Search Results (21)

When analyzing road safety across cultural boundaries, driver behavior is a crucial component to consider. Given that driver behavior directly affects both the likelihood of accidents and the severity of their implications, it is crucial to comprehend and analyze it. The present study examined the differences in dangerous, aberrant, and positive driving behaviors across China and Pakistan. The effects of these behaviors on road traffic accidents were also considered. In the study, 1253 respondents completed a questionnaire package consisting of the Dula Dangerous Driving Index (DDDI), Aberrant Driving Behavior Questionnaire (DBQ), Positive Driving Behavior Scale (PDBS), and items related to demographics. Generalized linear models were utilized to compare and determine the factors responsible for dangerous driving behaviors. Mean scores for DBQ and PDBS items were compared. Finally, binary logistic regression models were used to find the factors responsible for traffic accidents across both countries. The results indicated that aggressive and risky driving predicted traffic accidents in both countries, followed by errors and violations, which also predicted traffic accidents significantly. Positive driving behaviors predicted accidents negatively in both samples. Furthermore, it was found that Chinese drivers compared to Pakistani drivers are less aggressive and risk-taking and commit fewer violations and errors while driving. To increase road safety in Pakistan, traffic laws must be strictly enforced uniformly, and violations must result in severe penalties, i.e., demerit points or cancellation of a driver’s license. Programs for road safety awareness and education must be expanded. Employing national culturally concentrated road safety strategies may be a more effective way to encourage safe driving behaviors. Full article

Research interprets antisocial and illegal behavior among juveniles as an expression of needs, as a conscious action, or as an adherence to family, cultural, and social contexts. Professionals and researchers interested in the topic could benefit from reflections and insights on relapse prevention among justice-involved juveniles (JIJs). In light of these considerations, we investigated the criminal conduct of JIJs, identifying their background, individual characteristics, and the educational and rehabilitative programs of the 17 Italian youth detention centers from a sample of 234 JIJs (214 males and 20 females, 14–25 years old). The sample completed the following questionnaires: the high-risk situation checklist, deviant behavior questionnaire (DBQ), and the neighborhood perception questionnaire (NPQ). The study aims to provide a general overview of the justice-involved adolescents and young adults in Italian youth detention centers, focusing on perpetrator profiles, family systems and the quality of life in the Italian youth detention centers. To achieve our goals, we investigated their occupations and education, the perceived quality of life in their neighborhoods, the use of drugs, and the tendency to commit illegal or antisocial behaviors before incarceration. The study also explored the awareness related to the personal perception of the risk factors in relapse, with the aim of stimulating reflections on behavior and crime-related cognitions to promote relapse prevention. We discuss the main findings and future implications. Full article

The reliability and scalability of Linear Wireless Sensor Networks (LWSNs) are limited by the high packet loss probabilities (PLP) experienced by the packets generated at nodes far from the sink node. This is an important limitation in Smart City applications, where timely data collection is critical for decision making. Unfortunately, previous works have not addressed this problem and have only focused on improving the network’s overall performance. In this work, we propose a Distance-Based Queuing (DBQ) scheme that can be incorporated into MAC protocols for LWSNs to improve reliability and scalability without requiring extra local processing or additional signaling at the nodes. The DBQ scheme prioritizes the transmission of relay packets based on their hop distance to the sink node, ensuring that all packets experience the same PLP. To evaluate the effectiveness of our proposal, we developed an analytical model and conducted extensive discrete-event simulations. Our numerical results demonstrate that the DBQ scheme significantly improves the reliability and scalability of the network by achieving the same average PLP and throughput for all nodes, regardless of traffic intensities and network sizes. Full article

