Search Results (260)

Background/Objectives: Patients with an ileoanal pouch change their diet to manage their symptoms and will often resort to the internet for nutrition advice. Currently, no evidence-based dietary guidelines exist to inform online resources. Hence, this study aims to assess the quality of online nutrition information directed towards patients with an ileoanal pouch. Methods: A systematic Google search was conducted to identify consumer websites including information on nutrition for those with ileoanal pouches. Quality was assessed using the DISCERN instrument, and the readability of written content was assessed using the Flesch–Kincaid score. A summative content analysis was used to identify the frequency of particular topics. Websites were also assessed against standards from the National Institute for Health and Care Excellence (NICE) framework for shared decision-making support tools. Results: A total of 12 websites met the inclusion criteria. Mean total DISCERN scores across all websites are 33 out of 75, indicating that overall, the websites were of poor quality. The mean Flesch–Kincaid score was 57 out of 100, or “fairly difficult” in terms of readability. The main themes according to the content analysis were “general dietary advice for pouch”, “dietary strategies for symptom management”, “addressing risks associated with having a pouch”, and “optimisation of nutritional intake”. Overall, websites did not meet the standards for shared decision-making. Conclusions: Online nutrition information for patients with an ileoanal pouch is of poor quality and difficult to understand. There is a need for higher quality online resources for these patients, ideally co-produced with a multidisciplinary team and patient, to provide patients with good quality, understandable, and accessible nutrition information. Full article

Oxidative stress directly or indirectly contributes to the development and progression of various diseases; therefore, regulating oxidative stress is a promising strategy for preventing or treating these conditions. The unique substances in soybeans, soy isoflavones, notably genistein, which have a strong antioxidant capacity, are considered to regulate various signaling pathways, alleviate oxidative stress, and improve gut microbiota imbalance as well as mitochondrial dysfunction. In this literature review, we summarize the latest research on genistein, providing evidence of its development and application as a potential drug for preventing and treating five selected diseases (Parkinson’s disease, Alzheimer’s disease, diabetes mellitus, cardiovascular disease, and cancers). The literature was searched using keywords that include tripartite combinations of genistein and oxidative stress, along with each of the five selected diseases, from PubMed, Science Direct, and Google Scholar between 2014 and 2024. According to current in vitro, in vivo, and clinical trials, we comprehensively discuss the therapeutic dose used to target various disease entities to achieve optimal efficacy and meet safety requirements. Moreover, considering the poor water solubility and limited bioavailability of genistein, strategies for improving its therapeutic efficacy, such as combining it with exercise, existing medications, and advanced technologies, as well as applying nanotechnology, were assessed. Therefore, this review aims to provide robust evidence for the development and application of genistein as a potential therapeutic agent or functional food for preventing and treating these diseases. Full article

The concept of the 15-minutes city [15 MC] focuses on providing important services within proximity and accessibility through active travel like walking or biking. While this model is becoming popular in urban planning and academic discourse, its implementation faces challenges in both densely populated developing and developed countries. This study aims to conduct a systematic review of recent literature to (1) identify the core components of the 15 MC model, (2) examine planning tools and strategies used in its implementation, (3) compare successes and challenges across global contexts, particularly in densely populated and resource-constrained areas, and (4) offer practical recommendations for adapting the model to meet local needs. The study reviewed 33 research papers published in the last five years [2019–2024]. Following PRISMA guidelines, a structured screening and selection process was conducted using databases such as Scopus, Web of Science, and Google Scholar. Thematic analysis revealed major challenges for implementing the 15 MC in the Global South, including urban informality, gaps in infrastructure, and complex governance issues. Moreover, the review points out the potential risks of exclusion and gentrification if the specific needs of different contexts are not considered. While high-income countries tend to focus on sustainability and making neighborhoods walkable, developing countries struggle with deeper structural problems that make equitable implementation harder. This study emphasizes the need for locally adaptive frameworks in planning 15 MCs and aims to develop inclusive urban policies that support Sustainable Development Goal 11, which seeks to make cities inclusive, safe, resilient, and sustainable. Full article

