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40 Results Found

  • Article
  • Open Access
24 Citations
6,999 Views
18 Pages

Mitochondrial-Targeted Antioxidant MitoQ-Mediated Autophagy: A Novel Strategy for Precise Radiation Protection

  • Xingting Bao,
  • Xiongxiong Liu,
  • Qingfeng Wu,
  • Fei Ye and ,
  • Zheng Shi,
  • Dan Xu,
  • Jinhua Zhang,
  • Zhihui Dou,
  • Guomin Huang and
  • Chao Sun
  • + 6 authors+ 1 author

10 February 2023

Radiotherapy (RT) is one of the most effective cancer treatments. However, successful radiation protection for normal tissue is a clinical challenge. Our previous study observed that MitoQ, a mitochondria-targeted antioxidant, was adsorbed to the inn...

(This article belongs to the Special Issue Iron Metabolism, Redox Balance and Neurological Diseases)
  • Article
  • Open Access
16 Citations
4,097 Views
17 Pages

LncRSPH9-4 Facilitates Meningitic Escherichia coli-Caused Blood–Brain Barrier Disruption via miR-17-5p/MMP3 Axis

  • Bojie Xu,
  • Ruicheng Yang,
  • Jiyang Fu,
  • Bo Yang and ,
  • Jiaqi Chen,
  • Chen Tan,
  • Huanchun Chen and
  • Xiangru Wang
  • + 3 authors+ 0 author

Brain microvascular endothelial cells (BMECs) constitute the structural and functional basis for the blood–brain barrier (BBB) and play essential roles in bacterial meningitis. Although the BBB integrity regulation has been under extensive investigat...

(This article belongs to the Section Molecular Genetics and Genomics)
  • Article
  • Open Access
6 Citations
1,863 Views
18 Pages

LncRNA RP11-297P16.4 Promotes the Invasion and Metastasis of Non-Small-Cell Lung Carcinoma by Targeting the miR-145-5p/MMP-2/9 Axis

  • Wei Wang,
  • Yu Lu,
  • Guang-Mei Qin,
  • Lin-Feng Ni and ,
  • Bai-Xue Xu,
  • Chao-Feng Liu,
  • Bao-Feng Yu,
  • Hai-Long Wang and
  • Min Pang
  • + 4 authors+ 0 author

Background/Objectives: Long noncoding RNAs (lncRNAs) participate in the occurrence and development of non-small-cell lung carcinoma (NSCLC). But for certain lncRNAs, their effects on NSCLC remain unclear. This work discovered that lncRNA RP11-297P16....

(This article belongs to the Section Cancer Biology and Oncology)
  • Article
  • Open Access
37 Citations
48,285 Views
11 Pages

The bench press exercise is one of the most used for training and for evaluating upper-body strength. The aim of the current study was to evaluate the electromyographic (EMG) activity levels of the pectoralis major (PM) in its three portions (upper p...

(This article belongs to the Special Issue Monitoring and Evaluation of Training in Sport and Exercise)
  • Article
  • Open Access
8 Citations
5,039 Views
16 Pages

8 June 2016

Using the q-integral representation of Sears’ nonterminating extension of the q-Saalschütz summation, we derive a reduction formula for a kind of double q-integrals. This reduction formula is used to derive a curious double q-integral formula, and al...

(This article belongs to the Special Issue Symmetry in Orthogonal Polynomials)
  • Article
  • Open Access
3 Citations
1,651 Views
34 Pages

Background: The modernization of Traditional Chinese Medicine (TCM) is hindered by a “structure-blind” bottleneck: establishing molecular mechanisms for complex formulations with uncharacterized chemical constituents. Conventional computa...

(This article belongs to the Special Issue Artificial Intelligence-Assisted Drug Discovery)
  • Article
  • Open Access
6 Citations
2,709 Views
20 Pages

5 December 2024

In the wake of quantum computing advancements and quantum algorithmic progress, quantum algorithms are increasingly being employed to address a myriad of combinatorial optimization problems. Among these, the Independent Domination Problem (IDP), a de...

