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Search Results (730)

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20 pages, 813 KiB  
Review
Exploring Design Thinking Methodologies: A Comprehensive Analysis of the Literature, Outstanding Practices, and Their Linkage to Sustainable Development Goals
by Matilde Martínez Casanovas
Sustainability 2025, 17(15), 7142; https://doi.org/10.3390/su17157142 - 6 Aug 2025
Abstract
Design Thinking (DT) has emerged as a relevant methodology for addressing global challenges aligned with the United Nations Sustainable Development Goals (SDGs). This study presents a systematic literature review, conducted following PRISMA 2020 guidelines, which analyzes 42 peer-reviewed publications from 2013 to 2023. [...] Read more.
Design Thinking (DT) has emerged as a relevant methodology for addressing global challenges aligned with the United Nations Sustainable Development Goals (SDGs). This study presents a systematic literature review, conducted following PRISMA 2020 guidelines, which analyzes 42 peer-reviewed publications from 2013 to 2023. Through inductive content analysis, 10 core DT principles—such as empathy, iteration, user-centeredness, and systems thinking—I identified and thematically mapped to specific SDGs, including goals related to health, education, innovation, and climate action. The study also presents five real-world cases from diverse sectors such as technology, healthcare, and urban planning, illustrating how DT has been applied to address practical challenges aligned with the SDGs. However, the review identifies persistent gaps in the field: the lack of standardized evaluation frameworks, limited integration across SDG domains, and weak adaptation of ethical and contextual considerations, particularly in vulnerable communities. As a response, this paper recommends the adoption of structured impact assessment tools (e.g., Cities2030, Responsible Design Thinking), integration of design justice principles, and the development of participatory, iterative ecosystems for innovation. By offering both conceptual synthesis and applied insights, this article positions Design Thinking as a strategic and systemic approach for driving sustainable transformation aligned with the 2030 Agenda. Full article
(This article belongs to the Section Sustainable Education and Approaches)
23 pages, 782 KiB  
Article
From Local Actions to Global Impact: Overcoming Hurdles and Showcasing Sustainability Achievements in the Implementation of SDG12
by John N. Hahladakis
Sustainability 2025, 17(15), 7106; https://doi.org/10.3390/su17157106 - 5 Aug 2025
Abstract
This study examines the progress, challenges, and successes in implementing Sustainable Development Goal 12 (SDG12), focusing on responsible consumption and production, using Qatar as a case study. The State has integrated Sustainable Consumption and Production (SCP) into national policies, established coordination mechanisms, and [...] Read more.
This study examines the progress, challenges, and successes in implementing Sustainable Development Goal 12 (SDG12), focusing on responsible consumption and production, using Qatar as a case study. The State has integrated Sustainable Consumption and Production (SCP) into national policies, established coordination mechanisms, and implemented action plans aligned with SDG12 targets. Achievements include renewable energy adoption, waste management reforms, and sustainable public procurement, though challenges persist in rationalizing fossil fuel subsidies, addressing data gaps, and enhancing corporate sustainability reporting. Efforts to reduce food loss and waste through redistribution programs highlight the country’s resilience, despite logistical obstacles. The nation has also advanced hazardous waste management, environmental awareness, and sustainable tourism policies, though gaps in data systems and policy coherence remain. Qatar’s approach provides a valuable local-to-global example of balancing resource-dependent economies with sustainability goals. Its strategies and lessons offer potential adaptability for other nations, especially those facing similar challenges in achieving SDG12. By strengthening data systems, enhancing policy integration, and fostering regional and international cooperation, Qatar’s efforts underscore the importance of aligning economic growth with environmental stewardship, serving as a blueprint for global sustainability initiatives. Full article
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20 pages, 1083 KiB  
Article
The Risk of Global Environmental Change to Economic Sustainability and Law: Help from Digital Technology and Governance Regulation
by Zhen Cao, Zhuiwen Lai, Muhammad Bilawal Khaskheli and Lin Wang
Sustainability 2025, 17(15), 7094; https://doi.org/10.3390/su17157094 - 5 Aug 2025
Abstract
This research examines the compounding risks of global environmental change, including climate change, environmental law, biodiversity loss, and pollution, which threaten the stability of economic systems worldwide. While digital technology and global governance regulation are increasingly being proposed as solutions, their synergistic potential [...] Read more.
