Multifaceted Implications of Non-Coding RNAs in Cancer: From Biomarker Discovery to Therapeutic Target
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "RNA".
Deadline for manuscript submissions: 20 June 2025 | Viewed by 1907
Special Issue Editors
Interests: apoptosis; cancer; drug repositioning; metastasis; non-coding RNA; peptide based drug discovery; translational research; WNT signaling
Special Issues, Collections and Topics in MDPI journals
Interests: phytochemicals; apoptosis; chemoprevention; nano-formulation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nearly 60% of human cells’ transcriptome is made up of non-coding RNAs (ncRNAs), which play a role in controlling cellular pathways and functions that are related to both health and illness. Important cellular programs are often controlled by a highly complicated regulatory network involving multiple interacting ncRNAs. The disruption of these processes can significantly alter the cell’s fate, which aids in the development of cancer. Recent developments in next-generation sequencing (NGS) and single-cell sequencing technologies have further verified this notion. Accumulating evidence highlights the interaction between traditional ncRNAs, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), through binding sites. In competitive endogenous RNA (ceRNA) mechanisms, lncRNAs absorb miRNAs, suppressing their regulatory effects on mRNAs. Additionally, other ncRNA species, including vault RNAs (vtRNAs), PIWI-interacting RNAs (piRNAs), and small nucleolar RNAs (snoRNAs), have been linked to controlling gene expression. miRNAs and piRNAs, which are derived from snoRNAs, function in similar regulatory pathways.
This Special Issue welcomes original research, reviews, and systematic reviews that focus on recent advances related to the function, mechanisms, method of interactions, clinical applications, biomarker potential, and therapeutic implications of ncRNA in cancer.
Dr. Vikas Yadav
Dr. Hardeep Singh Tuli
Guest Editors
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Keywords
- non-coding RNA
- miRNA
- lncRNA
- circRNA
- piRNA
- snoRNA
- cancer biomarker
- cancer therapy
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