(This article belongs to the Special Issue Quantum Computing in the NISQ Era)
  • Article
  • Open Access
17 Citations
2,999 Views
15 Pages

The mir-423-5p/MMP-2 Axis Regulates the Nerve Growth Factor-Induced Promotion of Chondrosarcoma Metastasis

  • Huey-En Tzeng,
  • Syuan-Ling Lin,
  • Louis-Anoop Thadevoos,
  • Chih-Yuan Ko and ,
  • Ju-Fang Liu,
  • Yu-Wen Huang,
  • Chih-Yang Lin,
  • Yi-Chin Fong and
  • Chih-Hsin Tang
  • + 4 authors+ 0 author

3 July 2021

A chondrosarcoma is a common tumor of the soft tissue and bone that has a high propensity to metastasize to distant organs. Nerve growth factor (NGF) is capable of promoting the progression and metastasis of several different types of tumors although...

  • Article
  • Open Access
713 Views
18 Pages

23 April 2026

This study explored individual differences among senior high school students in detecting and correcting logical errors in mathematical reasoning. Eight participants with high and average mathematical abilities each were recruited from a key high sch...

  • Article
  • Open Access
4 Citations
2,563 Views
12 Pages

Comparative and Functional Analysis of miRNAs and mRNAs Involved in Muscle Fiber Hypertrophy of Juvenile and Adult Goats

  • Sanbao Zhang,
  • Qiongwen Zhang,
  • Lili Yang,
  • Xiaotong Gao and ,
  • Ting Chen,
  • Tianbao Li,
  • Wenyue Sun,
  • Yufan Liu,
  • Zihua Zheng and
  • Qinyang Jiang
  • + 9 authors+ 4 authors

25 January 2023

MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate several pathway intermediates and affect the skeletal muscle development in mice, pigs, sheep, and cattle. However, to date, only a small number of miRNAs have been rep...

(This article belongs to the Section Animal Genetics and Genomics)
  • Article
  • Open Access
1,717 Views
18 Pages

9 October 2025

At a particular frequency, most materials and objects of interest exhibit a polarization signature, or Mueller matrix, of limited dimensionality, with many matrix elements either negligibly small or redundant due to symmetry. Robust design of a polar...

(This article belongs to the Section Optical Sensors)
  • Article
  • Open Access
3 Citations
3,971 Views
15 Pages

7 January 2019

In order to solve all or some eigenvalues lied in a cluster, we propose a weighted block Golub-Kahan-Lanczos algorithm for the linear response eigenvalue problem. Error bounds of the approximations to an eigenvalue cluster, as well as their correspon...

(This article belongs to the Special Issue Mathematics and Engineering)
  • Article
  • Open Access
989 Views
17 Pages

25 November 2025

This paper presents a new Residual-based Sparse Approximate Inverse algorithm, designed to be automatic, computationally efficient, and highly parallelizable. After briefly reviewing Frobenius-norm-based preconditioning techniques and identifying two...

  • Article
  • Open Access
3 Citations
4,343 Views
15 Pages

21 December 2021

To date, many interesting subclasses of analytic functions involving symmetrical points and other well celebrated domains have been investigated and studied. The aim of our present investigation is to make use of certain Janowski functions and a Math...

(This article belongs to the Special Issue Symmetries of Difference Equations, Special Functions and Orthogonal Polynomials)
  • Article
  • Open Access
5 Citations
1,589 Views
18 Pages

MicroRNA-125b-5p Drives MMP-2 Expression via Activation of RAGE-38MAPK-p65/p50NF-κB Axis: A Novel Mechanism in Human Lung Cancer Cells

  • Yusuf Saleem Khan,
  • Aisha Farhana,
  • Mohammed Kuddus,
  • Syed Monowar Alam Shahid and ,
  • Abdullah Alsrhani,
  • Abuzar Abdulwahab Osman,
  • Ghorashy E. Y. Mohammed,
  • Muhammad Ikram Ullah and
  • Zafar Rasheed
  • + 4 authors+ 0 author

14 October 2025

Dysregulated microRNA-mediated control of matrix metalloproteinase-2 (MMP-2) plays a pivotal role in lung cancer (LC) progression, though the inflammatory signaling mechanisms governing its regulation remain poorly understood. This study reveals how...

