Search Results (220)

Non-communicable diseases (NCDs) such as cardiovascular disease, diabetes, cancer, and chronic respiratory conditions are the leading causes of death globally, largely driven by modifiable lifestyle factors. With growing interest in dietary strategies for NCDs prevention and management, functional foods like watercress (Nasturtium officinale) have attracted attention for their rich phytochemical content and potential health benefits. This narrative review synthesizes 88 sources published between 2019 and March 2025, exploring the effects of watercress bioactive compounds on major NCDs. Watercress is abundant in glucosinolates, isothiocyanates (especially phenethyl isothiocyanate), flavonoids, vitamins, and minerals. These compounds contribute to antioxidant, anti-inflammatory, and metabolic regulatory effects. Preclinical and clinical studies show that watercress supplementation may improve lipid profiles, reduce oxidative stress, and modulate inflammation in cardiovascular and respiratory conditions. It also appears to enhance insulin function and reduce blood glucose levels. In cancer models, watercress extracts exhibit antiproliferative, pro-apoptotic, and chemoprotective properties, with selective toxicity towards cancer cells and protective effects on normal cells. These findings highlight the therapeutic potential of watercress as a dietary adjunct in NCDs prevention and management, supporting the need for further clinical research. Full article

Background/Objectives: Recent research indicates a global transition from healthy and balanced diets to unhealthy Westernized dietary patterns (WDPs). This transition is linked to increased rates of non-communicable diseases (NCDs), e.g., obesity, type 2 diabetes, and cardiovascular diseases, often preceded by metabolic syndrome (MetS). Therefore, the objective of this study was to develop a diet quality index, termed Westernized Diet Index (WDI), to assess adherence to WDPs and its association with main cardiometabolic health issues, for which MetS and its components were chosen as representatives of NCDs. Methods: The development of the WDI was driven by a semi-systematic and comprehensive examination of the literature (n = 491 articles) that evaluated the influence of WDP components on health outcomes. The scoring algorithm involved multiple steps, assigning scores based on study design, sample size, and the direction of food effects on health outcomes. Results: The final developed index encompassed 30 food groups/items. It was revealed that soft drinks, processed foods, red meat, sodium, and hydrogenated fats had the most detrimental effects on health, significantly influencing the index’s coefficients. In contrast, dietary fiber, plant-based metabolites, vitamins, minerals, nuts/seeds, and fish had the most substantial beneficial impacts. Conclusions: The WDI aligns with the existing literature on the importance of specific food items and with other validated diet quality indices, e.g., the Dietary Inflammatory Index (DII) and Alternate Healthy Eating Index (AHEI). Thus, the WDI can provide evidence for clinicians and researchers in formulating evidence-based dietary guidelines as well as strategies for the prevention and treatment of diet-related health issues. However, further validation is proposed to verify the WDI’s capability across different contexts. Full article

The growing global prevalence of non-communicable diseases (NCDs) is drawing an increasing amount of attention to the health-promoting potential of whole-grain dietary fibers. Whole grains are rich sources of both soluble dietary fiber (SDF) and insoluble dietary fiber (IDF), contributing distinct physicochemical properties and playing vital roles in promoting human health. This review provides a comprehensive analysis of the dietary fiber compositions of various whole grains, including wheat, oats, barley, rye, corn, sorghum, and rice, highlighting their structural characteristics, physiochemical properties, and associated health benefits. The physicochemical properties of dietary fibers, such as solubility, water- and oil-holding capacity, viscosity, swelling ability, and bile-acid-binding capacity, contribute significantly to their technological applications and potential health benefits, particularly in the prevention of NCDs. Although there is growing evidence supporting their health benefits, global whole-grain intake remains below recommended levels. Therefore, promoting whole-grain intake and developing fiber-rich functional foods are essential for enhancing public health and preventing chronic diseases. Future research should focus on enhancing the bioavailability and functionality of whole-grain dietary fibers, optimizing the methods by which they are extracted, and exploring their potential applications in the food and pharmaceutical industries. Full article

There is a confirmed and ongoing need to encourage adherence to healthy dietary patterns in the general population in western societies, given their recognized positive impact in preventing non-communicable diseases (NCDs). A potentially very effective solution is the use of digital tools such as apps and web apps, which can reach a large number of people quickly. Still, to be effective, it is necessary to better understand how participant engagement in these interventions works, to identify the motivations that may lead them to drop out, and to evaluate the effectiveness of these interventions. In our study, an innovative web app designed to encourage adherence to the Mediterranean diet (EATMED) was tested in an intervention study, evaluating adherence to the Mediterranean diet before and after the use of the web app in a cohort of people, compared to a control group, using the MEDI-lite questionnaire. The Health and Taste Attitude Scale questionnaire was also administered to all participants to assess interest in healthy foods and diets, as well as attitudes toward food. The study showed that the score of the Food as Reward subscale of the HTAS had a significant effect on dropout from the intervention study, and that the use of the app among participants who remained resulted in a two-point increase in adherence to the Mediterranean diet, according to the MEDI-lite questionnaire. These results indicate the effectiveness of the EATMED tool and provide useful insights into how to understand and mitigate dropout in digital nutrition interventions. Full article

