From Pathogenesis to Therapies: Innovations in Kidney Disease
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 18
Special Issue Editors
Interests: renal ischemia-reperfusion injury; renal fibrosis; acute kidney injury
Interests: chronic kidney disease; ureteral obstructive nephropathy; macrophage–myofibroblast transition
Special Issue Information
Dear Colleagues,
We are pleased to invite you and your colleagues to submit a manuscript to our Special Issue “From Pathogenesis to Therapies: Innovations in Kidney Disease”. We believe that your contributions will greatly enhance the quality of our journal and enrich scientific research in the field of nephrology.
Currently, 850 million people worldwide suffer from various kidney diseases, among which acute kidney injury (AKI) is characterized by high mortality and incidence rates. Ischemia is one of the most common causes of AKI, but subsequent maladaptive tissue repair determines the fate of the disease progression to chronic kidney disease (CKD) and even end-stage renal disease (ESRD), which requires kidney transplantation or life-long renal replacement therapy (RRT). In the local renal niche, macrophages undergo differentiation into multiple phenotypes and modify the microenvironment by means of paracrine signaling, thus playing vital roles in mediating renal damage, inflammatory responses, repair processes, and fibrosis. During disease development, it remains unclear how pro-inflammatory and pro-fibrosis macrophages coexist and which signaling cues (e.g., TGF-β, hypoxia-inducible factors) drive their transition from a repair-promoting to a profibrotic phenotype. Therefore, identifying novel and specific targets (such as key regulatory factors, abnormally activated signaling molecules, or specific cell subpopulations) is of great significance for developing drugs that block renal fibrosis and delay or even reverse renal injury.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
(1) Mechanisms of macrophages in renal ischemia-reperfusion injury;
(2) The differential roles of macrophages during renal ischemia-reperfusion injury;
(3) The functional roles of immune cells and their related mechanisms in different stages of AKI;
(4) The cross-talk between immune cells and renal tubular epithelial cells in renal ischemia-reperfusion injury;
(5) The functional roles of renal tubular epithelial cells and their related mechanisms in different stages of renal ischemia-reperfusion injury.
We look forward to receiving your contributions.
Dr. Tao Qiu
Dr. Jiefu Zhu
Dr. Chenglin Wu
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- renal ischemia-reperfusion injury
- acute kidney injury
- renal fibrosis
- chronic kidney disease
- ureteral obstructive nephropathy
- kidney transplantation
- macrophage-myofibroblast transition
- inflammation
- fibroblast activation
- chronic allograft rejection
- potential therapy
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