Search Results (71)

Nocardia, an easily missed but potentially fatal opportunistic pathogen, can lead to serious infections like lung and brain abscesses. Intranasal inoculation (IN) is the traditional approach for constructing a Nocardia-induced pneumonia mice model, while it usually only results in limited local bacterial infection in the lungs. To comprehensively assess infection dynamics across distinct pulmonary inoculation routes in mice models, this study compared the pathogenicity of three different Nocardia farcinica pneumonia models established via IN, intratracheal aerosolization (ITA), and intratracheal instillation (ITI). C57BL/6J mice were infected with N. farcinica through IN, ITA and ITI with comparative analyses of bacterial distribution in lungs, survival rate, weight, bacterial load, inflammatory cytokines, histopathological characteristics and transcriptome differences. The findings suggest that ITA N. farcinica infections caused severer clinical symptoms, higher mortality, pulmonary bacterial load, levels of inflammatory cytokines in bronchoalveolar lavage fluid, and more significant histopathological damage to lungs than IN and ITI. Furthermore, ITA resulted in better lung bacterial distribution and delivery efficiency than ITI and IN. Transcriptome analysis of lungs from N. farcinica infected mice via IN, ITA and ITI revealed significant differential gene expression, whereas ITA route resulted in a larger fold change. ITA provides a more consistent and severe model of N. farcinica pneumonia in mice than IN and ITI, which can make the bacteria more evenly distributed in the lungs, leading to more severe pathological damage and higher mortality rates. In conclusion, ITA is an optimal route for developing animal models of N. farcinica pneumonia infections. Full article

In the sustainable evolution of the entrepreneurial ecosystem, the efficiency of early-stage capital allocation directly affects the intergenerational transmission capacity of innovation resources. The financing barriers caused by information asymmetry urgently require institutional solutions. This study, based on tracking data from 19,463 startups in China’s information technology sector (2016–2019), analyzes how government-certified incubators (GCIs) optimize the sustainability of the entrepreneurial ecosystem through signaling mechanisms. The empirical results show that collaboration with a GCI can significantly increase the likelihood of IT startups securing venture capital by approximately 25%. This effect is not only due to the strict screening and resource support provided by GCIs, but also due to their role in amplifying internal signals from startups, such as the experience of founders and intellectual property. Notably, in the IT sector, the impact of GCIs is more significant for startups traditionally disadvantaged, particularly those led by female founders. Our research demonstrates that GCIs drive the sustainable development of the entrepreneurial ecosystem through three signaling mechanisms: (1) institutional certification screening, which optimizes the intergenerational allocation efficiency of ecosystem resources; (2) the signaling validation–amplification mechanism, which enhances the value of intellectual property and founder experience, alleviating investors’ challenges in quantifying startup potential; (3) inclusive signal rebalancing, where GCI certification significantly improves the funding success rate of female founders, breaking traditional market biases in screening disadvantaged groups and supporting the inclusive and sustainable development of the entrepreneurial ecosystem. These findings provide a new pathway for emerging economies to optimize the resilience of their entrepreneurial ecosystems through policy tools: for governments, GCIs achieve sustainable development goals at low institutional cost; for investors, the signal integration mechanism reduces investment information friction; and for entrepreneurs, certification endorsements accelerate market validation of sustainable business models. Full article

The problems of easy cracking, high brittleness, and low bond strength of ordinary Portland cement and sulphoaluminate cement (OPC-SAC) composites limit their application as rapid repair materials. In this study, glass fibers (GFs) were added to OPC-SAC composites with the content of 0.0–1.5% to improve their properties. Fluidity, mechanical properties, bond properties, and drying shrinkage properties were researched, and their microstructure was characterized by SEM and ICT. Hydration products at different curing ages were studied by XRD and FTIR. The results showed that GFs improved the mechanical properties of OPC-SAC composites. The 28 d flexural strength, compressive strength, and bond strength of specimens with 0.5% GFs reached maximum values, increasing by 22.1%, 12.1%, and 82.9%, respectively, compared with the control group without GFs.. GFs significantly inhibited the drying shrinkage of composites, and the inhibitory effect was magnified with the content of GFs. Adding 0.5% of GFs could reduce the porosity of specimens, decrease the volume proportion of pores (>10 mm³), and refine the pore structure. In summary, 0.5% is recommended as the optimal content of GFs to be added into the OPC-SAC composites. Full article