Indonesia faces significant challenges in meeting food security targets due to rapid agricultural land loss, with approximately 1.22 million hectares of rice fields converted between 1990 and 2022. Therefore, this study developed a prediction model for the loss of rice fields by 2030, incorporating land productivity attributes, specifically rice cropping intensity/RCI, using geospatial technology—a novel method with a resolution of approximately 10 m for quantifying ecosystem service (ES) impacts. Land use/land cover data from Landsat images (2013, 2020, 2024) were classified using the Random Forest algorithm on Google Earth Engine. The prediction model was developed using a Multi-Layer Perceptron Neural Network and Markov Cellular Automata (MLP-NN Markov-CA) algorithms. Additionally, time series Sentinel-1A satellite imagery was processed using K-means and a hierarchical clustering analysis to map rice fields and their RCI. The validation process confirmed high model robustness, with an MLP-NN Markov-CA accuracy and Kappa coefficient of 83.90% and 0.91, respectively. The present study, which was conducted in Indramayu Regency (West Java), predicted that 1602.73 hectares of paddy fields would be lost within 2020–2030, specifically 980.54 hectares (61.18%) and 622.19 hectares (38.82%) with 2 RCI and 1 RCI, respectively. This land conversion directly threatens ES, resulting in a projected loss of 83,697.95 tons of rice production, which indicates a critical degradation of service provisioning. The findings provide actionable insights for land use planning to reduce agricultural land conversion while outlining the urgency of safeguarding ES values. The adopted method is applicable to regions with similar characteristics. Full article

Indigenous Peoples have stewarded Indigenous traditional ecological knowledges (TEK) for millennia. Health-related TEK represents vital knowledge that promotes Indigenous health and wellbeing. Yet, the intergenerational protection of TEK continues to be threatened by various factors, including climate change, which underscores the importance of strengthening and supporting Indigenous-managed TEK repositories. Using a scoping review methodology, we aimed to identify documents for setting up health-related TEK repositories within Indigenous communities. A systematic search was completed in multiple databases—Medline, PubMed, CABI abstracts, Canadian Public Policy Collection, and JSTOR—with manual searches carried out on relevant Indigenous repositories and Google. Content analysis was then carried out with the nine documents meeting our inclusion criteria. We characterized six overarching categories and twelve sub-categories from the included documents. These categories covered impacts on Indigenous TEK repositories resulting from colonial processes, with TEK being seen as diverse, living knowledge protected by longstanding cultural protocols. Concerns surrounding TEK repository management included the need for platforming Indigenous data sovereignty and Indigenous Peoples’ access and ownership. Wise practices of Indigenous-led repository development demonstrated clear examples of data governance processes in action. Indigenous communities were seen to be vital in contributing to key policies and protocols that protect health-related TEK. Full article

Narrative therapy generally avoids medical language and diagnostic labels, instead emphasizing collaborative dialogue centered on values and strengths. How does this approach apply to children diagnosed with Attention Deficit Hyperactivity Disorder (ADHD), the most common neurodevelopmental condition? This study presents the first scoping review on this topic. A systematic search of five databases (APA PsycNET, PubMed, Web of Science, ProQuest, and Google Scholar) identified 24 records meeting the inclusion criteria. Four key insights emerged relating to the therapies: (1) philosophical foundations; (2) unique perspective on ADHD; (3) practical interventions (e.g., externalizing and separating the problem from the child, identifying ‘sparkling moments’); (4) reported effectiveness. Further research is recommended to evaluate the therapy’s empirical impact and explore its potential to empower children by co-creating a ‘health-side story’ that shifts focus from problems to strengths, relationships, and values. Full article

