Search Results (83)

Background: Particulate matter (PM_2.5) inhalation induces pulmonary disorders through oxidative stress. Veratramine (VRT), a steroidal alkaloid derived from Veratrum species, exhibits protective pharmacological potential. Therefore, this study aims to investigate the protective effects of VRT against PM_2.5-induced oxidative injury and the underlying molecular mechanisms. Methods: In vitro experiments were conducted using pulmonary artery endothelial cells (HPAECs), which were exposed to PM_2.5 (25–100 μg/mL) ± VRT (2–50 μM) or Dexamethasone (DEX; 50 μM) for 24–48 h. Measurements included 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide viability, Lactate dehydrogenase ELISA, 2′,7′-dichlorodihydrofluorescein diacetate reactive oxygen species (ROS), superoxide dismutase/catalase kits, and Western blots (Bax, serum, and glucocorticoid-regulated kinase 1 (SGK1), microtubule-associated protein 1 light chain 3 (LC3), Toll-like receptor (TLR4), and mechanistic target of rapamycin (mTOR)). Results: PM_2.5 exposure reduced HPAEC viability in a dose- and time-dependent manner, likely due to increased lactate dehydrogenase leakage and intracellular ROS accumulation. Oxidative stress correlated with altered superoxide dismutase and catalase activities, with suppression of SGK1, a key factor in cell survival. VRT treatment enhanced cell viability, mitigated oxidative stress, and restored SGK1 expression. Moreover, VRT promoted mTOR phosphorylation and markedly suppressed PM_2.5-induced increases in TLR4, MyD88, and the autophagy markers LC3 II and Beclin 1. Conclusions: Collectively, these findings indicate that VRT protects against PM_2.5-induced pulmonary injury by modulating oxidative stress and the mTOR-associated autophagy pathway, highlighting its potential as a therapeutic candidate for PM_2.5-related respiratory disorders. Full article

This study investigated the fault ride through capability of inverter-based resources in weak distribution networks and proposes a fault-oriented reactive power compensation strategy using only point of common coupling voltage measurements. The proposed strategy determines the reactive power command based on the minimum phase voltage, which represents the most severely depressed phase during unbalanced faults, without fault type detection or sequence component analysis. As a result, the same control framework can be applied to single-line-to-ground, double-line-to-ground, and three-phase faults. A detailed MATLAB/Simulink model of a Korean distribution feeder was developed using actual system parameters. The proposed strategy was compared with a no control case and a conservative fixed capacity reactive power injection scheme derived from commonly adopted power factor limits. Simulation results show that the no control case provides no voltage support, while the fixed capacity approach yields limited improvement in weak grids. In contrast, the proposed strategy maintains stable inverter operation and improves voltage recovery. At locations with an extremely low weighted short circuit ratio of 0.303, the proposed strategy prevents inverter tripping during temporary faults and satisfies low voltage ride through requirements, demonstrating its practical effectiveness. Full article

Background: Autism Spectrum Disorder (ASD) involves social, emotional, and behavioral challenges, and conventional therapies show limited effectiveness. Aims: To evaluate the effect of Yoga Therapy (YT) on neurophysiological regulation and behavioral functioning in individuals with ASD. Methods: Thirty-six autistic individuals, aged 6 to 25 years and with Childhood Autism Rating Scale (CARS) scores above 15, were randomly assigned to yoga (YG) and control (CG) groups. YG received 60 min YT sessions twice weekly for six months alongside a regular school routine, while CG followed only a regular school routine. Handgrip strength (HGS), visual reaction time (VRT), systolic (SBP) and diastolic (DBP) blood pressure, heart rate (HR), and CARS scores were assessed at pre-, mid-, and post-intervention. Repeated measures ANOVA and Pearson’s correlation were used for statistical analysis. Results: The study showed an increase in HGS (Δ = 3.27 kg) and a reduction in VRT (Δ = −523.86 ms) with a marked decrease in total CARS score (Δ = −5.67), p < 0.01 in YG. There was a mild, non-significant reduction in cardiovascular (CV) dysfunction in YG, while CG showed no significant changes across all measures. Conclusion: Biweekly YT sessions over six months enhanced neurophysiological regulation, improving sensorimotor integration and accelerating cognitive, emotional, and behavioral outcomes in individuals with ASD. Full article

