Search Results (9,740)

Social determinants of health (SDoH) comprise a broad array of social conditions, such as access to food and housing, that facilitate or impede individual behavior. The aim of this study was to assess the association between SDoH and cigarette smoking-related outcomes among U.S. adults (aged ≥18 years) by using data from the 2023 Behavioral Risk Factor Surveillance System (BRFSS). Cross-sectional data were obtained from the Social Determinants and Health Equity (SD/HE) module, conducted in 33 states, the District of Columbia, and Puerto Rico as part of the 2023 BRFSS. We examined four indicators of adverse SDoH (i.e., food insecurity, housing insecurity, utility insecurity, and lack of reliable transportation) and three cigarette smoking-related outcomes (i.e., cigarette smoking status, menthol cigarette smoking, and past-year quit attempt). All analyses were conducted with SAS 9.4 and used BRFSS sampling weights to adjust for the complex sampling design. Among 45,160 respondents, 2991 (7.8%) were adults who smoked cigarettes in the past month, of whom 570 (16.5%) reported making a quit attempt in the past 12 months. Menthol cigarette use was reported by 634 (22.0%) adults who smoked cigarettes in the past month. In adjusted analyses, each SDoH measure (i.e., food insecurity (aOR = 1.70, 95% CI: 1.19–2.41, p < 0.01), housing insecurity (aOR = 1.66, 95% CI: 1.06–2.59, p < 0.05), utility insecurity (aOR = 1.92, 95% CI: 1.01–3.65, p < 0.05), and lack of reliable transportation (aOR = 1.67, 95% CI: 1.03–2.73, p < 0.05)) was significantly associated with making a quit attempt in the past 12 months. Food insecurity was significantly associated with the odds of current cigarette smoking. Food insecurity and utility insecurity were independent risk factors for using menthol cigarettes. U.S. adults experiencing adverse SDoH are trying to stop smoking at higher rates than adults not experiencing adverse SDoH. Findings demonstrate that SDoH is a strong predictor of cigarette smoking status, menthol cigarette smoking, and past-year quit attempts among U.S. adults. Full article

Salicylic acid (SA) is a key signaling molecule regulating secondary metabolism and stress responses in plants, but its preharvest role as a low-cost elicitor in cannabis remains underexplored. This study evaluated the effects of preharvest foliar SA application at different concentrations and application intervals on pigments, antioxidants, and cannabinoids in Cannabis sativa L. leaves and inflorescences. In leaves, moderate SA (0.1 M) significantly enhanced total phenolic content, total flavonoid content, and antioxidant activity (%DPPH inhibition), while higher concentrations suppressed these responses, reflecting a regulated metabolic trade-off rather than irreversible tissue damage. A significant interaction between SA concentration and preharvest time was observed for chlorophyll a (p < 0.01), whereas chlorophyll b and total chlorophyll were not significantly influenced by the interaction. In inflorescences, short-term application of 0.1 M SA (1 h preharvest) maximized phenolics, flavonoids, antioxidant capacity, and pigment accumulation, whereas the untreated controls showed the lowest levels. Cannabinoids exhibited distinct responses: Δ⁹-tetrahydrocannabinol (Δ⁹-THC), total tetrahydrocannabinol (Total THC), and tetrahydrocannabinolic acid (THCA) peaked at 0.1 M SA applied 1 h preharvest, while cannabidiol (CBD) was less concentration-dependent, with maximum accumulation observed at 1.0 M SA applied 24 h preharvest. Preharvest SA elicitation strongly modulated cannabis secondary metabolism. Short-term application of moderate SA promoted total phenolic, total flavonoid, antioxidant, pigment, and THC-group cannabinoid accumulation, while CBD displayed broader tolerance to concentration and application timing. These findings highlighted the potential of SA as a preharvest elicitor to improve cannabis phytochemical quality. Full article

