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27 Results Found

  • Article
  • Open Access
5 Citations
3,188 Views
14 Pages

Pro-Angiogenetic Effects of Purified Extracts from Helix aspersa during Zebrafish Development

  • Daniela Zizioli,
  • Andrea Mastinu,
  • Alessia Muscò,
  • Sara Anna Bonini,
  • Dario Finazzi,
  • Rosaria Avisani,
  • Giovanni Battista Kron Morelli,
  • Sergio Pecorelli and
  • Maurizio Memo

Helix aspersa is a species of land snail belonging to the Helicidae family, widespread in the Mediterranean and continental area up to Northern Europe. In some areas it is appreciated as a food, but is mostly considered a parasite of gardens and cult...

  • Article
  • Open Access
32 Citations
4,708 Views
15 Pages

An 1H NMR- and MS-Based Study of Metabolites Profiling of Garden Snail Helix aspersa Mucus

  • Nikolay G. Vassilev,
  • Svetlana D. Simova,
  • Miroslav Dangalov,
  • Lyudmila Velkova,
  • Venceslav Atanasov,
  • Aleksandar Dolashki and
  • Pavlinka Dolashka

2 September 2020

Metabolic profiling based on 1H nuclear magnetic resonance (NMR) spectroscopy was applied with the aim to investigate the functional role of the metabolites in lyophilized mucus from the garden snail Helix aspersa. Twenty metabolites were unambiguous...

  • Article
  • Open Access
41 Citations
9,613 Views
23 Pages

In Vitro Influence of Extracts from Snail Helix aspersa Müller on the Colon Cancer Cell Line Caco-2

  • Magdalena Matusiewicz,
  • Iwona Kosieradzka,
  • Tomasz Niemiec,
  • Marta Grodzik,
  • Hanna Antushevich,
  • Barbara Strojny and
  • Małgorzata Gołębiewska

Colorectal cancer is the third most widely diagnosed cancer. Extracts from snails may modulate growth and development of colorectal cancer cells. The objective of this study was to determine the chemical composition of tissues derived from Helix aspe...

  • Article
  • Open Access
3 Citations
5,748 Views
20 Pages

Effect of Helix aspersa Mucus on the Regeneration of Skin with Photoaging Features in Different Methods of Application

  • Mariola Marchlewicz,
  • Justyna Wojnarowicz,
  • Aleksandra Wilk,
  • Kamila Misiakiewicz-Has,
  • Barbara Wiszniewska,
  • Kamila Szumilas and
  • Ewa Duchnik

21 August 2024

Skin aging is associated with both intrinsic and extrinsic aging, with extrinsic aging caused by environmental factors and overlaying the effects of chronological aging. The main aim of this study was to evaluate the effect of preparations containing...

  • Article
  • Open Access
2 Citations
4,148 Views
18 Pages

15 September 2024

In recent years, snail mucus (SM) has become popular as an active ingredient in cosmetic and pharmaceutical products. In turn, snail eggs (SEs) also seem to be a promising active compound, but the biological activities of SEs are significantly less k...

  • Article
  • Open Access
13 Citations
4,036 Views
9 Pages

Antifungal Activity of Soft Tissue Extract from the Garden Snail Helix aspersa (Gastropoda, Mollusca)

  • Hoda H. Abd-El Azeem,
  • Gamalat Y. Osman,
  • Hesham R. El-Seedi,
  • Ahmed M. Fallatah,
  • Shaden A. M. Khalifa and
  • Mohamed M. Gharib

Gastropods comprise approximately 80% of molluscans, of which land snails are used variably as food and traditional medicines due to their high protein content. Moreover, different components from land snails exhibit antimicrobial activities. In this...

  • Article
  • Open Access
4 Citations
2,702 Views
11 Pages

21 July 2022

In the years 2020–2022, a survey was carried out with the aim of controlling the entomofauna present in seven Sardinian snail farms. The sampling was carried out during the spring–summer and autumn–winter periods, corresponding to t...

  • Article
  • Open Access
2 Citations
1,565 Views
10 Pages

Metabolomic Prediction of Cadmium Nephrotoxicity in the Snail Helix aspersa maxima

  • Aude Devalckeneer,
  • Marion Bouviez,
  • Amandine Gautier and
  • Jean-Marie Colet

17 August 2024

The decontamination of polluted soils is a major socioeconomic issue in many industrialized countries. In situ remediation approaches are nowadays preferred to ex situ techniques, but they require among others the use of bioindicators, which are sens...

