citations
1,265 Views
23 Pages

Carbopol® 940 Hydrogel Functionalised with Plasma-Activated Water: An Advanced Platform for Controlled ROS Delivery and Antimicrobial Applications

  • Alma Neli Hernández-Arias,
  • Benjamín Gonzalo Rodríguez-Méndez,
  • Régulo López-Callejas,
  • Diego Medina-Castro,
  • Antonio Mercado-Cabrera,
  • Rosendo Peña-Eguiluz,
  • Bethsabet Jaramillo-Sierra and
  • Raúl Valencia-Alvarado

7 May 2026

The antimicrobial resistance crisis necessitates innovative systems for delivering oxidising agents. This study reports the development of a Carbopol® 940 hydrogel functionalised with plasma-activated water (PAW) for the stabilisation and control...

(This article belongs to the Section Gel Analysis and Characterization)
  • Article
  • Open Access
38 Citations
159 Views

Pathogens Isolated From Deep Soft Tissue and Bone in Patients With Diabetic Foot Infections

  • M. Bulent Ertugrul,
  • Selcuk Baktiroglu,
  • Serpil Salman,
  • Seher Unal,
  • Murat Aksoy,
  • Kezban Berberoglu and
  • Semra Calangu

Background: We sought to determine the similarity of pathogens isolated from soft tissue and bone in patients with diabetic foot infections. It is widely believed that soft-tissue cultures are adequate in the determination of causative bacteria in pa...

  • Article
  • Open Access
3 Citations
267 Views

Treatment of Nonhealing Diabetic Foot Wounds with Vaporous Hyperoxia Therapy in Conjunction with Standard Wound Care

  • Dustin Kruse,
  • Kenneth Morgan,
  • Jeremy Christensen,
  • Brian S. Derner and
  • Brett Sachs

Background: Vaporous hyperoxia therapy (VHT), a patented US Food and Drug Administration 510 (k)–cleared technology, is an adjunct therapy used in conjunction with standard wound care (SWC). Vaporous hyperoxia therapy is said to improve the health of...

  • Article
  • Open Access
21 Citations
297 Views

Ovine Forestomach Matrix in the Surgical Management of Complex Lower-Extremity Soft-Tissue Defects: A Retrospective Multicenter Case Series

  • Brandon A. Bosque,
  • Shane G. Dowling,
  • Barnaby C.H. May,
  • Richard Kaufman,
  • Igor Zilberman,
  • Nooshin Zolfaghari,
  • Howie Que,
  • James Longobardi,
  • Joseph Skurka and
  • M. Mark Melin
  • + 1 author

Background: Chronic lower-extremity defects may lead to major amputations and have severe consequences on patient quality of life and mortality. Dermal matrices have become part of the reconstructive ladder and are often deployed in these scenarios t...

  • Article
  • Open Access
17 Citations
6,749 Views
15 Pages

The Effect of Vibration on the Acceleration of Wound Healing of Diabetic Neuropathic Foot Ulcer: A Prospective Experimental Study on Human Patients

  • Sitti Syabariyah,
  • Elly Nurachmah,
  • Budiman Darmo Widjojo,
  • Sabarinah Prasetyo,
  • Hiromi Sanada,
  • Irianto,
  • Gojiro Nakagami,
  • Suriadi,
  • Tutur Kardiatun and
  • Urfa Khairatun Hisan

Diabetic foot ulcers are a common complication that occurs in approximately 15 percent of patients with diabetes mellitus. Over 60% of diabetic foot ulcers are caused by underlying neuropathy. Former studies on diabetic animals with foot wounds found...

  • Article
  • Open Access
10 Citations
4,170 Views
22 Pages

Prevalence and Molecular Characterization of Carbapenemase-Producing Multidrug-Resistant Bacteria in Diabetic Foot Ulcer Infections

  • Mohd Saleem,
  • Soha Abdallah Moursi,
  • Tahani Nasser Almofeed Altamimi,
  • Mohammed Salem Alharbi,
  • Alwaleed Mohammad Alaskar,
  • Sahar Adly Hassan Hammam,
  • Ehab Rakha,
  • Ozair Ilyas Syed Muhammad,
  • Hamoud Abdulmohsin Almalaq and
  • Azharuddin Sajid Syed Khaja
  • + 1 author

Background: Diabetic foot ulcers (DFUs) represent severe complications in diabetic patients, often leading to chronic infections and potentially resulting in nontraumatic lower-limb amputations. The increasing incidence of multidrug-resistant (MDR) b...

(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
  • Article
  • Open Access
5 Citations
2,201 Views
10 Pages

Revisiting Antibiotic-Impregnated Cement Spacer for Diabetic Osteomyelitis of the Foot

  • Farouk Khury,
  • Ihab Karkabi,
  • Elias Mazzawi,
  • Doron Norman,
  • Eyal A. Melamed and
  • Eli Peled

1 December 2024

Introduction: Despite the rising global awareness and improvement of socioeconomic and living standards, the prevalence of diabetic osteomyelitis (DOM) and its complications has been increasing rapidly. This study aims to investigate the long-term pr...

  • Article
  • Open Access
1,923 Views
15 Pages

Segmental Pulse Volume Recordings at the Forefoot Level as a Valuable Diagnostic Tool for Detection of Peripheral Arterial Disease in the Diabetic Foot Syndrome

  • Andreas Nützel,
  • Lilly Juliane Undine Reik,
  • Maximilian Hamberger,
  • Christian Lottspeich,
  • Sinan Deniz,
  • Anja Löw,
  • Holger Schneider,
  • Hans Polzer,
  • Sebastian Baumbach and
  • Michael Czihal

Introduction: Evidence for the diagnostic yield of noninvasive diagnostic assessment for the diagnosis of peripheral arterial disease (PAD) in diabetic foot syndrome (DFS) is poor. Pulse volume recordings (PVRs) at the forefoot level could be a valua...

(This article belongs to the Special Issue Peripheral Artery Disease and Diabetic Foot Ulcer: From Bench to Clinic (2nd Edition))
  • Article
  • Open Access
1 Citations
1,168 Views
14 Pages

Background: Diabetic foot ulcers (DFUs) are considered a prevalent complication of diabetes mellitus, frequently accompanied with compromised peripheral circulation, slower healing, as well as high risk of infection in addition to risk of amputation....

(This article belongs to the Section Clinical Care)