South Africa continues to experience a high HIV prevalence, necessitating innovative prevention strategies aligned with the UNAIDS 95-95-95 targets. Long-acting injectable pre-exposure prophylaxis (PrEP), such as cabotegravir (CAB-LA), offers a promising alternative to daily oral regimens. However, the perspectives of primary healthcare workers (PHCWs)—key implementers of this intervention—remain underexplored. This scoping review aims to systematically map existing literature on PHCWs’ knowledge, awareness, perceptions, barriers, facilitators, and implementation experiences related to injectable PrEP within the South African healthcare context. The review will follow the Arksey and O’Malley framework, enhanced by Levac et al., and will be reported following PRISMA-ScR guidelines. A comprehensive search will be conducted across PubMed, Scopus, CINAHL (EBSCOhost), Web of Science, and Google Scholar, without language or date restrictions. The search strategy will employ both controlled vocabulary (e.g., MeSH and CINAHL Subject Headings) and free-text terms. Studies meeting the inclusion criteria will be managed using EndNote X20 and appraised using the Mixed Methods Appraisal Tool (MMAT) 2018 version. Data will be synthesized thematically and presented narratively and in tabular form. By consolidating PHCWs’ perspectives, this review will identify implementation challenges, training needs, and systemic barriers, informing the development of context-specific strategies for PrEP rollout. The findings are expected to support the design of effective, culturally relevant educational interventions and guide policymakers in strengthening HIV prevention efforts in high-burden settings. Full article

The coordination of school- and community-based mental health services is a promising strategy to respond to the rising mental health needs of youth. Out-of-school time (OST) programs are an under-utilized community-based resource that may be leveraged to help meet this need. We conducted a scoping review to (a) identify practices that facilitate the coordination of care between schools and OST programs and (b) examine whether such practices align with those used in existing models of expanded school mental health (ESMH). EBSCOhost, PsycINFO, PubMed, Google Scholar, ERIC Scopus, MedLine, ScienceDirect, and national organization websites were used to identify articles, including peer-reviewed (n = 2) and grey literature (n = 7) published from 2004 to 2024 that were written in English and described U.S.-based schools and programs. Coordination practices were coded inductively and categorized as a school/program, district/community, or state-level practice. Practices within the vision/mission alignment, coordinating daily operations, training, and resource/information sharing domains were identified at the highest frequency. Many of the strategies identified are included in existing models of ESMH. Thus, expanding coordination models to include OST may be a feasible direction for increasing the capacity of communities to meet the mental health needs of youth. Given the paucity of research in this area, further empirical research is needed. Full article

Background/Objectives: In 2010, approximately 60.5 million people were affected by glaucoma, making it the leading cause of permanent vision impairment globally. With the rise of telehealth tools and technological advancements in glaucoma care, this review aims to provide an up-to-date analysis regarding remote monitoring systems in glaucoma management. Methods: A systematic literature search (in compliance with PRISMA guidelines) was conducted across six databases (CINAHL, MEDLINE, PsycINFO, Web of Science, Scopus, and Cochrane Library) and one grey literature source (Google Scholar), covering the period from 2000 to 2024. Relevant studies meeting predefined inclusion criteria were identified and analyzed. Results: The search identified 21 eligible studies focusing on various glaucoma telemonitoring tools. Several studies demonstrated the potential for continuous remote intraocular pressure (IOP) monitoring and highlighted the effectiveness of home-based visual field-testing technologies (e.g., Melbourne Rapid Fields, Eyecatcher, and VF-Home), which showed results closely matching in-clinic tests. All 21 studies underwent risk of bias assessment with appropriate tools based on study design, and none showed a high overall risk of bias, indicating robust methodology. Conclusions: Glaucoma telemonitoring tools are feasible and cost-effective, helping to reduce patient travel and waiting times and improving patient satisfaction. However, periodic in-person examinations remain necessary to optimally monitor disease progression and adjust treatments. Future directions should focus on interdisciplinary collaboration and the development of advanced algorithms (including artificial intelligence) to further enhance patient outcomes in teleglaucoma care. Full article

