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1,308 Results Found

  • Article
  • Open Access
1 Citations
1,622 Views
17 Pages

15 September 2023

In this study, the internal relationships among oil bodies (OBs), the protein–phospholipid interactions in aqueous phase, oil–water interface behavior, and the stability of reconstituted OBs were analyzed from the bulk phase, interface, a...

  • Article
  • Open Access
1,206 Views
17 Pages

6 August 2025

Sodium p-perfluorous nonenoxybenzenesulfonate (OBS) has been proposed as a substitute for perfluorooctanesulfonic acid (PFOS), yet it has garnered increasing attention due to its environmental persistence and potential toxicity. Despite these concern...

  • Article
  • Open Access
17 Citations
4,573 Views
14 Pages

Skeletal Lipocalin-2 Is Associated with Iron-Related Oxidative Stress in ob/ob Mice with Sarcopenia

  • Eun Bee Choi,
  • Jae Hun Jeong,
  • Hye Min Jang,
  • Yu Jeong Ahn,
  • Kyu Hyeon Kim,
  • Hyeong Seok An,
  • Jong Youl Lee,
  • Eun Ae Jeong,
  • Jaewoong Lee and
  • Hyun Joo Shin
  • + 2 authors

Obesity and insulin resistance accelerate aging-related sarcopenia, which is associated with iron load and oxidative stress. Lipocalin-2 (LCN2) is an iron-binding protein that has been associated with skeletal muscle regeneration, but details regardi...

  • Article
  • Open Access
12 Citations
3,157 Views
12 Pages

22 April 2023

Type 2 diabetes is a disease characterized by hyperglycemia and is a growing health problem worldwide. Since many known diabetes drugs are side effects, it is necessary to develop natural substances with guaranteed safety. HM-chromanone isolated from...

  • Communication
  • Open Access
10 Citations
2,762 Views
10 Pages

Cytidine Alleviates Dyslipidemia and Modulates the Gut Microbiota Composition in ob/ob Mice

  • Kaixia Niu,
  • Pengpeng Bai,
  • Junyang Zhang,
  • Xinchi Feng and
  • Feng Qiu

24 February 2023

Cytidine and uridine are endogenous metabolites in the pyrimidine metabolism pathway, and cytidine is a substrate that can be metabolized into uridine via cytidine deaminase. Uridine has been widely reported to be effective in regulating lipid metabo...

  • Article
  • Open Access
9 Citations
3,463 Views
14 Pages

4 April 2022

The present study evaluates the National Aeronautics Space Administration (NASA) Earth Exchange Global Daily Downscaled Projections (NEX-GDDP) dataset that provides statistically downscaled CMIP5 historical and future climate projections of the daily...

  • Article
  • Open Access
12 Citations
4,904 Views
18 Pages

Meta-Inflammation and De Novo Lipogenesis Markers Are Involved in Metabolic Associated Fatty Liver Disease Progression in BTBR ob/ob Mice

  • Lucas Opazo-Ríos,
  • Manuel Soto-Catalán,
  • Iolanda Lázaro,
  • Aleix Sala-Vila,
  • Luna Jiménez-Castilla,
  • Macarena Orejudo,
  • Juan Antonio Moreno,
  • Jesús Egido and
  • Sebastián Mas-Fontao

Metabolic associated fatty liver disease (MAFLD) is a hepatic manifestation of metabolic syndrome and usually associated with obesity and diabetes. Our aim is to characterize the pathophysiological mechanism involved in MAFLD development in Black Tan...

  • Article
  • Open Access
1,979 Views
23 Pages

18 February 2025

Climate projections based on global climate models (GCMs) are generally subject to large uncertainties, as the models only reflect the local climate in the past to a limited extent. Statistical downscaling is the most cost-effective approach to ident...

