1,485 Results Found

An improved passive CR-39-based direct 222Rn/220Rn progeny detector with 3 detection channels was designed and tested in this study to measure and calculate equilibrium equivalent concentration (EEC) of both 222Rn and 220Rn without the equilibrium fa...

Studies on the individuation of surface and buried faults in seismic areas using geochemical methods can be considered a valid approach for improving sustainability in the risk assessment framework. Appropriate scientific knowledge of structural geol...

(1) Background: As the demand for 212Pb for clinical theranostics rises, empirical studies that examine the radiation safety implications of different 224Ra sources are needed to facilitate discussions with local authorities for the translation of 20...

The study concerns the analysis of 220Rn (thoron) recorded in the surface soil in two sites of the Campi Flegrei caldera (Naples, Southern Italy) characterized by phases of volcanic unrest in the seven-year period 1 July 2011–31 December 2017. Thoron...

Neonatal γ-immunoglobulin (IgG) Fc receptor (FcγRn) is a receptor that transports IgG across the intestinal mucosa, placenta, and mammary gland, ensuring the balance of IgG and albumin in the body. These functions of FcγRn depend on...

Quantitative real-time PCR and Western blot methods were developed to assess neonatal Fc-receptor (FcRn) mRNA and protein expression in human FcRn transgenic mice, Swiss Webster mice, and in select human tissues. Additionally, FcRn turnover was evalu...

The immune system is a complex network of multiple cells, tissues, and organs that protects the body against foreign pathogenic invaders. However, the immune system may mistakenly attack healthy cells and tissues due to the cross-reactivity of anti-p...

The neonatal Fc receptor (FcRn) is highly expressed in the renal proximal tubule and is important for the reclamation of albumin by cellular transcytosis to prevent its loss in the urine. The initial event of this transcellular transport mechanism is...

RNS60 is a physically modified saline solution hypothesized to contain oxygen nanobubbles. It has been reported to reduce ischemia/reperfusion injury in a pig model of acute myocardial infarction. We investigated the effects of RNS60 during cardiac h...

Indoor radon (Rn) concentration is pointed out by the World Health Organization (WHO) as the second leading cause of lung cancer. Adopting mitigation measures based on ventilation procedures is an effective solution for most cases. However, the occur...

Although many viral and bacterial pathogens cause diarrhea, enterotoxigenic E. coli (ETEC) is one of the most frequently encountered in impoverished regions where it is estimated to kill between 300,000 and 700,000 children and infants annually. Crit...

Understanding the biological mechanisms underlying the pH-dependent nature of FcRn binding, as well as the various factors influencing the affinity to FcRn, was concurrent with the arrival of the first recombinant IgG monoclonal antibodies (mAbs) and...

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play a pivotal role in the dynamic cell signaling systems in plants, even under biotic and abiotic stress conditions. Over the past two decades, various studies have endorsed the notio...

System-wide quantitative characterization of human neonatal Fc receptor (FcRn) properties is critical for understanding and predicting human PK (pharmacokinetics) as well as the distribution of mAbs and Fc-fusion proteins using PBPK (physiologically-...

This study investigates the radiological impact of 222Rn activity concentrations in bottled drinking water sourced from local markets in Baghdad, Iraq. Utilizing the solid-state nuclear track detector (SSNTD) technique with CR-39 detectors, 222Rn act...

Scaling is one of the complex operations in the Residue Number System (RNS). This operation is necessary for RNS-based implementations of deep neural networks (DNNs) to prevent overflow. However, the state-of-the-art RNS scalers for special moduli se...

A non-positional residue number system (RNS) enjoys particularly efficient implementation of addition and multiplication, but non-modular arithmetic operations in RNS-like number comparison are known to be difficult. In this paper, a new technique fo...

Nursing educators need strategies for preparing students to be successful in the National Council Licensure Examination (NCLEX-RN®). Understanding the educational practices used is an important step in informing curricular decisions and helping r...

In this work, a novel approach for the standardization of low-level 222Rn emanation is presented. The technique is based on the integration of a 222Rn source, directly, with an α-particle detector, which allows the residual 222Rn to be continuo...

Drug-resistant epilepsy (DRE) is often treated with surgery or neuromodulation. Specifically, responsive neurostimulation (RNS) is a widely used therapy that is programmed to detect abnormal brain activity and intervene with tailored stimulation. Des...

The present paper outlines characteristics of thoron and its progeny in the indoor environment. Since the half-life of thoron (220Rn) is very short (55.6 s), its behavior is quite different from the isotope radon (222Rn, half-life 3.8 days) in the en...

Radon (222Rn) is the second most common cause of lung cancer after smoking. As radon poses a significant risk to human health, radon-affected areas should be identified to ensure people’s awareness of risk and remediation. The primary goal of t...

Number comparison has long been recognized as one of the most fundamental non-modular arithmetic operations to be executed in a non-positional Residue Number System (RNS). In this paper, a new technique for designing comparators of RNS numbers repres...

222Rn and 226Ra concentrations of less than a few to several thousands of Bq L−1 have been observed in several underground bodies of water around the world. Although regulations for these concentrations in water have been implemented internatio...

As a developmental toxicant, Zika virus (ZIKV) attacks both the growing nervous system, causing congenital Zika syndrome, and the placenta, resulting in pathological changes and associated adverse fetal outcomes. There are no vaccines, antibodies, or...

