Search Results (8)

Humans are routinely exposed to complex mixtures such as polycyclic aromatic hydrocarbons (PAHs) rather than to single compounds, as are often assessed for hazards. Cytochrome P450 enzymes (CYPs) metabolize PAHs, and multiple PAHs found in mixtures can compete as substrates for individual CYPs (e.g., CYP1A1, CYP1B1, etc.). The objective of this study was to assess competitive inhibition of metabolism of PAH mixtures in humans and evaluate a key assumption of the Relative Potency Factor approach that common human exposures will not cause interactions among mixture components. To test this objective, we co-incubated binary mixtures of benzo[a]pyrene (BaP) and dibenzo[def,p]chrysene (DBC) in human hepatic microsomes and measured rates of enzymatic BaP and DBC disappearance. We observed competitive inhibition of BaP and DBC metabolism and measured inhibition coefficients (K_i), observing that BaP inhibited DBC metabolism more potently than DBC inhibited BaP metabolism (0.061 vs. 0.44 µM K_i, respectively). We developed a physiologically based pharmacokinetic (PBPK) interaction model by integrating PBPK models of DBC and BaP and incorporating measured metabolism inhibition coefficients. The PBPK model predicts significant increases in BaP and DBC concentrations in blood AUCs following high oral doses of PAHs (≥100 mg), five orders of magnitude higher than typical human exposures. We also measured inhibition coefficients of Supermix-10, a mixture of the most abundant PAHs measured at the Portland Harbor Superfund Site, on BaP and DBC metabolism. We observed similar potencies of inhibition coefficients of Supermix-10 compared to BaP and DBC. Overall, results of this study demonstrate that these PAHs compete for the same enzymes and, at high doses, inhibit metabolism and alter internal dosimetry of exposed PAHs. This approach predicts that BaP and DBC exposures required to observe metabolic interaction are much higher than typical human exposures, consistent with assumptions used when applying the Relative Potency Factor approach for PAH mixture risk assessment. Full article

Background: the role of bile acid (BA)-induced farnesoid X receptor (Fxr) signaling in liver regeneration following associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) was investigated in a rat model. Methods: Male Wistar rats underwent portal vein ligation (PVL) (n = 30) or ALPPS (n = 30). Animals were sacrificed pre-operatively and at 24, 48, 72, or 168 h after intervention. Regeneration rate, Ki67 index, hemodynamic changes in the hepatic circulation, and BA levels were assessed. Transcriptome analysis of molecular regulators involved in the Fxr signaling pathway, BA transport, and BA production was performed. Results: ALLPS induced more extensive liver regeneration (p < 0.001) and elevation of systemic and portal BA levels (p < 0.05) than PVL. The mRNA levels of proteins participating in hepatic Fxr signaling were comparable between the intervention groups. More profound activation of the intestinal Fxr pathway was observed 24 h after ALPPS compared to PVL. Conclusion: Our study elaborates on a possible linkage between BA-induced Fxr signaling and accelerated liver regeneration induced by ALPPS in rats. ALPPS could trigger liver regeneration via intestinal Fxr signaling cascades instead of hepatic Fxr signaling, thereby deviating from the mechanism of BA-mediated regeneration following one-stage hepatectomy. Full article

This paper proposes a battery voltage model that is suitable for variable operation. The model combines the features of the Kinetic Battery Model (KiBaM) and voltage model (VM), and it improves the accuracy and quality of the solution, addressing four characteristics of operation: charging, discharging, rest after charge, and rest after discharge. This model will be known as 4-KiVM and shows low impact on computational burden. The proposed model can keep track of the voltage even when the load is inverted or turned off. To calibrate and validate the model, a NASA-provided dataset was used composed of a battery with variable charges and discharges, simulating real applications. A metaheuristic method based on tabu search is used to extract constants from this dataset and validate this hybrid model. In addition, a comparison of performance of the 4-KiVM against KiBaM, VM, and the electric circuit model (ECM) was made, showing its advantages. The results of the simulations showed a good prediction of the battery voltage response and SOC prediction in random (variable) use. Full article