Among pollution remediation technologies, advanced oxidation processes (AOPs) are genuinely efficient since they are based on the production of strong, non-selective oxidants, mainly hydroxyl radicals (·OH), by a set of physicochemical methods. The biological counterparts of AOPs, which may be referred to as advanced bio-oxidation processes (ABOPs), have begun to be investigated since the mechanisms of induction of ·OH production in fungi are known. To contribute to the development of ABOPs, advanced oxidation of a wide number of dyes by the white-rot fungus Pleurotus eryngii, via a quinone redox cycling (QRC) process based on Fenton’s reagent formation, has been described for the first time. The fungus was incubated with 2,6-dimethoxy-1,4-benzoquinone (DBQ) and Fe³⁺-oxalate, with and without Mn²⁺, leading to different ·OH production rates, around twice higher with Mn²⁺. Thanks to this process, the degradative capacity of the fungus increased, not only oxidising dyes it was not otherwise able to, but also increasing the decolorization rate of 20 dyes by more than 7 times in Mn²⁺ incubations. In terms of process efficacy, it is noteworthy that with Mn²⁺ the degradation of the dyes reached values of 90–100% in 2–4 h, which are like those described in some AOPs based on the Fenton reaction. Full article

Pain is one of the most prevalent and difficult to manage symptoms in cancer patients, and conventional drugs present a range of adverse reactions. The development of β-cyclodextrins (β-CD) complexes has been used to avoid physicochemical and pharmacological limitations due to the lipophilicity of compounds such as p-Cymene (PC), a monoterpene with antinociceptive effects. Our aim was to obtain, characterize, and measure the effect of the complex of p-cymene and β-cyclodextrin (PC/β-CD) in a cancer pain model. Initially, molecular docking was performed to predict the viability of complex formation. Afterward, PC/β-CD was obtained by slurry complexation, characterized by HPLC and NMR. Finally, PC/β-CD was tested in a Sarcoma 180 (S180)-induced pain model. Molecular docking indicated that the occurrence of interaction between PC and β-CD is favorable. PC/β-CD showed complexation efficiency of 82.61%, and NMR demonstrated PC complexation in the β-CD cavity. In the S180 cancer pain model, PC/β-CD significantly reduced the mechanical hyperalgesia, spontaneous nociception, and nociception induced by non-noxious palpation at the doses tested (p < 0.05) when compared to vehicle differently from free PC (p > 0.05). Therefore, the complexation of PC in β-CD was shown to improve the pharmacological effect of the drug as well as reducing the required dose. Full article

Road traffic collisions are a major issue for public health. Depression is characterized by mental, emotional and executive dysfunction, which may have an impact on driving behaviour. Patients with depression (N = 39) and healthy controls (N = 30) were asked to complete questionnaires and to drive on a driving simulator in different scenarios. Driving simulator data included speed, safety distance from the preceding vehicle and lateral position. Demographic and medical information, insomnia (Athens Insomnia Scale, AIS), sleepiness (Epworth Sleepiness Scale, ESS), fatigue (Fatigue Severity Scale, FSS), symptoms of sleep apnoea (StopBang Questionnaire) and driving (Driver Stress Inventory, DSI and Driver Behaviour Questionnaire, DBQ) were assessed. Gender and age influenced almost all variables. The group of patients with depression did not differ from controls regarding driving behaviour as assessed through questionnaires; on the driving simulator, patients kept a longer safety distance. Subjective fatigue was positively associated with aggression, dislike of driving, hazard monitoring and violations as assessed by questionnaires. ESS and AIS scores were positively associated with keeping a longer safety distance and with Lateral Position Standard Deviation (LPSD), denoting lower ability to keep a stable position. It seems that, although certain symptoms of depression (insomnia, fatigue and somnolence) may affect driving performance, patients drive more carefully eliminating, thus, their impact. Full article

Vehicle cybersecurity is a serious concern, as modern vehicles are vulnerable to cyberattacks. How drivers respond to situations induced by vehicle cyberattacks is safety critical. This paper sought to understand the effect of human drivers’ risky driving style on response behavior to unexpected vehicle cyberattacks. A driving simulator study was conducted wherein 32 participants experienced a series of simulated drives in which unexpected events caused by vehicle cyberattacks were presented. Participants’ response behavior was assessed by their change in velocity after the cybersecurity events occurred, their post-event acceleration, as well as time to first reaction. Risky driving style was portrayed by scores on the Driver Behavior Questionnaire (DBQ) and the Brief Sensation Seeking Scale (BSSS). Half of the participants also received training regarding vehicle cybersecurity before the experiment. Results suggest that when encountering certain cyberattack-induced unexpected events, whether one received training, driving scenario, participants’ gender, DBQ-Violation scores, together with their sensation seeking measured by disinhibition, had a significant impact on their response behavior. Although both the DBQ and sensation seeking have been constantly reported to be linked with risky and aberrant driving behavior, we found that drivers with higher sensation seeking tended to respond to unexpected driving situations induced by vehicle cyberattacks in a less risky and potentially safer manner. This study incorporates not only human factors into the safety research of vehicle cybersecurity, but also builds direct connections between drivers’ risky driving style, which may come from their inherent risk-taking tendency, to response behavior to vehicle cyberattacks. Full article