This research examines the compounding risks of global environmental change, including climate change, environmental law, biodiversity loss, and pollution, which threaten the stability of economic systems worldwide. While digital technology and global governance regulation are increasingly being proposed as solutions, their synergistic potential in advancing economic sustainability has been less explored. How can these technologies mitigate environmental risks while promoting sustainable and equitable development, aligning with the Sustainable Development Goals? We analyze policy global environmental data from the World Bank and the United Nations, as well as literature reviews on digital interventions, artificial intelligence, and smart databases. Global environmental change presents economic stability and rule of law threats, and innovative governance responses are needed. This study evaluates the potential for digital technology to be leveraged to enhance climate resilience and regulatory systems and address key implementation, equity, and policy coherence deficits. Policy recommendations for aligning economic development trajectories with planetary boundaries emphasize that proactive digital governance integration is indispensable for decoupling growth from environmental degradation. However, fragmented governance and unequal access to technologies undermine scalability. Successful experiences demonstrate that integrated policies, combining incentives, data transparency, and multilateral coordination, deliver maximum economic and environmental co-benefits, matching digital innovation with good governance. We provide policymakers with an action plan to leverage technology as a multiplier of sustainability, prioritizing inclusive governance structures to address implementation gaps and inform legislation. Full article
(This article belongs to the Special Issue Innovations in Environment Protection and Sustainable Development)
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24 pages, 1464 KiB  
Review
An Overview of the Italian Roadmap for the Implementation of Circular Economy in the Energy Transition of Buildings
by Marilena De Simone and Daniele Campagna
Buildings 2025, 15(15), 2755; https://doi.org/10.3390/buildings15152755 - 5 Aug 2025
Abstract
An important task for the European Union is to transpose agreements and international standards in regulation and directives that are binding on member states. The resultant European action plans and directives identify priority areas in the building and energy sectors where circular economy [...] Read more.
An important task for the European Union is to transpose agreements and international standards in regulation and directives that are binding on member states. The resultant European action plans and directives identify priority areas in the building and energy sectors where circular economy principles can be applied. Italy records a general circular materials rate of 20.8%, surpassing the mean European value. But low recycling rates are still registered in the construction sector. This paper aims to assess the position of Italy with respect to the European regulatory framework on circularity in the energy transition of buildings. Firstly, the government’s initiatives and technical standards are introduced and commented upon. Secondly, the study illustrates the current Italian platforms, networks, and public and private initiatives highlighting opportunities and obstacles that the energy sector has to overcome in the area of circularity. It emerges that Italian policies still use voluntary tools that are not sufficiently in line with an effective circular economy model. Moreover, data collection plays a crucial role in accelerating the implementation of future actions. Italy should consider the foundation of a National Observatory for the Circular Economy to elaborate European directives, harmonize regional policies, and promote the implementation of effective practices. Full article
(This article belongs to the Special Issue Research on Sustainable Energy Performance of Green Buildings)
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20 pages, 1801 KiB  
Article
Territorially Stratified Modeling for Sustainable Management of Free-Roaming Cat Populations in Spain: A National Approach to Urban and Rural Environmental Planning
by Octavio P. Luzardo, Ruth Manzanares-Fernández, José Ramón Becerra-Carollo and María del Mar Travieso-Aja
Animals 2025, 15(15), 2278; https://doi.org/10.3390/ani15152278 - 4 Aug 2025
Abstract
This study presents the scientific and methodological foundation of Spain’s first national framework for the ethical management of community cat populations: the Action Plan for the Management of Community Cat Colonies (PACF), launched in 2025 under the mandate of Law 7/2023. This pioneering [...] Read more.