(1) Background: Variants of the interleukin-1 receptor antagonist (IL1RN) gene, encoding an anti-inflammatory cytokine, are associated with asthma. Asthma is a chronic inflammatory disease of the airway influenced by interactions between genetic vari...

Water in arid and semi-arid environments is characterized by the presentation of complex interactions, where dissolved chemical species in high concentrations have negative effects on the water quality. Radon is present in areas with a high uranium a...

Monoclonal antibodies are biopharmaceuticals with a very long half-life due to the binding of their Fc portion to the neonatal receptor (FcRn), a pharmacokinetic property that can be further improved through engineering of the Fc portion, as demonstr...

Understanding dynamic groundwater–surface water interactions in alluvial plains is critical for sustainable water resource management, yet seasonal variability and spatial heterogeneity of these exchanges remain imprecisely quantified. Here, we...

Antibody-mediated autoimmune diseases are common, can involve any organ system, and pose a large burden for patients and healthcare systems. Most antibody-mediated diseases are mediated by IgG antibodies. Selective targeting of pathogenic antibodies...

Ascomycete fungi usually produce small hydrophobic asexual conidia that are easily dispersed and essential for long-term survival under a variety of environmental conditions. Several upstream signaling regulators have been documented to control conid...

Radon is the main source of natural radioactivity, and its measurement is considered extremely important in radioprotection, given its relationship with the occurrence of lung cancer. In the last two years, measurements of this radioactive gas were c...

Background: Baobab fruit is valued for its nutritional and medicinal benefits. Although it is acknowledged that baobab pulp is beneficial for health, studies that link its nutraceutical properties to the ability to eliminate reactive species (ROS and...

Background: Brucellosis poses a significant public health challenge, necessitating effective vaccine development. Current vaccines have limitations such as safety concerns and inadequate mucosal immunity. This study aims to develop an FcRn-targeted m...

Dual Radon (222Rn) and δ18O-δ2H isotopes were utilized to (a) detect the origin of water, (b) pinpoint groundwater inflow zones and (c) determine rates of groundwater inflows in an expanding lake in central Ethiopia. The lake area expande...

The bioavailability of a monoclonal antibody (mAb) or another therapeutic protein after subcutaneous (SC) dosing is challenging to predict from first principles, even if the impact of injection site physiology and drug properties on mAb bioavailabili...

Natural radionuclides may occur in groundwater and pose health risks when present in elevated concentrations. This study evaluates the quality of shallow groundwater in Nysa County (SW Poland) based on the activity concentrations of natural radionucl...

Using Monte Carlo (with Geant4) and COMSOL simulations, the authors have defined a useful tool to reproduce the alpha spectroscopy of 222Rn, 220Rn and their ionized daughters by measurement systems based on electrostatic collection on a silicon detec...

Nitric oxide (NO) has been firmly established as a key signaling molecule in plants, playing a significant role in regulating growth, development and stress responses. Given the imperative of sustainable agriculture and the urgent need to meet the es...

Bud endodormancy is an important, complex process subject to both genetic and epigenetic control, the mechanism of which is still unclear. The endogenous hormone abscisic acid (ABA) and its signaling pathway play important roles in the endodormancy p...

Understanding the connectivity between surface water and groundwater is key to sound geo-hazard prevention and mitigation in a waterscape such as the Jiuzhaigou Natural World Heritage Site in the southeast Tibetan Plateau, China. In this study, we us...

Probiotics play an important role against infectious pathogens, such as Escherichia coli (E. coli), mainly through the production of antimicrobial compounds and their immunomodulatory effect. This protection can be detected both on the live probiotic...

Background: The humanized monoclonal antibody (mAb) hu5A10 specifically targets and internalizes prostate cancer cells by binding to prostate specific antigen (PSA). Preclinical evaluations have shown that hu5A10 is an excellent vehicle for prostate...

Persistent infection with high-risk human papilloma virus (HR-HPV) is the main risk factor for the development of invasive cervical cancer although is not sufficient to cause cervical cancer. Several host and environmental factors play a key role in...

Etiological factors involved in myelodysplastic syndrome (MDS) include immunologic, oxidative stress and inflammatory factors, among others, and these are targets for microRNAs (miRNs). Here, we evaluated whether some miRNs may affect tumor developme...

This paper presents a meteorological approach to identify local and remote sources driving the variability of surface daily radon concentrations. To this purpose, hourly 222Rn concentration and surface meteorological measurements, and air mass trajec...

This paper explores the security of a single-stage residue number system (RNS) pseudorandom number generator (PRNG), which has previously been shown to provide extremely high-quality outputs when evaluated through available RNG statistical test suite...

Radiosurgery (SRS) is a primary treatment for intracranial metastatic disease, but it can lead to cerebral radiation necrosis (RN) in approximately 25% of cases. Unlike tumor progression (TP), which indicates a lack of response to treatment, RN sugge...

Induction of fetal hemoglobin (HbF) ameliorates the clinical severity of β-thalassemias. Histone methyltransferase LSD1 enzyme removes methyl groups from the activating chromatin mark histone 3 lysine 4 at silenced genes, including the γ-globin genes...

Neuropsychological outcomes following temporal lobe resection for drug-resistant epilepsy (DRE) are well established. For instance, left anterior temporal lobectomy (LATL) is associated with a greater risk for cognitive morbidity compared to right (R...