Search Results (64)

TXS 0506+056 is a blazar associated with neutrino events. The study on its variation mechanics and periodicity analysis is meaningful to understand other BL Lac objects. The local cross-correlation function (LCCF) analysis presents a 3$\sigma$ correlation in both the $\gamma$-ray versus optical and optical versus radio light curves. The time lag analysis suggests that the optical and $\gamma$-ray band share the same emission region, located upstream of the radio band in the jet. We use both the weighted wavelet Z-transform and generalized Lomb–Scargle methods to analyze the periodicity. We find two plausible quasi-periodic oscillations (QPOs) at ${506}_{-56}^{+133}$ days and ${175}_{-7}^{+15}$ days for the light curve of the optical band. For the $\gamma$-ray band, we find that the spectrum varies with the softer when brighter (SWB) trend, which could be explained naturally if a stable very high energy component exists. For the optical band, TXS 0506+056 exhibits a harder when brighter (HWB) trend. We discover a trend transition from HWB to SWB in the X-ray band, which could be modeled by the shift in peak frequency assuming that the X-ray emission is composed of the synchrotron and the inverse Compton (IC) components. The flux correlations of $\gamma$-ray and optical bands behave anomalously during the period of neutrino events, indicating that there are possible other hadronic components associated with neutrino. Full article

In this work, we present updated models of the spectral energy distributions (SEDs) for two high-frequency-peaked BL Lac objects (HBLs), that is, 1ES 0414+009 and 1ES 1959+650. The hard gamma-ray spectra observed during their flaring states suggest the presence of an additional emission component beyond the standard synchrotron self-Compton (SSC) scenario. We explore the possibility that this hard gamma-ray emission arises from inverse Compton (IC) scattering by Bethe–Heitler pairs produced along the line of sight, pointing to a more complex high-energy emission mechanism in these sources. Full article

Light alcohol consumption (LAC) may reduce the incidence and improve the prognosis of ischemic stroke. Recently, we found that LAC promotes cerebral angiogenesis and inhibits early inflammation following ischemic stroke. In addition, LAC upregulates lipocalin-type prostaglandin D2 synthase (L-PGDS) in the brain. Thus, we determined the role of endothelial L-PGDS in the protective effect of LAC. In in vitro studies, chronic exposure to low-concentration ethanol upregulated L-PGDS and significantly increased the proliferation in cultured C57BL/6J mouse brain microvascular endothelial cells (MBMVECs). AT-56, a selective L-PGDS inhibitor, abolished low-concentration ethanol exposure-induced proliferation. In in vivo studies, 8-week gavage feeding with 0.7 g/kg/day ethanol, defined as LAC, promoted cerebral angiogenesis under physiological conditions and following ischemic stroke in male C57BL/6J mice. In addition, LAC inhibited the post-ischemic expression of adhesion molecules, neutrophil infiltration, and microglial activation. AT-56 and endothelial cell (EC)-specific L-PGDS conditional knockout did not significantly alter cerebral angiogenesis and post-ischemic inflammation in the control mice but eliminated the pro-angiogenic and anti-inflammatory effects of LAC. Furthermore, EC-specific L-PGDS conditional knockout alleviated the neuroprotective effect of LAC against cerebral ischemia/reperfusion injury. These findings suggest that endothelial L-PGDS may be crucial in the pro-angiogenic and anti-inflammatory effects of LAC against ischemic stroke. Full article

Active galactic nuclei (AGNs) exhibit significant luminosity variations across the entire electromagnetic spectrum, with timescales ranging from hours to years. Studying the optical variability of AGNs provides crucial insights into their physical properties. In this study, we explore the intra-night optical variability (INOV) of AGNs using data from the TESS satellite’s all-sky survey. We derive differential light curves for a sample of 56 AGNs from 30-min cadence TESS full-frame images. Our analysis confirms that BL Lac objects typically exhibit stronger INOV compared to quasars, which generally show weaker variability. The duty cycle for INOV with an amplitude greater than 3% is approximately $4\pm 0.7\%$ for quasars and $22\pm 5\%$ for BL Lac objects. For INOV with an amplitude exceeding 10%, the corresponding duty cycle decreases to about $0.5\pm 0.3\%$ and $5\pm 2\%$, respectively. Furthermore, we identify a potential linear-log relationship between the duty cycle and the INOV amplitude, based on results from this study and previous findings, particularly from the ARIES program. Full article