  • Article
  • Open Access
4 Citations
4,071 Views
14 Pages

Micro-Current Stimulation Can Modulate the Adipogenesis Process by Regulating the Insulin Signaling Pathway in 3T3-L1 Cells and ob/ob Mice

  • Hana Lee,
  • Jin-Ho Lee,
  • Doyong Kim,
  • Donghyun Hwang,
  • Minjoo Lee,
  • Halim Chung,
  • Tack-Joong Kim and
  • Han Sung Kim

1 February 2023

Obesity is a disease in which fat is abnormally or excessively accumulated in the body, and many studies have been conducted to overcome it with various techniques. In this study, we evaluated whether micro-current stimulation (MCS) can be applied to...

  • Article
  • Open Access
6 Citations
6,930 Views
12 Pages

Pharmacological Effects of the Water Fraction of Key Components in the Traditional Chinese Prescription Mai Tong Fang on 3T3-L1 Adipocytes and ob/ob Diabetic Mice

  • Liang Ma,
  • Li Huang,
  • Heying Pei,
  • Zhuowei Liu,
  • Caifeng Xie,
  • Lei Lei,
  • Xiaoxin Chen,
  • Haoyu Ye,
  • Aihua Peng and
  • Lijuan Chen

16 September 2014

Mai Tong Fang (MTF), a Chinese herbal combination, has been used for the treatment of diabetic nephropathy in traditional medical clinics in China. However, the anti-adipogenic and anti-hyperglycemic effects of MTF have not been fully elucidated, so...

  • Article
  • Open Access
19 Citations
6,379 Views
16 Pages

7 December 2017

Since the discovery of the anti-diabetic effects of zinc (Zn) complex, we synthesized several Zn complexes and evaluated their effects using the KKAy type 2 diabetes mouse model. Recently, we demonstrated that organo-chalcogen (sulfur and selenium) Z...

  • Article
  • Open Access
4 Citations
2,615 Views
16 Pages

Synbiotic Supplementation Modulates Gut Microbiota, Regulates β-Catenin Expression and Prevents Weight Gain in ob/ob Mice: Preliminary Findings

  • Sebastião Mauro B. Duarte,
  • José Tadeu Stefano,
  • Lucas A. M. Franco,
  • Roberta C. Martins,
  • Bruna D. G. C. Moraes,
  • Denise Frediani Barbeiro,
  • Nathalia Oliveira,
  • Junia Marielle Teixeira Rodrigues Neri,
  • Bruno Cogliati and
  • Denise Siqueira Vanni
  • + 3 authors

10 September 2022

Background: Obesity is one of the main health problems in the world today, and dysbiosis seems to be one of the factors involved. The aim of this study was to examine the impact of synbiotic supplementation on obesity and the microbiota in ob/ob mice...

  • Article
  • Open Access
84 Citations
6,773 Views
27 Pages

Oxidative Balance Scores (OBSs) Integrating Nutrient, Food and Lifestyle Dimensions: Development of the NutrientL-OBS and FoodL-OBS

  • Ángela Hernández-Ruiz,
  • Belén García-Villanova,
  • Eduardo J. Guerra-Hernández,
  • Cayetano Javier Carrión-García,
  • Pilar Amiano,
  • María-José Sánchez and
  • Esther Molina-Montes

31 January 2022

Oxidative Balance Scores (OBS) are tools that allow us to assess the individual’s antioxidant state by ranking both antioxidant and pro-oxidant components of dietary and lifestyle factors. Our aim was to develop novel OBSs accounting for either...

  • Article
  • Open Access
22 Citations
4,344 Views
22 Pages

Anti-Obesity and Anti-Hyperglycemic Effects of Meretrix lusoria Protamex Hydrolysate in ob/ob Mice

  • Min Ju Kim,
  • Ramakrishna Chilakala,
  • Hee Geun Jo,
  • Seung-Jae Lee,
  • Dong-Sung Lee and
  • Sun Hee Cheong

Meretrix lusoria (M. lusoria) is an economically important shellfish which is widely distributed in South Eastern Asia that contains bioactive peptides, proteins, and enzymes. In the present study, the extracted meat content of M. lusoria was enzymat...

