1,496 Results Found

Intending to contribute to sustainable agriculture by “New Green Revolution,” we developed a large-grain/semidwarf isogenic line “Koshihikari sd1GW2” that incorporates both the large-grain gene GW2 and semidwarf gene sd1. GW2...

Seed size is one of the most important traits determining the yield of cereal crops. Many studies have been performed to uncover the mechanism of seed development. However, much remains to be understood, especially at the molecular level, although se...

The first detection of gravitational waves from the binary black merger GW150914 started the era of gravitational astronomy. The observation of the binary neutron star merger GW170817 and of its associated electromagnetic counterpart GRB 170817A star...

GW4869, a cell-permeable, selective inhibitor of neutral sphingomyelinase is a pharmacological agent that blocks the production and release of extracellular vesicles (EVs). Our previous studies have shown that GW4869 inhibits flaviviral loads in tick...

Candida albicans (C. albicans) is one of the most common fungi in the human body; it is an opportunistic pathogen and can cause candidiasis. Extracellular vesicles (EVs) derived from the host cells have a potentially protective effect against pathoge...

We present a method for analyzing the symmetries of excited states previously calculated with the popular GW-BSE approach. These are expressed through the Tamm-Dancoff approximation using the so-called batches representation. The method allows to est...

Background: Combination therapy with the administration of GW5074 and sorafenib significantly induced necrotic death in various cancer cells in vivo, as well as prolonging the survival of an animal disease model due to significant suppression of the...

In practice, the object detection algorithm is limited by a complex detection environment, hardware costs, computing power, and chip running memory. The performance of the detector will be greatly reduced during operation. Determining how to realize...

Gravity wave (GW) activities play a prominent role in the complex coupling process of wave–wave and wave–background circulation around mid-low-latitude and equatorial areas. The wavelengths are wide, from about 10 m to 100 km, with a peri...

Parkinson’s disease (PD) is a chronic neurodegenerative disorder associated with dopamine neuron loss and motor dysfunction. Neuroprotective agents that prevent dopamine neuron death hold great promise for slowing the disease’s progressio...

Inflammation is critical in the development of acute liver failure (ALF). Peroxisome proliferator-activated receptor delta (PPARδ) regulates anti-inflammatory responses and is protective in several diseases such as obesity and cancer. However,...

Flow stability is extremely important for hydraulic turbines, especially for 1 GW hydraulic turbines, and has a strong impact on mesh stability. However, turbines often operate under non-design conditions, and current research on this aspect is still...

In 2015, the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO) and Advanced Virgo began observing the Universe in a revolutionary way. Gravitational waves from cosmic sources were detected for the first time, confirming their existe...

The role of astroglial and microglial cells in the pathogenesis of epilepsy is currently under active investigation. It has been proposed that the activity of these cells may be regulated by the agonists of peroxisome proliferator-activated nuclear r...

The density dependence of nuclear symmetry energy is among the most uncertain parts of the Equation of State (EOS) of dense neutron-rich nuclear matter. It is currently poorly known especially at suprasaturation densities partially because of our poo...

The process of bone regeneration is complicated, and it is still a major clinical challenge to regenerate critical-size bone defects caused by severe trauma, infection, and tumor resection. Intracellular metabolism has been found to play an important...

In addition to motor dysfunction, patients with Parkinson’s disease (PD) are often affected by neuropsychiatric disorders, such as anxiety and depression. In animal models, activation of the endocannabinoid (eCB) system produces anxiolytic and...

Background/Objectives: Clinical studies have demonstrated a correlation between alterations in the expression level of TRα and TRβ receptors in ovarian cancer cells and overall survival. Celecoxib and GW0742, commonly known as a COX-2 inhi...

On 14 August 2019, the LIGO/Virgo collaboration observed a compact object with mass $\sim {2.59}_{-0.09}^{+0.08}{M}_{\odot }$, as a component of a system where the main companion was a black hole with mass $\sim 23M_{\odot }$. A scientific debate initiated concerning the identification o...

Organic-molecule fluorophores with emission wavelengths in the second near-infrared window (NIR-II, 1000–1700 nm) have attracted substantial attention in the life sciences and in biomedical applications because of their excellent resolution and sensi...

As living standards rise, there has been a growing emphasis on quality traits related to rice’s taste potential. Recent studies explored correlations among quality traits, but the influence of major genes governing a specific quality trait on o...

The characteristics of constitutive behavior and microstructure evolution of GW103K magnesium alloy were investigated via hot compression tests at a strain rate of 0.001–1 s⁻¹ and a temperature of 623–773 K. The rheological stress o...

Background and Objectives: ADAM17, a sheddase that regulates cytokine and receptor ectodomains, amplifies inflammatory signaling. Acute liver injury (ALI) is driven by dysregulated inflammation, accompanied by both oxidative and endoplasmic reticulum...

Molecular orientations and interfacial morphologies have critical effects on the electronic states of donor/acceptor interfaces and thus on the performance of organic photovoltaic devices. In this study, we explore the energy levels and charge-transf...

The airway wall remodeling observed in asthma is associated with subepithelial fibrosis and enhanced activation of human bronchial fibroblasts (HBFs) in the fibroblast to myofibroblast transition (FMT), induced mainly by transforming growth factor-&b...