Background: Functional dizziness and persistent postural-perceptual dizziness (PPPD) involve mutually reinforcing vestibular symptoms and anxiety. Non-pharmacological interventions, such as vestibular rehabilitation therapy (VRT) and cognitive behavioral therapy (CBT), aim to address both mechanisms, yet their overall effectiveness remains unclear. Methods: We systematically examined randomized controlled trials (RCTs) published between 2000 and 2025 that evaluated VRT, CBT, or multimodal approaches for adults with functional or chronic dizziness (including PPPD and related functional dizziness constructs) accompanied by significant anxiety. Twelve RCTs (513 participants) met the criteria, involving individuals with PPPD, chronic subjective dizziness, chronic vestibular disorders with prominent anxiety, and residual dizziness after benign paroxysmal positional vertigo. Results: Conventional VRT delivered in clinic or as structured home-based programs produced small-to-moderate improvements in dizziness-related disability versus usual care. Combining VRT with CBT or psychologically informed components yielded larger and more consistent reductions in disability and maladaptive dizziness-related beliefs. CBT-based interventions reduced anxiety and dizziness-related distress compared with supportive controls. Emerging modalities, including virtual-reality-based VRT, non-invasive neuromodulation, and heart-rate-variability biofeedback, showed potential, although they were limited by small samples and methodological issues. Most trials had some risk-of-bias concerns and evidence certainty ranged from very low to moderate. Conclusions: Integrated multimodal rehabilitation shows promise, although larger, high-quality RCTs using standardized procedures and outcome measures are required. Full article

Objective: This short-term prospective observational study aimed to evaluate the efficacy of vestibular rehabilitation therapy (VRT) in Patients Diagnosed with Persistent Postural-Perceptual Dizziness (PPPD). Methods: Given the exploratory design, the small sample (n = 25) and absence of a formal power calculation limit precision, findings should be interpreted as preliminary, and confirmatory trials are warranted. Patients were assessed before (T1), immediately after a five-week vestibular rehabilitation program (T2), and again three months later without continued therapy (T3). Clinical symptoms were assessed using the Dizziness Handicap Inventory (DHI). A Generalized Estimating Equations (GEE) model was used to analyze changes in dizziness-related physical, emotional, and functional impacts over time, accounting for sex and its interaction with time. Statistical significance was tested using the Wald test, with results reported as estimated means and standard errors (SEs), and a significance level set at p ≤ 0.05. Results: The mean age of participants was 44.48 ± 14.43 years, and the majority were women (84%). In the functional domain, the mean score difference was 6.69 points between T1 and T2 (p = 0.018), 7.11 points between T1 and T3 (p = 0.013), and 0.42 points between T2 and T3 (p > 0.05). In the emotional domain, the mean difference was 4.12 points between T1 and T2 (p = 0.008), 4.40 points between T1 and T3 (p = 0.005), and 0.29 points between T2 and T3 (p > 0.05). In the physical domain, the mean difference was 3.77 points between T1 and T2 (p = 0.024), 4.32 points between T1 and T3 (p = 0.009), and 0.55 points between T2 and T3 (p > 0.05). For the total score, the mean difference was 14.58 points between T1 and T2 (p = 0.005), 15.83 points between T1 and T3 (p = 0.003), and 1.25 points between T2 and T3 (p > 0.05). The moment variable had a statistically significant effect across all domains. Sex had a significant effect only in the emotional domain, with women consistently reporting higher scores than men. Conclusions: This study demonstrates that a five-week vestibular rehabilitation program significantly improves the physical, emotional, and functional impacts of dizziness in patients with PPPD, with these benefits largely sustained three months after the intervention. Emotional improvements were particularly notable among women, highlighting potential sex-related differences in response to treatment. These findings underscore the importance of addressing emotional health in PPPD management and support the long-term effectiveness of vestibular rehabilitation in improving patient outcomes. Full article

Precision agriculture can determine the amount of nitrogen (N) required in each area to optimize yield and nitrogen use efficiency (NUE). The use of variable rate technology (VRT) for planning N fertilization has often relied on techniques that are unfeasible for farmers with limited resources. This study aims to present a variable fertilization plan for wheat and barley, along with a protocol to determine the optimal timing for the second nitrogen (N) application, thereby minimizing the need for in situ crop monitoring. Two approaches are studied: a more straightforward sensor-based method and a map-based method. The sensor-based approach involved modeling the maximum NDVI based on the observed value at the time of application and the required N level, achieving an R² of 0.55 ± 0.06 and 0.72 ± 0.04, an MAE of 0.025 ± 0.002 and 0.039 ± 0.002, and an RMSE of 0.049 ± 0.007 and 0.055 ± 0.004 for wheat and barley, respectively. The map-based approach relied on training models to estimate the nitrogen dose to be applied based on the target yield and reflectance data from Sentinel-2 at the time of application. Using random forest algorithms, an R² of 0.97 ± 0.01 and 0.96 ± 0.02, an MAE of 3.33 ± 0.20 kg N ha⁻¹ and 2.01 ± 0.13 kg N ha⁻¹, and an RMSE of 4.79 ± 0.31 kg N ha⁻¹ and 3.27 ± 0.58 kg N ha⁻¹ for wheat and barley, respectively. Full article