  • Article
  • Open Access
1,199 Views
18 Pages

Background: Polluted soils represent a major problem in many industrialized countries that urgently requires appropriate health risk assessment. The One Health concept that considers a close relationship between human and animal health and ecosystems...

  • Article
  • Open Access
20 Citations
4,230 Views
16 Pages

Nutritional Composition, Fatty Acids Profile, Mineral Content, Antioxidant Activity and Acute Toxicity of the Flesh of Helix aspersa Müller

  • Marouane Aouji,
  • Hamada Imtara,
  • Amine Rkhaila,
  • Bouchra Bouhaddioui,
  • Ahmad Alahdab,
  • Mohammad Khalid Parvez,
  • Mohamed Saleh Alzahrani,
  • Lalla Aicha Lrhorfi and
  • Rachid Bengueddour

29 August 2023

Humans consume snail flesh as part of their diet. To assess its nutritional value and toxicity, chemical analyses were conducted to confirm the presence of protein, total and reduced carbohydrates, fat, fatty acid composition and mineral components....

  • Article
  • Open Access
6 Citations
2,649 Views
18 Pages

Assessment of the In Vitro and In Vivo Antitumor Activity of Hemocyanins from Helix aspersa, Helix lucorum, and Rapana venosa in a Graffi Myeloid Tumor Model

  • Ani Georgieva,
  • Katerina Todorova,
  • Ivan Iliev,
  • Valeria Dilcheva,
  • Ivelin Vladov,
  • Svetlozara Petkova,
  • Aleksandar Dolashki,
  • Lyudmila Velkova,
  • Pavlina Dolashka and
  • Reneta Toshkova

Hemocyanins are oxygen-transporting glycoproteins in the hemolymph of some invertebrate species that attracted scientific interest as potential anticancer agents. The present study aims to assess the in vitro and in vivo anticancer activity of hemocy...

  • Article
  • Open Access
27 Citations
4,126 Views
14 Pages

Hemocyanins from Helix and Rapana Snails Exhibit in Vitro Antitumor Effects in Human Colorectal Adenocarcinoma

  • Ani Georgieva,
  • Katerina Todorova,
  • Ivan Iliev,
  • Valeriya Dilcheva,
  • Ivelin Vladov,
  • Svetlozara Petkova,
  • Reneta Toshkova,
  • Lyudmila Velkova,
  • Aleksandar Dolashki and
  • Pavlina Dolashka

Hemocyanins are oxygen-transporting glycoproteins in the hemolymph of arthropods and mollusks that attract scientific interest with their diverse biological activities and potential applications in pharmacy and medicine. The aim of the present study...

  • Article
  • Open Access
9 Citations
2,299 Views
9 Pages

Evaluating GlicoPro Tear Substitute Derived from Helix aspersa Snail Mucus in Alleviating Severe Dry Eye Disease: A First-in-Human Study on Corneal Esthesiometry Recovery and Ocular Pain Relief

  • Antonio Ballesteros-Sánchez,
  • José-María Sánchez-González,
  • Giovanni Roberto Tedesco,
  • Carlos Rocha-de-Lossada,
  • Gianluca Murano,
  • Antonio Spinelli,
  • Cosimo Mazzotta and
  • Davide Borroni

12 March 2024

Background: To evaluate the effects of 10% GlicoPro tear substitute therapy in patients with severe dry eye disease (DED). Methods: In this prospective longitudinal study, 30 individuals receiving 10% GlicoPro four times daily for DED were evaluated....

  • Article
  • Open Access
23 Citations
8,393 Views
12 Pages

The Protective Effect of Snail Secretion Filtrate in an Experimental Model of Excisional Wounds in Mice

  • Enrico Gugliandolo,
  • Francesco Macrì,
  • Roberta Fusco,
  • Rosalba Siracusa,
  • Ramona D’Amico,
  • Marika Cordaro,
  • Alessio Filippo Peritore,
  • Daniela Impellizzeri,
  • Tiziana Genovese and
  • Rosalia Crupi
  • + 3 authors

20 August 2021

Wound healing is a physiological process comprising several coordinated phases, such as inflammation, proliferation, and remodeling. For centuries, Helix aspersa Muller mucus has been known to have biological properties that are useful for treating s...

