High-Throughput Experimentation has undergone an outstanding evolution in the past two decades and has proven to be a game-changer in the acceleration of reaction discovery and optimization. Despite a good implementation in the pharmaceutical industr...
A small, low-cost, self-produced photometer is implemented into a synthesis robot and combined with a modified UV chamber to enable automated sampling and online characterization. In order to show the usability of the new approach, two different reve...
In this study, we developed an experimental model for microalgae cultivation and CO2 fixation [...]
Compared to heterogenous Ziegler–Natta systems (ZNS), ansa-metallocene catalysts for the industrial production of isotactic polypropylene feature a higher cost-to-performance balance. In particular, the C2-symmetric bis(indenyl) ansa-zirconocen...
Compositionally graded cylinders of Ti–Mn alloys were produced using the Laser Engineered Net Shaping (LENS™) technique, with Mn content varying from 0 to 12 wt.% along the cylinder axis. The cylinders were subjected to different post-build heat trea...
Artificial intelligence (AI) and machine learning (ML) algorithms possess the capability to accelerate the design of novel materials; however, their advancement in materials science is severely hindered by a fundamental deficit of experimental data,...
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression in both animals and plants. By pairing to microRNA responsive elements (mREs) on target mRNAs, miRNAs play gene-regulatory roles, producing remarkable changes in several physio...
The implementation of a dialysis method for the simultaneous purification of different polymer materials in a commercially available automated parallel synthesizer (APS) is discussed. The efficiency of this “unattended” automated parallel dialysis (A...
Transcriptional analysis of complex biological scenarios has been used extensively, even though sometimes the results of such analysis may prove imprecise or difficult to interpret due to an overwhelming amount of information. In this study, a large-...
To address the challenge of imprecise detection and control of fertilizer application rates caused by high granular flow during fertilization operations, a parallel diversion detection method with real-time application rate regulation is proposed. Th...
Catalytic cracking of hexane over steamed ZSM-5 is studied under steady state and dynamic conditions to elucidate the role of the active sites on the product distribution. The product distribution from the riser simulator representing the dynamic sta...
The direct conversion of synthesis gas could open up economically viable routes for the efficient production of ethanol. RhMn/SiO2 represents one of the most active systems reported thus far. Potential improvements were reported by added dopants, i.e...
A series of Co/TiO2 catalysts was tested in a parameters field study for Fischer‒Tropsch synthesis (FTS). All catalysts were prepared by the conventional impregnation technique to obtain an industrially relevant Co content of 10 wt % or 20 wt %, resp...
Being the major renewable source of bio-aromatics, lignin possesses considerable potential for the chemical industry as raw material. Kraft lignin is a couple product of paper industry with an annual production of 55,000,000 ton/y and is considered t...
A rapid and high throughput protocol to measure the catalase activity in vitro has been designed. Catalase is an enzyme with unusual kinetic properties because it does not follow the standard Michaelis–Menten model and is inactivated by H2O2. T...
The starting point of successful hazard assessment is the generation of unbiased and trustworthy data. Conventional toxicity testing deals with extensive observations of phenotypic endpoints in vivo and complementing in vitro models. The increasing d...
The automated dialysis of polymers in synthetic robots is described as a first approach for the purification of polymers using an automated protocol. For this purpose, a dialysis apparatus was installed within a synthesis robot. Therein, the polymer...
In bioprocess development, the host and the genetic construct for a new biomanufacturing process are selected in the early developmental stages. This decision, made at the screening scale with very limited information about the performance in larger...
Controlling grain size in polycrystalline nickel base superalloy is vital for obtaining required mechanical properties. Typically, a uniform and fine grain size is required throughout forging process to realize the superplastic deformation. Strain am...
The workflow of a high throughput screening setup for the rapid identification ofnew and improved sensor materials is presented. The polyol method was applied to preparenanoparticular metal oxides as base materials, which were functionalised by surfa...
The urgent need to mitigate anthropogenic CO2 emissions has spurred innovative approaches for CO2 capture and utilization [...]
In the evolving landscape of sustainable biopharmaceutical process development, the utilization of bacteria in the production of various compounds via fermentation has attracted extensive attention from scientists. A successful fermentation process a...
Bacteriophages (phages) represent promising therapeutic agents. Their clinical use is challenged by the rapid rise of resistant bacterial clones. To overcome this problem, phages can be trained in vitro to improve their ability to cope with the possi...
Graph neural networks (GNNs) have rapidly matured into a unifying, end-to-end framework for energy-materials discovery. By operating directly on atomistic graphs, modern angle-aware and equivariant architectures achieve formation-energy errors near 1...
Combining Response Surface Methodology (RSM) with Central Composite Design (CCD) is a powerful statistical approach to optimizing materials in energy storage systems. This study presents an open-source Python (v3.8+) framework that replicates and val...