Video denoising in extremely low-light surveillance scenarios is a challenging task in computer vision, as it suffers from harsh noise and insufficient signal to reconstruct fine details. The denoising algorithm for these scenarios encounters challenges such as the lack of ground truth, and the noise distribution in the real world is far more complex than in a normal scene. Consequently, recent state-of-the-art (SOTA) methods like VRT and Turtle for video denoising perform poorly in this low-light environment. Additionally, some methods rely on raw video data, which is difficult to obtain from surveillance systems. In this paper, a denoising method is proposed based on the trilateral filter, which aims to denoise real-world low-light surveillance videos. Our trilateral filter is a weighted filter, allocating reasonable weights to different inputs to produce an appropriate output. Our idea is inspired by an experimental finding: noise on stationary objects can be easily suppressed by averaging adjacent frames. This led us to believe that if we can track moving objects accurately and filter along their trajectories, the noise may be effectively removed. Our proposed method involves four main steps. First, coarse motion vectors are obtained by bilateral search. Second, an amplitude-phase filter is used to judge and correct erroneous vectors. Third, these vectors are refined by a full search in a small area for greater accuracy. Finally, the trilateral filter is applied along the trajectory to denoise the noisy frame. Extensive experiments have demonstrated that our method achieves superior performance in terms of visual effects and quantitative tests. Full article

The superiority of Variable Resistance Training (VRT) over traditional Constant Resistance Training (CRT) for enhancing lower-limb performance is debated, with previous meta-analyses limited by aggregating disparate exercises. This systematic review and meta-analysis, the first to focus exclusively on the squat, compared the acute and long-term effects of VRT versus CRT on maximal strength and explosive power. Following PRISMA guidelines, 20 studies were analyzed (literature search up to 15 June 2025), with Hedges’ g used for effect size (ES) calculation. Results demonstrated VRT’s superiority for both acute (ES = 0.34) and long-term adaptations. Acutely, effects peaked with an 8–12 min recovery (ES = 0.43). Long-term, VRT produced greater gains in maximal strength (ES = 0.31) and explosive power (ES = 0.17). Subgroup analyses on maximal strength revealed that elastic bands were highly effective (ES = 0.67), particularly in trained individuals (ES = 0.35), males (ES = 0.41), within cycles < 8 weeks (ES = 0.44), and at frequencies of ≤2 sessions/week (ES = 0.45). For explosive power, chains were most effective (ES = 0.37), significantly improving jumping performance but not sprinting. In conclusion, VRT is a more effective modality for squat training; optimal programs should utilize elastic bands for strength and chains for power, with strength-focused blocks being short-term (<8 weeks) and lower-frequency (≤2 sessions/week) for trained individuals. Full article

