18 Results Found

Advanced Search

Select all

Results per page

Select all

Article

16 Citations

4,143 Views

18 Pages

Retinal Vascular Study Using OCTA in Subjects at High Genetic Risk of Developing Alzheimer’s Disease and Cardiovascular Risk Factors

Inés López-Cuenca,
Elena Salobrar-García,
Lidia Sánchez-Puebla,
Eva Espejel,
Lucía García del Arco,
Pilar Rojas,
Lorena Elvira-Hurtado,
José A. Fernández-Albarral,
Federico Ramírez-Toraño and
Ana I. Ramírez
+ 4 authors

J. Clin. Med.2022, 11(11), 3248;https://doi.org/10.3390/jcm11113248

6 June 2022

In 103 subjects with a high genetic risk of developing Alzheimer’s disease (AD), family history (FH) of AD and ApoE ɛ4 characterization (ApoE ɛ4) were analyzed for changes in the retinal vascular network by OCTA (optical coherence tom...

Full Article

Article

5 Citations

3,547 Views

15 Pages

Characterization of Retinal Drusen in Subjects at High Genetic Risk of Developing Sporadic Alzheimer’s Disease: An Exploratory Analysis

Inés López-Cuenca,
Elena Salobrar-García,
Inés Gil-Salgado,
Lidia Sánchez-Puebla,
Lorena Elvira-Hurtado,
José A. Fernández-Albarral,
Federico Ramírez-Toraño,
Ana Barabash,
Jaisalmer de Frutos-Lucas and
Rosa de Hoz
+ 3 authors

J. Pers. Med.2022, 12(5), 847;https://doi.org/10.3390/jpm12050847

23 May 2022

Having a family history (FH+) of Alzheimer’s disease (AD) and being a carrier of at least one ɛ4 allele of the ApoE gene are two of the main risk factors for the development of AD. AD and age-related macular degeneration (AMD) share one of...

Full Article

Article

30 Citations

6,784 Views

13 Pages

Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer’s Disease: An OCT Study

Inés López-Cuenca,
Rosa de Hoz,
Elena Salobrar-García,
Lorena Elvira-Hurtado,
Pilar Rojas,
José A. Fernández-Albarral,
Ana Barabash,
Juan J. Salazar,
Ana I. Ramírez and
José M. Ramírez

J. Clin. Med.2020, 9(6), 1728;https://doi.org/10.3390/jcm9061728

3 June 2020

In this case control study, we examined the retinal thickness of the different layers in the macular region and peripapillary retinal nerve fiber layer (RNFL) with optical coherence tomography (OCT) in healthy cognitive subjects (from 51 to 74 years...

Full Article

Article

10 Citations

4,172 Views

14 Pages

Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer’s Disease

Inés López-Cuenca,
Rosa de Hoz,
Celia Alcántara-Rey,
Elena Salobrar-García,
Lorena Elvira-Hurtado,
José A. Fernández-Albarral,
Ana Barabash,
Federico Ramírez-Toraño,
Jaisalmer de Frutos-Lucas and
José M. Ramírez
+ 2 authors

Biomedicines2021, 9(6), 638;https://doi.org/10.3390/biomedicines9060638

2 June 2021

A family history (FH+) of Alzheimer’s disease (AD) and ɛ4 allele of the ApoE gene are the main genetic risk factors for developing AD, whereas ɛ4 allele plays a protective role in age-related macular degeneration. Ocular vascular changes have been re...

Full Article

Article

9 Citations

3,510 Views

9 Pages

Association between Hypothyroidism Onset and Alzheimer Disease Onset in Adults with Down Syndrome

Florence Lai,
Nathaniel D. Mercaldo,
Cassandra M. Wang,
Micaela S. Hersch,
Giovi G. Hersch and
Herminia Diana Rosas

Brain Sci.2021, 11(9), 1223;https://doi.org/10.3390/brainsci11091223

16 September 2021

Adults with Down syndrome (DS) have an exceptionally high frequency of Alzheimer disease (AD) with a wide variability in onset, from 40 to 70 years of age. Equally prevalent in DS is hypothyroidism. In this study, we sought to quantify the relationsh...

Full Article

Article

2,011 Views

10 Pages

APOE Polymorphism Is Associated with Changes in the Kynurenine Pathway

Per G. Farup,
Helge Rootwelt and
Knut Hestad

Genes2023, 14(10), 1955;https://doi.org/10.3390/genes14101955

18 October 2023

Background: APOE polymorphism and the Kynurenine pathway (KP) are associated with many disorders, but little is known about associations between APOE polymorphism and the KP. This study explored the associations between the KP and APOE polymorphism i...