In the current era, which is characterized by increasing demand for high-precision location and navigation capabilities, various industries, including those involved in intelligent vehicle systems, logistics, augmented reality, and more, heavily rely on accurate location information to optimize processes and deliver personalized experiences. In this context, the integration of Global Navigation Satellite System (GNSS) and inertial sensor technologies in smartphones has emerged as a critical solution to meet these demands. This research paper presents an algorithm that combines a GNSS with a modified downdate algorithm (MDDA) for satellite selection and integrates inertial navigation systems (INS) in both loosely and tightly coupled configurations. The primary objective was to harness the inherent strengths of these onboard sensors for navigation in challenging environments. These algorithms were meticulously designed to enhance performance and address the limitations encountered in harsh terrain. To evaluate the effectiveness of these proposed systems, vehicular experiments were conducted under diverse GNSS observation conditions. The experimental results clearly illustrate the considerable improvements achieved by the recommended tightly coupled (TC) algorithm when integrated with MDDA, in contrast to the loosely coupled (LC) algorithm. Specifically, the TC algorithm demonstrated a remarkable reduction of over 90% in 2D position root mean square error (RMSE) and a 75% reduction in 3D position RMSE when compared to solutions utilizing the weighting matrix provided by Google with all visible satellites. These findings underscore the substantial advancements in precision resulting from the integration of GNSS and INS technologies, thereby unlocking the full potential of transformative applications in the realm of intelligent vehicle navigation. Full article

To investigate whether the skid resistance of the ramp meets the requirements of vehicle driving safety and stability, the simulation using the ideal driver model is inaccurate. Therefore, considering the driver’s driving habits, this paper proposes the use of Unmanned aerial vehicles (UAVs) for the collection and extraction of vehicle driving information. To process the collected UAV video, the Google Collaboration platform is used to modify and compile the “You Only Look Once” version 5 (YOLOv5) algorithm with Python 3.7.12, and YOLOv5 is retrained with the captured video. The results show that the precision rate P and recall rate R have satisfactory results with an F1 value of 0.86, reflecting a good P-R relationship. The loss function also stabilized at a very low level after 70 training epochs. Then, the trained YOLOv5 is used to replace the Faster R-CNN detector in the DeepSORT algorithm to improve the detection accuracy and speed and extract the vehicle driving information from the perspective of UAV. By coding, the coordinate information of the vehicle trajectory is extracted, the trajectory is smoothed, and the frame difference method is used to calculate the real-time speed information, which is convenient for the establishment of a real driver model. Full article

Background: Endometriosis is a benign gynecologic condition that has the risk of malignant transformation in approximately 0.5–1% of cases, most of which develop into endometriosis-associated ovarian cancers (EAOCs), such as clear cell and endometrioid adenocarcinomas. The current systematic review aims to condense recent information on the genetic and molecular mechanisms, clinical risk factors, and possible therapeutic targets of the malignant transformation of endometriosis. Methods: A systematic literature search of PubMed, Europe PMC, and Google Scholar was carried out according to PRISMA guidelines for articles published until December 2024. Following a screening of 44,629 titles, 43 full articles were included after meeting inclusion criteria. No case reports or reviews were included, and articles had to mention a malignant transformation of endometriosis and not just a diagnosis of cancer. The quality and risk of bias of studies were evaluated using ROBINS-I. Results: Malignant transformation of endometriosis is associated with genetic alterations, including ARID1A mutations, microsatellite instability, and abnormal PI3K/Akt and mTOR pathway activation. Increased oxidative stress, inflammation-driven mismatch repair deficiency, and epigenetic alterations like RUNX3 and RASSF2 hypermethylation are implicated in carcinogenesis. Clinical risk factors are advanced age (40–60 years), large ovarian endometriomas (>9 cm), postmenopausal status, and prolonged estrogen exposure. Imaging techniques like MR relaxometry and risk models based on machine learning are highly predictive for early detection. Conclusions: Endometriosis carcinogenesis is a multifactorial process driven by genetic changes, oxidative stress, and inflammatory mechanisms. Identification of high-risk individuals through molecular and imaging biomarkers may result in early detection and personalized therapy. Further research should aim at the development of more precise predictive models and exploration of precision medicine approaches to inhibit the emergence of EAOC. Full article