Objectives: Surface-Guided Radiation Therapy (SGRT) has been widely adopted in breast cancer radiotherapy, particularly for improving setup accuracy and motion management. Recently, its application in lung cancer has attracted growing interest due to similar needs for precision. This study investigates the feasibility and clinical utility of SGRT in lung cancer treatment, focusing on its effectiveness in patient setup and real-time motion monitoring under frameless immobilization conditions. Materials and Methods: A total of 204 treatment records from 17 patients with primary lung cancer who underwent radiotherapy at Korea University Guro Hospital between October 2024 and April 2025 were retrospectively analyzed. Patients were initially positioned using the Identify system (Varian) in the CT suite, with surface data transferred to the treatment room system. Alignment was performed to within ±1 cm and ±2° across six degrees of freedom. Cone-beam CT (CBCT) was acquired prior to treatment for verification, and treatment commenced when the Distance to Correspondence Surface (DCS) was ≤0.90. Setup deviations from the Identify system were recorded and compared with CBCT in three translational axes to evaluate positioning accuracy and PTV displacement. Results and Conclusions: The Identify system was shown to provide high setup accuracy and reliable real-time motion monitoring in lung cancer radiotherapy. Its ability to detect patient movement and automatically interrupt beam delivery contributes to enhanced treatment safety and precision. In addition, even though the maximum longitudinal (Lng) shift reached up to −1.83 cm with surface-guided setup, and up to 1.78 cm (Lat) 5.26 cm (Lng), 9.16 cm (Vrt) with CBCT-based verification, the use of Identify’s auto-interruption mode (±1 cm in translational axes, ±2° in rotational axes) allowed treatment delivery with PTV motion constrained within ±0.02 cm. These results suggest that, due to significant motion in the longitudinal direction, appropriate PTV margins should be considered during treatment planning. The Identify system enhances setup accuracy in lung cancer patients using a surface-guided approach and enables real-time tracking of intra-fractional errors. SGRT, when implemented with systems such as Identify, shows promise as a feasible alternative or complement to conventional IGRT in selected lung cancer cases. Further studies with larger patient cohorts and diverse clinical settings are warranted to validate these findings. Full article

Background: Clinical trials and serological studies have demonstrated that vaccine-induced antibodies can cross-react with some non-vaccine serotypes. However, there are limited longitudinal data on the impact of pneumococcal conjugate vaccines (PCV) on cross-reactive serotypes after implementation in immunization programs. This study examines the impact of PCVs on pneumococcal disease cases due to potential cross-reactive serotypes. Methods: Eleven countries with serotyped invasive pneumococcal disease (IPD) surveillance data that had introduced PCV10 or PCV13 were identified. The analysis focused on IPD cases due to serotypes included in PCV10 and PCV13 (PCV10/13 VTs: 6B, 9V, 19F, 23F; PCV13 only VTs: 6A, 19A) and to vaccine-related serotypes (VRTs: 6C, 9N, 23A, 23B) that may be immunologically related to VTs in children under 5 years old. For each country, the number of IPD cases were charted over time according to serogroup. Results: Following PCV introduction, reductions in VT IPD cases were observed in all countries, while some VRT IPD cases remained unchanged or increased. Serotype 19A cases declined in PCV13 countries but increased in countries that introduced PCV10. VRT 6C cases rose in PCV10 countries but showed minimal change in PCV13 countries. In PCV13 countries, 9N cases remained unchanged while 23A and 23B experienced modest increases. Conclusions: The inclusion of VT 19A in PCV13, but not in PCV10, may account for the significant increase in VRT 19A cases in PCV10 countries. The slight change in VRT 6C cases in PCV13 countries compared to the significant rise in PCV10 countries suggests that PCV13 provides cross-protection for serotype 6C through serotype 6A. Cross-protection could not be determined for other VRTs, as their cases increased or remained unchanged or had insufficient data for evaluation. Full article

In this work, an innovative process chain is set up for the regular provision of fertilization consultation services to farmers for a variety of crops, within a precision agriculture framework. The central hub of this mechanism is a geographic information system (GIS), while a 5 × 5 m point grid is the information carrier. Potential data sources include soil samples, satellite imagery, meteorological parameters, yield maps, and agronomic information. Whenever big data are available per crop, decision-making is supported by machine learning systems (MLSs). All the map data are uploaded to a farm management information system (FMIS) for visualization and storage. The recipe maps are transmitted wirelessly to variable rate technologies (VRTs) for applications in the field. To a large degree, the process chain has been automated with programming at many levels. Currently, four different service modules based on the new process chain are available in the market. Full article

Robust robot manipulation hinges on effective state estimation. The VRT 6 robot leverages an inertia measurement unit with triaxial gyroscopes, magnetometers, and accelerometers, as well as a position sensor, but these sensors are plagued by noise that demands rigorous filtering. To tackle this, an adaptively scaled unscented Kalman filter was employed. The filter’s scaling parameter was meticulously optimized using density- and moment-based techniques, as both system properties and estimated state impact this crucial parameter. A Maximum Likelihood Estimation (ML) substantiates the enhanced quality of the estimated velocity and acceleration, on par with the position estimate. Minimizing measurement prediction error (MMPE) also shows better results with less RMSE when compared to fixed-kappa values, and the quality of position estimates is higher with the increase in the domain of the scaling parameter. By carefully selecting the adaptive scaling parameters’ range to minimize sigma point weights and ensure the positive definiteness of the covariance matrix, this enhanced UKF method achieved markedly superior state estimates compared to standard UKF implementations. Full article