  • Article
  • Open Access
4 Citations
2,694 Views
19 Pages

29 June 2023

An analysis of observation data was conducted on the chemical composition of river and groundwater in the Ob River basin, covering more than 23 thousand samples taken from the network of governmental monitoring of surface and groundwater, the materia...

  • Article
  • Open Access
10 Citations
2,690 Views
18 Pages

A Data-Driven OBE Magnetic Interference Compensation Method

  • Yizhen Wang,
  • Qi Han,
  • Dechen Zhan and
  • Qiong Li

12 October 2022

Aeromagnetic compensation is a technology used to reduce aircraft magnetic interference, which plays an important role in aeromagnetic surveys. In addition to maneuvering interferences, the onboard electronic (OBE) interference has been proven to be...

  • Review
  • Open Access
10 Citations
4,181 Views
13 Pages

OB-Folds and Genome Maintenance: Targeting Protein–DNA Interactions for Cancer Therapy

  • Sui Par,
  • Sofia Vaides,
  • Pamela S. VanderVere-Carozza,
  • Katherine S. Pawelczak,
  • Jason Stewart and
  • John J. Turchi

3 July 2021

Genome stability and maintenance pathways along with their requisite proteins are critical for the accurate duplication of genetic material, mutation avoidance, and suppression of human diseases including cancer. Many of these proteins participate in...

  • Article
  • Open Access
13 Citations
5,045 Views
21 Pages

23 March 2023

This paper reports the results of a study on the implementation of a sustainable teaching model based on the OBE (Outcome-Based Education) concept and the TSEM (Teach, Study, Evaluate, and Manage) framework in computer science and technology at Ningb...

  • Article
  • Open Access
10 Citations
5,894 Views
17 Pages

Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms

  • Eunyoung Lee,
  • Emily L. Miedzybrodzka,
  • Xilin Zhang,
  • Ryo Hatano,
  • Junki Miyamoto,
  • Ikuo Kimura,
  • Kosuke Fujimoto,
  • Satoshi Uematsu,
  • Sergio Rodriguez-Cuenca and
  • Antonio Vidal-Puig
  • + 3 authors

10 September 2019

As glucose-dependent insulinotropic polypeptide (GIP) possesses pro-adipogenic action, the suppression of the GIP hypersecretion seen in obesity might represent a novel therapeutic approach to the treatment of obesity. However, the mechanism of GIP h...

  • Article
  • Open Access
6 Citations
2,634 Views
14 Pages

Predictive Role of Leptin Receptor (Ob-R) Overexpression in Patients with Early Breast Cancer Receiving Neoadjuvant Systemic Treatment

  • Laura García-Estévez,
  • Isabel Calvo,
  • Silvia Pérez,
  • Isabel Gallegos,
  • Eva Díaz,
  • Miguel Sampayo-Cordero,
  • Sara S Oltra and
  • Gema Moreno-Bueno

29 June 2021

The primary aim of this retrospective study was to investigate the correlation between the immunohistochemical expression of Ob-R (leptin receptor) with pCR (pathological complete response) in early breast cancer patients receiving neoadjuvant system...

  • Article
  • Open Access
10 Citations
3,969 Views
23 Pages

9 July 2021

Here we summarize a long-term study on qualitative and quantitative composition of zooplankton (Cladocera, Copepoda, Rotifera) in the Ob River. We carried out these investigations at 13 sampling stations of the Middle and Low Ob in the years 1994, 19...

  • Article
  • Open Access
5 Citations
2,059 Views
13 Pages

1 June 2023

For many of the Siberian rivers, and the Upper Ob in particular, 70–80% of the volume of the annual water runoff is formed during the spring flood. Thus, factors influencing the formation of water runoff during the spring flood are paramount. W...

  • Article
  • Open Access
20 Citations
4,287 Views
18 Pages

10 December 2021

Satellite altimetry is an efficient instrument for detection dynamical processes in the World Ocean, including reconstruction of geostrophic currents and tracking of mesoscale eddies. Satellite altimetry has the potential to detect large river plumes...