This study presents the scientific and methodological foundation of Spain’s first national framework for the ethical management of community cat populations: the Action Plan for the Management of Community Cat Colonies (PACF), launched in 2025 under the mandate of Law 7/2023. This pioneering legislation introduces a standardized, nationwide obligation for trap–neuter–return (TNR)-based management of free-roaming cats, defined as animals living freely, territorially attached, and with limited socialization toward humans. The PACF aims to support municipalities in implementing this mandate through evidence-based strategies that integrate animal welfare, biodiversity protection, and public health objectives. Using standardized data submitted by 1128 municipalities (13.9% of Spain’s total), we estimated a baseline population of 1.81 million community cats distributed across 125,000 colonies. These data were stratified by municipal population size and applied to national census figures to generate a model-ready demographic structure. We then implemented a stochastic simulation using Vortex software to project long-term population dynamics over a 25-year horizon. The model integrated eight demographic–environmental scenarios defined by a combination of urban–rural classification and ecological reproductive potential based on photoperiod and winter temperature. Parameters included reproductive output, mortality, sterilization coverage, abandonment and adoption rates, stochastic catastrophic events, and territorial carrying capacity. Under current sterilization rates (~20%), our projections indicate that Spain’s community cat population could surpass 5 million individuals by 2050, saturating ecological and social thresholds within a decade. In contrast, a differentiated sterilization strategy aligned with territorial reproductive intensity (50% in most areas, 60–70% in high-pressure zones) achieves population stabilization by 2030 at approximately 1.5 million cats, followed by a gradual long-term decline. This scenario prioritizes feasibility while substantially reducing reproductive output, particularly in rural and high-intensity contexts. The PACF combines stratified demographic modeling with spatial sensitivity, offering a flexible framework adaptable to local conditions. It incorporates One Health principles and introduces tools for adaptive management, including digital monitoring platforms and standardized welfare protocols. While ecological impacts were not directly assessed, the proposed demographic stabilization is designed to mitigate population-driven risks to biodiversity and public health without relying on lethal control. By integrating legal mandates, stratified modeling, and realistic intervention goals, this study outlines a replicable and scalable framework for coordinated action across administrative levels. It exemplifies how national policy can be operationalized through data-driven, territorially sensitive planning tools. The findings support the strategic deployment of TNR-based programs across diverse municipal contexts, providing a model for other countries seeking to align animal welfare policy with ecological planning under a multi-level governance perspective. Full article
(This article belongs to the Section Animal System and Management)
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23 pages, 715 KiB  
Article
Research on the Development of the New Energy Vehicle Industry in the Context of ASEAN New Energy Policy
by Yalin Mo, Lu Li and Haihong Deng
Sustainability 2025, 17(15), 7073; https://doi.org/10.3390/su17157073 - 4 Aug 2025
Abstract
The green transformation of traditional energy structures and the development of the new energy industry are crucial drivers of sustainable development in the country. The ASEAN Plan of Action for Energy Cooperation (2016–2025; APAEC [2016–2025]), established in 2016, has significantly promoted the growth [...] Read more.