This study involved 45 finishing Limousin young bulls (initial BW 350 ± 15 kg; aged 250 ± 20 days) reared under commercial conditions and randomly assigned for 250 days to three dietary treatments: a control diet without olive cake (CTR), and diets including partially destoned dried olive cake at 10% (OC10) or 15% (OC15) of dry matter. The effects of the dietary inclusion of partially destoned dried olive cake (DOC) on the physicochemical properties, intramuscular fatty acid composition, nutritional lipid indices, and antioxidant profile of the Longissimus dorsi muscle were evaluated. Meat pH was measured at 45 min, 24 h, and 7 days of aging. Instrumental color, proximate composition, fatty acid profile, lipid nutritional indices, total phenolic content (TPC), individual polyphenols, and antioxidant capacity were determined. Data were analyzed by ANOVA using PROC GLIMMIX in SAS, with orthogonal contrasts to evaluate linear and quadratic responses to olive cake inclusion. Treatments did not affect post mortem pH, and color differences observed at 24 h were not present after 7 days of aging. Crude protein content was lower in OC-fed groups, while total lipid content tended to increase; sodium chloride concentration was higher in OC15 meat. Olive cake supplementation reduced hypercholesterolemic saturated fatty acids and increased stearic, oleic, and polyunsaturated fatty acids, including α-linolenic acid, EPA, and DPA, improving PUFA/SFA and UFA/SFA ratios and reducing atherogenic and thrombogenic indices. Despite a higher peroxidability index, OC groups showed greater muscle TPC and antioxidant capacity, the presence of detectable hydroxytyrosol and tyrosol suggests a possible contribution of dietary olive phenolics or their metabolites, although the exact mechanisms underlying their appearance in muscle tissue remain to be fully elucidated. Overall, partially destoned DOC can be included up to 15% of the finishing diet to improve beef nutritional and functional quality within sustainable circular systems. Full article

Background: Apples and pears, as important economic fruit crops, are frequently threatened by various diseases, including Valsa canker. Given the numerous advantages of disease resistance breeding, the identification of key resistance genes is particularly important. This study aimed to identify the “Duli-G03” (Pyrus betulifolia) resistance gene PbeZFP3 and clarify its regulatory mechanism in disease resistance via JA/SA pathways, providing a theoretical basis for resistant breeding. Results: In this study, we identified a C2H2-type transcription factor, PbeZFP3, in the Valsa canker-resistant rootstock “Duli-G03”. Expression analysis revealed that PbeZFP3 is induced by both Valsa pyri (Vp) and Vp metabolites (VpM). Transient expression in pear and apple fruits and stable expression in suspension cells confirmed that PbeZFP3 positively regulates Valsa canker resistance. Meanwhile, PbeZFP3 not only enhances the resistance of “Duli-G03” cells to Botrytis cinerea infection, but may also act as a negative regulator against Colletotrichum fructicola. The overexpression of PbeZFP3 in “Duli-G03” significantly upregulated the expression of genes related to jasmonic acid (JA) and salicylic acid (SA) signaling. Conclusions: These findings demonstrate that the jasmonic acid (JA) and salicylic acid (SA) signaling pathways are involved in the enhanced Valsa canker resistance conferred by PbeZFP3 overexpression. A deeper understanding of this host resistance mechanism will provide theoretical support for breeding strategies aimed at developing disease-resistant fruit trees. Full article

To improve the extrusion processing of wood–plastic composites (WPCs), functional additives known as internal lubricants are incorporated into the composite formulations. The lubricants play a crucial role in decreasing the melt viscosity of WPCs, which in turn has a positive impact on energy consumption, productivity, and overall composite performance. This study shows the effect of suberinic acids (SAs), extracted from birch outer bark via alkaline water and water–ethanol hydrolysis at different pH values, on the processing behavior and properties of a recycled polypropylene-based composite filled with pine microfibers. The extracted SAs were characterized by gas chromatography–mass spectrometry, Fourier transform infrared spectroscopy, gel permeation chromatography, thermogravimetric analysis, and differential scanning calorimetry. The conducted analyses revealed notable differences in the chemical composition, molecular weight, and molecular polydispersity of the SAs. Betulin was identified as the dominant component (49–86%). The pine sawdust was treated with 2% NaOH at 90 °C for 90 min prior to composite fabrication. The incorporation of 4.0 wt% SAs into the WPC formulations reduced the extruder rotor’s maximum and minimum torques torque, indicating improved processability of the composite. Mechanical and wetting properties of the WPC samples were evaluated. The samples containing SAs exhibited an increased elongation at break by 37.9–51.6% and bending deformation by 12.8–17.5%, depending on the extraction conditions of SAs, accompanied by a slight reduction in the mechanical properties and slight increase in water sorption compared with the composite filled with the alkaline-treated pine microfibers. The results showed enhanced flexibility and ductility in the SAs-containing WPCs. The presence of a 1.0 wt% maleic anhydride-grafted polypropylene in the samples led to an increase their mechanical properties, along with the reduced water sorption. Full article

