Search Results (67)

Ulmus glabra Huds. is a mesophilic, montane broadleaf tree with high ecological value, commonly found in temperate riparian and floodplain forests across Türkiye. Its populations in Türkiye have declined due to anthropogenic disturbances and climatic pressures that cause habitat fragmentation and threaten the species’ long-term survival. In this research, we used Maximum Entropy (MaxEnt) to build species distribution models (SDMs) and applied the Restoration Planner (RP) tool to identify and prioritize critical restoration sites under both current and projected climate scenarios (SSP245, SSP370, SSP585). The SDMs highlighted areas of high suitability, primarily along the Black Sea coast. Future projections show that habitat fragmentation and shifts in suitable areas are expected to worsen. To systematically compare restoration options across different future scenarios, we derived and applied four spatial network status indicators using the RP tool. Specifically, we calculated Restoration Pixels (REST_PIX), Average Distance of Restoration Pixels from the Network (AVDIST_RP), Change in Equivalent Connected Area (ΔECA), and Restoration Efficiency (EFFIC) using the RP tool. For the 1 <-> 2 restoration pathways, the highest efficiency (EFFIC = 38.17) was recorded under present climate conditions. However, the largest improvement in connectivity (ΔECA = 60,775.62) was found in the 4 <-> 5 pathway under the SSP585 scenario, though this required substantial restoration effort (REST_PIX = 385). Temporal analysis noted that the restoration action will have most effectiveness between 2040 and 2080, while between 2081 and 2100, increased habitat fragmentation can severely undermine ecological connectivity. The result indicates that incorporation of habitat suitability modeling into restoration planning can help to design cost-effective restoration actions for degraded land. Moreover, the approach used herein provides a reproducible framework for the enhancement of species sustainability and habitat connectivity under varying climate conditions. Full article

Head-up displays (HUDs) can effectively enhance driving safety by projecting information—such as speed and maps—onto the windshield, thereby reducing blind spots caused by drivers looking down. As drivers need to observe road conditions within a wider horizontal viewing field, and considering that the observed angle in a vertical direction is relatively small, it becomes reasonable for an HUD to present a larger horizontal viewing angle than vertical viewing angle. This paper proposes a method to independently regulate the horizontal and vertical viewing angles. The original microstructure morphology is modeled as an ellipsoid, and the curvatures of the ellipsoid’s major and minor axes are calculated according to the required viewing angles. The simulation results show that the horizontal viewing angle corresponding to 85% of the maximum luminance increases from 2° without the film to 20° with the film, while the vertical viewing angle increases from 2° to 8°. The optical film with the designed microstructures is prepared and measured. The practical measurement results indicate that the tested horizontal and vertical viewing angles exhibit significant differentiation. At 85% of the maximum luminance, the horizontal viewing angle increases from 2° without the film to 23° with the film, while the vertical viewing angle increases from 2° to 10°. These results meet the requirements for independently regulating horizontal and vertical viewing angles and widening the horizontal viewing angle. Full article

Tau protein plays a pivotal role in maintaining neuronal structure and function through its regulation of microtubule stability and neuronal polarity. Encoded by the MAPT gene, Tau exists in multiple isoforms due to alternative mRNA splicing, with differential expression in the central and peripheral nervous systems. In healthy neurons, tau mRNA is selectively localized and translated in axons, a process tightly regulated by untranslated regions (UTRs) and RNA-binding proteins such as HuD and FMRP. Pathologically, Tau undergoes hyperphosphorylation, misfolding, and aggregation, which contribute to neurodegeneration in a range of disorders collectively known as tauopathies. Alzheimer’s disease (AD) is the most prevalent tauopathy, where abnormal Tau accumulation in the temporal and frontal lobes correlates with cognitive decline and behavioral symptoms. Other tauopathies, including Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD), Frontotemporal Dementia with Parkinsonism (FTDP-17), and Pick’s disease, are distinguished by the predominance of specific Tau isoforms (3R or 4R), cellular distribution, and affected brain regions. Notably, astroglial tauopathies highlight the pathological role of Tau accumulation in glial cells, expanding the understanding of neurodegeneration beyond neurons. Despite advances in imaging biomarkers (e.g., Tau-PET) and molecular diagnostics, effective disease-modifying therapies for tauopathies remain elusive. Ongoing research targets Tau through immunotherapies, splicing modulators, kinase inhibitors, and antisense oligonucleotides, aiming to mitigate Tau pathology and its deleterious effects. Understanding the multifaceted roles of Tau in neuronal and glial contexts is critical for developing future therapeutic strategies against tauopathies. Full article