  • Article
  • Open Access
627 Views
19 Pages

Integrative ATAC-Seq and RNA-Seq Analysis Identifies a WD40 Repeat Protein, ObWPA, as a Significant Regulator of the Purple Coloration in Syringa oblata

  • Liting Man,
  • Lulu Zhang,
  • Ying Mao,
  • Senyan Zhang,
  • Guiying Liu,
  • Guanghua Ma,
  • Haihong Wang,
  • Wenjie Zhao,
  • Shaofei Tong and
  • Wenlu Yang
  • + 1 author

30 September 2025

Lilac (Syringa spp.) is a widely cultivated ornamental plant prized for its fragrant aroma and attractive flower colors. However, the molecular mechanisms governing its flower pigmentation remain poorly understood. In this study, we performed integra...

  • Article
  • Open Access
8 Citations
3,285 Views
23 Pages

Enhancement of Methane Catalysis Rates in Methylosinus trichosporium OB3b

  • Dipayan Samanta,
  • Tanvi Govil,
  • Priya Saxena,
  • Venkata Gadhamshetty,
  • Lee R. Krumholz,
  • David R. Salem and
  • Rajesh K. Sani

9 April 2022

Particulate methane monooxygenase (pMMO), a membrane-bound enzyme having three subunits (α, β, and γ) and copper-containing centers, is found in most of the methanotrophs that selectively catalyze the oxidation of methane into methan...

  • Article
  • Open Access
6 Citations
2,634 Views
17 Pages

Trace Elements in Sediments of Two Lakes in the Valley of the Middle Courses of the Ob River (Western Siberia)

  • Vladimir P. Shevchenko,
  • Dina P. Starodymova,
  • Sergey N. Vorobyev,
  • Ramiz A. Aliev,
  • Lyudmila P. Borilo,
  • Larisa G. Kolesnichenko,
  • Artyom G. Lim,
  • Andrey I. Osipov,
  • Vladislav V. Trufanov and
  • Oleg S. Pokrovsky

24 November 2022

Lake sediments accumulate various pollutants and act as efficient natural archives suitable for reconstruction the environmental conditions of the past. In contrast to fairly good knowledge of mineral sediments in lakes of European and North America...

  • Article
  • Open Access
660 Views
5 Pages

Wpływ menopauzy na nasilenie obturacyjnego bezdechu sennego (OBS) u kobiet

  • Robert Pływaczewski,
  • Michał Bednarek,
  • Przemysław Bieleń,
  • Luiza Jonczak,
  • Dorota Górecka and
  • Paweł Śliwiński

3 June 2007

Wstęp: U kobiet obturacyjny bezdech senny (OBS) najczęściej występuje po menopauzie. Celem pracy było porównanie zaawansowania OBS u kobiet po menopauzie (grupa E−) oraz u kobiet z zachowaną aktywnością estrogenową (kobiety przed menopauzą lub stosu...

  • Article
  • Open Access
1 Citations
1,078 Views
7 Pages

Nykturia u chorych na obturacyjny bezdech senny (OBS)

  • Robert Pływaczewski,
  • Anna Stokłosa,
  • Michał Bednarek,
  • Justyna Czerniawska,
  • Przemysław Bieleń,
  • Dorota Górecka and
  • Paweł Śliwiński

3 June 2007

Wstęp: Nykturia (≥2 epizodów oddawania moczu w nocy) jest częstym objawem obturacyjnego bezdechu sennego (OBS). Wzrost ciśnienia w jamie brzusznej w czasie bezdechów, zwiększone wydzielanie przedsionkowego peptydu sodopędnego (ANP), stosowanie leków...

  • Article
  • Open Access
3 Citations
2,227 Views
18 Pages

26 August 2023

Ambient noise plays a crucial role in influencing the observation quality at seismic stations. By studying the distribution patterns of ambient noise, we can gain initial insights into the noise conditions within a specific research area. This paper...

