Search Results (33)

Background and hypothesis: Per- and polyfluoroalkyl substances (PFAS) are highly persistent synthetic chemicals that can accumulate in renal tissue and potentially disrupt kidney function. Most prospective studies on PFAS–renal associations have focused on middle-aged or older adults, leaving uncertainty about whether similar patterns exist in younger populations. Methods: We investigated decade-long trajectories of plasma concentrations of 11 PFAS and their longitudinal associations with estimated glomerular filtration rate (eGFR) among 529 Taiwanese adolescents and young adults (aged 12–30 years) enrolled in the prospective YOung TAiwanese Cohort (YOTA), with measurements obtained in 2006–2008 and 2017–2019. Results: Nearly all plasma PFAS declined significantly over the 10-year period. Despite these reductions, higher baseline levels and greater annualized increases (Δln-PFAS/Δt) in linear perfluorooctanoic acid (PFOA), linear and branched perfluorooctane sulfonic acid (PFOS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) were consistently associated with larger eGFR gains over time (β = 0.33–0.40, q < 0.05). In complementary models using follow-up eGFR as the outcome, both baseline and cumulative PFAS changes (Δln-PFAS) remained positively associated with higher eGFR (β = 1.71–3.84, q < 0.05). Polynomial analyses further indicated mild non-linear exposure–response patterns for several PFAS, suggesting that renal effects may deviate from linearity across exposure ranges. The composite PFAS exposure index (mean of standardized ln-PFAS concentrations) was robustly associated with higher eGFR across sensitivity analyses excluding participants with chronic conditions. These associations were more pronounced among individuals with greater metabolic or physiological vulnerability. Conclusions: Higher PFAS exposure was associated with elevated eGFR in young adults, which may be consistent with early glomerular hyperfiltration or other renal hemodynamic alterations. These findings raise the hypothesis of early renal stress in early life and underscore the need for ongoing biomonitoring and longitudinal follow-up with additional kidney injury markers to clarify long-term renal consequences. Full article

Due to widespread industrial applications and increased discharges, concentrations of polyfluoroalkyl substances (PFAS) in potential drinking water sources have risen significantly, putting more people at risk of PFAS exposure. This study aimed to systematically clarify the occurrence characteristics (concentrations, detection frequencies, and temporal trends) of PFAS in global potential drinking water sources over the past decade, assess their oral exposure risks, and identify key PFAS species with high detection frequencies, high contamination levels, or high toxicity risks, thereby providing scientific support for the development of targeted control technologies and management strategies. This study systematically searched and reviewed the relevant literature published between 2014 and 2024 on PFAS levels in global potential drinking water sources, extracting data on PFAS concentrations, detection information, and sampling characteristics. Using the U.S. Environmental Protection Agency (EPA) Reference Dose (RfD) for oral exposure as the Acceptable Daily Intake (ADI), we evaluated the exposure risks of eight specific PFAS via the Risk Quotient for Specific Contaminants (RQ_RSC) model and analyzed the annual detection trends of the top thirty PFAS with the highest detection frequencies. Regarding total PFAS contamination, China, Brazil, Germany, South Africa, and the Danube River Basin exhibited particularly high levels, with China being the most severely contaminated. Risk assessment indicated that 45.6% of global potential drinking water sources were at high risk (RQ_RSC > 1), while 48.4% were at low risk (RQ_RSC < 0.2). Among the evaluated PFAS, PFOA, PFOS, PFDA, and GenX were associated with higher toxicity exposure risks. For the identified key concern PFAS, it is necessary to simplify detection techniques, promote targeted large-scale safe treatment technologies, and explore intelligent monitoring tools to reduce regulatory lag, thereby effectively monitoring, preventing, and controlling PFAS contamination. Full article