  • Communication
  • Open Access
11 Citations
4,911 Views
9 Pages

30 January 2021

Members of the Phylum Mollusca include shellfish such as oysters and squid but also the edible garden snail known as Helix aspersa. This snail species is consumed as a delicacy in countries including France (where they are known as petit-gris), south...

  • Article
  • Open Access
36 Citations
10,950 Views
18 Pages

Allantoin from Valuable Romanian Animal and Plant Sources with Promising Anti-Inflammatory Activity as a Nutricosmetic Ingredient

  • Rodica Mihaela Dinica,
  • Cristina Sandu,
  • Andreea Veronica Dediu Botezatu,
  • Anna Cazanevscaia Busuioc,
  • Fanica Balanescu,
  • Maria Daniela Ionica Mihaila,
  • Caterina Nela Dumitru,
  • Bianca Furdui and
  • Alina Viorica Iancu

11 September 2021

Helix aspersa (HA), Helix pomatia (HP) and Symphytum officinale are common organisms in Romania’s biosphere, widely known for their allantoin content and their therapeutic properties. Herein, the allantoin was separated and quantified from the aqueou...

  • Article
  • Open Access
13 Citations
4,107 Views
9 Pages

Snail Mucus Filtrate Reduces Inflammation in Canine Progenitor Epidermal Keratinocytes (CPEK)

  • Laura Messina,
  • Fabio Bruno,
  • Patrizia Licata,
  • Davide Di Paola,
  • Gianluca Franco,
  • Ylenia Marino,
  • Alessio Filippo Peritore,
  • Salvatore Cuzzocrea,
  • Enrico Gugliandolo and
  • Rosalia Crupi

21 July 2022

Atopic dermatitis (AD) is an inflammatory and allergic disease, whose multifactorial etiopathogenesis is the consequence of the link between the genetic, immunological and environmental components. The complexity and difficulty in understanding the c...

  • Article
  • Open Access
2,663 Views
16 Pages

Modified Hemocyanins from Rapana thomasiana and Helix aspersa Exhibit Strong Antitumor Activity in the B16F10 Mouse Melanoma Model

  • Emiliya Stoyanova,
  • Nikolina Mihaylova,
  • Nikola Ralchev,
  • Silviya Bradyanova,
  • Iliyan Manoylov,
  • Yuliana Raynova,
  • Krassimira Idakieva and
  • Andrey Tchorbanov

7 October 2024

Melanoma is one of the most common tumors worldwide, and new approaches and antitumor drugs for therapy are being investigated. Among the promising biomolecules of natural origin for antitumor research are gastropodan hemocyanins—highly immunog...

  • Article
  • Open Access
1,981 Views
12 Pages

Garden Snail Predatory Insects’ Modus Operandi Under Laboratory Conditions

  • Giulia Murgia,
  • Valentina Coroneo,
  • Carlo Zuddas,
  • Sara Maria Pani and
  • Maria Paola Cogoni

5 November 2024

Heliciculture farms are susceptible to significant biotic issues that can impact snail breeding, among them, the entomofauna predation of snails. Predatory insects can cause damage to snail shells during predation, and sometimes, the specific type of...

  • Article
  • Open Access
11 Citations
5,988 Views
9 Pages

18 February 2022

In the last years, the environmental impacts of cosmetics production have received growing interest from consumers, industries and the scientific community. Therefore, the selection and evaluation of more sustainable ingredients for cosmetic preparat...

  • Article
  • Open Access
15 Citations
4,560 Views
15 Pages

Effectiveness of Snail Slime in the Green Synthesis of Silver Nanoparticles

  • Maria Francesca Di Filippo,
  • Valentina Di Matteo,
  • Luisa Stella Dolci,
  • Beatrice Albertini,
  • Barbara Ballarin,
  • Maria Cristina Cassani,
  • Nadia Passerini,
  • Giovanna Angela Gentilomi,
  • Francesca Bonvicini and
  • Silvia Panzavolta

1 October 2022

The development of green, low cost and sustainable synthetic routes to produce metal nanoparticles is of outmost importance, as these materials fulfill large scale applications in a number of different areas. Herein, snail slime extracted from Helix ...