We demonstrate a monolithically integrated photonic chip that combines an optical spiking neuron with a tunable synaptic element. The spiking neuron is realized using a quantum-well Fabry–Perot laser integrated with a saturable absorber (FP-SA), while a semiconductor optical amplifier (SOA) functions as a photonic synapse. Two photonic-crystal (PC) mirrors define the laser cavity and enable effective modulation of the synaptic weight. Experimental results further confirm the capability of the SOA for continuous and controllable synaptic weight tuning. This work represents an important step toward scalable on-chip photonic spiking neural networks. Full article

Injection molding has been used for many years in the fabrication of thermoplastic parts with different complexities. With metal and ceramic injection molding, it is possible to realize at the end of the related process chain sintered metal and ceramic parts. Parts made from glass are rather seldom realized applying powder technology methods. This work describes the production of devices made from a commercial soda-lime glass applying the process chain of powder injection molding, covering the individual process steps like compounding, shaping, debinding, and sintering. In the first step, a binder consisting of polyethylene glycol (PEG) with different average molecular masses (4000, 8000, and 20,000 g/mol), polyvinyl butyral (PVB), and stearic acid (SA) were used for compounding new feedstocks with a solid load of 55 Vol% and 60 Vol%. As filler, a soda-lime glass with an average particle size of 6.1 µm, an almost symmetrical particle size distribution, a specific surface area of 0.78 m²/g, and a spherical morphology was applied. The measured equilibrium torque during compounding was low, with values between 2.5 and 5.5 Nm depending on the solid load and average molecular mass of the investigated PEG. All feedstock possessed a pseudoplastic flow behavior in the shear rate range between 10 and 3500 1/s. Small disk-shaped parts, as well as large cuboids and plates, were injection molded to a good quality. These green bodies were pre-debinded in water to remove the PEG, subsequently followed by thermal debinding to eliminate the remaining organic moieties. The concluding sintering in the temperature range between 660 and 680 °C delivered glass parts with huge density values close to 100% of the theoretical value, as measured by the Archimedes method. The principal feasibility of glass injection molding with a suitable feedstock system could be demonstrated successfully. Full article

Banana is a nutritious food of great global economic importance. However, water deficit negatively impacts banana plant development. Therefore, it is essential to study efficient water use and develop technologies capable of maintaining fruit quality after harvest, extending the shelf life, and reducing losses. This study aimed to evaluate the efficiency of post-harvest applications of salicylic acid, gibberellic acid, and Trichoderma harzianum on ‘Nanicão’ banana fruits produced under controlled water deficit during different phenological stages, aiming to extend the shelf life and maintain nutritional quality. The experimental design was completely randomized in a 4 × 4 factorial scheme, comprising four irrigation management strategies based on crop evapotranspiration (ETc)—100% ETc throughout the cultivation cycle (E1) and 50% ETc during the juvenile stage (E2), fruiting stage (E3), and both juvenile/fruiting stages (E4)—and four post-harvest fruit conservation strategies: WC, control (distilled water); GA3, 200 mg L⁻¹ of gibberellic acid; SA, 4.5 mM of salicylic acid; and TRIC, 1.5 mL L⁻¹ of Trichoderma harzianum. There were four replications. The use of gibberellic acid at a concentration of 200 mg L⁻¹ is the most effective strategy to extend the shelf life and maintain the post-harvest quality of ‘Nanicão’ banana fruits produced under water restrictions during the juvenile stage. Full article

Background: Extremely low birth weight (ELBW) neonates (<1000 g) contribute significantly to global neonatal and under-five mortality, with heightened vulnerability in resource-limited settings. Objectives: The overall aim of this manuscript is to evaluate the survival outcomes and associated factors among ELBW infants in a resource-limited tertiary care setting in South Africa. Methods: This retrospective cohort study examined survival outcomes, causes of death, and associated morbidities among 192 ELBW infants admitted to Frere Hospital, South Africa (SA), between January 2020 and February 2025. Kaplan–Meier survival analysis and multivariable Poisson regression were used to identify predictors of mortality. Results: Overall, 42% of neonates survived to discharge. Common morbidities included respiratory distress syndrome (78%) and extreme prematurity (30%). Extreme prematurity (<28 weeks) was associated with a markedly increased risk of mortality (adjusted IRR = 0.20; 95% CI: 0.08–0.53; p < 0.001), while caesarean section conferred a protective effect compared to vaginal delivery (adjusted IRR = 0.38; 95% CI: 0.23–0.64; p < 0.001). Conclusions: The findings highlight that strengthened antenatal care, consistent neonatal resuscitation, and equitable intensive care remain essential. Policy-driven investment in surfactant therapy, CPAP, and infection control is critical; without such measures, ELBW infants’ mortality will continue to be disproportionately high in resource-limited settings. Full article