Per- and polyfluoroalkyl substances (PFASs) are persistent and bioaccumulative contaminants frequently detected in animal-derived foods, raising concerns for consumer health. In 2020, the European Food Safety Authority (EFSA) established a group tolerable weekly intake (TWI) of 4.4 ng/kg bw per week for four PFAS (PFOA, PFNA, PFOS, PFHxS) based on immunotoxicity, prompting the European Commission to set maximum levels in food. However, many other PFAS are present in the diet, and their cumulative risk is poorly characterized. This study applied the Relative Potency Factor (RPF) approach, using hepatic toxicity as the reference endpoint. The RPF approach addresses a key challenge in assessing human dietary exposure to PFAS by enabling cumulative risk assessment for complex mixtures found in food, moving beyond single-compound evaluations. Occurrence data from EFSA’s 2020 opinion were combined with European consumption data for fish, meat, eggs, and milk across four population groups (toddlers, adolescents, adults, elderly). Exposure estimates, expressed in PFOA equivalents, were compared with the group TWI. Results showed toddlers as the most vulnerable, with cumulative exposure approaching or exceeding TWI through fish, meat, and eggs, while milk contributed less. PFOS and PFOA were the main contributors across all food categories, with PFNA and PFDA also relevant, especially in younger populations. The findings highlight the added value of the RPF approach for cumulative PFAS risk assessment and emphasize the need for updated monitoring, refinement of potency factors for under-studied PFAS, and continued regulatory measures to protect high-risk consumers. Full article

This study investigated the occurrence, sources, and health risks of 21 per- and polyfluoroalkyl substances (PFAS) in commercially available shellfish and crustaceans from Zhejiang Province, China. Among the 306 samples analyzed, 87.9% contained at least one detectable PFAS. Perfluorooctanoic acid (PFOA) was the most frequently detected PFAS (64.7%), followed by perfluorooctanesulfonic acid (PFOS) (53.8%), perfluorononanoic acid (PFNA) (52.9%), and perfluorodecanoic acid (PFDA) (50.0%). The total PFAS in shellfish and crustaceans ranged from ND to 0.86 to 173 ng/g wet weight, with a median of 4.11 ng/g ww; the median concentration of total PFAS followed this order: marine crustaceans > fresh-water crustaceans > bivalves. Estimation of the human intake of adult consumers, the estimated daily intake (EDI) of Σ₂₁ PFAS ranged from 0.01 to 15.7 ng/kg bw/day; 0.31% of the adult study population had Σ₄PFAS exposure levels resulting in Hazard Quotient (HQ) values > 1, which may represent a potential public health concern for these individuals. Long-term exposure risks for specific PFCAs such as perfluoroundecanoic acid (PFUdA) and perfluorotridecanoic acid (PFTrDA) merit concern. Full article

Sjogren’s syndrome is an autoimmune disease that may be triggered by environmental factors. While the impact of perfluoroalkyl substances (PFASs) on the human immune system has been investigated, their specific effect on Sjogren’s syndrome remains unreported. We conducted this study to evaluate the association between PFAS exposure and clinical manifestations of pSS. In total, 136 patients with pSS and 148 healthy controls in the Second Affiliated Hospital of Zhejiang University School of Medicine were investigated. The concentrations of perfluoroundecanoic acid (PFUdA) in the pSS group were statistically significantly higher than those in the healthy control group. Compared to patients without leukopenia and thrombocytopenia, those with the condition had significantly lower concentrations of perfluorononanoic acid (PFNA). The serum levels of PFNA and perfluorodecanoic acid (PFDA) were found to be lower in patients with a high antinuclear antibody (ANA) titer compared to those with a low ANA titer. The serum levels of PFNA were found to be lower in patients who were anti-Sjögren’s syndrome A (anti-SSA)-positive compared to those who were anti-SSA-negative. These results indicate that the levels of serum PFASs may be correlated with the disease activity in pSS patients, and there might be an association between PFASs and the onset of pSS. Full article