The green transformation of traditional energy structures and the development of the new energy industry are crucial drivers of sustainable development in the country. The ASEAN Plan of Action for Energy Cooperation (2016–2025; APAEC [2016–2025]), established in 2016, has significantly promoted the growth of the new energy sector and enhanced energy structures across Association of Southeast Asian Nations (ASEAN). This initiative has also inspired these countries to develop corresponding industrial policies aimed at supporting the new energy vehicle (NEV) industry, resulting in significant growth in this sector within the ASEAN region. This paper analyzes the factors influencing the development of the NEV industry in the context of ASEAN’s new energy policies, drawing empirical insights from data collected across six ASEAN countries from 2013 to 2024. Following the implementation of the APAEC (2016–2025), it was observed that ASEAN countries reached a consensus on energy development and cooperation, collaboratively advancing the NEV industry through regional policies. Furthermore, factors such as national governance, financial development, education levels, and the size of the automotive market positively contribute to the growth of the NEV industry in ASEAN. Conversely, high energy consumption can hinder its progress. Additionally, further research indicates that the APAEC (2016–2025) has exerted a more pronounced impact on countries with robust automotive industry foundations or those prioritizing relevant policies. The findings of this paper offer valuable insights for ASEAN countries in the formulating policies for the NEV industry, optimizing energy structures, and achieving low-carbon energy transition and sustainable development. Full article
(This article belongs to the Section Energy Sustainability)
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17 pages, 284 KiB  
Article
Exploring the Motivation for Media Consumption and Attitudes Toward Advertisement in Transition to Ad-Supported OTT Plans: Evidence from South Korea
by Sang-Yeon Kim, Jeong-Hyun Kang, Hye-Min Byeon, Yoon-Taek Sung, Young-A Song, Ji-Won Lee and Seung-Chul Yoo
J. Theor. Appl. Electron. Commer. Res. 2025, 20(3), 198; https://doi.org/10.3390/jtaer20030198 - 4 Aug 2025
Viewed by 50
Abstract
As ad-supported subscription models proliferate across over-the-top (OTT) media platforms, understanding the psychological mechanisms and perceptual factors that underlie consumers’ transition decisions becomes increasingly consequential. This study integrates the Uses and Gratifications framework with a contemporary motivation-based perspective to examine how users’ media [...] Read more.
As ad-supported subscription models proliferate across over-the-top (OTT) media platforms, understanding the psychological mechanisms and perceptual factors that underlie consumers’ transition decisions becomes increasingly consequential. This study integrates the Uses and Gratifications framework with a contemporary motivation-based perspective to examine how users’ media consumption motivations and advertising attitudes predict intentions to adopt ad-supported OTT plans. Data were collected via a nationally representative online survey in South Korea (N = 813). The sample included both premium subscribers (n = 708) and non-subscribers (n = 105). The findings reveal distinct segmentation in decision-making patterns. Among premium subscribers, switching intentions were predominantly driven by intrinsic motivations—particularly identity alignment with content—and by the perceived informational value of advertisements. These individuals are more likely to consider ad-supported plans when ad content is personally relevant and cognitively enriching. Conversely, non-subscribers exhibited greater sensitivity to extrinsic cues such as the entertainment value of ads and the presence of tangible incentives (e.g., discounts), suggesting a hedonic-reward orientation. By advancing a dual-pathway explanatory model, this study contributes to the theoretical discourse on digital subscription behavior and offers actionable insights for OTT service providers. The results underscore the necessity of segment-specific advertising strategies: premium subscribers may be engaged through informative and identity-consistent advertising, while non-subscribers respond more favorably to enjoyable and benefit-laden ad experiences. These insights inform platform monetization efforts amid the evolving dynamics of consumer attention and subscription fatigue. Full article
(This article belongs to the Section Digital Marketing and the Connected Consumer)
19 pages, 3259 KiB  
Article
Examining the Impact of National Planning on Rural Residents’ Disposable Income in China—The Case of Functional Zoning
by Junrong Ma, Chen Liu and Li Tian
Land 2025, 14(8), 1587; https://doi.org/10.3390/land14081587 - 3 Aug 2025
Viewed by 226
Abstract
The growth of rural residents’ disposable income is essential for narrowing the income gap between urban and rural areas and promoting integrated development. This study explores how China’s National Main Functional Zoning Plan influences rural household income through its regulatory impact on construction [...] Read more.