(This article belongs to the Special Issue MicroRNAs as Biomarkers and Therapeutic Targets in Human Diseases)
  • Article
  • Open Access
10 Citations
2,730 Views
18 Pages

7 July 2021

Andrews gave a remarkable interpretation of the Rogers–Ramanujan identities with the polynomials ρe(N,y,x,q), and it was noted that ρe(∞,−1,1,q) is the generation of the fifth-order mock theta functions. In the present investigation, several interest...

(This article belongs to the Special Issue Theory and Applications of Special Functions in Mathematical Physics)
  • Article
  • Open Access
2 Citations
1,362 Views
33 Pages

Computational Representation of Fractional Inequalities Through 2D and 3D Graphs with Applications

  • Muhammad Younis,
  • Ahsan Mehmood,
  • Muhammad Samraiz,
  • Gauhar Rahman and ,
  • Salma Haque,
  • Ahmad Aloqaily and
  • Nabil Mlaiki
  • + 2 authors+ 0 author

The aim of this research article is to use the extended fractional operators involving the multivariate Mittag–Leffler (M-M-L) function, we provide the generalization of the Hermite–Hadamard–Fejer (H-H-F) inequalities. We relate the...

(This article belongs to the Topic Fractional Calculus: Theory and Applications, 2nd Edition)
  • Article
  • Open Access
12 Citations
5,592 Views
15 Pages

A Computational Method for Classifying Different Human Tissues with Quantitatively Tissue-Specific Expressed Genes

  • JiaRui Li,
  • Lei Chen,
  • Yu-Hang Zhang,
  • XiangYin Kong and ,
  • Tao Huang and
  • Yu-Dong Cai
  • + 1 author+ 0 author

7 September 2018

Tissue-specific gene expression has long been recognized as a crucial key for understanding tissue development and function. Efforts have been made in the past decade to identify tissue-specific expression profiles, such as the Human Proteome Atlas a...

(This article belongs to the Special Issue Systems Analytics and Integration of Big Omics Data)
  • Article
  • Open Access
69 Citations
6,229 Views
18 Pages

Tissue Expression Difference between mRNAs and lncRNAs

  • Lei Chen,
  • Yu-Hang Zhang,
  • Xiaoyong Pan,
  • Min Liu and ,
  • Shaopeng Wang,
  • Tao Huang and
  • Yu-Dong Cai
  • + 2 authors+ 0 author

31 October 2018

Messenger RNA (mRNA) and long noncoding RNA (lncRNA) are two main subgroups of RNAs participating in transcription regulation. With the development of next generation sequencing, increasing lncRNAs are identified. Many hidden functions of lncRNAs are...

(This article belongs to the Special Issue Computational Models in Non-Coding RNA and Human Disease)
  • Article
  • Open Access
2 Citations
4,510 Views
16 Pages

Radius of Star-Likeness for Certain Subclasses of Analytic Functions

  • Caihuan Zhang,
  • Mirajul Haq,
  • Nazar Khan,
  • Muhammad Arif and ,
  • Khurshid Ahmad and
  • Bilal Khan
  • + 1 author+ 0 author

19 December 2021

In this paper, we investigate a normalized analytic (symmetric under rotation) function, f, in an open unit disk that satisfies the condition ℜfzgz>0, for some analytic function, g, with ℜz+1−2nzgz>0,∀n∈N. We calcula...

(This article belongs to the Special Issue Symmetry in Geometric Functions and Mathematical Analysis II)
  • Article
  • Open Access
5 Citations
2,040 Views
15 Pages

Third Hankel Determinant for Subclasses of Analytic and m-Fold Symmetric Functions Involving Cardioid Domain and Sine Function

  • Ayman Alahmade,
  • Zeeshan Mujahid,
  • Ferdous M. O. Tawfiq,
  • Bilal Khan and ,
  • Nazar Khan and
  • Fairouz Tchier
  • + 1 author+ 0 author

10 November 2023

In this research, we define a few subclasses of analytic functions which are connected to sine functions and the cardioid domain in the unit disk. We investigate initial coefficient bounds, the Fekete–Szego problem and second and third Hankel d...