  • Article
  • Open Access
12 Citations
1,958 Views
29 Pages

Small Organisms in a Large River: What Provides the High Diversity of Scaled Chrysophytes in the Ob River?

  • Anna Bessudova,
  • Yelena Likhoshway,
  • Alena Firsova,
  • Elena Mitrofanova,
  • Mikhail Koveshnikov,
  • Andrey Soromotin,
  • Vitaly Khoroshavin and
  • Vladimir Kirillov

25 August 2023

Currents are one of the main factors favoring the dispersal of microscopic planktic organisms over inland lakes and rivers. Large rivers of the northern hemisphere, flowing from south to north, can increase the diversity of northern latitudes with bo...

  • Article
  • Open Access
34 Citations
14,972 Views
26 Pages

17 June 2023

With the advent of the digital age and Industry 4.0, the communication skills of engineering students has been exerting gradually increasing influence on the need for enhanced student employability. To address this issue, this study evaluates the inf...

  • Article
  • Open Access
1,133 Views
15 Pages

19 August 2025

Perfluorooctane sulfonate (PFOS) is a representative persistent organic pollutant that exerts toxic effects on aquatic organisms. As an alternative to PFOS, sodium p-perfluorous nonenoxybenzene sulfonate (OBS) has been frequently detected in aquatic...

  • Article
  • Open Access
7 Citations
4,843 Views
14 Pages

Antrodia cinnamomea Confers Obesity Resistance and Restores Intestinal Barrier Integrity in Leptin-deficient Obese Mice

  • Yi-Ting Tsai,
  • Jhen-Wei Ruan,
  • Cherng-Shyang Chang,
  • Mei-Lan Ko,
  • Hsiu-Chuan Chou,
  • Chi-Chien Lin,
  • Chiao-Mei Lin,
  • Chih-Ting Huang,
  • Yu-Shan Wei and
  • En-Chi Liao
  • + 3 authors

10 March 2020

Obesity is associated with metabolic disorders. Thus, obesity prevention and treatment are essential for health. Antrodia cinnamomea (AC) is a multifunctional medicinal fungus used for the treatment of various diseases and for preventing diet-induced...

  • Article
  • Open Access
1,217 Views
8 Pages

Uwulopalatofaryngoplastyka (UPPP) jako zabieg nieskuteczny w leczeniu ciężkiego obturacyjnego bezdechu sennego (OBS)

  • Robert Pływaczewski,
  • Michał Bednarek,
  • Luiza Jonczak,
  • Justyna Czerniawska,
  • Dorota Górecka and
  • Paweł Śliwiński

3 June 2007

Wstęp: Uwulopalatofaryngoplastyka (UPPP) jest jedną z najczęściej wykonywanych operacji w leczeniu chirurgicznym obturacyjnego bezdechu sennego. Celem pracy była ocena efektów UPPP u pacjentów chorych na OBS. Materiał i metody: Zbadano 22 otyłych...

  • Article
  • Open Access
9 Citations
3,110 Views
21 Pages

Drought Characterization in Croatia Using E-OBS Gridded Data

  • João F. Santos,
  • Lidija Tadic,
  • Maria Manuela Portela,
  • Luis Angel Espinosa and
  • Tamara Brleković

31 October 2023

Droughts are among the major natural hazards that are spreading to many parts of the world, with huge multi-dimensional impacts. An extensive analysis of drought phenomenon is presented for continental Croatia based on a meteorological E-OBS gridded...

  • Brief Report
  • Open Access
2,047 Views
10 Pages

Systematic Analysis of UFMylation Family Genes in Tissues of Mice with Metabolic Dysfunction-Associated Steatotic Liver Disease

  • Mingdi Jiang,
  • Chenlu Zhang,
  • Zhengyao Zhang,
  • Yingying Duan,
  • Shuaiyong Qi,
  • Qingyu Zeng,
  • Jiabao Wang,
  • Jiawen Zhang,
  • Yu Jiang and
  • Ying Wang
  • + 2 authors

27 December 2024

Background/Objectives: UFMylation, a newly identified ubiquitin-like modification, modulates a variety of physiological processes, including endoplasmic reticulum homeostasis maintenance, DNA damage response, embryonic development, and tumor progress...