Neglecting preventive healthcare policies has contributed to the global surge in chronic diseases, increased hospitalizations, declining quality of care, and escalating costs. Non-communicable diseases (NCDs)—notably cardiovascular conditions, diabetes, and cancer—consume over 80% of healthcare expenditure and account for more than 60% of global deaths, which are projected to exceed 75% by 2030. Poor diets, sedentary lifestyles, regulatory loopholes, and underfunded public health initiatives are driving this crisis. Compounding the issue are flawed policies, congressional lobbying, and conflicts of interest that prioritize costly, hospital-based, symptom-driven care over identifying and treating to eliminate root causes and disease prevention. Regulatory agencies are failing to deliver their intended functions. For instance, the U.S. Food and Drug Administration’s (FDA) broad oversight across drugs, devices, food, and supplements has resulted in inefficiencies, reduced transparency, and public safety risks. This broad mandate has allowed the release of unsafe drugs, food additives, and supplements, contributing to the rising childhood diseases, the burden of chronic illness, and over-medicalization. The author proposes separating oversight responsibilities: transferring authority over food, supplements, and OTC products to a new Food and Nutraceutical Agency (FNA), allowing the FDA to be restructured as the Drug and Device Agency (DDA), to refocus on pharmaceuticals and medical devices. While complete reform requires Congressional action, interim policy shifts are urgently needed to improve public health. Broader structural changes—including overhauling the Affordable Care Act, eliminating waste and fraud, redesigning regulatory and insurance systems, and eliminating intermediaries are essential to reducing costs, improving care, and transforming national and global health outcomes. The information provided herein can serve as a White Paper to help reform health agencies and healthcare systems for greater efficiency and lower costs in the USA and globally. Full article

Metabolism is a complex network of biochemical pathways that break down macromolecules to produce energy essential for cellular function. Disruptions in metabolic homeostasis are closely linked to noncommunicable diseases (NCDs) such as cardiovascular disease, type 2 diabetes, and cancer, which are leading causes of death worldwide. Many NCD-associated conditions, including obesity and insulin resistance, stem from metabolic dysfunction, and current therapies often fall short in preventing disease progression, highlighting the need for novel therapeutic targets. Microproteins, small proteins of ≤100–150 amino acids, have recently emerged as important regulators of metabolism. Encoded by short open reading frames (sORFs), many of these proteins were historically overlooked due to their small size and misclassification as noncoding RNAs. Advances in genomics and proteomics have revealed that these sORFs can encode functional proteins with critical roles in metabolic pathways. In this review, we highlight the microproteins involved in energy metabolism, mitochondrial function, and nutrient signaling. We discuss their emerging roles in the pathogenesis of NCDs and explore their potential as novel therapeutic targets. As microprotein biology continues to evolve, these small but powerful regulators may offer new strategies for treating metabolic dysfunction and reducing the global burden of NCDs. Full article

Background: Ready-to-eat cereals (RTECs) are a large, heterogeneous category of cereals designed to fit into busy lifestyles with minimal preparation time. Methods: This systematic review evaluated nutrient intake data from seven national surveys. Using PubMed and Science Direct (1 January 2004 until 16 September 2024), we investigated RTECs in relation to their contributions to macro, micronutrient and food group intakes, breakfast/diet quality and effects on health with focus on non-communicable disease (NCD) prevention. The search was restricted to Systematic Reviews (SRs), meta-analyses (MAs), randomised controlled trials (RCTs) and observational studies. Fifty-one publications were obtained. Studies related to health outcomes and NCD risk were graded using an updated Scottish Intercollegiate Guidelines Network approach. Results: Grade A evidence: Based on high-quality MA, SRs, or RCTs, this showed that RTEC consumption was associated with improved nutrient intakes (particularly fibre and micronutrients), reduced cardiovascular disease and mortality. One good-quality Grade A meta-analysis showed that total whole grain intake which included cereals was associated with a reduced risk of total cancer. Grade B evidence: Based largely on observational evidence, this showed that RTEC consumption was associated with reduced risk of overweight and obesity, body mass index and composition improvements and type 2 diabetes risk. For food group intakes, breakfast/diet quality and lipid profiles, more well-designed studies were needed (Grade D evidence). Conclusions: There is consistent evidence that RTECs generally have positive or neutral effects on nutritional status and NCD prevention. Strongest evidence exists for RTEC and micronutrient intakes, reduced risk of cardiovascular diseases (CVDs), body weight regulation, and reduced type 2 diabetes risk. Public health messaging should recognise that RTECs, especially whole-grain, higher-fibre and lower-sugar varieties, may help to reinforce micronutrient intakes and a range of health outcomes. Full article