The proliferation of single-use petroleum-based foams in protective packaging has become a major source of persistent plastic waste, posing significant challenges to environmental sustainability. To address this issue, we developed a fully biodegradable cushioning foam from bamboo, a rapidly renewable biomass, using an environmentally benign deep eutectic solvent (DES) process that avoids harsh chemical bleaching. The resulting lignin-containing cellulose nanofibril (LCNF)/sodium alginate (SA) foam exhibits low density (0.23 g/cm³), high compressive strength (0.24 MPa at 70% strain), and excellent elasticity (90% recovery at 50% strain), enabled by a dual-network structure of Ca²⁺-crosslinked SA and entangled LCNFs. Critically, the material is fully compostable and leaves no microplastic residues, offering a circular end-of-life pathway. In real-world banana drop tests, it matched the performance of commercial expanded polyethylene (EPE) while outperforming polyethylene bubble wrap. This work demonstrates a practical, scalable route to replace fossil-derived cushioning materials with a bio-based alternative that aligns with the principles of cleaner production and circular economy. Full article

Oxidative stress-induced endometrial injury has been shown to contribute to infertility; however, effective strategies that can simultaneously scavenge reactive oxygen species (ROS) and restore mitochondrial and antioxidant homeostasis remain elusive. In this study, we isolated extracellular nanovesicles from Artemisia argyi (A-NVs) and investigated their protective effects on H₂O₂-damaged human endometrial stromal cells (hESCs). We discovered that A-NVs possess a typical lipid bilayer structure and contain a variety of bioactive components. Our metabolomic analysis indicates that A-NVs can be regarded as a “natural drug reservoir”, in which flavonoids account for approximately 10.8%. We demonstrate that A-NVs can be efficiently taken up by cells, improve cell viability, reduce intracellular and mitochondrial ROS levels, enhance superoxide dismutase (SOD) activity, upregulate the expression of catalase (CAT), SOD1, and SOD2, and partially restore mitochondrial membrane potential. Mechanistically, A-NVs exert antioxidant effects by activating the SIRT1/PGC-1α/Nrf2 signaling axis. SIRT1 activation further alleviates H₂O₂-induced premature senescence, as evidenced by a 71.8% reduction in SA-β-Gal-positive cells compared with the H₂O₂ group, together with downregulation of p53 and p21 expression. These positive protective effects can be blocked by the SIRT1 inhibitor EX-527, confirming the central role of this pathway. Collectively, our findings demonstrate that A-NVs can maintain redox and mitochondrial homeostasis while inhibiting oxidative stress-related senescence progression, underscoring their application potential in endometrial repair and functional recovery. Full article

Urban green spaces (UGSs) are crucial for public health by supporting leisure-time physical activities (LTPAs), but the mechanisms by which micro-scale UGS features shape different LTPA types remain unclear. In this study, the relationship between the micro-scale features of UGSs and LTPAs was investigated in 63 sample plots of nine comprehensive parks in downtown Shanghai. Using the behavior annotation method and multiple linear regression analysis, we identified significant correlations between the UGS features and LTPA types. The results showed that sitting and chatting (SC) activities had the highest participation rate at 46.84%, while sports and fitness (SF) activities had the lowest at 9.82%. Walking and sightseeing (WS) activities and culture and entertainment (CE) activities accounted for 19.99% and 23.35% of participants, respectively. Spatial accessibility (SA) and canopy coverage ratios (CCRs) were significantly negatively correlated with SC, while seat number (SN), ground-cover density (D_GNC), and three-dimensional green quantity (TGQ) were positively correlated. For WS, SN and tree density (D_TREE) were positively correlated, while TGQ was negatively correlated. CE activities were positively associated with SN, D_TREE, and Shannon’s diversity index of ground-cover (SHI_GNC) but negatively associated with Shannon’s diversity index of trees (SHI_TREE). The regression models explained 65.9%, 38.3%, and 44.3% of the variance in SC, WS, and CE, respectively, while the overall model was not significant for SF. These findings highlight the need to optimize rest facilities, vegetation diversity, and spatial layout in UGS design to accommodate diverse LTPA needs and foster health-oriented environments. The conclusions are mainly applicable to seasons with mild climates, and LTPA characteristics in different seasons require further verification. Full article