Historical application of wastewater treatment sludge (biosolids) has introduced per- and polyfluoroalkyl substances (PFAS) into agricultural systems and led to contamination of crops and livestock. Previous work validated a dynamic exposure and population toxicokinetic (DE_PopTK) modeling approach for estimating perfluorooctane sulfonic acid (PFOS) and perfluorohexane sulfonic acid (PFHxS) concentrations in cattle tissues at sites primarily dominated by water contamination. This work expands the efforts to validate the DE_PopTK model at a self-contained beef farm in Maine with PFAS exposures from feed grown on site where soil is contaminated from historical biosolids applications. The model is also extended to estimate perfluorodecanoic acid (PFDA) exposure and tissue levels. Farm-specific data were obtained to consider farm management practices, spatial variation of PFAS in soil, animal growth, and seasonal and annual variability in estimating daily exposures based on water, feed, and soil intake. A dynamic exposure pattern was observed as cattle accumulated PFAS while consuming feed grown on contaminated land and eliminated it while grazing on non-contaminated pastures. Model-estimated PFOS and PFDA levels in serum and muscle were in good agreement with biomonitoring data collected at the farm over a four-year period to reflect periods of accumulation and depuration, with the percentage error ranging from 16% to 73% when comparing modeled and measured data. Our findings demonstrated that understanding farm exposures and collecting site-specific data were integral to model performance. The model was applied to simulate management strategies and complement economic analyses to demonstrate that, with modifications to management practices, it is feasible for the farm to achieve lower PFOS and PFDA levels in beef and maintain economic viability despite elevated PFAS soil levels. Full article

Per- and polyfluoroalkyl substances (PFAS) are used in consumer products and manufacturing. Perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA) are long-chain PFAS composed of 9, 10, and 11 carbons, respectively, which exert sublethal toxicity to aquatic species. Here, we review the data regarding the environmental fate and ecotoxicology of these understudied long-chain PFAS in fish. The objectives of this study were to (1) compile the literature to compare physiological or molecular signaling pathways disrupted by PFNA, PFDA, or PFUnDA; and (2) uncover potential biomarkers and pathways of toxicity of longer-chain PFAS using gene ontology computational approaches to shed light on their mechanism of action. Studies show that PFAS have a range of effects on fish, including developmental issues, changes in gene expression, and behavioral modifications. Based on our review, PFNA has been studied more frequently in fish compared to PFDA and PFUnDA; however, longer-chained PFAS are proposed to pose greater toxicity. Based on the computational approach, prominent pathways affected by PFNA include insulin signaling [“Insulin -> CEBPA/CTNNB/FOXA/FOXO”, “Insulin -> STAT Expression Targets”], immune system signaling [“TNF -> STAT Expression Targets”, “IL6 Expression Targets”, and “IL2 Expression Targets”], and growth hormone/prolactin signaling [“GH1/PRLR Expression Targets”, “PRL/GHR -> STAT Expression Targets”, “PRL/PRLR Expression Targets”]. Several transcripts related to cholesterol metabolism were also affected by PFNA. This review summarizes the current knowledge on the distribution, fate, and ecotoxicology of PFNA, PFDA, and PFUnDA in teleost fish, highlighting potential physiological and molecular responses that could aid in assessing long-chain PFAS toxicity in future studies. Full article

This study investigated the spatiotemporal distribution of perfluoroalkyl substances (PFASs) in the Daku River, Taoyuan, with a particular focus on source apportionment and associated ecological and human health risks. The total PFAS concentrations ranged from below the detection limits to 185 ng/L, with perfluorooctanoic acid (PFOA) emerging as the predominant compound, followed by perfluorobutanesulfonic acid (PFBS). Elevated PFAS levels were observed downstream of the confluence between the Daku River and Litouzhou ditch, suggesting contributions from industrial activities. Principal component analysis (PCA) and positive matrix factorization (PMF) were employed to identify important components and factors that explain different compounds. Factor 1 (dominated by PFUnA) was attributed to sources such as food packaging and textiles. Factor 2 (PFBS, PFHxS, PFOS) originated from agricultural inputs and wastewater discharges linked to the semiconductor and photonics industries. Factor 3 (PFOA, PFNA, PFDA) was primarily associated with fluoropolymer manufacturing, electronics, chemical engineering, machinery, and coating production. Ecological risk assessments showed no significant threats (RQ < 0.1) for PFBS, PFPA, PFNA, PFOS, and PFDA. Human health risk evaluations based on the Health Risk Index (HRI < 1), likewise, indicated negligible risk from crop and vegetable consumption in the Daku River area. These findings underscore the importance of continued monitoring and targeted pollution management strategies to safeguard environmental quality and public health. Full article