  • Article
  • Open Access
13 Citations
1,999 Views
14 Pages

Coefficient Inequalities for Multivalent Janowski Type q-Starlike Functions Involving Certain Conic Domains

  • Muhammad Sabil Ur Rehman,
  • Qazi Zahoor Ahmad,
  • Isra Al-shbeil,
  • Sarfraz Ahmad and ,
  • Ajmal Khan,
  • Bilal Khan and
  • Jianhua Gong
  • + 2 authors+ 0 author

23 September 2022

In the current work, by using the familiar q-calculus, first, we study certain generalized conic-type regions. We then introduce and study a subclass of the multivalent q-starlike functions that map the open unit disk into the generalized conic domai...

(This article belongs to the Special Issue Special Functions and Polynomials: Theory, Practice, Applications, and Modeling)
  • Article
  • Open Access
12 Citations
3,960 Views
17 Pages

Fourth Hankel Determinant Problem Based on Certain Analytic Functions

  • Huo Tang,
  • Muhammad Arif,
  • Mirajul Haq,
  • Nazar Khan and ,
  • Mustaqeem Khan,
  • Khurshid Ahmad and
  • Bilal Khan
  • + 2 authors+ 0 author

24 March 2022

In recent years, the Hankel determinant bounds for different subclasses of analytic, starlike and symmetric starlike functions have been discussed and studied by the many well-known authors. In this paper, we first consider a new subclass of analytic...

(This article belongs to the Special Issue Symmetry in Pure Mathematics and Real and Complex Analysis)
  • Article
  • Open Access
28 Citations
3,619 Views
11 Pages

The logarithmic functions have been used in a verity of areas of mathematics and other sciences. As far as we know, no one has used the coefficients of logarithmic functions to determine the bounds for the third Hankel determinant. In our present inv...

(This article belongs to the Special Issue New Trends in Geometric Function Theory)
  • Article
  • Open Access
13 Citations
2,576 Views
20 Pages

Applications of Symmetric Conic Domains to a Subclass of q-Starlike Functions

  • Shahid Khan,
  • Nazar Khan,
  • Aftab Hussain,
  • Serkan Araci and ,
  • Bilal Khan and
  • Hamed H. Al-Sulami
  • + 1 author+ 0 author

12 April 2022

In this paper, the theory of symmetric q-calculus and conic regions are used to define a new subclass of q-starlike functions involving a certain conic domain. By means of this newly defined domain, a new subclass of normalized analytic functions in...

(This article belongs to the Special Issue Symmetry in Pure Mathematics and Real and Complex Analysis)
  • Article
  • Open Access
6 Citations
2,889 Views
18 Pages

Two New Bailey Lattices and Their Applications

  • Zeya Jia,
  • Bilal Khan,
  • Praveen Agarwal,
  • Qiuxia Hu and
  • Xinjing Wang

28 May 2021

In our present investigation, we develop two new Bailey lattices. We describe a number of q-multisums new forms with multiple variables for the basic hypergeometric series which arise as consequences of these two new Bailey lattices. As applications,...

(This article belongs to the Special Issue Applications of Symmetric Functions Theory to Certain Fields)
  • Article
  • Open Access
5 Citations
3,590 Views
8 Pages

Third Hankel Determinant for a Subclass of Univalent Functions Associated with Lemniscate of Bernoulli

  • Najeeb Ullah,
  • Irfan Ali,
  • Sardar Muhammad Hussain,
  • Jong-Suk Ro and ,
  • Nazar Khan and
  • Bilal Khan
  • + 1 author+ 0 author

This paper deals with a new subclass of univalent function associated with the right half of the lemniscate of Bernoulli. We find the upper bound of the Hankel determinant H3(1) for this subclass by applying the Carlson–Shaffer operator to it....

(This article belongs to the Special Issue New Trends in Geometric Function Theory)
  • Article
  • Open Access
38 Citations
3,278 Views
12 Pages

Coefficient Estimates for a Subclass of Meromorphic Multivalent q-Close-to-Convex Functions

  • Lei Shi,
  • Bakhtiar Ahmad,
  • Nazar Khan,
  • Muhammad Ghaffar Khan and ,
  • Serkan Araci,
  • Wali Khan Mashwani and
  • Bilal Khan
  • + 2 authors+ 0 author

1 October 2021

By making use of the concept of basic (or q-) calculus, many subclasses of analytic and symmetric q-starlike functions have been defined and studied from different viewpoints and perspectives. In this article, we introduce a new class of meromorphic...