Full Article

Article

76 Citations

15,494 Views

11 Pages

Association of Strawberries and Anthocyanidin Intake with Alzheimer’s Dementia Risk

Puja Agarwal,
Thomas M Holland,
Yamin Wang,
David A Bennett and
Martha Clare Morris

Nutrients2019, 11(12), 3060;https://doi.org/10.3390/nu11123060

14 December 2019

Background: Strawberries have been identified to have antioxidant and anti-inflammatory properties that improve neuronal function and cognition, mostly in animal studies. It is unknown if the consumption of strawberries or related bioactives may redu...

Full Article

Article

7 Citations

2,947 Views

18 Pages

Apolipoprotein ɛ4 Status and Brain Structure 12 Months after Mild Traumatic Injury: Brain Age Prediction Using Brain Morphometry and Diffusion Tensor Imaging

Torgeir Hellstrøm,
Nada Andelic,
Ann-Marie G. de Lange,
Eirik Helseth,
Kristin Eiklid and
Lars T. Westlye

J. Clin. Med.2021, 10(3), 418;https://doi.org/10.3390/jcm10030418

22 January 2021

Background: Apolipoprotein E (APOE) ɛ4 is associated with poor outcome following moderate to severe traumatic brain injury (TBI). There is a lack of studies investigating the influence of APOE ɛ4 on intracranial pathology following mild traumatic bra...

Full Article

Article

3 Citations

2,681 Views

13 Pages

The Effect of APOE ɛ4 on the Functional Connectivity in Frontoparietal Network in Hypertensive Patients

Dandan Wang,
Chang Xu,
Wenxiao Wang,
Hui Lu,
Junying Zhang,
Furu Liang and
Xin Li

Brain Sci.2022, 12(5), 515;https://doi.org/10.3390/brainsci12050515

19 April 2022

Allele 4 of the apolipoprotein E gene (APOE ε4) and hypertension are considered risk factors for Alzheimer’s Disease (AD). The detection of differences in cognitive function and brain networks between hypertensive patients who are APOE...

Full Article

Article

9 Citations

4,323 Views

12 Pages

APOE ɛ4 Is Associated with Postprandial Inflammation in Older Adults with Metabolic Syndrome Traits

Yannik Bernd Schönknecht,
Silke Crommen,
Birgit Stoffel-Wagner,
Martin Coenen,
Rolf Fimmers,
Peter Stehle,
Alfredo Ramirez and
Sarah Egert

Nutrients2021, 13(11), 3924;https://doi.org/10.3390/nu13113924

2 November 2021

The apolipoprotein E (APOE) polymorphism impacts blood lipids and biomarkers of oxidation and inflammation, contributing to an isoform-dependent disease risk. We investigated the effect of the APOE genotype on postprandial metabolism after consumptio...

Full Article

Article

6 Citations

6,007 Views

14 Pages

Association of APOE (rs429358 and rs7412) and PON1 (Q192R and L55M) Variants with Myocardial Infarction in the Pashtun Ethnic Population of Khyber Pakhtunkhwa, Pakistan

Naveed Rahman,
Zakiullah,
Asif Jan,
Muhammad Saeed,
Muhammad Asghar Khan,
Zahida Parveen,
Javaid Iqbal,
Sajid Ali,
Waheed Ali Shah and
Fazli Khuda
+ 1 author

Genes2023, 14(3), 687;https://doi.org/10.3390/genes14030687

10 March 2023

Coronary Artery Diseases (CAD) remains the top among Non-communicable Diseases (NCDs). Variations in Apolipoprotein E (APOE) and Paroxonase 1 (PON1) have been associated with Myocardial Infarction (MI) in several populations. However, despite the hig...

Full Article

Article

5 Citations

2,686 Views

9 Pages

Dementia and Risk Factors: Results from a Prospective, Population-Based Cohort Study

Simona Villani,
Ottavia Eleonora Ferraro,
Tino Emanuele Poloni and
Antonio Guaita

Life2022, 12(7), 1055;https://doi.org/10.3390/life12071055

14 July 2022

The incidence rate of dementia varies between studies. The influence of some sociodemographic factors is reasonably established, but less is known about the role of comorbidities, which are common in the elderly. The objectives of this study was to e...