  • Article
  • Open Access
3 Citations
6,424 Views
20 Pages

13 October 2018

Ocean Bottom Seismometers (OBS) placed on the seafloor surface are utilized for measuring the ocean bottom seismic waves. The vibration of OBS excited by underwater noise on its surface may interfere with its measured results of seismic waves. In thi...

  • Article
  • Open Access
9 Citations
8,515 Views
9 Pages

5 October 2022

Due to spontaneous deficiency in leptin, ob/ob mice are one of the most commonly used experimental animal models in diabetes research. In this study, we reported a quick and easy-to-conduct genotyping method using tetra-primer amplification refractor...

  • Article
  • Open Access
3 Citations
2,387 Views
17 Pages

17 April 2024

As an alternative for perfluorooctane sulfonic acid (PFOS), sodium p-perfluorononyloxybenzene sulfonate (OBS) has been widely used in petroleum, fire-fighting materials, and other industries. In order to efficiently and economically remove OBS contam...

  • Article
  • Open Access
3 Citations
1,977 Views
14 Pages

Amino Group-Driven Adsorption of Sodium p-Perfluorous Nonenoxybenzene Sulfonate in Water by the Modified Graphene Oxide

  • Mengyuan Lu,
  • Yang Liu,
  • Xinning Zheng,
  • Wenjuan Liu,
  • Yang Liu,
  • Jia Bao,
  • Ao Feng,
  • Yueyao Bao,
  • Jiangyong Diao and
  • Hongyang Liu

8 May 2024

Sodium p-perfluorous nonenoxybenzene sulfonate (OBS) is one of the key alternatives to perfluoroalkyl substances (PFASs). Its widespread tendency has increased extensive contamination in the aquatic environment. However, the present treatment technol...

  • Article
  • Open Access
662 Views
15 Pages

Compared with point-to-point underwater wireless optical communication (UWOC) systems with a single direction, the underwater multi-faceted optical base station (OBS) offers independent fields of view and directions for each receiving detector, suppo...

  • Article
  • Open Access
31 Citations
6,039 Views
15 Pages

Leptin Receptor Metabolism Disorder in Primary Chondrocytes from Adolescent Idiopathic Scoliosis Girls

  • Yun-Jia Wang,
  • Hong-Gui Yu,
  • Zhen-Hai Zhou,
  • Qiang Guo,
  • Long-Jie Wang and
  • Hong-Qi Zhang

To investigate the underlying mechanisms of low metabolic activity of primary chondrocytes obtained from girls with adolescent idiopathic scoliosis (AIS); AIS is a spine-deforming disease that often occurs in girls. AIS is associated with a lower bon...

  • Article
  • Open Access
21 Citations
5,237 Views
16 Pages

Immune Cell Induced Migration of Osteoprogenitor Cells Is Mediated by TGF-β Dependent Upregulation of NOX4 and Activation of Focal Adhesion Kinase

  • Sabrina Ehnert,
  • Caren Linnemann,
  • Romina H. Aspera-Werz,
  • Daria Bykova,
  • Sara Biermann,
  • Leonie Fecht,
  • Peter M. De Zwart,
  • Andreas K. Nussler and
  • Fabian Stuby

The cytokines secreted by immune cells have a large impact on the tissue, surrounding a fracture, e.g., by attraction of osteoprogenitor cells. However, the underlying mechanisms are not yet fully understood. Thus, this study aims at investigating mo...