Background/Objectives: Neutrophils have recently gained significant attention due to their heterogeneity in tumor settings. The gene expression profiles of neutrophils from different tumor types are of great interest. Murine splenic neutrophils reflect the immune status of the organism and could be a source of tumor-associated neutrophils in tumor-bearing mice. However, information about appropriate reference genes for RT-qPCR analysis of murine neutrophils in the literature is lacking. The aim of this study was to identify stably expressed reference genes in murine splenic neutrophils. Methods: Bone marrow- and spleen-derived neutrophils were isolated from healthy C57Bl/6 and CBA/LacSto mice. Spleen-derived neutrophils were isolated from mice with Lewis lung carcinoma (LLC) and drug-resistant lymphosarcoma (RLS₄₀). RNA was isolated and used for RT-qPCR analysis of 10 selected reference genes. Analysis of reference gene stability was performed using four different algorithms (BestKeeper, NormFinder, geNorm, ΔCt method), and comprehensive ranking was constructed using RefFinder. Results: The Ct values for the reference genes were in the range of 16.73–30.83 with the highest expression levels observed for B2m and the lowest for Sdha. Differences in the stability ranking performed by different algorithms were observed; however, the overall ranking of the studied reference genes was as follows, from most to least stably expressed: Tbp, Hprt1, Ywhaz, B2m, Gapdh, Actb, Sdha, Eef2, Rack1, and Rpl13a. Using Tbp or Rpl13a for RT-qPCR data normalization significantly affected the interpretation of target gene expression. Conclusions: Tbp and Hprt1 are recommended reference genes for murine splenic neutrophils regardless of their activation status. Full article

We present a comprehensive investigation of mid-infrared (MIR) flux variability at 3.4 μm (W1 band) for a large sample of 3816 blazars, using Wide-field Infrared Survey Explorer (WISE) data through December 2022. The sample consists of 1740 flat-spectrum radio quasars (FSRQs), 1281 BL Lac objects (BL Lacs), and 795 blazars of uncertain type (BCUs). Considering Fermi Large Area Telescope detection, we classify 2331 as Fermi blazars and 1485 as non-Fermi blazars. Additionally, based on synchrotron peak frequency, the sample includes 2264 low-synchrotron peaked (LSP), 512 intermediate-synchrotron peaked (ISP), and 655 high-synchrotron peaked (HSP) sources. We conduct a comparative analysis of short- and long-term intrinsic variability amplitude (${\sigma }_m$), duty cycle (DC), and ensemble structure function (ESF) across blazar subclasses. The median short-term ${\sigma }_m$ values were $0.{181}_{-0.106}^{+0.153}$, $0.{104}_{-0.054}^{+0.101}$, $0.{135}_{-0.076}^{+0.154}$, $0.{173}_{-0.097}^{+0.158}$, $0.{177}_{-0.100}^{+0.156}$, $0.{096}_{-0.050}^{+0.109}$, and $0.{106}_{-0.058}^{+0.100}$ mag for FSRQs, BL Lacs, Fermi blazars, non-Fermi blazars, LSPs, ISPs, and HSPs, respectively. The median DC values were $71.{03}_{-22.48}^{+14.17}$, $64.{02}_{-22.86}^{+16.97}$, $68.{96}_{-25.52}^{+15.66}$, $69.{40}_{-22.17}^{+14.42}$, $71.{24}_{-21.36}^{+14.25}$, $63.{03}_{-33.19}^{+16.93}$, and $64.{63}_{-24.26}^{+15.88}$ percent for the same subclasses. The median long-term ${\sigma }_m$ values were $0.{137}_{-0.105}^{+0.408}$, $0.{171}_{-0.132}^{+0.206}$, $0.{282}_{-0.184}^{+0.332}$, $0.{071}_{-0.062}^{+0.143}$, $0.{218}_{-0.174}^{+0.386}$, $0.{173}_{-0.132}^{+0.208}$, and $0.{101}_{-0.077}^{+0.161}$ mag for the same subclasses, respectively. Our results reveal significant differences in 3.4 $\mathsf{\mu }$m flux variability among these subclasses. FSRQs (LSPs) exhibit larger ${\sigma }_m$ and DC values compared to BL Lacs (ISPs and HSPs). Fermi blazars display higher long-term ${\sigma }_m$ but lower short-term ${\sigma }_m$ relative to non-Fermi blazars, while DC distributions between the two groups are similar. ESF analysis further confirms the greater variability of FSRQs, LSPs, and Fermi blazars across a wide range of time scales compared to BL Lacs, ISPs/HSPs, and non-Fermi blazars. These findings highlight a close correlation between MIR variability and blazar properties, providing valuable insights into the underlying physical mechanisms responsible for their emission. Full article