This study addresses the pressing issue of high-ammonia nitrogen wastewater, such as landfill leachate, by developing immobilized microbial beads that combine high mechanical strength with efficient denitrification performance. The beads were prepared using a composite of sodium alginate (SA), carboxymethyl cellulose (CMC), and diatomite (DE), with a dual-ion (Ca²⁺-Al³⁺) stepwise cross-linking technique to encapsulate Alcaligenes faecalis. The material ratios were systematically optimized through single-factor and response surface methodology (RSM), identifying the optimal conditions as: SA 2.0%, CMC 1.5%, DE 1.0%, CaCl₂ 2.25%, and Al₂(SO₄)₃ 2.0%. Under these conditions, the beads achieved a mechanical strength of 3.20 N and exhibited an ammonia nitrogen removal rate of 93.10% after 96 h of treating actual landfill leachate (NH₃-N ≈ 1000 mg/L). In conclusion, the SA-CMC-DE dual-ion cross-linked beads demonstrate structural stability and efficient mass transfer, offering an economically viable and novel solution for the treatment of high-ammonia nitrogen wastewater. Full article

The recognition of microRNAs as components of animal-source foods (ASFs) with epigenetic characteristics and regulation has spurred research in an interesting direction, particularly in understanding their microRNAs (miRNAs) fraction. Thus, a constant supply of them through food intake, with equally conserved targets, may facilitate their accumulation in tissues rich in their targets. Here, we consider the potentially dominant miRNAs in animal-source foods (ASFs) documented in the literature, identified through a frequency-weighted ordinal recurrence approach. let-7d-5p, miR-101-3p, and miR-133b consistently showed dominant rankings in a product-specific manner in lean meat. In meat fat, let-7i-5p, miR-30c-5p, and miR-23a-3p were highly ranked. Among various types of meat offal, miR-145-5p, miR-92-5p, and miR-24-3p emerged as the predominant miRNAs. Similarly, in dairy products, miR-200a-3p, miR-200c-3p, miR-223-3p, miR-25-3p, miR-29a-3p, and miR-29b-3p were recurrently dominant, whereas miR-17-5p, miR-184, miR-30e-5p, and miR-92b-3p showed a comparable prevalence in seafood. Even though bioinformatic approaches suggest miRNAs from raw ASFs showed major enrichment of processes and pathways culminating in epithelial barrier integrity modulation, such putative functions tend to be equally enriched by predicted targets of the miRNAs in processed products. Product-specific highly ranked miRNAs from food categories stipulate possible preferential enrichment in contexts of cell–cell adhesion, cytoskeletal dynamics, and inflammatory control by meat (lean, fat, offal), immune homeostasis by dairy, and neural signalling by seafood, providing hypotheses for future functional studies. However, a limited understanding of their stability during gastrointestinal transit may present a more immediate limitation to their potential translational applicability. Full article

Waterlogged archaeological wood is highly vulnerable to degradation by wood-degrading microorganisms. Oregano essential oil (OEO) shows excellent antimicrobial activity against such microbes, but its high volatility and poor stability restrict direct application in cultural relic protection. This study aims to optimize the preparation of sodium alginate (SA)-based OEO microcapsules (OEO@SAM), characterize their structural and physicochemical properties, and evaluate their sustained-release antimicrobial performance for waterlogged archaeological wood conservation. OEO@SAM was fabricated via ionic crosslinking, with orthogonal experiments optimizing three key parameters: OEO:SA ratio, SA concentration, and CaCl₂ concentration. The microcapsules were characterized by morphological observation, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), etc. Encapsulation efficiency (EE), in vitro sustained-release kinetics, and antimicrobial activity against dominant wood-degrading microorganisms (isolated from waterlogged archaeological sites) were tested. The OEO:SA ratio was the dominant factor regulating EE: EE decreased sharply as the OEO:SA ratio increased, with the highest EE (24.05%) achieved at OEO:SA = 0.5, SA = 2%, and CaCl₂ = 3%. Meanwhile, only 0.71 g/L of OEO@SAM is required to inhibit bacterial growth and achieve the conservation of waterlogged archaeological wood. OEO@SAM exhibited stable sustained release (fitting the zero-order kinetic model) and significant antimicrobial activity against target microorganisms. It provides a new type of antibacterial and antifungal material for the in situ conservation of waterlogged archaeological wood. Full article