Chemokines are key proteins that regulate cell migration and immune responses and are essential for modulating the tumor microenvironment. Despite their close association with colon cancer, the expression patterns, prognosis, immunity, and specific r...
C10orf90, a tumor suppressor, can inhibit the occurrence and development of tumors. Therefore, we investigated the gene function of C10orf90 in various tumors using multiple pan-cancer datasets. Pan-cancer analysis results reveal that the expression...
Colon adenocarcinoma (COAD) demonstrates significant clinical heterogeneity across disease stages, gender, and age groups, posing challenges for unified therapeutic strategies. This study establishes a multi-dimensional stratification framework throu...
Mounting evidence from large-scale association studies has identified transmembrane BAX inhibitor motif-containing 1 (TMBIM1) as a promising candidate gene in colorectal cancer (CRC) pathogenesis. Our clinical analysis confirmed this association, dem...
Sialylation of glycoproteins is modified by distinct sialyltransferases such as ST3Gal, ST6Gal, ST6GalNAc, or ST8SIA with α2,3-, α2,6-, or α2,8-linkages. Alteration of these sialyltransferases causing aberrant sialylation is associa...
Colon adenocarcinoma (COAD) remains an important cause of cancer-related mortality worldwide. Epithelial–mesenchymal transition (EMT) is a key mechanism, promoting not only the invasive or metastatic phenotype but also resistance to therapy. Using bi...
Background/Objectives: Colon adenocarcinoma (COAD), the most prevalent form of colorectal cancer, remains a leading cause of cancer-related mortality. Advances in various treatments for COAD have significantly improved treatment outcomes. However, th...
(1) Ferroptosis is a type of cellular death caused by lipid-dependent iron peroxide, which plays a major role in cancer. Long noncoding RNAs (lncRNAs) are increasingly recognized as key regulating substances in ferroptosis; (2) RNA sequencing express...
Colon adenocarcinoma (COAD) is the most common type of gastrointestinal cancer and is still the third leading cause of cancer-related mortality worldwide. Accurate screening tools for early diagnosis and prediction of prognosis and precision treatmen...
The epithelial-mesenchymal transition (EMT) is an important process during metastasis in various tumors, including colorectal cancer (CRC). Thus, the study of its characteristics and related genes is of great significance for CRC treatment. In this s...
Background/Objectives: CD318 (also known as CDCP1) is a transmembrane protein that is overexpressed in many cancers and contributes to tumor progression, invasion, and metastasis by activating SRC family kinases through phosphorylation. Emerging evid...
3 September 2022
Despite the great progress in its early diagnosis and treatment, colon adenocarcinoma (COAD) is still poses important issues to clinical management. Therefore, the identification of novel biomarkers or therapeutic targets for this disease is importan...
Globally, colon adenocarcinoma (COAD) is one of the most frequent types of malignant tumors. About 40~50% of patients with advanced colon adenocarcinoma die from recurrence and metastasis. Long non-coding RNAs (lncRNAs) and 5-methylcytosine (5mC) reg...
Colon adenocarcinoma (COAD) is a frequently occurring and lethal cancer. Cuproptosis is an emerging type of cell death, and the underlying pathways involved in this process in COAD remain poorly understood. Transcriptomic and clinical data for COAD p...
Dietary patterns (DPs) explore one’s whole diet and can be used to investigate associations between dietary intake and obesity. This study investigates the DPs of community-dwelling adults (65–74 years, 36% male) and associations with bod...
Optimal dietary intakes are essential for the health of both breastfeeding women and their infants. Few recent dietary intake data exist concerning this group in New Zealand. This study aimed to determine the adherence to national dietary recommendat...
An optimal nutrient intake is required for the health of both breastfeeding women and their infants. This study aims to assess the nutrient adequacy of breastfeeding women living in New Zealand. A cohort of breastfeeding women residing in the Palmers...
BCG vaccine has been used for 100 years to prevent tuberculosis. Not all countries, including the United States, adopted the initial World Health Organization recommendation to use BCG. Moreover, many Western countries that had routinely used BCG hav...
The Bacillus Calmette-Guérin (BCG) vaccine has been used for over one hundred years to protect against the most lethal infectious agent in human history, tuberculosis. Over four billion BCG doses have been given and, worldwide, most newborns r...
Professor John Hermon-Taylor recently passed away on 16 October 2021 [...]
Selenium is essential for human health because it produces selenoproteins, which have antioxidant and anti-inflammatory roles. Recently published data have suggested high selenium status (high hair selenium concentration) improved outcomes in patient...
Serious games that integrate educational content with engaging gameplay mechanics hold promise for reducing cognitive load and increasing student motivation in STEM and health science education. This preliminary study presents the development and eva...