The growth of rural residents’ disposable income is essential for narrowing the income gap between urban and rural areas and promoting integrated development. This study explores how China’s National Main Functional Zoning Plan influences rural household income through its regulatory impact on construction land expansion. Using data from county−level administrative units across China, the research identified the construction land regulation index as a key mediating variable linking zoning policy to changes in household income. By shifting the analytical perspective from a traditional urban–rural classification to a framework aligned with the National Main Functional Zoning Plan, the study reveals how spatial planning tools, particularly differentiated land quota allocations, influence household income. The empirical results confirm a structured causal chain in which zoning policy affects land development intensity, which in turn drives rural income growth. This relationship varies across different functional zones. In key development zones, strict land control limits income potential by constraining land supply. In main agricultural production zones, moderate regulatory control enhances land use efficiency and contributes to higher income levels. In key ecological function zones, ecological constraints require diverse approaches to value realization. The investigation contributes both theoretical and practical insights by elucidating the microeconomic effects of national spatial planning policies and offering actionable guidance for optimizing land use regulation to support income growth tailored to regional functions. Full article
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15 pages, 943 KiB  
Systematic Review
The Implementation of Antimicrobial Consumption Surveillance and Stewardship in Human Healthcare in Post-Soviet States: A Systematic Review
by Zhanar Kosherova, Dariga Zhazykhbayeva, Ainur Aimurziyeva, Dinagul Bayesheva and Yuliya Semenova
Antibiotics 2025, 14(8), 749; https://doi.org/10.3390/antibiotics14080749 - 25 Jul 2025
Viewed by 360
Abstract
Background/Objectives: Antimicrobial consumption (AMC) surveillance and antimicrobial stewardship (AMS) constitute effective strategies to combat the increasing antimicrobial resistance rates worldwide. Post-Soviet countries (Armenia, Azerbaijan, Belarus, Estonia, Georgia, Kazakhstan, Kyrgyzstan, Latvia, Lithuania, Moldova, the Russian Federation, Tajikistan, Turkmenistan, Ukraine, and Uzbekistan) implemented various elements [...] Read more.
Background/Objectives: Antimicrobial consumption (AMC) surveillance and antimicrobial stewardship (AMS) constitute effective strategies to combat the increasing antimicrobial resistance rates worldwide. Post-Soviet countries (Armenia, Azerbaijan, Belarus, Estonia, Georgia, Kazakhstan, Kyrgyzstan, Latvia, Lithuania, Moldova, the Russian Federation, Tajikistan, Turkmenistan, Ukraine, and Uzbekistan) implemented various elements of AMC surveillance and AMS to different extents. The limited quantity and quality of data from post-Soviet countries make it difficult to assess health system performance; therefore, this region is a blind spot in global AMR monitoring. This systematic review assesses and characterises AMC surveillance and AMS implementation in post-Soviet countries. Methods: Evidence was compiled via a search in PubMed, Google Scholar, Embase, CyberLeninka, and Scopus. The eligibility criteria included AMC surveillance- and AMS-related papers in human health within defined regions and timelines. Some literature from the official websites of international and national health organisations was included in the search. Results: As a result of the searches, screening, and critical appraisal, three peer-reviewed publications and 31 documents were selected for analysis. Eleven out of fifteen countries with updated national action plans for combating antimicrobial resistance have defined AMC surveillance and AMS as strategic objectives. All 15 examined countries submitted antimicrobial consumption data to international networks and reported the existence of approved laws and regulations on antibiotic sales. However, disparities exist in the complexity of monitoring systems and AMS implementation between high-income and low-income countries in the region. Conclusions: This review provides key insights into the existing AMC surveillance and AMS implementation in former Soviet countries. Although the approach of this review lacks quantitative comparability, it provides a comprehensive qualitative framework for national-level AMC surveillance and AMS system assessment. Full article
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19 pages, 424 KiB  
Article
Preparing for the EU HTA Regulation: Insights from the Dutch Perspective
by Anne Willemsen, Maureen Rutten-van Mölken, Riam al Dulaimi, Hedi Schelleman, Wim Goettsch and Lonneke Timmers
J. Mark. Access Health Policy 2025, 13(3), 35; https://doi.org/10.3390/jmahp13030035 - 24 Jul 2025
Viewed by 921
Abstract
The European Health Technology Assessment (HTA) regulation (HTAR) came into effect in January 2025 and impacts the HTA process in all European Member States. Member States must give due consideration to the joint clinical assessment (JCA) report. This may require adaptations at the [...] Read more.