  • Article
  • Open Access
4 Citations
2,733 Views
18 Pages

Immunotherapeutic Potential of Mollusk Hemocyanins in Murine Model of Melanoma

  • Emiliya Stoyanova,
  • Nikolina Mihaylova,
  • Nikola Ralchev,
  • Silviya Bradyanova,
  • Iliyan Manoylov,
  • Yuliana Raynova,
  • Krassimira Idakieva and
  • Andrey Tchorbanov

15 May 2024

The development of antitumor drugs and therapy requires new approaches and molecules, and products of natural origin provide intriguing alternatives for antitumor research. Gastropodan hemocyanins-multimeric copper-containing glycoproteins have been...

  • Article
  • Open Access
3 Citations
1,451 Views
14 Pages

Quillaja lancifolia Immunoadjuvant Saponins Show Toxicity to Herbivores and Pathogenic Fungi

  • Anna C. A. Yendo,
  • Luana C. Colling,
  • Hélio N. Matsuura,
  • Lúcia R. B. Vargas,
  • José A. Martinelli,
  • Gabriela Z. Chitolina,
  • Marilene H. Vainstein and
  • Arthur G. Fett-Neto

20 April 2025

Saponins from leaves of Quillaja lancifolia, a native species from southern Brazil, show potent immunoadjuvant activity in experimental vaccine formulations. The accumulation of the immunoadjuvant saponin fraction QB-90 is induced in cultured leaf di...

  • Communication
  • Open Access
9 Citations
2,717 Views
9 Pages

Standardized Extract from Wastes of Edible Flowers and Snail Mucus Ameliorate Ultraviolet B-Induced Damage in Keratinocytes

  • Luca Vanella,
  • Valeria Consoli,
  • Ilaria Burò,
  • Maria Gulisano,
  • Manuela Stefania Giglio,
  • Ludovica Maugeri,
  • Salvatore Petralia,
  • Angela Castellano and
  • Valeria Sorrenti

Several studies have highlighted the ability of snail mucus in maintaining healthy skin conditions due to its emollient, regenerative, and protective properties. In particular, mucus derived from Helix aspersa muller has already been reported to have...

  • Article
  • Open Access
11 Citations
3,382 Views
14 Pages

Glutathione Depletion Disrupts Redox Homeostasis in an Anoxia-Tolerant Invertebrate

  • Marlize Ferreira-Cravo,
  • Daniel C. Moreira and
  • Marcelo Hermes-Lima

The upregulation of endogenous antioxidants is a widespread phenomenon in animals that tolerate hypoxia/anoxia for extended periods. The identity of the mobilized antioxidant is often context-dependent and differs among species, tissues, and stresses...

  • Article
  • Open Access
3 Citations
4,547 Views
18 Pages

Antitumor Properties of Epitope-Specific Engineered Vaccine in Murine Model of Melanoma

  • Emiliya Stoyanova,
  • Nikolina Mihaylova,
  • Nikola Ralchev,
  • Petya Ganova,
  • Silviya Bradyanova,
  • Iliyan Manoylov,
  • Yuliana Raynova,
  • Krassimira Idakieva and
  • Andrey Tchorbanov

14 June 2022

Finding new effective compounds of natural origin for composing anti-tumor vaccines is one of the main goals of antitumor research. Promising anti-cancer agents are the gastropodan hemocyanins–multimeric copper-containing glycoproteins used so...

  • Article
  • Open Access
35 Citations
7,129 Views
24 Pages

Characterization of Weissella viridescens UCO-SMC3 as a Potential Probiotic for the Skin: Its Beneficial Role in the Pathogenesis of Acne Vulgaris

  • Marcela Espinoza-Monje,
  • Jorge Campos,
  • Eduardo Alvarez Villamil,
  • Alonso Jerez,
  • Stefania Dentice Maidana,
  • Mariano Elean,
  • Susana Salva,
  • Haruki Kitazawa,
  • Julio Villena and
  • Apolinaria García-Cancino

Previously, we isolated lactic acid bacteria from the slime of the garden snail Helix aspersa Müller and selected Weissella viridescens UCO-SMC3 because of its ability to inhibit in vitro the growth of the skin-associated pathogen Cutibacterium acnes...