(This article belongs to the Special Issue Applications of Symmetric Functions Theory to Certain Fields)
  • Article
  • Open Access
37 Citations
2,342 Views
19 Pages

Sharp Bounds of the Fekete–Szegö Problem and Second Hankel Determinant for Certain Bi-Univalent Functions Defined by a Novel q-Differential Operator Associated with q-Limaçon Domain

  • Timilehin Gideon Shaba,
  • Serkan Araci,
  • Babatunde Olufemi Adebesin,
  • Fairouz Tchier and ,
  • Saira Zainab and
  • Bilal Khan
  • + 1 author+ 0 author

In this present paper, we define a new operator in conjugation with the basic (or q-) calculus. We then make use of this newly defined operator and define a new class of analytic and bi-univalent functions associated with the q-derivative operator. F...

(This article belongs to the Section General Mathematics, Analysis)
  • Article
  • Open Access
39 Citations
6,096 Views
15 Pages

Identification of the Gene Expression Rules That Define the Subtypes in Glioma

  • Yu-Dong Cai,
  • Shiqi Zhang,
  • Yu-Hang Zhang,
  • Xiaoyong Pan and ,
  • KaiYan Feng,
  • Lei Chen,
  • Tao Huang and
  • Xiangyin Kong
  • + 3 authors+ 0 author

13 October 2018

As a common brain cancer derived from glial cells, gliomas have three subtypes: glioblastoma, diffuse astrocytoma, and anaplastic astrocytoma. The subtypes have distinctive clinical features but are closely related to each other. A glioblastoma can b...

  • Article
  • Open Access
13 Citations
2,224 Views
13 Pages

Zalcman Functional and Majorization Results for Certain Subfamilies of Holomorphic Functions

  • Muhammad Ghafar Khan,
  • Bilal Khan,
  • Ferdous M. O. Tawfiq and
  • Jong-Suk Ro

8 September 2023

In this paper, we investigate sharp coefficient functionals, like initial four sharp coefficient bounds, sharp Fekete–Szegö functionals, and, for n=1 and 2, sharp Zalcman functionals are evaluated for class of functions associated with tan...

(This article belongs to the Special Issue Recent Advances in Complex Analysis and Applications)
  • Article
  • Open Access
6 Citations
2,480 Views
17 Pages

Fekete–Szegö Problem and Second Hankel Determinant for a Class of Bi-Univalent Functions Involving Euler Polynomials

  • Sadia Riaz,
  • Timilehin Gideon Shaba,
  • Qin Xin,
  • Fairouz Tchier and ,
  • Bilal Khan and
  • Sarfraz Nawaz Malik
  • + 1 author+ 0 author

Some well-known authors have extensively used orthogonal polynomials in the framework of geometric function theory. We are motivated by the previous research that has been conducted and, in this study, we solve the Fekete–Szegö problem as...

(This article belongs to the Special Issue Fractional Calculus and Hypergeometric Functions in Complex Analysis)
  • Article
  • Open Access
34 Citations
2,583 Views
15 Pages

Applications of q-Hermite Polynomials to Subclasses of Analytic and Bi-Univalent Functions

  • Caihuan Zhang,
  • Bilal Khan,
  • Timilehin Gideon Shaba,
  • Jong-Suk Ro and ,
  • Serkan Araci and
  • Muhammad Ghaffar Khan
  • + 1 author+ 0 author

In mathematics, physics, and engineering, orthogonal polynomials and special functions play a vital role in the development of numerical and analytical approaches. This field of study has received a lot of attention in recent decades, and it is gaini...

(This article belongs to the Special Issue New Trends in Geometric Function Theory)
  • Article
  • Open Access
37 Citations
6,901 Views
16 Pages

Analysis of Expression Pattern of snoRNAs in Different Cancer Types with Machine Learning Algorithms

  • Xiaoyong Pan,
  • Lei Chen,
  • Kai-Yan Feng,
  • Xiao-Hua Hu and ,
  • Yu-Hang Zhang,
  • Xiang-Yin Kong,
  • Tao Huang and
  • Yu-Dong Cai
  • + 3 authors+ 0 author

Small nucleolar RNAs (snoRNAs) are a new type of functional small RNAs involved in the chemical modifications of rRNAs, tRNAs, and small nuclear RNAs. It is reported that they play important roles in tumorigenesis via various regulatory modes. snoRNA...