Flower closure is a widespread yet understudied trait that may serve multiple functions in the success of plant reproduction. In this study, we investigated the role of flower closure in protecting pollen from rain-induced loss in lesser celandine (Ficaria verna Huds., 1762), an early-flowering species vulnerable to spring rains. Through simulated and natural rain experiments, we found that the flowers that were prevented from closing retained significantly fewer pollen grains compared to the control flowers. This demonstrates that flower closure effectively protects pollen from rain-induced flushing, thus enhancing reproductive success. Furthermore, flowers that were prevented from closing had fewer viable pollen grains than control flowers. We propose that the evolution of petal movement in F. verna was primarily driven by pressures favoring petal movement that protected pollen, with secondary contributions from herbivore avoidance. Flowers are unable to discriminate between low luminosity caused by cloudy weather and night, thus responding to both. Future studies should explore the relative importance of primary and secondary evolutionary drivers of flower closure across species, particularly in early-flowering plants facing complex environmental challenges. Full article

This study investigates the impact of extreme weather conditions (specifically heavy rain and fog) on drivers’ situational awareness by analyzing variations in illumination levels. The primary objective is to identify optimal color wavelengths for low-light environments, thereby providing a theoretical foundation for the design of augmented reality head-up display in adverse weather conditions. A within-subjects experimental design was employed with 26 participants in a simulated driving environment. Participants were exposed to different illumination levels and AR-HUD colors. Eye-tracking metrics, including fixation duration, visit duration, and fixation count, were recorded alongside situational awareness ratings to assess cognitive load and information processing efficiency. The results revealed that the yellow AR-HUD significantly enhanced situational awareness and reduced cognitive load in foggy conditions. While subjective assessments indicated no substantial effect of lighting conditions, objective measurements demonstrated the superior effectiveness of the yellow AR-HUD under foggy weather. These findings suggest that yellow AR-HUD navigation icons are more suitable for extreme weather environments, offering potential improvements in driving performance and overall road safety. Full article

Many important ecological processes play out over large geographic ranges, and accurate large-scale monitoring of populations is a requirement for their effective management. Of particular interest are agricultural weeds, which cause widespread economic and ecological damage. However, the scale of weed population data collection is limited by an inevitable trade-off between quantity and quality. Remote sensing offers a promising route to the large-scale collection of population state data. However, a key challenge is to collect high enough resolution data and account for between-site variability in environmental (i.e., radiometric) conditions that may make prediction of population states in new data challenging. Here, we use a multi-site hyperspectral image dataset in conjunction with ensemble learning techniques in an attempt to predict densities of an arable weed (Alopecurus myosuroides, Huds) across an agricultural landscape. We demonstrate reasonable predictive performance (using the geometric mean score-GMS) when classifiers are used to predict new data from the same site (GMS = 0.74-low density, GMS = 0.74-medium density, GMS = 0.7-High density). However, even using flexible ensemble techniques to account for variability in spectral data, we show that out-of-field predictive performance is poor (GMS = 0.06-low density, GMS = 0.13-medium density, GMS = 0.08-High density). This study highlights the difficulties in identifying weeds in situ, even using high quality image data from remote sensing. Full article

As the global traffic environment becomes increasingly complex, driving safety issues have become more prominent, making manual-response driving warning systems (DWSs) essential. Augmented reality head-up display (AR-HUD) technology can project information directly, enhancing driver attention; however, improper design may increase cognitive load and affect safety. Thus, the design of AR-HUD driving warning interfaces must focus on improving attention and reducing cognitive load. Currently, systematic research on AR-HUD DWS interfaces is relatively scarce. This paper proposes an ecological interface cognitive balance design strategy for AR-HUD DWS based on cognitive load theory and environmental interface design theory. The research includes developing design models, an integrative framework, and experimental validation suitable for warning scenarios. Research results indicate that the proposed design effectively reduces cognitive load and significantly decreases driver response and comprehension times, outperforming existing interfaces. This design strategy and framework possess promotional value, providing theoretical references and methodological guidance for AR-HUD warning interface research. Full article