The European Health Technology Assessment (HTA) regulation (HTAR) came into effect in January 2025 and impacts the HTA process in all European Member States. Member States must give due consideration to the joint clinical assessment (JCA) report. This may require adaptations at the national level. This paper describes the anticipated changes to the Dutch national HTA process and how the Dutch National Health Care Institute (Zorginstituut Nederland, ZIN) prepared for this, because sharing experience between Member States can be of general interest for future expansion of the EU HTAR. ZIN’s implementation activities were facilitated by a project-governance structure and by a continuous gap analysis of the current national assessment and appraisal process of medicinal products, resulting in a concrete action plan. The implementation of the HTAR has two major implications for ZIN’s HTA process, namely that the scoping phase starts much earlier and that the JCA report is the starting point for the national assessment. Gaps, challenges and issues were identified in the categories: information and knowledge, IT and template, communication and stakeholder engagement, capacity and resources, and financial aspects. Based on a thorough and well-defined implementation plan, ZIN is ready to implement the HTAR in national HTA processes and to take on (co-)assessor roles for JCA of medicinal products in 2025. Full article
(This article belongs to the Collection European Health Technology Assessment (EU HTA))
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38 pages, 7345 KiB  
Article
Retabit: A Data-Driven Platform for Urban Renewal and Sustainable Building Renovation
by Leandro Madrazo, Álvaro Sicilia, Adirane Calvo, Jordi Pascual, Enric Mont, Angelos Mylonas and Nadia Soledad Ibañez Iralde
Energies 2025, 18(15), 3895; https://doi.org/10.3390/en18153895 - 22 Jul 2025
Viewed by 271
Abstract
The Retabit platform is a data-driven tool designed to bridge the gap between building rehabilitation and urban regeneration by integrating energy, economic, and social dimensions into a single framework. Leveraging multiple public data sources, the platform provides actionable insights to local and national [...] Read more.
The Retabit platform is a data-driven tool designed to bridge the gap between building rehabilitation and urban regeneration by integrating energy, economic, and social dimensions into a single framework. Leveraging multiple public data sources, the platform provides actionable insights to local and national authorities, public housing agencies, urban planners, energy service providers, and research institutions, helping to align renovation initiatives with broader urban transformation goals and climate action objectives. The platform consists of two main components: Analyse, for examining building conditions through multidimensional indicators, and Plan, for designing and simulating renovation projects. Retabit contributes to more transparent and informed decision-making, encourages collaboration across sectors, and addresses long-term sustainability by incorporating participatory planning and impact evaluation. Its scalable structure makes it applicable across diverse geographic areas, policy contexts, and domains linked to sustainable urban development. Full article
(This article belongs to the Special Issue Performance Analysis of Building Energy Efficiency)
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13 pages, 233 KiB  
Article
Policy Makers’ Perceptions on Implementation of National Action Plans on Antimicrobial Resistance in South Africa and Eswatini Using Coordination, Accountability, Resourcing, Regulation and Ownership Framework (2018–2019)
by Kholiwe Shabangu, Sabiha Yusuf Essack and Sinegugu Evidence Duma
Antibiotics 2025, 14(7), 696; https://doi.org/10.3390/antibiotics14070696 - 11 Jul 2025
Viewed by 370
Abstract
Background: Antimicrobial resistance (AMR) is a global threat that affects humans, animals, plants, the environment, societies, and economies—requiring urgent coordinated action. In May 2015, the World Health Assembly (WHA) adopted the Global Action Plan (GAP) on AMR, urging member states to develop [...] Read more.