Full Article

Article

1 Citations

2,030 Views

21 Pages

Functional Glial Activation Mediates Phenotypic Effects of APOEɛ4 and Sex in Alzheimer’s Disease

Roger M. Lane,
Dan Li and
Taher Darreh-Shori

Neuroglia2024, 5(3), 323-343;https://doi.org/10.3390/neuroglia5030022

5 September 2024

Background: This study examined the impact of apolipoprotein ɛ4 (APOEɛ4) allele frequency and sex on the phenotype of Alzheimer’s disease (AD). Methods: This post hoc study evaluated the baseline characteristics, cerebrospinal fluid (...

Full Article

Article

3 Citations

3,175 Views

13 Pages

Evaluation of the Polygenic Risk Score for Alzheimer’s Disease in Russian Patients with Dementia Using a Low-Density Hydrogel Oligonucleotide Microarray

Anna Ikonnikova,
Anna Morozova,
Olga Antonova,
Alexandra Ochneva,
Elena Fedoseeva,
Olga Abramova,
Marina Emelyanova,
Marina Filippova,
Irina Morozova and
Dmitry Gryadunov
+ 5 authors

Int. J. Mol. Sci.2023, 24(19), 14765;https://doi.org/10.3390/ijms241914765

29 September 2023

The polygenic risk score (PRS), together with the ɛ4 allele of the APOE gene (APOE-ɛ4), has shown high potential for Alzheimer’s disease (AD) risk prediction. The aim of this study was to validate the model of polygenic risk in Russia...

Full Article

Article

10 Citations

6,682 Views

12 Pages

Associations of APOE Gene Variants rs429358 and rs7412 with Parameters of the Blood Lipid Profile and the Risk of Myocardial Infarction and Death in a White Population of Western Siberia

Sergey Semaev,
Elena Shakhtshneider,
Liliya Shcherbakova,
Dinara Ivanoshchuk,
Pavel Orlov,
Sophia Malyutina,
Valery Gafarov,
Yuliya Ragino and
Mikhail Voevoda

Curr. Issues Mol. Biol.2022, 44(4), 1713-1724;https://doi.org/10.3390/cimb44040118

13 April 2022

The present study aimed to analyze possible associations of rs7412 and rs429358 of the APOE gene with lipid profile parameters, the risk of myocardial infarction, and death in the mostly white population of Western Siberia (Russia). The study populat...

Full Article

Article

8 Citations

1,892 Views

10 Pages

Association of Common Variants of APOE, CETP, and the 9p21.3 Chromosomal Region with the Risk of Myocardial Infarction: A Prospective Study

Sergey Semaev,
Elena Shakhtshneider,
Liliya Shcherbakova,
Pavel Orlov,
Dinara Ivanoshchuk,
Sofia Malyutina,
Valery Gafarov,
Mikhail Voevoda and
Yuliya Ragino

Int. J. Mol. Sci.2023, 24(13), 10908;https://doi.org/10.3390/ijms241310908

30 June 2023

The individual risk of an unfavorable cardiovascular outcome is determined by genetic factors in addition to lifestyle factors. This study was aimed at analyzing possible associations of several genetic factors with the risk of myocardial infarction...

Full Article

Article

3 Citations

3,388 Views

20 Pages

Synergistic Effect between the APOE ε4 Allele with Genetic Variants of GSK3B and MAPT: Differential Profile between Refractory Epilepsy and Alzheimer Disease

Danira Toral-Rios,
Pavel Pichardo-Rojas,
Elizabeth Ruiz-Sánchez,
Óscar Rosas-Carrasco,
Rosa Carvajal-García,
Dey Carol Gálvez-Coutiño,
Nancy Lucero Martínez-Rodríguez,
Ana Daniela Rubio-Chávez,
Myr Alcántara-Flores and
Victoria Campos-Peña
+ 4 authors

Int. J. Mol. Sci.2024, 25(18), 10228;https://doi.org/10.3390/ijms251810228

23 September 2024

Temporal Lobe Epilepsy (TLE) is a chronic neurological disorder characterized by recurrent focal seizures originating in the temporal lobe. Despite the variety of antiseizure drugs currently available to treat TLE, about 30% of cases continue to have...

Full Article

Review

5 Citations

3,343 Views

14 Pages

Mass Spectrometry-Based Analysis of Lipid Involvement in Alzheimer’s Disease Pathology—A Review

Andrea R. Kelley

Metabolites2022, 12(6), 510;https://doi.org/10.3390/metabo12060510

2 June 2022

Irregularities in lipid metabolism have been linked to numerous neurodegenerative diseases. The roles of abnormal brain, plasma, and cerebrospinal fluid (CSF) lipid levels in Alzheimer’s disease (AD) onset and progression specifically have been...

Full Article