We utilized a sample from the Fermi-LAT 14-year Source Catalog by adjusting the flux detection threshold, enabling us to derive the intrinsic source count distribution $dN/d{F}_{25}$ of extragalactic blazars using nonparametric, unbinned methods developed by Efron and Petrosian and Lynden-Bell. Subsequently, we evaluated the contribution of blazars to the extragalactic gamma-ray background. Our findings are summarized as follows: (1) There is no significant correlation between flux and spectral index values among blazars and their subclasses FSRQs and BL Lacs. (2) The intrinsic differential distributions of flux values exhibit a broken-power-law form, with parameters that closely match previous findings. The intrinsic photon index distributions are well described by a Gaussian form for FSRQs and BL Lacs individually, while a dual-Gaussian model provides a more appropriate fit for blazars as a whole. (3) Blazars contribute 34.5% to the extragalactic gamma-ray background and 16.8% to the extragalactic diffuse gamma-ray background. When examined separately, FSRQs and BL Lacs contribute 19.6% and 13% to the extragalactic gamma-ray background, respectively. Full article

The BL Lacertae (BL Lac) object OJ 287 underwent an intense X-ray activity phase, exhibiting its brightest recorded X-ray flare in 2016–2017, characterized by much softer X-ray spectra and, concurrently, its first-ever recorded very-high-energy (VHE) emission (100–560 GeV), reported by the VERITAS observatory. Broadband spectral energy distribution reveals a new jet emission component similar to high-synchrotron-peaked BL Lac objects, thereby implying the soft X-ray spectrum for the synchrotron emission. Using the advantage of simultaneous X-ray and VHE spectral information, as well as the source being a low-synchrotron-peaked BL Lac object, we systematically explored the extragalactic background light (EBL) spectrum by demanding that the VHE spectrum cannot be harder than the X-ray spectrum. We used three different phenomenological forms of the EBL spectral shape (power-law, parabola, and polynomial) motivated by current constraints on the EBL with the Bayesian Monte Carlo approach to infer the credible EBL range. Our study favors an almost flat power-law spectral shape and is consistent with previous studies. The other spectral forms capable of capturing curvature though result in a better statistics value; the improvement is statistically insignificant given the additional parameters. Full article

We present the results of a comparison between different methods to estimate the power of relativistic jets from active galactic nuclei (AGN). We selected a sample of 32 objects (21 flat-spectrum radio quasars, 7 BL Lacertae objects, 2 misaligned AGN, and 2 changing-look AGN) from the very large baseline array (VLBA) observations at 43 GHz of the Boston University blazar program. We then calculated the total, radiative, and kinetic jet power from both radio and high-energy gamma-ray observations, and compared the values. We found an excellent agreement between the radiative power calculated by using the Blandford and Königl model with 37 or 43 GHz data and the values derived from the high-energy $\gamma$-ray luminosity. The agreement is still acceptable if 15 GHz data are used, although with a larger dispersion, but it improves if we use a constant fraction of the $\gamma$-ray luminosity. We found a good agreement also for the kinetic power calculated with the Blandford and Königl model with 15 GHz data and the value from the extended radio emission. We also propose some easy-to-use equations to estimate the jet power. Full article