Background: Antimicrobial resistance (AMR) is a global threat that affects humans, animals, plants, the environment, societies, and economies—requiring urgent coordinated action. In May 2015, the World Health Assembly (WHA) adopted the Global Action Plan (GAP) on AMR, urging member states to develop and implement their own National Action Plans (NAPs) using a One Health approach. Objective: Both South Africa and Eswatini have developed NAPs and are currently in the implementation phase. However, no study has explored policymakers’ perceptions regarding NAP implementation particularly concerning coordination, accountability, resourcing, regulation and ownership. Methods: This qualitative study employed a narrative approach to explore these perceptions in South Africa and Eswatini. A total of 36 key informants were recruited using purposive and snowball sampling methods. Data was collected between November 2018 and March 2019 and transcribed verbatim. Results: Findings revealed that while governance structures for implementing NAPs exist in South Africa and Eswatini, several critical areas require urgent attention. These include limited accountability across One Health sectors, the absence of dedicated national budgets for NAP implementation, poor intra- and inter- ministerial coordination, weak medicine regulation and enforcement, and delayed multisectoral ownership of the NAPs. Conclusions: To address AMR effectively, both countries must allocate dedicated budgets, improve multisectoral integration, and strengthen regulatory frameworks regarding antimicrobial access and use across all One Health sectors. A firm commitment from all sectors is required—not just formal endorsement of the NAPs—to ensure sustainable implementation and ownership. Full article
(This article belongs to the Special Issue A One Health Approach to Antimicrobial Resistance, 2nd Edition)
36 pages, 4581 KiB  
Article
Temporal Trends and Patient Stratification in Lung Cancer: A Comprehensive Clustering Analysis from Timis County, Romania
by Versavia Maria Ancusa, Ana Adriana Trusculescu, Amalia Constantinescu, Alexandra Burducescu, Ovidiu Fira-Mladinescu, Diana Lumita Manolescu, Daniel Traila, Norbert Wellmann and Cristian Iulian Oancea
Cancers 2025, 17(14), 2305; https://doi.org/10.3390/cancers17142305 - 10 Jul 2025
Viewed by 610
Abstract
Background/Objectives: Lung cancer remains a major cause of cancer-related mortality, with regional differences in incidence and patient characteristics. This study aimed to verify and quantify a perceived dramatic increase in lung cancer cases at a Romanian center, identify distinct patient phenotypes using unsupervised [...] Read more.
Background/Objectives: Lung cancer remains a major cause of cancer-related mortality, with regional differences in incidence and patient characteristics. This study aimed to verify and quantify a perceived dramatic increase in lung cancer cases at a Romanian center, identify distinct patient phenotypes using unsupervised machine learning, and characterize contributing factors, including demographic shifts, changes in the healthcare system, and geographic patterns. Methods: A comprehensive retrospective analysis of 4206 lung cancer patients admitted between 2013 and 2024 was conducted, with detailed molecular characterization of 398 patients from 2023 to 2024. Temporal trends were analyzed using statistical methods, while k-means clustering on 761 clinical features identified patient phenotypes. The geographic distribution, smoking patterns, respiratory comorbidities, and demographic factors were systematically characterized across the identified clusters. Results: We confirmed an 80.5% increase in lung cancer admissions between pre-pandemic (2013–2020) and post-pandemic (2022–2024) periods, exceeding the 51.1% increase in total hospital admissions and aligning with national Romanian trends. Five distinct patient clusters emerged: elderly never-smokers (28.9%) with the highest metastatic rates (44.3%), heavy-smoking males (27.4%), active smokers with comprehensive molecular testing (31.7%), young mixed-gender cohort (7.3%) with balanced demographics, and extreme heavy smokers (4.8%) concentrated in rural areas (52.6%) with severe comorbidity burden. Clusters demonstrated significant differences in age (p < 0.001), smoking intensity (p < 0.001), geographic distribution (p < 0.001), as well as molecular characteristics. COPD prevalence was exceptionally high (44.8–78.9%) across clusters, while COVID-19 history remained low (3.4–8.3%), suggesting a limited direct association between the pandemic and cancer. Conclusions: This study presents the first comprehensive machine learning-based stratification of lung cancer patients in Romania, confirming genuine epidemiological increases beyond healthcare system artifacts. The identification of five clinically meaningful phenotypes—particularly rural extreme smokers and age-stratified never-smokers—demonstrates the value of unsupervised clustering for regional healthcare planning. These findings establish frameworks for targeted screening programs, personalized treatment approaches, and resource allocation strategies tailored to specific high-risk populations while highlighting the potential of artificial intelligence in identifying actionable clinical patterns for the implementation of precision medicine. Full article
(This article belongs to the Section Cancer Epidemiology and Prevention)
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12 pages, 971 KiB  
Article
Detection of Microbial Growth on Indoor Building Materials in Two Countries Using qPCR
by Helena Rintala, Oliver Röhl, Pinja Tegelberg and Teija Meklin
Microorganisms 2025, 13(7), 1551; https://doi.org/10.3390/microorganisms13071551 - 1 Jul 2025
Viewed by 285
Abstract
According to several reports, 10–50% of buildings in Europe and worldwide suffer from moisture problems, which can lead to microbial growth in building materials. Unrepaired moisture and microbial damage can lead to the degradation of building structures and reduce visual appeal, resulting in [...] Read more.