A series (n = 22) of glasses from the site Kapucinski vrt (garden of the Capuchin monastery, 5th–17th c. CE) in Koper (Capodistria), a port town in the northern Adriatic, was measured using a combined PIXE and PIGE method. Koper has been continuously populated since the late Roman period, with a rich medieval history, thus offering an opportunity to study Early Medieval glass. Stemmed goblet fragments, in the original publication dated between the 6th–9th centuries CE, and several other vessel types (beakers and flasks or bottles and lamps) were selected for analysis. The measurements were expected to show the trends in glass production and consumption from Late Antiquity until the Middle Ages, notably the transition between natron to plant ash glass and the supply of fresh glass. Among the set of 22 glass vessel fragments, both natron and plant ash glass were identified. For finer classification, we relied on a newly developed method of Euclidean distances with respect to major concentrations. Natron glass of the types Foy 2.1 (9 examples), Magby (2 examples), and Levantine I (Apollonia; 2 examples) was found. Two glasses remain undetermined but testify to an Egyptian origin. Most natron glasses show signs of recycling. Among the three unrecycled glasses (about 20% of the whole set), there are two examples of Levantine glass and a Magby glass lamp; this may indicate a modest supply of fresh glass during the period. Plant ash glass may be attributed to the Early or High Middle Ages, exploiting the purified alkalis of the Levantine coasts (known as alume catino in later Venetian glassmaking), and the admixture of impurities in the siliceous sands suggests the circulation and consumption of glass that was produced and traded in the eastern Mediterranean since the 10th century CE. Full article

Hop is a key ingredient in beer production, and drying it allows it to be stored before use. Unfortunately, postharvest drying techniques can negatively affect hop quality. In this study, we compared drying using a hot stove (H), freeze-drying (F), and ventilated at room temperature (VRT) drying, focusing on the chemical quality and essential oil composition. To achieve 80% water removal, F and H took two days, while VRT took five days. F and H preserved a high content of total chlorophyll (F 81.89 g/kg dm; H 82.70 g/kg dm) and carotenoids (F 54.02 g/kg dm; H 54.71 g/kg dm). The hop storage index (HSI) increased with all drying techniques, but especially in F and H. The lowest amount of polyphenols was found in the H sample (348.48 g/kg dm), while the highest content was found in VRT (631.11 g/kg dm). Freeze-drying gave the best results, especially in relation to the amount of polyphenols and antioxidant power of the product. Regarding essential oils, in the class of sesquiterpene hydrocarbons, we found α-humulene (F 24.0%; VRT 24.7%; H 25.6%), β-caryophyllene (F 10.5%; VRT 9.4%; H 11.1%), and β-farnesene (F 6.8%; VRT 6.0%; H 7.4%). The total monoterpene hydrocarbon amount increased in the VRT sample. Thus, freeze-drying emerges as an alternative technique to the hot stove; however, the cost is high. Instead, drying at ventilated room temperature represents a sustainable and valid technique for preserving the aromatic characteristics and polyphenols of the product. Full article

Background: Vestibular physical therapy is a specific type of exercise intervention that is designed to treat symptoms caused by vestibular disorders and to enhance postural control. The level of expertise in the practice of vestibular rehabilitation therapy (VRT) varies widely around the world. The practice of VRT is advanced in some countries, yet practice may be less advanced in others. No previous studies have evaluated the knowledge and beliefs of vestibular rehabilitation in the Kingdom of Saudi Arabia (KSA) to date. Objective. This study aimed to evaluate the knowledge and beliefs about VRT among physical therapists in the KSA. Methods: We used an electronic cross-sectional survey containing 25 questions and divided into four sections: demographics, clinical experience, vestibular rehabilitation knowledge, and physical therapists’ beliefs. The survey was answered by 219 licensed physical therapists. Results: Of the 219 responders, 59 (27%) physical therapists reported having experience with VRT. A total of 119 (54%) participants felt confident talking to other medical members when managing persons with dizziness. Only 59 (26%) clinicians were using vestibular assessment techniques, and 103 (47%) clinicians used VRT if they had patients with vestibular disorders. The majority of physical therapists believed in the efficacy of vestibular rehabilitation. Conclusions: Although the majority of physical therapists consider vestibular rehabilitation a crucial aspect of their practice, they acknowledge having limited knowledge of vestibular disorders and treatment techniques. Full article