(This article belongs to the Special Issue Computational Models in Non-Coding RNA and Human Disease)
  • Article
  • Open Access
2 Citations
2,957 Views
12 Pages

Inclusion Relations for Dini Functions Involving Certain Conic Domains

  • Bilal Khan,
  • Shahid Khan,
  • Jong-Suk Ro,
  • Serkan Araci and ,
  • Nazar Khan and
  • Nasir Khan
  • + 1 author+ 0 author

In recent years, special functions such as Bessel functions have been widely used in many areas of mathematics and physics. We are essentially motivated by the recent development; in our present investigation, we make use of certain conic domains and...

(This article belongs to the Special Issue New Trends in Geometric Function Theory)
  • Article
  • Open Access
27 Citations
3,761 Views
18 Pages

Applications of Certain Conic Domains to a Subclass of q-Starlike Functions Associated with the Janowski Functions

  • Bilal Khan,
  • Hari Mohan Srivastava,
  • Nazar Khan,
  • Maslina Darus and ,
  • Qazi Zahoor Ahmad and
  • Muhammad Tahir
  • + 1 author+ 0 author

31 March 2021

In our present investigation, with the help of the basic (or q-) calculus, we first define a new domain which involves the Janowski function. We also define a new subclass of the class of q-starlike functions, which maps the open unit disk U, given b...

(This article belongs to the Special Issue Symmetry in Geometric Functions and Mathematical Analysis)
  • Article
  • Open Access
13 Citations
2,386 Views
12 Pages

Majorization Results Based upon the Bernardi Integral Operator

  • Isra Al-Shbeil,
  • Hari Mohan Srivastava,
  • Muhammad Arif,
  • Mirajul Haq and ,
  • Nazar Khan and
  • Bilal Khan
  • + 1 author+ 0 author

8 July 2022

By making use of some families of integral and derivative operators, many distinct subclasses of analytic, starlike functions, and symmetric starlike functions have already been defined and investigated from numerous perspectives. In this article, wi...

(This article belongs to the Section B: Mathematics)
  • Article
  • Open Access
32 Citations
3,092 Views
14 Pages

A Subclass of Multivalent Janowski Type q-Starlike Functions and Its Consequences

  • Qiuxia Hu,
  • Hari M. Srivastava,
  • Bakhtiar Ahmad,
  • Nazar Khan and ,
  • Muhammad Ghaffar Khan,
  • Wali Khan Mashwani and
  • Bilal Khan
  • + 2 authors+ 0 author

16 July 2021

In this article, by utilizing the theory of quantum (or q-) calculus, we define a new subclass of analytic and multivalent (or p-valent) functions class Ap, where class Ap is invariant (or symmetric) under rotations. The well-known class of Janowski...

(This article belongs to the Special Issue Integral Transformation, Operational Calculus and Their Applications)
  • Article
  • Open Access
14 Citations
2,494 Views
14 Pages

Certain Subclasses of Analytic Multivalent Functions Associated with Petal-Shape Domain

  • Lei Shi,
  • Hari M. Srivastava,
  • Muhammad Ghaffar Khan,
  • Nazar Khan and ,
  • Bakhtiar Ahmad,
  • Bilal Khan and
  • Wali Khan Mashwani
  • + 2 authors+ 0 author

3 November 2021

In this article, we introduce a new class of multivalent analytic functions associated with petal-shape region. Furthermore, some useful properties, such as the Fekete–Szegö inequality, and their consequences for some special cases are discussed. For...

(This article belongs to the Special Issue Complex Analysis)
  • Article
  • Open Access
47 Citations
7,303 Views
20 Pages

Identifying Methylation Pattern and Genes Associated with Breast Cancer Subtypes

  • Lei Chen,
  • Tao Zeng,
  • Xiaoyong Pan,
  • Yu-Hang Zhang and ,
  • Tao Huang and
  • Yu-Dong Cai
  • + 1 author+ 0 author

31 August 2019

Breast cancer is regarded worldwide as a severe human disease. Various genetic variations, including hereditary and somatic mutations, contribute to the initiation and progression of this disease. The diagnostic parameters of breast cancer are not li...

(This article belongs to the Collection Feature Papers in Molecular Biophysics)