Since its introduction, the Suzuki–Miyaura coupling has become one of the most widely applied carbon–carbon bond-forming reactions in medicinal chemistry and discovery-oriented synthesis. While substantial efforts have focused on catalyst...
The hydroformylation of olefins is one of the most important homogeneously catalyzed processes in industry to produce bulk chemicals. Despite the high catalytic activities and selectivity’s using rhodium-based homogeneous hydroformylation catalysts,...
The controllability and consistency in the fabrication of micro-textures on large-scale remains a challenge for existing production processes. Mask electrolyte jet machining (MEJM) is an alternative to Jet-ECM for controllable and high-throughput sur...
The interactions between Acute Myeloid Leukaemia (AML) leukemic stem cells and the bone marrow (BM) microenvironment play a critical role during AML progression and resistance to drug treatments. Therefore, the identification of novel therapies requi...
The conversion and utilization of carbon dioxide (CO2) have dual significance for reducing carbon emissions and solving energy demand. Catalytic reduction of CO2 is a promising way to convert and utilize CO2. However, high-performance catalysts with...
DNA-PKcs is a crucial protein target involved in DNA repair and response pathways, with its abnormal activity closely associated with the occurrence and progression of various cancers. In this study, we employed a deep learning-based screening and mo...
Calcium phosphates (CaP) represent an impressive kind of biomedical material due to their excellent biocompatibility, bioactivity, and biodegradability. Their morphology and structure highly influence their properties and applications. Whilst great p...
With the rapid development of wireless communication, Wireless Local Area Networks (WLANs) are widely deployed in high-density environments. Ensuring fast handovers and optimal AP selection during device roaming is critical for maintaining network th...
Delta compression is a promising technique for reducing the storage footprint of similar data. As the first step in delta compression, similarity detection has a significant impact on both the delta compression ratio (DCR) and the compression through...
To meet the high throughput requirement of communication systems, the design of high-throughput low-density parity-check (LDPC) decoders has attracted significant attention. This paper proposes a high-throughput GPU-based LDPC decoder, aiming at the...
Single-screw extrusion at high screw speeds is established nowadays since it allows for a high mass throughput at a comparatively small extruder size. Compared to conventional extrusion at low screw speeds, a considerable non-linearity in mass throug...
The development of high-throughput sequencing (next-generation sequencing technology (NGS)) and the continuous increase in experimental throughput require the upstream sample processing steps of NGS to be as simple as possible to improve the efficien...
Blue-phase liquid crystal (BPLC) is considered as the next-generation liquid crystal display material, but its practical application is seriously affected by a narrow temperature range and a long research period. In this paper, we used inkjet printin...
High-throughput, pillar-strip-based assays have been proposed as a drug-safety screening tool for developmental toxicity. In the assay described here, muscle cell culture and differentiation were allowed to occur at the end of a pillar strip (eight p...
Perovskites (ABX3) exhibit remarkable potential in optoelectronic conversion, catalysis, and diverse energy-related fields. However, the tunability of A, B, and X-site compositions renders conventional screening methods labor-intensive and inefficien...
The graph stream is defined as rapid edge streams on a huge domain of nodes. Nowadays, graph streams play important roles in network traffic, social networks, and cloud troubleshooting. Therefore, various summary structures for graph streams are prop...
The development of highly selective separation processes is a focus of current research. In 2016, the German Science Foundation funded a priority program SPP 2045 “MehrDimPart—highly specific multidimensional fractionation of fine particl...
High-throughput technologies have allowed researchers to obtain genome-wide data from a wide array of experimental model systems. Unfortunately, however, new data generation tends to significantly outpace data re-utilization, and most high throughput...
Multipath TCP (MPTCP) allows the system to use available paths through multiple network interfaces. This aggregation of bandwidth increases the throughput of the network but also consumes more energy to maintain connections between multiple interface...
The deployment of millimeter waves can fulfil the stringent requirements of high bandwidth and high energy efficiency in fifth generation (5G) networks. Still, millimeter waves communication is challenging because it requires line of sight (LOS). The...
Ensuring the freshness of high Value of Information (VoI) data has a significant practice meaning for marine observations and emergencies. The traditional forward method with an auv-aid is used to ensure the freshness of high VoI data. However, the m...
High resolution melting (HRM) is a convenient method for gene scanning as well as genotyping of individual and multiple single nucleotide polymorphisms (SNPs). This rapid, simple, closed-tube, homogenous, and cost-efficient approach has the capacity...
The continuing use of high-throughput assays to investigate cellular responses to infection is providing a large repository of information. Due to the large number of differentially expressed transcripts, often running into the thousands, the majorit...
The throughput of the pneumatic brake valve is a key parameter in ensuring fast and safe vehicle braking. The instantaneous value of this parameter determines the short response time of the system to an operator’s force. The scientific objectiv...
The use of microfluidics for analysis of biological and chemical compounds is flourishing, with droplet microfluidics being well suited for high-throughput single substance analysis. Nowadays, many new experimental set-ups are reported that combine v...
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