This paper presents a reinforcement learning framework for solving battery scheduling problems in order to extend the lifetime of batteries used in electrical vehicles (EVs), cellular phones, and embedded systems. Battery pack lifetime has often been the limiting factor in many of today’s smart systems, from mobile devices and wireless sensor networks to EVs. Smart charge-discharge scheduling of battery packs is essential to obtain super linear gain of overall system lifetime, due to the recovery effect and nonlinearity in the battery characteristics. Additionally, smart scheduling has also been shown to be beneficial for optimizing the system’s thermal profile and minimizing chances of irreversible battery damage. The recent rapidly-growing community and development infrastructure have added deep reinforcement learning (DRL) to the available tools for designing battery management systems. Through leveraging the representation powers of deep neural networks and the flexibility and versatility of reinforcement learning, DRL offers a powerful solution to both roofline analysis and real-world deployment on complicated use cases. This work presents a DRL-based battery scheduling framework to solve battery scheduling problems, with high flexibility to fit various battery models and application scenarios. Through the discussion of this framework, comparisons have also been made between conventional heuristics-based methods and DRL. The experiments demonstrate that DRL-based scheduling framework achieves battery lifetime comparable to the best weighted-k round-robin (kRR) heuristic scheduling algorithm. In the meantime, the framework offers much greater flexibility in accommodating a wide range of battery models and use cases, including thermal control and imbalanced battery. Full article

Accurate battery models are integral to the battery management system and safe operation of electric vehicles. Few investigations have been conducted on the influence of current rate (C-rate) on the available capacity of the battery, for example, the kinetic battery model (KiBaM). However, the nonlinear characteristics of lithium-ion batteries (LIBs) are closer to a fractional-order dynamic system because of their electrochemical materials and properties. The application of fractional-order models to represent physical systems is timely and interesting. In this paper, a novel fractional-order KiBaM (FO-KiBaM) is proposed. The available capacity of a ternary LIB module is tested at different C-rates, and its parameter identifications are achieved by the experimental data. The results showed that the estimated errors of available capacity in the proposed FO-KiBaM were low over a wide applied current range, specifically, the mean absolute error was only 1.91%. Full article

The operation of Wireless Sensor Networks (WSNs) is subject to multiple constraints, among which one of the most critical is available energy. Sensor nodes are typically powered by electrochemical batteries. The stored energy in battery devices is easily influenced by the operating temperature and the discharge current values. Therefore, it becomes difficult to estimate their voltage/charge behavior over time, which are relevant variables for the implementation of energy-aware policies. Nowadays, there are hardware and/or software approaches that can provide information about the battery operating conditions. However, this type of hardware-based approach increases the battery production cost, which may impair its use for sensor node implementations. The objective of this work is to propose a software-based approach to estimate both the state of charge and the voltage of batteries inWSN nodes based on the use of a temperature-dependent analytical battery model. The achieved results demonstrate the feasibility of using embedded analytical battery models to estimate the lifetime of batteries, without affecting the tasks performed by the WSN nodes. Full article

Energy consumption is a major issue in Wireless Sensor Networks (WSNs), as nodes are powered by chemical batteries with an upper bounded lifetime. Estimating the lifetime of batteries is a difficult task, as it depends on several factors, such as operating temperatures and discharge rates. Analytical battery models can be used for estimating both the battery lifetime and the voltage behavior over time. Still, available models usually do not consider the impact of operating temperatures on the battery behavior. The target of this work is to extend the widely-used Kinetic Battery Model (KiBaM) to include the effect of temperature on the battery behavior. The proposed Temperature-Dependent KiBaM (T-KiBaM) is able to handle operating temperatures, providing better estimates for the battery lifetime and voltage behavior. The performed experimental validation shows that T-KiBaM achieves an average accuracy error smaller than 0.33%, when estimating the lifetime of Ni-MH batteries for different temperature conditions. In addition, T-KiBaM significantly improves the original KiBaM voltage model. The proposed model can be easily adapted to handle other battery technologies, enabling the consideration of different WSN deployments. Full article

Energy consumption is a major concern in context-aware smartphone sensing. This paper first studies mobile device-based battery modeling, which adopts the kinetic battery model (KiBaM), under the scope of battery non-linearities with respect to variant loads. Second, this paper models the energy consumption behavior of accelerometers analytically and then provides extensive simulation results and a smartphone application to examine the proposed sensor model. Third, a Markov reward process is integrated to create energy consumption profiles, linking with sensory operations and their effects on battery non-linearity. Energy consumption profiles consist of different pairs of duty cycles and sampling frequencies during sensory operations. Furthermore, the total energy cost by each profile is represented by an accumulated reward in this process. Finally, three different methods are proposed on the evolution of the reward process, to present the linkage between different usage patterns on the accelerometer sensor through a smartphone application and the battery behavior. By doing this, this paper aims at achieving a fine efficiency in power consumption caused by sensory operations, while maintaining the accuracy of smartphone applications based on sensor usages. More importantly, this study intends that modeling the battery non-linearities together with investigating the effects of different usage patterns in sensory operations in terms of the power consumption and the battery discharge may lead to discovering optimal energy reduction strategies to extend the battery lifetime and help a continual improvement in context-aware mobile services. Full article