Spinal cerebrospinal fluid (CSF) leaks can be caused by tears in the dura and are challenging to treat. Traditional methods of treating spinal CSF leakage include nonsurgical management, epidural blood patches (EBP), and direct surgical repair. Minimally invasive surgery (MIS) is rapidly progressing within neurosurgery due to its advantages for patient safety and comfort. Existing MIS techniques to spine surgery utilize a rigid endoscope, which has limitations when reaching smaller areas requiring greater degrees of visualization. The simultaneous use of a flexible endoscope and wearable heads-up display (wHUD) improves access and visualization in these small areas while allowing the surgeon to maintain optimal ergonomics. In this article, we review minimally invasive approaches to spine surgery and the management of spinal CSF leaks. We also demonstrate a novel minimally invasive technique utilizing flexible endoscopy and a wHUD to treat a case of recurrent CSF leak. We describe the successful utilization of this technology and provide the groundwork for future practitioners to incorporate this approach into their practice. Full article

Understanding how climate change influences the geographical distribution of species within an ecological niche is essential for predicting habitat shifts and informing conservation efforts. This study evaluates the impact of climate change on habitat suitability and ecological connectivity of wych elm (Ulmus glabra Huds.) in Türkiye. The study explores the future distribution of U. glabra and how its connectivity is affected by habitat fragmentation arising from changing climatic conditions. Contextually, this paper aims to achieve two primary objectives: estimating the potential geographical ranges of U. glabra under different climate scenarios and assessing alterations in ecological connections between current and future habitats. The maximum entropy (MaxEnt) model was used along with Morphological Spatial Pattern Analysis (MSPA), and the Probability of Connectivity (PC) index was applied to show possible transformations in distribution patterns of U. glabra over time. The findings suggest that there will be a reduction in the suitability of locations for the species. Moreover, it is expected that under future climate scenarios, ecological connectivity will decline, especially from 2061 to 2100 in the SSP585 scenario. Notably, significant alterations are anticipated during the latter half of the twenty-first century, mainly outside the coastal areas of the Black Sea, where extensive regions would become unsuitable. Additionally, the species is projected to shift its range, decreasing its presence in inland regions while expanding along the coasts. The results show the vulnerability of this species against climate change, thereby demanding adaptive conservation measures to preserve it within the forest ecosystems of Türkiye. Full article

Augmented Reality Head-Up Displays (AR-HUDs) enhance driver perception and safety, yet optimal hazard warning design remains unclear. This study examines three AR-HUD crash warning icon types (BD, BR, BW) across various turning scenarios. Using a 360-degree video-based driving simulation with 36 participants, eye-tracking metrics were collected. Results show BW icons, dynamically linked to hazards, significantly improve drivers’ pedestrian risk awareness and visual attention allocation compared to BD and BR systems. BW consistently demonstrated longer gaze duration, higher fixation counts, and shorter time to first fixation across all turns. BD and BR icons were more susceptible to lane changes, potentially diverting attention from hazards. Findings suggest prioritizing dynamic tracking warning icons over fixed-position alternatives to minimize visual competition and distraction, providing crucial insights for AR-HUD optimization in automated vehicles. Full article

Although handheld ultrasound devices (HUDs) are commonplace, their ability to diagnose fecal retention (FR) remains unclear. This prospective observational study examined HUDs’ usefulness in diagnosing FR in patients with constipation in a palliative care setting. Between 10 December 2020 and 30 June 2022, we compared rectal ultrasonographic findings obtained using HUDs with clinical manifestations in 64 males and 70 females (48%, 52%, 68 ± 11 years old) with constipation who had undergone computed tomography (CT). FR was diagnosed using a HUD and compared with CT and digital rectal examination (DRE) results. In total, 42 (31%), 42 (31%), and 41 (31%) patients were diagnosed using HUDs, CT, and DRE, respectively. Thirty-nine (93%) patients in the CT group were also diagnosed with FR using HUDs. A total of 89 of 92 patients with a negative CT diagnosis also had a negative HUD diagnosis. Among the 41 patients in the DRE group, 37 were also diagnosed with FR using HUDs. Among 93 patients with a negative DRE diagnosis, 86 had a negative HUD diagnosis. The sensitivity, specificity, positive predictive value, and negative predictive value of HUDs for CT were 93%, 97%, 93%, and 97%, respectively. Those of HUDs for DRE were 88%, 94%, 86%, and 95%, respectively. The concordance rates for FR diagnosis were 128/134 for CT and HUDs and 123/134 for DRE and HUDs. HUD was useful for diagnosing FR in this setting. HUDs could provide valuable support for appropriate treatment selection. Developing a constipation treatment algorithm based on rectal ultrasonographic findings is warranted in the future. Full article