The drug barbital (Bar) has a strong sedative–hypnotic effect. The intermolecular charge transfer compounds associated with the chemical reactions between Bar and some π acceptors, such as 2,6-dibromoquinone-4-chloroimide (DBQ), tetracyanoquinodimethane (TCNQ), chloranil (CHL), and chloranilic acid (CLA), have been synthesized and isolated in solid state. The synthesized products have the molecular formulas (Bar–DBQ), (Bar–TCNQ), (Bar–CHL), and (Bar–CLA) with 1:1 stoichiometry based on Raman, IR, TG, ¹H NMR, XRD, SEM, and UV-visible analysis techniques. Additionally, the comparative analysis of molecular docking between the donor reactant moiety, Bar, and its four CT complexes was conducted using two neurotransmitter receptors (dopamine and serotonin). The docking results obtained from AutoDockVina software were investigated by a molecular dynamics simulation technique with 100ns run. The molecular mechanisms behind receptor–ligand interactions were also looked into. The DFT computations were conducted using theory at the B3LYP/6-311G++ level. In addition, the HOMO LUMO electronic energy gap and the CT complex’s optimal geometry and molecule electrostatic potential were examined. Full article

Ciclesonide is an inhaled corticosteroid used to treat asthma and has been repurposed as a treatment for mildly ill COVID-19 patients, but its precise mechanism of action is unclear. Herein, we report that ciclesonide blocks the coronavirus-induced production of the cytokines IL-6, IL-8, and MCP-1 by increasing IκBα protein levels and significantly decreasing p65 nuclear translocation. Furthermore, we found that the combination of ciclesonide and dbq33b, a potent tylophorine-based coronavirus inhibitor that affects coronavirus-induced NF-κB activation a little, additively and synergistically decreased coronavirus-induced IL-6, IL-8, and MCP-1 cytokine levels, and synergistically inhibited the replication of both HCoV-OC43 and SARS-CoV-2. Collectively, the combination of ciclesonide and dbq33b merits consideration as a treatment for COVID-19 patients who may otherwise be overwhelmed by high viral loads and an NF-κB-mediated cytokine storm. Full article

The charge transfer interactions between the seproxetine (SRX) donor and π-electron acceptors [picric acid (PA), dinitrobenzene (DNB), p-nitrobenzoic acid (p-NBA), 2,6-dichloroquinone-4-chloroimide (DCQ), 2,6-dibromoquinone-4-chloroimide (DBQ), and 7,7′,8,8′-tetracyanoquinodi methane (TCNQ)] were studied in a liquid medium, and the solid form was isolated and characterized. The spectrophotometric analysis confirmed that the charge–transfer interactions between the electrons of the donor and acceptors were 1:1 (SRX: π-acceptor). To study the comparative interactions between SRX and the other π-electron acceptors, molecular docking calculations were performed between SRX and the charge transfer (CT) complexes against three receptors (serotonin, dopamine, and TrkB kinase receptor). According to molecular docking, the CT complex [(SRX)(TCNQ)] binds with all three receptors more efficiently than SRX alone, and [(SRX)(TCNQ)]-dopamine (CTcD) has the highest binding energy value. The results of AutoDock Vina revealed that the molecular dynamics simulation of the 100 ns run revealed that both the SRX-dopamine and CTcD complexes had a stable conformation; however, the CTcD complex was more stable. The optimized structure of the CT complexes was obtained using density functional theory (B-3LYP/6-311G++) and was compared. Full article

