Application of Dehydrated Amniotic Membrane Allografts in Advanced Diabetic Foot Ulceration: Case Report and Review of Literature
Abstract
:1. Introduction
2. Case Presentation Section
2.1. Dehydrated Human Amniotic Membrane Allografts
2.2. Patient History
3. Discussion
4. Results
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Appendix A
Test Kits
- HBcAb: Catalog number: 06P06, Abbott Laboratories, Abbott Park, IL, USA;
- HbsAg: Catalog number: 06P02, Abbott Laboratories, Abbott Park, IL, USA;
- HCV: Catalog number: 06P04, Abbott Laboratories, Abbott Park, IL, USA;
- HIV1, HIV2, plus O: Catalog number: 06P01, Abbott Laboratories, Abbott Park, IL, USA;
- HTLV-I/II: Catalog number: 06P07, Abbott Laboratories, Abbott Park, IL, USA;
- RPR: Catalog number: 900025, Arlington Scientific, Springville, UT, USA;
- HIV1, HCV, HBV, NAT: Catalog number: 303330, 303331, 303719, 303334, 303344;
- WNV: Catalog number: 07001061190, Roche Diagnostics, Indianapolis, IN, USA.
Appendix B
Appendix B.1. Wound Size
- Length × width less than 4 square cm;
- Length × width between 4 and 16 square cm;
- Length × width between 16.1 and 36 square cm;
- Length × width between 36.1 and 80 square cm;
- Length × width greater than 80 square cm.
Appendix B.2. Depth
- Non-blanchable erythema on intact skin;
- Partial-thickness skin loss involving epidermis and/or dermis;
- Full-thickness skin loss involving damage or necrosis of subcutaneous tissue; may extend down to but not through underlying fascia; and/or mixed partial and full-thickness and/or tissue layers obscured by granulation tissue;
- Obscured by necrosis;
- Full-thickness skin loss with extensive destruction, tissue necrosis, or damage to muscle, bone, or supporting structures.
Appendix B.3. Edges
- Instinct, diffuse, none clearly visible;
- Distinct, outline clearly visible, attached, even with wound base;
- Well-defined, not attached to wound base;
- Well-defined, not attached to wound base, rolled under, thickened;
- Well-defined, fibrotic, scarred, or hyperkeratotic.
Appendix B.4. Necrotic Tissue Amount
- None visible;
- <25% of wound bed covered;
- 25% to 50% of wound covered;
- >50% and <75% of wound covered;
- 75% to 100% of wound covered.
Appendix B.5. Epithelialization
- 100% wound covered, surface intact;
- 75% to <100% wound covered and/or epithelial tissue extends >0.5 cm into wound bed;
- 50% to <75% wound covered and/or epithelial tissue extends to <0.5 cm into wound bed;
- 25% to <50% wound covered;
- <25% wound covered.
References
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Date of Examination | DFU Measurements |
---|---|
25 January 2022 | 5.5 cm × 4.5 cm × 0.3 cm |
1 February 2022 | 5.3 cm × 4.3 cm × 0.1 cm |
8 February 2022 | 5.1 cm × 4.4 cm × 0.1 cm |
15 February 2022 | 5.0 cm × 3.9 cm × 0.1 cm |
22 February 2022 | 4.2cm × 3.5 cm × 0.1 cm |
1 March 2022 | 3.1 cm × 1.8 cm × 0.1 cm |
8 March 2022 | 0.9 cm × 0.8 cm × superficial |
15 March 2022 | 0.0 cm × 0.0 cm × superficial |
Application #1 | Application #2 | Application #3 | Application #4 | Application #5 | Application #6 | Application #7 | Final Visit | |
---|---|---|---|---|---|---|---|---|
Size | 3 | 3 | 3 | 2 | 2 | 2 | 1 | 1 |
Depth | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 1 |
Edges | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 1 |
Necrotic Tissue Amount | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
Epithelization | 5 | 5 | 5 | 4 | 4 | 4 | 4 | 1 |
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Becker, C.; Regulski, M.; Martin, S.; Barrett, T. Application of Dehydrated Amniotic Membrane Allografts in Advanced Diabetic Foot Ulceration: Case Report and Review of Literature. Reports 2022, 5, 28. https://doi.org/10.3390/reports5030028
Becker C, Regulski M, Martin S, Barrett T. Application of Dehydrated Amniotic Membrane Allografts in Advanced Diabetic Foot Ulceration: Case Report and Review of Literature. Reports. 2022; 5(3):28. https://doi.org/10.3390/reports5030028
Chicago/Turabian StyleBecker, Catherine, Matthew Regulski, Scott Martin, and Tyler Barrett. 2022. "Application of Dehydrated Amniotic Membrane Allografts in Advanced Diabetic Foot Ulceration: Case Report and Review of Literature" Reports 5, no. 3: 28. https://doi.org/10.3390/reports5030028