  • Article
  • Open Access
8 Citations
3,852 Views
15 Pages

Pankun: A New Generation of Broadband Ocean Bottom Seismograph

  • Dan Liu,
  • Ting Yang,
  • Yizhi Wang,
  • Yuechu Wu and
  • Xinfeng Huang

23 May 2023

This paper presents a new broadband ocean bottom seismograph (OBS) developed by the SUSTech OBS lab for passive-source seafloor seismic observations. This instrument, called Pankun, has several key features that set it apart from traditional OBS inst...

  • Article
  • Open Access
16 Citations
5,718 Views
19 Pages

A Hybrid MCDM Model for Evaluating Open Banking Business Partners

  • Alexander Kuan Daiy,
  • Kao-Yi Shen,
  • Jim-Yuh Huang and
  • Tom Meng-Yen Lin

10 March 2021

Open banking (OB) is an emerging business field in the financial sector, which relies on intensive collaboration between banks and non-banking service providers. However, how to evaluate OB business partners from multiple perspectives for banks is un...

  • Communication
  • Open Access
1 Citations
2,312 Views
12 Pages

The Expression of Genes Related to Reverse Cholesterol Transport and Leptin Receptor Pathways in Peripheral Blood Mononuclear Cells Are Decreased in Morbid Obesity and Related to Liver Function

  • Carlos Jiménez-Cortegana,
  • Soledad López-Enríquez,
  • Gonzalo Alba,
  • Consuelo Santa-María,
  • Gracia M. Martín-Núñez,
  • Francisco J. Moreno-Ruiz,
  • Sergio Valdés,
  • Sara García-Serrano,
  • Cristina Rodríguez-Díaz and
  • Ailec Ho-Plágaro
  • + 4 authors

Obesity is frequently accompanied by non-alcoholic fatty liver disease (NAFLD). These two diseases are associated with altered lipid metabolism, in which reverse cholesterol transport (LXRα/ABCA1/ABCG1) and leptin response (leptin receptor (Ob-...

  • Article
  • Open Access
3 Citations
2,397 Views
19 Pages

Mannan-Binding Lectin Is Associated with Inflammation and Kidney Damage in a Mouse Model of Type 2 Diabetes

  • Gry H. Dørflinger,
  • Charlotte B. Holt,
  • Steffen Thiel,
  • Jesper N. Bech,
  • Jakob A. Østergaard and
  • Mette Bjerre

Autoreactivity of the complement system may escalate the development of diabetic nephropathy. We used the BTBR OB mouse model of type 2 diabetes to investigate the role of the complement factor mannan-binding lectin (MBL) in diabetic nephropathy. Fem...

  • Article
  • Open Access
1 Citations
574 Views
24 Pages

6 November 2025

Ocean-bottom seismic (OBS) surveys have been applied in marine oil and gas exploration. In the typical OBS observation geometry, the source and receiver are located on/near different datums, i.e., the sea surface and the seafloor. Besides the desired...

  • Article
  • Open Access
46 Citations
11,843 Views
12 Pages

Fatty Acid Elongation in Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma

  • Sonja M. Kessler,
  • Yvette Simon,
  • Katja Gemperlein,
  • Kathrin Gianmoena,
  • Cristina Cadenas,
  • Vincent Zimmer,
  • Juliane Pokorny,
  • Ahmad Barghash,
  • Volkhard Helms and
  • Nico Van Rooijen
  • + 6 authors

4 April 2014

Non-alcoholic steatohepatitis (NASH) represents a risk factor for the development of hepatocellular carcinoma (HCC) and is characterized by quantitative and qualitative changes in hepatic lipids. Since elongation of fatty acids from C16 to C18 has re...

  • Review
  • Open Access
38 Citations
8,782 Views
26 Pages

Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice—A Mechanistic Systematic Review

  • Albert Stachura,
  • Ishani Khanna,
  • Piotr Krysiak,
  • Wiktor Paskal and
  • Paweł Włodarski

Type II diabetes mellitus (T2DM) is one of the most prevalent diseases in the world, associated with diabetic foot ulcers and impaired wound healing. There is an ongoing need for interventions effective in treating these two problems. Pre-clinical st...

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