Multimodal large language models (MLLMs) and vision–language models (VLMs) have rapidly entered medicine, demonstrating promising performance in clinical reasoning, radiology report generation, and visual question answering (VQA). However, many...
Flood-control reservoirs are often used as a structural measure to mitigate fluvial floods, and numerical models are a fundamental tool for assessing their effectiveness. This work aims to analyze the suitability of fully 2D shallow-water models to s...
This study compares the numerical results obtained with an axisymmetric quasi two-dimensional (Q2D) model with those from two different types of dimensional models for smooth–turbulent transient flows generated by an instantaneous valve closure...
Extensive medical research has revealed evidence of a strong association between hippocampus atrophy and age-related diseases such as Alzheimer’s disease (AD). Therefore; segmentation of the hippocampus is an important task that can help clinic...
Among the methods of 3D reconstruction, the automatic generation of 3D models from building documentation is one of the most accessible and inexpensive. For 30 years, researchers have proposed multiple methods to automatically generate 3D models from...
Over the past decades, research has made impressive breakthroughs towards drug delivery systems, resulting in a wide range of multifunctional engineered nanoparticles with biomedical applications such as cancer therapy. Despite these significant adva...
Hepatic ischemia–reperfusion injury (IRI) is a major clinical challenge in liver surgery and transplantation, contributing to postoperative complications and graft dysfunction. The pathogenesis of hepatic IRI is complex and multifactorial, invo...
Urban pluvial floods are the outcome of the incapacity of drainage systems to convey the runoff generated by intense rainfall events. Cities have been struggling to control such hazards due to several pressures, such as urbanization increase, more fr...
We pose the following research question, “what are (i) the minimum required computation grid and (ii) the required form of hydrodynamic equations, i.e., shallow water equations (SWE) or diffusion wave equations (DWE), in 2D modeling to minimize...
Background/Objectives: Advanced 3D cell culture techniques enhance the physiological relevance of in vitro models, while supporting the 3Rs principles (Reduction, Refinement, and Replacement) of animal experimentation. In this context, 3D collagen-ba...
Two-dimensional (2D) and three-dimensional (3D) cloud-resolving model (CRM) results from the Tropical Rainfall Measuring Mission Kwajalein Experiment (KWAJEX) were applied to analyze the diurnal cycle of cloud development in the tropics. Cloud develo...
This study investigates two sulfonylpurine derivatives, Pur-6-NH2-SS and Pur-6-Mor-SS, which contain amino and morpholino substituents, for their anticancer potential in 2D and 3D models of human cervical adenocarcinoma (HeLa) cells. Cell cycle distr...
Research on converting 2D raster drawings into 3D vector data has a long history in the field of pattern recognition. Prior to the achievement of machine learning, existing studies were based on heuristics and rules. In recent years, there have been...
Dietary flavones 6,3´,4´-trihydroxyflavone (6,3´,4´-HOFL) and 7,3´,4´-trihydroxyflavone (7,3´,4´-HOFL) showed preliminary antioxidant and anti-inflammatory activities in a two-dimensional (2D) cell cult...
In this study, a new method called “3D-Space” have been developed to obtain 3D models of prismatic machine parts using 2D technical drawings. The algorithm basicaly works in the following manner: 3 basic views (i.e. top, front, left side) of an objec...
Three-dimensional survey is a key technology for documenting, monitoring, and analysing artifacts, buildings, and areas. Photogrammetry from drones makes it possible to survey and monitor impervious areas and, thanks to their manoeuvrability and redu...
The implementation of digital tools into science education is a major demand of various stakeholders, such as teachers, schools and ministries of education. However, teaching innovations and the introduction of new competences need to be carefully te...
Introduction: Pancreatic cancer (PC) is one of the most aggressive and lethal malignancies, calling for enhanced research. Pancreatic ductal adenocarcinoma (PDAC) represents 70–80% of all cases and is known for its resistance to conventional th...
Background: According to the World Health Organization (WHO), approximately 5% of children and 2.5% of adults suffer from attention deficit hyperactivity disorder (ADHD). This disorder can have significant negative consequences on people’s live...
Wildfires increasingly threaten human life, ecosystems, and infrastructure, with events like the 2025 Palisades and Eaton fires in Los Angeles County underscoring the urgent need for more advanced prediction frameworks. Existing physics-based and dee...
Background: Photodynamic therapy (PDT) is a cancer treatment that combines a photosensitizer (PS), light, and oxygen to generate reactive oxygen species (ROS), leading to tumor cell death. PDT efficacy depends largely on PS accumulation within tumors...
In recent years, the field of skeletal muscle tissue engineering has experienced significant advancements, evolving from traditional two-dimensional (2D) cell cultures to increasingly sophisticated three-dimensional (3D) engineered constructs. While...
Background/Objectives: Foreign-body aspiration (FBA) is a common and largely preventable pediatric emergency, yet current safety standards and risk assessments rely predominantly on object size and on anecdotal descriptions and bronchoscopy findings....
Since the clearance between the guide rail and the roller reduces the efficiency of the 2D pump, this paper proposes a novel 2D piston pump with stacked taper roller sets to eliminate the effect of the clearance. The structure of the 2D pump is intro...
Multidrug resistance (MDR) remains a major obstacle in the treatment of ovarian cancer. MDR is often mediated by the overexpression of ATP-binding cassette (ABC) transporters, such as P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP)....