In view of the issues including the incomplete identification of alternatives and difficulty in tracing pollution sources in PFAS pollution monitoring in surface water, this study took typical surface waters with intensive human activities as the object to perform PFAS screening. A nontarget analysis based on high-resolution mass spectrometry was developed, coupled with a modified solid phase extraction pretreatment method, to achieve the comprehensive screening of 12 legacy carboxylic acids and sulfonic acids, as well as 2 novel alternatives in water. Surface water samples were collected from typical functional areas of human activity to reveal the spatial differential distribution of PFAS concentrations. The long-chain PFASs showed a high detected concentration, among which PFOS, PFUnDA, and PFOA concentrations were especially high in urban complex pollution areas, while PFDA, PFOS, and PFOA were the main components in agricultural areas. The two exposure patterns showed a certain degree of differentiation, which may be related to different pollution sources. PFASs with a long carbon chain, especially chlorine-substituted sulfonic acid, are high-persistent-risk substances. This study provided the data basis for the prevention and control of PFAS pollution in surface water, and supported the treatment of emerging pollutants in the region. Full article

The soil-washing technique has been successfully utilized for the remediation of PFAS-contaminated soils. Prior studies have shown that the organic carbon (OC) content and grain size of soil determined the efficiency of PFAS removal during washing. However, most of the past studies have focused on soils with a low OC content, typically ranging from 0–3%. In this study, we explored the use of a novel process where soil washing was combined with air bubbling (or foam fractionation) to aid in the removal of PFAS from high OC-content soils (~4–20%). Treatment with air bubbling of high OC soil (~20%) with perfluorobutane sulfonate (PFBS) and perfluorooctanoate (PFOA) did not enhance their removal, as they featured low surface activity. However, we observed an improvement in the extraction of perfluorooctane sulfonate (PFOS) from 27% to 42% with bubbling, consistent with the higher surface activity of PFOS compared to PFOA and PFBS. Perfluorodecanoic acid (PFDA) was irreversibly adsorbed to the high OC soil and was not removed efficiently by both bubbling and soil washing. A slight improvement in PFDA removal (6–13%) was observed when a co-surfactant (cetyltrimethylammonium chloride) was added and when the OC content was reduced to ~4% by the addition of nonorganic sand to the contaminated soil prior to soil washing. This suggested that the interaction of PFDA with OC was the dominant factor determining its extraction from soil. In conclusion, our results indicated that soil washing alone was sufficient for the removal of short-chain PFAS from soil. Although bubbling had a mild effect on the removal of some long-chain PFAS from the solution, it did not help in the overall removal of PFAS from high OC soils, highlighting the difficulty in the treatment of high OC-content soils and that immobilization of PFAS would be an ideal approach in managing such contaminated sites. Full article

PFAS are a group of synthetic chemicals that have been reported to be associated with adverse health outcomes. However, the relationship of PFAS exposure with psoriasis risk has not been reported. Utilizing data from the 2003–2018 NHANES, we explored the relationship of PFAS exposure with psoriasis risk. Our study included 5370 participants and examined serum levels of five PFAS compounds: PFOA, PFOS, PFHxS, PFNA, and PFDA, along with self-reported psoriasis status. Generalized linear regression, quantile g-computation, repeated hold out WQS regression, and BKMR models were employed to assess individual and combined effects of PFAS on psoriasis risk. We found each doubling the PFOS concentration was associated with a 19% increased risk of psoriasis (OR: 1.19; 95% CI: 1.01, 1.41) in the overall population. Sex-stratified analyses indicated significant associations between PFOA and PFNA exposure and psoriasis risk in females. Mixture analyses using WQS regression indicated that PFAS mixtures were associated with an 11% increased risk of psoriasis (OR: 1.11, 95% CI: 1.01, 1.22) in females in both the negative and positive direction. BKMR analyses also indicated a positive trend of PFAS mixtures with psoriasis risk in females. Our findings indicate a possible association between PFAS exposure and psoriasis risk, particularly in females. Full article