The X-ray defect detection system for weld seams in deep-sea manned spherical shells is nonlinear and complex, posing challenges such as motor parameter variations, external disturbances, coupling effects, and high-precision dual-motor coordination requirements. To address these challenges, this study proposes a deep reinforcement learning-based control scheme, leveraging DRL’s capabilities to optimize system performance. Specifically, the TD3 algorithm, featuring a dual-critic structure, is employed to enhance control precision within predefined state and action spaces. A composite reward mechanism is introduced to mitigate potential motor instability, while CP-MPA is utilized to optimize the performance of the proposed m-TD3 composite controller. Additionally, a synchronous collaborative motion compensator is developed to improve coordination accuracy between the dual motors. For practical implementation and validation, a PMSM simulation model is constructed in MATLAB/Simulink, serving as an interactive training platform for the DRL agent and facilitating efficient, robust training. The simulation results validate the effectiveness and superiority of the proposed optimization strategy, demonstrating its applicability and potential for precise and robust control in complex nonlinear defect detection systems. Full article

To address the urgent demand for autonomous rapid initial alignment of vehicular inertial navigation systems in complex battlefield environments, this study overcomes the technical limitations of traditional stationary base alignment methods by proposing a robust moving-base autonomous alignment approach based on multi-source information fusion. First, a federal Kalman filter-based multi-sensor fusion architecture is established to effectively integrate odometer, laser Doppler velocimeter, and SINS data, resolving the challenge of autonomous navigation parameter calculation under GNSS-denied conditions. Second, a dual-mode fault diagnosis and isolation mechanism is developed to enable rapid identification of sensor failures and system reconfiguration. Finally, an environmentally adaptive dynamic alignment strategy is proposed, which intelligently selects optimal alignment modes by real-time evaluation of motion characteristics and environmental disturbances, significantly enhancing system adaptability in complex operational scenarios. The experimental results show that the method proposed in this paper can effectively improve the accuracy of vehicle-mounted alignment in motion, achieve accurate identification, effective isolation, and reconstruction of random incidental faults, and improve the adaptability and robustness of the system. This research provides an innovative solution for the rapid deployment of special-purpose vehicles in GNSS-denied environments, while its fault-tolerant mechanisms and adaptive strategies offer critical insights for engineering applications of next-generation intelligent navigation systems. Full article

Internal phosphorus (P) loading is a key driver of waterbody eutrophication. Various sediment P indexes are developed to assess sediment P risks by linking them to water column P, but their seasonal reliability remains underexplored. This study evaluated, for the first time, sediment P status in the Xiashan reservoir, a large shallow reservoir in northern China serving 9.4 million people. The ability of three P indexes, including exchangeable P (Ex-P), Olsen P (Olsen-P), and diluted HCl-extractable P (HCl-P), to predict water column P concentrations was tested across February, May, and August. Sediments in the Xiashan reservoir exhibited moderate total P levels (531–650 mg kg⁻¹) but high P availability, with Ex-P, Olsen-P, and HCl-P in ranges of 19–35, 58–101, and 327–444 mg kg⁻¹, respectively, likely due to sandy composition. Water column P concentrations significantly correlate with August sediment P indexes (r = 0.42–0.81) but not with February and May sediments, highlighting the ability of August sediment P indexes to predict water column P across seasons. Sampling in August is recommended to efficiently identify critical zones for internal P loading, with Ex-P as the preferred indicator given its simple extraction and strong correlation with water column P (r = 0.81). Full article

As a sustainable alternative technology to the cost- and energy-intensive Haber–Bosch method, electrochemical nitrogen (N₂) reduction offers direct conversion of N₂ to NH₃ under ambient conditions. Direct use of noble metals or non-noble metals as electrocatalytic materials results in unsatisfactory electrocatalytic properties because of their low electrical conductivity and stability. Herein, three-dimensional flexible carbon nanofiber (CNF/TiO₂@CoS) nanostructures were prepared on the surface of CNF by using electrospinning, a hydrothermal method, and in situ growth. We investigated the behavior of CNFs/TiO₂@CoS as an electrocatalytic material in 0.1 M sodium sulfate. The highest ammonia yield of the material was 4.61 × 10⁻¹¹ mol s⁻¹ cm⁻² at −0.45 V vs. RHE, and the highest Faraday efficiency, as well as superior long-term durability, was 8.3% at −0.45 V vs. RHE. This study demonstrates the potential of firecracker-shaped nanofiber templates for loading varied noble metals or non-noble metals as a novel development of hybrid composites for electrocatalytic nitrogen reduction. Full article