Seasonal affective disorder is characterized by depression during fall/winter as a result of shorter daylight. Catalepsy is a syndrome of some grave mental diseases. Both the neurotransmitter serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) are involved in the pathophysiological mechanisms underlying catalepsy and depressive disorders. The aim was to compare the response of behavior and brain plasticity to photoperiod alterations in catalepsy-resistant C57BL/6J and catalepsy-prone CBA/Lac male mice. Mice of both strains were exposed for six weeks to standard-day (14 h light/10 h darkness) or short-day (4 h light/20 h darkness) conditions. Short photoperiod increased depressive-like behavior in both strains. Only treated CBA/Lac mice demonstrated increased cataleptic immobility, decreased brain 5-HT level, and the expression of Tph2 gene encoding the key enzyme for 5-HT biosynthesis. Mice of both strains maintained under short-day conditions, compared to those under standard-day conditions, showed a region-specific decrease in the brain transcription of the Htr1a, Htr4, and Htr7 genes. After a short photoperiod exposure, the mRNA levels of the BDNF-related genes were reduced in CBA/Lac mice and were increased in the C57BL/6J mice. Thus, the predisposition to catalepsy considerably influences the photoperiodic changes in neuroplasticity, wherein both C57BL/6J and CBA/Lac mice can serve as a powerful tool for investigating the link between seasons and mood. Full article

Numerous studies suggest that high-energy (HE) neutrinos and ultra-high-energy (UHE) cosmic rays could originate from extremely high-synchrotron peaked (EHSP) BL Lacs, which have been identified as effective particle accelerators. Due to the discovery of HE-neutrinos by the IceCube telescope, these hypotheses may shortly have the opportunity to be tested. In this work, we use a two-zone leptohadronic model to explain the spatial coincidence of three EHSP BL Lac: 1RXS J09462.5+010459, 1ES 1101-232, and 3HSP J095507.9+355101 with the arrival of track-like neutrinos. Our results for 1RXS J09462.5+010459 and 1ES 1101-232 indicate that the model accurately describes the electromagnetic emission and neutrino events without increasing the fluxes in the measured bands. In addition, the X-ray flaring state of 3HSP J095507.9+355101 can be explained by our model, but the measured ultraviolet flux during the neutrino arrival time window cannot be explained. For all cases, the broadband emission and neutrino arrival are better described by hard proton distributions ≈1.5. Finally, the proton luminosity required to explain the neutrino fluxes is slightly higher than the Eddington limit with a photopion efficiency of ≈0.1 for non-flaring state cases. On the other hand, for the flaring state of 3HSP J095507.9+355101, the proton luminosity must be higher than the Eddington limit at least by one order of magnitude, even if the photopion efficiency reaches unity. Full article

BL Lac objects are active galactic nuclei notable for a beamed nonthermal radiation, which is generated in one of the relativistic jets forming a small angle to the observer’s line-of-sight. The broadband spectra of BL Lacs show a two-component spectral energy distribution (SED). High-energy-peaked BL Lacs (HBLs) exhibit their lower-energy (synchrotron) peaks at UV to X-ray frequencies. The origin of the higher-energy SED component, representing the $\gamma$-ray range in HBLs, is still controversial and different emission scenarios (one- and multi-zone synchrotron self-Compton, hadronic etc.) are proposed. In $\gamma$-rays, HBLs show a complex flaring behavior with rapid and large-amplitude TeV-band variations on timescales down to a few minutes. This review presents a detailed characterization of the hypothetical emission mechanisms which could contribute to the $\gamma$-ray emission, their application to the nearby TeV-detected HBLs, successes in the broadband SED modeling and difficulties in the interpretation of the observational data. I also overview the unstable processes to be responsible for the observed $\gamma$-ray variability and particle energization up to millions of Lorentz factors (relativistic shocks, magnetic reconnection, turbulence and jet-star interaction). Finally, the future prospects for solving the persisting problems by means of the dedicated gamma-ray observations and sophisticated simulations are also addressed. Full article