CB₁ and CB₂ cannabinoid receptors are members of the GPCR superfamily that modulate the effects of endocannabinoids. CB₁ is the most abundant CB receptor in the central nervous system, while CB₂ is present both peripherally and in the brain. CB₂ play...

We investigate the possibility that GW170817 was not the merger of two conventional neutron stars (NS), but involved at least one if not two hybrid stars with a quark matter core that might even belong to a third family of compact stars. To this end,...

Bladder cancer aggressiveness is correlated with abnormal N-cadherin transmembrane glycoprotein expression. This protein is cleaved by the metalloprotease ADAM10 and the γ-secretase complex releasing a pro-angiogenic N-terminal fragment (NTF) a...

We develop a Bayesian analysis method for selecting the most probable equation of state under a set of constraints from compact star physics, which now include the tidal deformability from GW170817. We apply this method for the first time to a two-pa...

Genetic analysis of “InochinoIchi,” an exceptionally large grain rice variety, was conducted through five continuous backcrosses with Koshihikari as a recurrent parent using the large grain F₃ plant in Koshihikari × Inochinoichi as...

GW501516, also known by the name of cardarine, is a synthetic peroxisome-proliferator-activated receptor delta (PPR-δ) agonist agent developed for applications in the treatment of metabolic disorders and cardiovascular diseases. A broad polymor...

Ionization potentials (IPs) and electron affinities (EAs) are important quantities input into most models for calculating the open-circuit voltage (V_oc) of organic solar cells. We assess the semi-empirical density-functional tight-binding (DFTB) meth...

A 43-year-old male, sport coach, presented him-self at the Emergency unit of a local hospital for epigastric pain, myalgia pain and severe headache. He claimed having used for some days a combination of GW1516 (cardarine), a peroxisome proliferator-a...

Cardarine (C₂₁H₁₈F₃NO₃S₂), better known by the popular name of GW501516, is a peroxisome proliferator-activated receptor delta (PPR-δ) agonist that presents potential use in the approach of cardiovascular diseases and metabolic disorders, dysli...

Neuroinflammation is a key process of many neurodegenerative diseases and other brain disturbances, and astrocytes play an essential role in neuroinflammation. Therefore, the regulation of astrocyte responses for inflammatory stimuli, using small mol...

Since the definitions of the two-dimensional (2D) optical absorption coefficient and photoconductivity are independent of the thickness of 2D materials, they are more suitable than the dielectric function to describe the optical properties of 2D mate...

For gravitational wave (GW) detected neutron star mergers, one of the leading candidates for electromagnetic (EM) counterparts is the afterglow from an ultra-relativistic jet. Where this afterglow is observed, it will likely be viewed off-axis, such...

In this study, multiple remote sensing data were used to quantitatively evaluate the contributions of surface water, soil moisture and groundwater to terrestrial water storage (TWS) changes in five groundwater resources zones of Inner Mongolia (GW_I,...

Covalent agonists of PPARγ cause unique receptor conformational changes and behave as selective PPARγ modulators, whereas there are few covalent agonists other than endogenous unsaturated fatty acids metabolites. Previously, we establishe...

The spatial–temporal distribution of the global gravity wave (GW) potential energy (Ep) at the lower stratosphere of 20–35 km is studied using the dry temperature profiles from multi- Global Navigation Satellite System (GNSS) radio occult...

Geothermal water (GW) resources are highly valued as clean, renewable energy sources. In this study, a comprehensive analysis of water chemistry and isotope data from 25 GW samples was conducted to gain insights into the hydrochemical characteristics...

The valuation of Goodwill (GW) has remained one of the several critical issues in financial analysis. This aspect is particularly important for mergers and acquisitions due to the significance of intangible assets. This study delves into the capitali...

Interactions between groundwater and surface water (GW-SW interactions) play a crucial role in the hydrological cycle; thus, the quantification of GW-SW interactions is essential. In this study, a cumulative exchange fluxes method based on mass balan...

Nanoscale geranium waste (GW) and magnesium nanoparticle/GW nanocomposites (Mg NP/GW) were prepared using green synthesis. The Mg NP/GW samples were subjected to characterization using X-ray diffraction (XRD) and Fourier-transform infrared spectrosco...

The management of droughts is a challenging issue, especially in water scarcity areas, where this problem will be exacerbated in the future. The aim of this paper is to identify potential groundwater (GW) bodies with reduced vulnerability to pumping,...

The gravity wave (GW) potential energy (Ep) in the lower stratosphere (LS) of the altitude range between 20 and 30 km over the Indian region (60°E–100°E, 0°–30°N) is retrieved using the dry temperature profiles from the Co...

Microglia are major players in scar formation after an injury to the spinal cord. Microglia proliferation, differentiation, and survival are regulated by the colony-stimulating factor 1 (CSF1). Complete microglia elimination using CSF1 receptor (CSF1...

Blood–brain barrier dysfunction (BBB) is a primary characteristic of experimental autoimmune encephalomyelitis (EAE), an experimental model of multiple sclerosis (MS). We have previously shown that blocking microglial proliferation using GW2580...

We investigate the energy of the gravitational wave from a binary black hole merger by the coalescence of two Kerr black holes with an orbital angular momentum. The coalescence is constructed to be consistent with particle absorption in the limit in...

Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor five-year survival rate of less than 10%. Immune suppression along with chemoresistance are obstacles for PDAC therapeutic treatment. Innate immune cells, such as tumor-associated macropha...