PFASs are a variety of ecologically persistent compounds of anthropogenic origin loosely included in many industrial products. In these, the carbon chain can be fully (perfluoroalkyl substances) or partially (polyfluoroalkyl substances) fluorinated. Their ubiquitous presence in many environmental compartments over the years and their long-lasting nature have given rise to concerns about the possible adverse effects of PFASs on ecosystems and human health. Among a number of remediation technologies, adsorption has been demonstrated to be a manageable and cost-effective method for the removal of PFASs in aqueous media. This study tested two novel and eco-friendly adsorbents (pinewood and date seeds biochar) on six different PFASs (PFOS, GenX, PFHxA, PFOA, PFDA, and PFTeDA). Batch sorption tests (24 h) were carried out to evaluate the removal efficiency of each PFAS substance in relation to the two biochars. All samples of liquid phase were analyzed by a developed and then a well-established method: (i) pre-treatment (centrifugation and filtration) and (ii) determination by high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS/MS). The results evidenced a comparable adsorption capacity in both materials but greater in the long-chain PFASs. Such findings may lead to a promising path towards the use of waste-origin materials in the PFAS remediation field. Full article

As industrial processes grow increasingly complex, fault identification becomes challenging, and even minor errors can significantly impact both productivity and system safety. Fault detection and diagnosis (FDD) has emerged as a crucial strategy for maintaining system reliability and safety through condition monitoring and abnormality recovery to manage this challenge. Statistical-based FDD methods that rely on large-scale process data and their features have been developed for detecting faults. This paper overviews recent investigations and developments in statistical-based FDD methods, focusing on probabilistic models. The theoretical background of these models is presented, including Bayesian learning and maximum likelihood. We then discuss various techniques and methodologies, e.g., probabilistic principal component analysis (PPCA), probabilistic partial least squares (PPLS), probabilistic independent component analysis (PICA), probabilistic canonical correlation analysis (PCCA), and probabilistic Fisher discriminant analysis (PFDA). Several test statistics are analyzed to evaluate the discussed methods. In industrial processes, these methods require complex matrix operation and cost computational load. Finally, we discuss the current challenges and future trends in FDD. Full article

Perfluorodecanoic acid (PFDA), an enduring and harmful organic pollutant, is widely employed in diverse food-related sectors. Our previous studies have provided evidence that PFDA has the potential to facilitate obesity and hepatic fat accumulation induced by high-fat diet (HFD) intake. Epigallocatechin-3-gallate (EGCG), a polyphenol found in green tea, has been suggested to possess potential preventive effects against metabolic abnormalities and fatty liver. The purpose of this research was to investigate the effects of EGCG on PFDA-exacerbated adiposity and hepatic lipid accumulation in HFD-fed mice. The results showed that EGCG reduced body weight gain; tissue and organ weights; blood glucose, serum insulin, HOMA-IR, leptin, and lipid parameters; serum inflammatory cytokines (IL−1β, IL−18, IL−6, and TNF−α); and hepatic lipid accumulation in PFDA-exposed mice fed an HFD. Further work showed that EGCG improved liver function and glucose homeostasis in mice fed an HFD and co-exposed to PFDA. The elevated hepatic mRNA levels of SREBP-1 and associated lipogenic genes, NLRP3, and caspase−1 in PFDA-exposed mice fed an HFD were significantly decreased by EGCG. Our work provides evidence for the potential anti-obesity effect of EGCG on co-exposure to HFD and PFDA and may call for further research on the bioactivity of EGCG to attenuate the endocrine disruption effects of long-term exposure to pollutants. Full article

The extensive use and bioaccumulation of Perfluoroalkyl Substances (PFAS) over time raise concerns about their impact on health, including mental issues such as depression. This study aims to evaluate the association between PFAS and depression. In addition, considering the importance of PFAS as an endocrine disruptor and in adipogenesis, the analyses will also be stratified by body fat status. A cross-sectional study with 479 subjects (56.4% women, 25–89 years) was conducted. Four PFAS were measured: perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluorooctane sulfonate (PFOS). The Poisson regression model was applied using robust error variances. The fully adjusted model included age, sex, educational level, income, smoking, physical activity, body fat percentage, and the questionnaire to assess depression. The prevalence of depression and high body fat was 7.9% and 41.1%, respectively. Only PFOA was significantly associated with depression in the entire sample (prevalence rate (PR): 1.91; confidence interval (CI95%): 1.01–3.65). However, in the group with normal adiposity, PFOA (3.20, CI95%: 1.46–7.01), PFNA (2.54, CI95%: 1.29–5.00), and PFDA (2.09, CI95%: 1.09–4.00) were also significant. Future research should investigate the role of obesity as well as the biological plausibility and possible mechanisms increasing the limited number of evidences between PFAS and depression. Full article