Caregiving for dependent older adults presents significant health and occupational challenges, particularly in rural Thailand. This study examines predictors of health-related quality of life (HR-QOL) among in-home caregivers, focusing on health promotion, non-communicable diseases (NCDs) prevention, and occupational health practices. An analytic cross-sectional study was conducted among 701 caregivers across 23 districts in Nakhon Si Thammarat, southern Thailand. Data were collected through structured questionnaires assessing socio-demographics, health behaviors, working conditions, and HR-QOL using the Thai SF-36V2. Stepwise regression analysis identified key predictors of HR-QOL. Our findings indicate that most caregivers were female (81.5%), middle-aged (mean age: 47.7 years), and had moderate education levels. Over half experienced moderate exposure to occupational hazards, including physical, biological, ergonomic, and psychosocial risks, contributing to job strain, inadequate rest, and strained relationships. HR-QOL scores suggested that a significant proportion of caregivers had moderate to poor quality of life, particularly in physical health domains. Stepwise regression analysis showed that better self-reported health promotion behaviors and occupational hazard prevention practices were positively associated with HR-QOL, whereas the presence of NCDs had a negative impact. These findings highlight the need for targeted interventions to enhance caregivers’ well-being and inform public health strategies for strengthening community-based care systems. Full article

Rice is a staple food crop widely consumed across the world. It is rich in carbohydrates, quality protein, and micronutrients. The grain protein content (GPC) in rice varies considerably. Although it is generally lower than that of other major cereals, the quality of protein is superior. GPC and its components are complex quantitative traits influenced by both genetics and environmental factors. Glutelin is the major protein fraction (70–80%) in rice. Rice protein is rich in lysine, methionine, and cysteine along with other amino acids. Globally, Protein–Energy Malnutrition (PEM) is a major concern, particularly in Asia and Africa. Additionally, non-communicable diseases (NCDs) including diabetes, cancer, cardiovascular diseases, hypertension, and obesity are on the rise due to various reasons including changes in lifestyle and consumption patterns. Rice plays a very important part in the daily human diet, and therefore, substantial research efforts focus on the genetic characterization of GPC and understanding its role in the prevention of NCDs. The contribution of both rice grain and bran protein in improving human health is an established fact. The present study summarizes the different aspects of rice grain protein including its variability, composition, factors affecting it, and its industrial uses and more importantly its role in human health. Full article

Whey is a natural by-product of the cheese-making process and represents a valuable source of nutrients, including vitamins, all essential amino acids and proteins with high quality and digestibility characteristics. Thanks to its different techno-functional characteristics, such as solubility, emulsification, gelling and foaming, it has been widely exploited in food manufacturing. Also, advances in processing technologies have enabled the industrial production of a variety of whey-based products exerting biological activities. The beneficial properties of whey proteins (WPs) include their documented effects on cardiovascular, digestive, endocrine, immune and nervous systems, and their putative role in the prevention and treatment of non-communicable diseases (NCDs). In this regard, research on their application for health enhancement, based on the optimization of product formulation and the development of pharmaceuticals, is highly relevant. Beyond the health and nutritionally relevant effects as in in vivo animal studies, the allergenicity of WPs and WP hydrolysates is also herein tackled and discussed, as well as their potential role as therapeutics for immune tolerance and so-called tolerogenic effects. Grounded on the WPs’ health-promoting functions, this paper presents the latest research showing the potential of whey-derived peptides as an alternative strategy in NCD treatment. This work also reports a careful analysis of their current use, also revealing which obstacles limit their full exploitation, thus highlighting the future challenges in the field. Concluding, safety considerations, encompassing WP allergenicity, are also discussed, providing some insights on the role of WPs and peptides in milk allergen immunotolerance. Full article

Non-communicable diseases (NCDs) are the leading cause of death worldwide, with cardiovascular disease (CVD) accounting for half of all NCD-related deaths. The biological onset of CVD may occur long before the development of clinical symptoms, hence the urgent need to understand the molecular alterations underpinning CVD, which would facilitate intervention strategies to prevent or delay the onset of the disease. There is evidence to suggest that CVD develops through a complex interplay between genetic, lifestyle, and environmental factors. Epigenetic modifications, including DNA methylation, serve as proxies linking genetics and the environment to phenotypes and diseases. In the past decade, a growing list of studies has implicated DNA methylation in the early events of CVD pathogenesis. In this regard, screening for these epigenetic marks in asymptomatic individuals may assist in the early detection of CVD and serve to predict the response to therapeutic interventions. This review discusses the current literature on the relationship between blood-based DNA methylation alterations and CVD in humans. We highlight a set of differentially methylated genes that show promise as candidates for diagnostic and prognostic CVD biomarkers, which should be prioritized and replicated in future studies across additional populations. Finally, we discuss key limitations in DNA methylation studies, including genetic diversity, interpatient variability, cellular heterogeneity, study confounders, different methodological approaches used to isolate and measure DNA methylation, sample sizes, and cross-sectional study design. Full article