Background: At Indonesian level crossings, traversed by logistics trains, there are still frequent cases of accidents. The overall mishaps in 2020 were 199 cases of accidents at level crossings involving road drivers. Mental load factors affect the behavior of drivers on the road; Methods: this study, field observations and surveys were carried out using the Driver Behavior Question-naire (DBQ) and NASA TLX to measure mental load; Results: The results showed that 62% of drivers had a very high mental load factor. The mental load factors are effort, frustration, and temporal demand. Meanwhile, based on the results of DBQ, the type of behavior that is often carried out is Violation; Conclusions: From the results of field observations, it is also known that there is a significant influence between time and type of vehicle on violations. Thus, it was necessary to improve facilities and systems at level crossings to provide convenience and reduce the volume of transportation going through level crossings to reduce the risk of accidents and violations at level crossings. Full article

Sepsis remains a leading cause of death in ICUs all over the world, with pediatric sepsis accounting for a high percentage of mortality in pediatric ICUs. Its complexity makes it difficult to establish a consensus on genetic biomarkers and therapeutic targets. A promising strategy is to investigate the regulatory mechanisms involved in sepsis progression, but there are few studies regarding gene regulation in sepsis. This work aimed to reconstruct the sepsis regulatory network and identify transcription factors (TFs) driving transcriptional states, which we refer to here as master regulators. We used public gene expression datasets to infer the co-expression network associated with sepsis in a retrospective study. We identified a set of 15 TFs as potential master regulators of pediatric sepsis, which were divided into two main clusters. The first cluster corresponded to TFs with decreased activity in pediatric sepsis, and GATA3 and RORA, as well as other TFs previously implicated in the context of inflammatory response. The second cluster corresponded to TFs with increased activity in pediatric sepsis and was composed of TRIM25, RFX2, and MEF2A, genes not previously described as acting in a coordinated way in pediatric sepsis. Altogether, these results show how a subset of master regulators TF can drive pathological transcriptional states, with implications for sepsis biology and treatment. Full article

Professional drivers play a key role in urban road network safety. It is therefore important to employ safer drivers, also find the problem, and train the existing ones. However, a direct driving test may not be very useful solely because of drivers’ consciousness. This study introduces a latent predictor to expect driving behaviors, by finding the relation between taxi drivers’ psychological characteristics and their driving behaviors. A self-report questionnaire was collected from 245 taxi drivers by which their demographic characteristics, psychological characteristics, and driving behaviors were obtained. The psychological characteristics include instrumental attitude, subjective norm, sensation seeking, aggressive mode, conscientiousness, life satisfaction, premeditation, urgency, and selfishness. Driving behaviors questionnaire (DBQ) provides information regarding drivers’ violations, aggressive violations, errors, and lapses. The standard linear regression model is used to determine the relationship between driving behavior and psychological characteristics of drivers. The findings show that social anxiety and selfishness are the best predictors of the violations; aggressive mode is a significant predictor of the aggressive violations; urgency has a perfect impact on the errors; and finally, life satisfaction, sensation seeking, conscientiousness, age, and urgency are the best predictors of the lapses. Full article

Driver behavior has been considered as the most critical and uncertain criteria in the study of traffic safety issues. Driver behavior identification and categorization by using the Fuzzy Analytic Hierarchy Process (FAHP) can overcome the uncertainty of driver behavior by capturing the ambiguity of driver thinking style. The main goal of this paper is to examine the significant driver behavior criteria that influence traffic safety for different traffic cultures such as Hungary, Turkey, Pakistan and China. The study utilized the FAHP framework to compare and quantify the driver behavior criteria designed on a three-level hierarchical structure. The FAHP procedure computed the weight factors and ranked the significant driver behavior criteria based on pairwise comparisons (PCs) of driver’s responses on the Driver Behavior Questionnaire (DBQ). The study results observed “violations” as the most significant driver behavior criteria for level 1 by all nominated regions except Hungary. While for level 2, “aggressive violations” is observed as the most significant driver behavior criteria by all regions except Turkey. Moreover, for level 3, Hungary and Turkey drivers evaluated the “drive with alcohol use” as the most significant driver behavior criteria. While Pakistan and China drivers evaluated the “fail to yield pedestrian” as the most significant driver behavior criteria. Finally, Kendall’s agreement test was performed to measure the agreement degree between observed groups for each level in a hierarchical structure. The methodology applied can be easily transferable to other study areas and our results in this study can be helpful for the drivers of each region to focus on highlighted significant driver behavior criteria to reduce fatal and seriously injured traffic accidents. Full article