Cultural norms, beliefs, and practices influence parental expectations, children’s responses, and the acceptance of behaviour management techniques (BMTs) in paediatric dentistry. Despite this, the existing guidelines often adopt a standardized approach, overlooking critical cultural differences. This scoping review maps the links between culture and behaviour management strategies in paediatric dental settings. A scoping review following PRISMA guidelines was conducted across PubMed, Cochrane Library, Web of Science, Google Scholar, and hand-searched sources from the inception of the databases to 31 January 2025. A total of 671 studies were identified, with 15 meeting the inclusion criteria. Data on the key findings were inductively analyzed to assess cultural influences on parental acceptance, child behavior, and communication. The findings show that non-invasive BMTs such as TellShow–Do and positive reinforcement were the most accepted across cultures, while passive and active restraints were least accepted, especially in Western populations. Parental preferences varied; Jordanian parents were more accepting of passive restraint than German parents, while general anaesthesia was preferred in Bahrain. Cultural norms shaped communication styles—Latino families emphasized warm interpersonal interactions, whereas Pakistani families exhibited limited parental involvement due to language barriers. Black and Hispanic Medicaid-enrolled mothers in the U.S. reported lower satisfaction with pain management, highlighting disparities in culturally competent care. In conclusion, cultural factors significantly influence paediatric behaviour management in dental clinics. Integrating cultural competence into practice can enhance communication, improve patient compliance, and promote equitable care. Further research is needed, particularly in Africa and South America, to inform globally inclusive behaviour management guidelines. Full article

Objectives: There is strong evidence that not enough physical activity is among the most critical risk factors for cancer disease and premature mortality. The literature on the benefits of regular physical activity regarding cancer disease has grown in the last decades. This review aimed to present the current findings on the effect of prediagnosis physical activity on cancer incidence and mortality published between January 2019 and October 2024; this study summarizes the previous evidence, as well as the literature underlying biological mechanisms operating in the exercise–cancer relationship. The review also highlights gaps in the existing research and identifies future research directions. Methods: Medline/PubMed, ScienceDirect, and Google Scholar were searched with the search terms “physical activity” and “physical exercise” in conjunction with the MeSH terms for “cancer” and “carcinoma”. Primary, review, and meta-analysis studies published in English were included if they reported a measure of the effect size of prediagnosis physical activity on cancer incidence and/or cancer mortality. Results: Evidence from 37 observational studies and 10 reviews were included in this systematic review; 22 studies reported the effect of physical activity on cancer incidence, and 15 studies on cancer mortality. Of the 37 included observational studies, 19 confirmed the previous evidence that physical activity significantly decreased all-cancer-combined and cancer-specific site incidences, and 10 studies focused on cancer mortality. However, the molecular mechanisms involved in this process require future studies. The most convincing evidence maintains the effects of physical activity on body weight and fat, insulin resistance, sex hormones, regulation of redox homeostasis, enhancing the antioxidant defense system, and reducing oxidative stress. Conclusions: These data demonstrate substantial prevention against several cancer incidences and mortality among patients who performed regular physical activity, of which dose meets at least the WHO’s guidelines. Further prospective cohort studies and long-term RCT studies are warranted to address a safe and personalized activity dose for cancer-site prevention, identify more precisely the biological mechanisms operating in the physical activity–cancer relationship, and promote the benefits of being physically active. Full article

Digital Twin (DT) technology is emerging as a powerful tool for optimizing energy efficiency and industrial sustainability. By creating virtual replicas of physical systems, DTs enable real-time monitoring, predictive maintenance, and resource optimization, offering new opportunities to meet growing energy demands. Despite its potential, the comprehension of DT technology’s applications, benefits, and challenges remains limited. This systematic review explores the role of Digital Twins in energy efficiency across various industries. A structured literature search was conducted in IEEE Xplore, Elsevier, Springer, MDPI, and Google Scholar, following PRISMA 2020 guidelines. After applying the predefined inclusion criteria, 50 studies were selected for in-depth analysis. The findings highlight that DT implementation can lead to energy savings of up to 30%, reduce operational costs, and improve predictive maintenance strategies. Their impact is particularly notable in smart buildings, manufacturing, and industrial processes, where real-time data analytics contribute to better energy management. However, significant barriers remain, including high implementation costs, data security risks, and the complexity of integrating DTs with existing infrastructures. By synthesizing the current research, this review underscores the transformative potential of Digital Twins while identifying key challenges that need to be addressed for their wider adoption. Future efforts should focus on developing standardized methodologies, reducing implementation costs, and enhancing cybersecurity measures to maximize their benefits in energy efficiency and sustainability. Full article