The health of different countries evolves in parallel with their economic development. Communicable diseases play a more prominent role in low-income countries compared with high-income countries, while non-communicable diseases (NCDs) have become dominant in developing and developed economies. This transition has been accompanied by public health efforts to prevent NCDs, resulting in improvements in total life expectancy at birth (TLE). It is recognized that health determinants are not confined to healthcare systems, but that social determinants play a key role in health inequalities. The rapid increase in life expectancy at birth has led to increasing numbers of older adults, where health inequalities are accentuated. The current UN Decade of Healthy Aging calls for a life-course approach to building intrinsic capacity, maintaining function, and avoiding dependency with age instead of avoiding mortality and morbidity. TLE in Hong Kong is one of the highest in the world as a result of public health preventive efforts and an essentially free hospital system. However, the increase in TLE has not been accompanied by the same magnitude of increase in health span, resulting in an increasing dependency burden. Geography, culture, dietary and smoking habits, physical activity, urban planning, and neighbourhood cohesion are some of the social determinants affecting TLE and also health inequalities. With population ageing, it would be appropriate to focus on the social determinants affecting health span to maintain functional independence rather than prolonging life. A whole-of-society response instead of relying solely on the adaptation of health and social care systems would be needed, together with more nuanced metrics to measure health span. Full article

Background/Objectives: Non-communicable diseases (NCDs) are the leading cause of preventable morbidity and mortality globally. To reduce the prevalence of NCDs, the World Health Organization issued guidelines for a healthy lifestyle, which have been adopted in various countries. Our study aimed to evaluate the dietary habits of the ethnic Hungarian population of Romania, allowing us to identify potential differences in nutritional behavior compared to the country’s general population. Methods: A cross-sectional, observational, questionnaire-based study was conducted to collect information on eating behavior, food purchasing habits, and dietary patterns among ethnic Hungarians, the largest minority group in Romania. The obtained data were interpreted using multivariate data analysis (MVDA), including principal component analysis models (PCA-X) to establish pattern recognition and data clustering, and orthogonal partial least squares discriminant analysis (OPLS-DA) models to examine class differences between the identified clusters. Results: A total of 247 valid questionnaires were evaluated; the most represented groups were females (67.2%), young adults aged 18 to 30 (56.3%), individuals with normal body mass index (54.7%), and those with a higher education level (45.7%). Health-conscious purchasing and eating behaviors were more characteristic of middle-aged and older adults, females, and those with a higher education level. Young adults appear to have a more varied diet, but overconsumption of unhealthy food products and a lack of interest in healthy dietary habits is evident. Conclusions: Appropriate nutritional education is necessary for all age groups; however, programs targeting young adult Hungarians are especially important, as most expressed little interest in healthy eating habits. Further research examining the underlying relationship between dietary habits and cultural factors as well as socio-economic factors could offer new opportunities to promote a healthy lifestyle. Full article

Background/Objectives: Diet quality is important for the prevention of non-communicable diseases (NCDs), which are now responsible for leading causes of death worldwide. Although health professionals often recommend diet improvement for the treatment and management of many NCDs, patients continually struggle to make dietary changes and maintain them long-term. This may be due to an interplay of many factors that affect dietary quality. This paper discusses some lifestyle-related factors that may offer additional points of intervention for health professionals to use to increase diet quality. Methods: This review examines the effects of exercise, sleep, mindfulness practice, meal socialization, social media use, and tobacco and alcohol use on diet quality. Studies examining the effects of these factors on diet were found by searching PubMed, CINAHL, and Google Scholar. Results: Evidence suggests that a positive relationship between exercise, adequate sleep, and all forms of mindfulness have positive effects on diet quality. Meal socialization’s effects on diet quality were nuanced. Individuals tend to eat similarly to those they share a meal with. However, food quantity intake may be affected by the physical characteristics of individuals with whom people share a meal. Social media use was found to have negative effects on diet quality in those who used it excessively and was found to promote disordered eating patterns. Both tobacco and alcohol use were found to have negative impacts on diet quality. Conclusions: Using these findings, health professionals may be able to educate people about lifestyle-related factors that can improve diet quality. Full article