In this work, we study the parameter space of neutrino-emitting BL Lacs under the framework of the one-zone lepto-hadronic model. We show that constraints on the model come from various aspects of observations such as the variability timescale of blazar flares, gamma ray opacity and the spectral energy distribution of electromagnetic emission, as well as the inferred neutrino emissivity of the blazar. We apply our method to two potential neutrino sources, i.e., TXS 0506+056 and PKS 0735+178, which are BL Lacs. Then, we explore and summarize the allowed range of parameters such as the bulk Lorentz factor and the blob radius under different distributions of injected protons. We find that the parameter space that is available to explain the BL Lac–neutrino association is sensitive to the proton distribution, and usually, an injected proton luminosity significantly exceeding the Eddington luminosity is required for both sources. Our results suggest that the simple lepto-hadronic one-zone model may not be a reasonable interpretation for BL Lac–neutrino associations. Full article

Ischemic stroke is one of the leading causes of death and disability worldwide. Neurogenesis plays a crucial role in postischemic functional recovery. Alcohol dose-dependently affects the prognosis of ischemic stroke. We investigated the impact of light alcohol consumption (LAC) on neurogenesis under physiological conditions and following ischemic stroke. C57BL/6J mice (three months old) were fed with 0.7 g/kg/day ethanol (designed as LAC) or volume-matched water (designed as control) daily for eight weeks. To evaluate neurogenesis, the numbers of 5-bromo-2-deoxyuridine (BrdU)⁺/doublecortin (DCX)⁺ and BrdU⁺/NeuN⁺ neurons were assessed in the subventricular zone (SVZ), dentate gyrus (DG), ischemic cortex, and ischemic striatum. The locomotor activity was determined by the accelerating rotarod and open field tests. LAC significantly increased BrdU⁺/DCX⁺ and BrdU⁺/NeuN⁺ cells in the SVZ under physiological conditions. Ischemic stroke dramatically increased BrdU⁺/DCX⁺ and BrdU⁺/NeuN⁺ cells in the DG, SVZ, ischemic cortex, and ischemic striatum. The increase in BrdU⁺/DCX⁺ cells was significantly greater in LAC mice compared to the control mice. In addition, LAC significantly increased BrdU⁺/NeuN⁺ cells by about three folds in the DG, SVZ, and ischemic cortex. Furthermore, LAC reduced ischemic brain damage and improved locomotor activity. Therefore, LAC may protect the brain against ischemic stroke by promoting neurogenesis. Full article

Mrk 501 is one of the most prominent TeV-emitting blazars and belongs to the class of high synchrotron peaked (HSP) blazars. The Doppler factors derived from the jet kinematics are much too low to provide sufficient beaming for the detected high-energy emission (the so-called Lorentz factor crisis). This BL Lac object is also a prime example of a misaligned AGN with an approximately 90${}^{\circ }$ difference in orientation between the inner parsec-scale jet and the kpc-scale jet structure. We have performed a detailed analysis of the pc-scale jet kinematics, based on 23 years of VLBA observations (at 15 GHz) and find, in addition to robustly consolidating the already claimed stationary jet features and a hinted absence of component ejections, a significant drift of the outer nuclear jet. The two outermost jet features move with somewhat higher but still subluminal speeds. Albeit, they move orthogonally to the inner jet, which itself does not partake in the drifting motion. The effect of this intriguing kinematics is that the jet appears strongly curved at first (1995) but then appears to straighten out (2018). To our knowledge, this is the first time that the orthogonal swing of just the outer part of a nuclear jet has been observed. We discuss the possible physical nature of this turning maneuver. In addition, we report evidence for jet emission, which most likely originates in a spine–sheath structure. Full article