Medical education requires learners to integrate complex basic science knowledge with clinical reasoning, with endocrinology posing particular challenges due to nonlinear feedback and system-level interactions. Although serious games may enhance lear...
Bromoepiandrosterone (BEA), a synthetic analog of the adrenal steroid DHEA, holds promise as a host-directed therapy for both active and latent tuberculosis (TB). Unlike DHEA, BEA lacks hormonal side effects yet retains potent immunomodulatory activi...
In the original publication [...]
Low dietary fibre intake has been associated with poorer health outcomes, therefore having the ability to be able to quickly assess an individual’s dietary fibre intake would prove useful in clinical practice and for research purposes. Current dietar...
Iodine is an essential micronutrient required for thyroid function, and is essential during pregnancy for growth and development. Manatū Hauora (MoH) recommends an iodine supplement of 150 µg/day during pregnancy and breastfeeding. To redu...
Clinical and histological similarities between sarcoidosis and tuberculosis have driven repeated investigations looking for a mycobacterial cause of sarcoidosis. Over 50 years ago, “anonymous mycobacteria” were suggested to have a role in...
Plant metabolites that have shown activity against bacteria and/or environmental fungi represent valuable leads for the identification and development of novel drugs against clinically important human pathogenic fungi. Plants from the genus Eremophil...
In women, the menopausal transition is characterized by acid-base imbalance, estrogen deficiency and rapid bone loss. Research into nutritional factors that influence bone health is therefore necessary. In this study, the relationship between nutrien...
31 August 2019
Physical activity plays an important role in the maintenance of bone health from childhood through adulthood. This study aimed to explore the associations between self-reported physical activity (PA), activity energy expenditure (AEE), heel ultrasoun...
Increasingly, Johne’s disease of ruminants and human Crohn’s disease are regarded as the same infectious disease: paratuberculosis. Mycobacterium avium ss. paratuberculosis (MAP) is the cause of Johne’s and is the most commonly link...
Young adulthood is an important stage in the accrual of bone mass. Young women are often unaware of the need, and how to optimize modifiable risk factors, particularly intake of nutrients associated with good bone health. In this study, an accessible...
Introduction: The gut microbiome, the totality of micro-organisms and their collective genetic makeup plays a significant role in bone health. [...]
Dietary patterns analyse how combinations of foods are eaten. Little is known about the dietary
patterns of older adults living in New Zealand [...]
Dietary patterns examine how combinations of foods are eaten. Little is known about the dietary patterns of older adults living in New Zealand, and how these dietary patterns are associated with various socio-demographic factors. [...]
We would like to thank Moran and Sanchez Fernandez [...]
The authors would like to make the following correction to our recent publication [...]
Bacille Calmette–Guerin (BCG) vaccination is widely practiced around the world to protect against the mycobacterial infection tuberculosis. BCG is also effective against the pathogenic mycobacteria that cause leprosy and Buruli’s ulcer. B...
Bariatric surgery is an increasingly utilised method of establishing weight loss and resolving obesity-related comorbidities. [...]
Iron deficiency (ID) is one of the most common nutritional disorders, even in developed
countries [...]
Objective: Indigenous food systems of Melanesia contain vast genetic, biological and culture diversity. [...]
New Zealand (NZ) has one of the highest rates of Inflammatory Bowel Disease (IBD), a collective term for three chronic inflammatory conditions that affect the gastrointestinal tract. [...]
Aggressive cancer cells are characterized by their capacity to proliferate indefinitely and to propagate a heterogeneous tumor comprised of subpopulations with varying degrees of metastatic propensity and drug resistance properties. Particularly daun...
Dietary patterns analyse combinations of foods eaten. This cross-sectional study identified dietary patterns and their nutrients. Associations between dietary patterns and socio-demographic and lifestyle factors were examined in older New Zealand adu...
Over the last century, nutrition research and public health in New Zealand have been inspired by Dr Muriel Bell, the first and only state nutritionist. Some of her nutritional concerns remain pertinent today. However, the nutritional landscape is tra...
Indigenous Solomon Islanders, like many living in Pacific Small Island Developing States (PSIDS), are currently experiencing the global syndemic—the combined threat of obesity, undernutrition, and climate change. This mixed-method study aimed t...
Background: Cytokines, chemokines and CRP are known inflammatory markers. [...]
Background: It is not feasible in large population studies to measure bone density using Dual Xray Absorptiometry (DXA) due to cost and accessibility [...]
Background: Critical determinants of bone health are genetics, diet and physical activity.
Women face challenges to the modifiable risk factors [...]
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