Photodynamic therapy (PDT) is a therapeutic option for cancer, in which photosensitizer (PS) drugs, light, and molecular oxygen generate reactive oxygen species (ROS) and induce cell death. First- and second-generation PSs presented with problems tha...
Signaling-pathway analyses and the investigation of gene responses to different stimuli are usually performed in 2D monocultures. However, within the glomerulus, cells grow in 3D and are involved in direct and paracrine interactions with different gl...
The invasion of skin tissue by Staphylococcus aureus is mediated by mechanisms that involve sequential breaching of the different stratified layers of the epidermis. Induction of cell death in keratinocytes is a measure of virulence and plays a cruci...
Background: Amyotrophic lateral sclerosis (ALS) is still a global health challenge, as there is no effective treatment due to the inadequacy of conventional experimental platforms for comprehending pathogenic mechanisms and developing therapy. Object...
Cancer is a complex disease arising from a homeostatic imbalance of cell-intrinsic and microenvironment-related mechanisms. A multimodal approach to treat cancer that includes surgery, chemotherapy, and radiation therapy often fails in achieving tumo...
Epithelial ovarian cancer (EOC) remains a lethal malignancy requiring novel therapeutic strategies due to high recurrence and chemoresistance. This study evaluated the combined antitumor effect of metformin and the co-transfection of tumor-suppressor...
Ovarian cancer remains a leading cause of gynecological cancer-related mortality. Although the standard therapy is usually effective at first, the development of multidrug resistance (MDR) significantly limits the efficacy of the treatment. Topotecan...
In Slovenia, flood hazard mapping follows a standardized model-based procedure, defined by the EU Floods Directive. On the other hand, erosion hazard mapping remains largely empirical due to the absence of a unified methodology. Recent advances in 2D...
We compared three methods for deriving communication viewsheds, which indicate the coverage areas for transmitter points from high-resolution digital surface models. Communication viewsheds were analyzed with a novel 3D Fresnel zone method, as well a...
Transcriptome profiling of 3D models compared to 2D models in various cancer cell lines shows differential expression of TGF-β-mediated and cell adhesion pathways. Presence of TGF-β in these cell lines shows an increased invasion potential...
The role of metalloproteinases (MMPs) on the migration and invasion of cancer cells has been correlated with tumor aggressiveness, namely with the up-regulation of MMP-2 and 9. Herein, two pyridine-containing macrocyclic compounds, [15]pyN5 and [16]p...
Background: Ovarian cancer accounts for more deaths than any other cancer of the female reproductive system. Despite standard care, recurrence due to tumor spread and chemoresistance is common, highlighting the need for novel therapies. Mesenchymal s...
Psoriasis is a chronic immune-mediated skin disease that involves the interaction of immune and skin cells, and is characterized by cytokine-driven epidermal hyperplasia, deviant differentiation, inflammation, and angiogenesis. Because the available...
Bats are important reservoirs of zoonotic pathogens and valuable models for studying antiviral tolerance and neuroinflammation within a One Health framework. However, chiropteran neural 2D-in vitro models remain limited. Here, we established and char...
The role of astrocytes in the glioblastoma (GBM) microenvironment is poorly understood; particularly with regard to cell invasion and drug resistance. To assess this role of astrocytes in GBMs we established an all human 2D co-culture model and a 3D...
An urban flood simulation model based on TELEMAC-2D was constructed, and the inundation data of two measured rainstorms (7 June 2018 and 16 September 2018) were selected to validate the model. Flooding processes were simulated under 12 designed rainf...
Model based definition (MBD) is the core of product digital research and development. The extension of the scope and content of the product model is an important way to improve the application ability of MBD methodology. In view of the demand of the...
Cardiovascular diseases (CVD), the leading cause of death worldwide, and their strong association with fibrosis highlight the pressing need for innovative antifibrotic therapies. In vitro models have emerged as valuable tools for replicating cardiac...
With the increase of three-dimensional (3D) printing applications in many areas of life, a large amount of 3D printing data is copied, shared, and used several times without any permission from the original providers. Therefore, copyright protection...
While 1D, 2D, and coupled 1D/2D models are widely used in flood extent mapping, a significant research gap remains in comparative analyses of 2D and coupled 1D/2D approaches. Study of the Dinsiz Stream Basin is of critical importance due to its proxi...
The paper is devoted to further development of an accelerated method for simulation of the two-dimensional surface waves at infinite depth with the use of a two-dimensional model derived with simplifications of the three-dimensional equations for pot...
Increasing urbanisation has inevitably led to the continuous construction of buildings. Urban expansion and densification processes reshape cities and, in particular, the third dimension (3D), thus calling for a technical shift from 2D to 3D for prop...
With the development of 3D printing, weapons are easily printed without any restriction from the production managers. Therefore, anti-3D weapon model detection is necessary issue in safe 3D printing to prevent the printing of 3D weapon models. In thi...
In the last decades, 3D city models appear to have been predominantly used for visualisation; however, today they are being increasingly employed in a number of domains and for a large range of tasks beyond visualisation. In this paper, we seek to un...
Most fabrication methods for three-dimensional (3D) geological symbols are limited to two types: directly increasing the dimensionality of a 2D geological symbol or performing appropriate modeling for an actual 3D geological situation. The former can...
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