Augmented reality (AR) technology has been widely applied across a variety of fields, with head-up displays (HUDs) being one of its prominent uses, offering immersive three-dimensional (3D) experiences and interaction with digital content and the real world. AR-HUDs face challenges such as limited field of view (FOV), small eye-box, bulky form factor, and absence of accommodation cue, often compromising trade-offs between these factors. Recently, optical waveguide based on pupil replication process has attracted increasing attention as an optical element for its compact form factor and exit-pupil expansion. Despite these advantages, current waveguide displays struggle to integrate visual information with real scenes because they do not produce accommodation-capable virtual content. In this paper, we introduce a lensless accommodation-capable holographic system based on a waveguide. Our system aims to expand the eye-box at the optimal viewing distance that provides the maximum FOV. We devised a formalized CGH algorithm based on bold assumption and two constraints and successfully performed numerical observation simulation. In optical experiments, accommodation-capable images with a maximum horizontal FOV of 7.0 degrees were successfully observed within an expanded eye-box of 9.18 mm at an optimal observation distance of 112 mm. Full article

This study investigated the reliability of measuring the median nerve cross-sectional area (CSA) at the carpal tunnel inlet using a handheld ultrasound device (HUD) compared to a standard ultrasound system, focusing on intra- and inter-operator reproducibility among novice and expert operators. Employing a prospective cross-sectional design, 37 asymptomatic adults were assessed using both devices, with measurements taken by an expert with over five years of experience and a novice with less than six months. The CSA was determined using manual tracing and ellipse methods, with reproducibility evaluated through intraclass correlation coefficients (ICCs) and agreement assessed via Bland–Altman plots. Results showed a high degree of agreement between the devices, with excellent intra-operator reproducibility (ICC > 0.80) for the expert, and moderate reproducibility for the novice (ICCs ranging from 0.539 to 0.841). Inter-operator reliability was generally moderate, indicating acceptable consistency across different experience levels. The study concludes that HUDs are comparable to standard ultrasound systems for assessing median nerve CSA in asymptomatic subjects, with both devices providing reliable measurements. This supports the use of HUDs in diverse clinical environments, particularly where access to traditional ultrasound is limited. Further research with a larger sample and symptomatic patients is recommended to validate these findings. Full article

An understudied problem in plant heavy metal biology is the effects of acute versus gradual or chronic metal exposure. The aim of the present study was to compare the growth and physiological responses of Rumex hydrolapathum Huds. plants subjected to gradual or acute Mn stress treatment in controlled conditions. Heavy metal was applied to substrate either as one 1.00 g L⁻¹ Mn dose (acute treatment) or the same dose in four steps of increasing amounts within 12 days (gradual treatment). Peroxidase activity in actively photosynthesizing leaves was used for monitoring induced biochemical changes resulting from Mn treatment. The number of leaves per plant significantly increased in the case of gradual treatment with Mn, but this effect was not statistically significant for acute treatment. Leaf fresh mass significantly decreased in both cases due to the decrease in leaf water content, but dry biomass of leaves was not affected, with no significant differences between the two types of treatments. A significantly lower chlorophyll fluorescence parameter Performance Index in large leaves of plants under the acute Mn treatment than in plants under the gradual treatment was evident. An increase in leaf peroxidase activity by Mn treatment was proportional to the metal dose received, but plants in the acute treatment with 1.00 g L⁻¹ Mn had a significantly lower peroxidase response in comparison to the gradual treatment with 1.00 g L⁻¹ Mn. In conclusion, under gradual treatment, biochemical changes related to the induction of tolerance to the heavy metal are expressed, as indicated by the continuous increase in leaf peroxidase activity after each treatment step. Full article

As the next generation of in-vehicle intelligent platforms, the augmented reality heads-up display (AR-HUD) has a huge information interaction capacity, can provide drivers with auxiliary driving information, avoid the distractions caused by the lower head during the driving process, and greatly improve driving safety. However, AR-HUD systems still face great challenges in the realization of multi-plane full-color display, and they cannot truly achieve the integration of virtual information and real road conditions. To overcome these problems, many new devices and materials have been applied to AR-HUDs, and many novel systems have been developed. This study first reviews some key metrics of HUDs, investigates the structures of various picture generation units (PGUs), and finally focuses on the development status of AR-HUDs, analyzes the advantages and disadvantages of existing technologies, and points out the future research directions for AR-HUDs. Full article