According to several reports, 10–50% of buildings in Europe and worldwide suffer from moisture problems, which can lead to microbial growth in building materials. Unrepaired moisture and microbial damage can lead to the degradation of building structures and reduce visual appeal, resulting in economic losses; they can also result in adverse health effects for the building’s occupants. Consequently, robust and reliable methods for the detection of abnormal microbiological conditions in buildings are needed, alongside skilled technical investigations, to plan appropriate renovation actions. In this work, 964 building material samples, which were obtained as part of routine building investigations in two countries, were analyzed for their fungal content using the qPCR method. Cultivation analysis was performed using the same samples, according to corresponding national guidelines. In a sample subset, the total cell counts after staining with acridine orange were determined. The microbial concentrations obtained with all three methods correlated well. Threshold values for the qPCR results were determined using cultivation as a reference method for both countries separately, with similar values obtained for both datasets. Hence, qPCR has great potential to become a standard method of detecting microbes in indoor environments. Full article
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25 pages, 1159 KiB  
Article
Analysis of Sustainable Development Goals (2016–2030) and Their Integration into Tourism Activities in Lago Agrio Canton, Sucumbíos Province: SDG 9 (Industry, Innovation, and Infrastructure) and SDG 15 (Life on Land)
by Patricia Marisol Chango-Cañaveral, Pablo Alejandro Quezada-Sarmiento and Valeria Jaqueline Morales-Herrera
Sustainability 2025, 17(13), 6023; https://doi.org/10.3390/su17136023 - 30 Jun 2025
Viewed by 669
Abstract
This study analyzes the integration of Sustainable Development Goals (SDGs) 9 (Industry, Innovation, and Infrastructure) and 15 (Life on Land) into the tourism development strategies of Lago Agrio Canton, Sucumbíos Province, Ecuador. The main objective is to assess how tourism can serve as [...] Read more.
This study analyzes the integration of Sustainable Development Goals (SDGs) 9 (Industry, Innovation, and Infrastructure) and 15 (Life on Land) into the tourism development strategies of Lago Agrio Canton, Sucumbíos Province, Ecuador. The main objective is to assess how tourism can serve as a driver for sustainable infrastructure development, environmental conservation, and inclusive local growth, in alignment with the 2030 Agenda. A qualitative methodology was adopted, involving documentary analysis with exploratory and descriptive scopes. The sources included national development plans, regional policy frameworks, institutional reports, and the relevant academic literature. This study employed territorial indicators related to infrastructure quality, ecosystem protection, and stakeholder participation to evaluate SDG alignment. The results highlight that sustainable tourism practices—particularly those incorporating corporate social responsibility and environmental stewardship—can stimulate innovation and enhance resilience in underdeveloped territories. Wetlands and forested areas emerge as key natural assets with strong potential for ecological tourism and sustainable investment. The findings suggest that collaborative actions between the public and private sectors, guided by SDGs 9 and 15, can generate long-term benefits, including biodiversity preservation, improved service infrastructure, and economic inclusion for local communities. Overall, the research underscores the potential of sustainable tourism as a practical mechanism for localizing the SDGs in fragile yet high-value ecological regions. Full article
(This article belongs to the Special Issue Innovative Learning Environments and Sustainable Development)
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