Cisplatin-based platinum compounds are important clinical chemotherapeutic agents that participate in most tumor chemotherapy regimens. Through density-functional theory calculations, the formation and stability of the inorganic oxide carrier, the mechanisms of the hydrolysis reaction of the activated platinum compound, and its binding mechanism with DNA bases can be studied. The higher the oxidation state of Pt (II to IV), the more electrons transfer from the magnesia–gold composite material to the platinum compound. After adsorption on the composite carrier, 5d←2p coordination bonds of Pt-N are strengthened. For flat and oblique adsorption modes of cisplatin, there is no significant difference in the density of states of the gold and magnesium oxide film, indicating the maintenance of the heterojunction structural framework. However, there are significant changes in the electronic states of cisplatin itself with different adsorption configurations. In the flat configuration, the band gap width of cisplatin is larger than that of the oblique configuration. The Cl-Pt bond range in the Pt(III) compound shows a clear charge reduction on the magnesia film, indicating the Cl-Pt bond is an active site with the potential for decomposition and hydrolysis. The substitution of chloride ions by water can lead to hydrolysis products, enhancing the polarization of the composite and showing strong charge separation. The hydrolysis of the free platinum compound is endothermic by 0.309 eV, exceeding the small activation energy barrier of 0.399 eV, indicating that hydrolysis of this platinum compound is easily achievable. ADME (absorption, distribution, metabolism, and excretion) prediction parameters indicate that hydrolysis products have good ESOL (Estimated SOLubility) solubility and high gastrointestinal absorption, consistent with Lipinski’s rule. During the coordination reaction process, there are significant changes in the distribution of frontier molecular orbitals, with the HOMO (highest occupied molecular orbital) of the initial state primarily located on the purine base, providing the possibility for electron transfer to the empty orbitals of the platinum compound in the LUMO (lowest unoccupied molecular orbital). The HOMO and HOMO-1 of the transition state and product are mainly distributed on the platinum compound, indicating clear electron transfer and orbital rearrangement. The activation energy barrier for the purine coordination reaction with the hydrolysis products is reduced to 0.61 eV, and the dipole moment gradually decreases to 6.77 Debye during the reaction, indicating a reduction in the system’s charge separation and polarization. This contribution is anticipated to provide a new theoretical clue for developing inorganic oxide carriers of platinum compounds. Full article

In the Huanggangliang–Ganzhuermiao metallogenic belt in the southern Great Xing’an Range, the Haobugao Pb–Zn deposit is the most widespread skarn-type polymetallic deposit. The observed mineralization processes in this area are closely associated with both magmatic and tectonic activity. The zircon U–Pb ages of two granitoid phases are 134.0 ± 0.6 Ma and 133.4 ± 0.9 Ma (Early Cretaceous). High SiO₂ content (average mass fractions of 77.98 wt.% and 73.25 wt.%), high alkalinity (average mass fractions of 6.19 wt.% and 8.78 wt.%), and low CaO levels (average mass fractions of 0.16 wt.% and 0.12 wt.%) are characteristic of these rocks. They are also enriched in high-field-strength elements (HFSEs) (Th, U, Ta, Zr, Hf, etc.) and depleted in large ion lithophile elements (LILEs) (Ba, Sr, etc.). Furthermore, the Nb/Ta ratios (7.80~8.82, 10.00~10.83) point to a crustal origin of the magma. The zircon Hf isotopic compositions suggest that the melting of young crust derived from Meso-Neoproterozoic and Neoproterozoic depleted mantle gave rise to the magma in these granite porphyries. These rocks formed in an extensional environment driven by the subduction and retreat of the Paleo-Pacific plate during the Early Cretaceous. Full article

Foamed concrete is increasingly utilized in engineering due to its light weight, excellent thermal insulation, fire resistance, etc. However, its low strength has always been the most crucial factor limiting its large-scale application. This study introduced an innovative method to enhance the strength of foamed concrete by using nano-Al₂O₃ (NA) as a foam stabilizer. NA was introduced into a foaming agent containing sodium dodecyl sulfate (SDS) and hydroxypropyl methylcellulose (HPMC) to prepare a highly stable foam. This approach significantly improved the foam stability and the strength of foamed concrete. Its drainage volume, settlement distance, microstructure, and stabilizing action were investigated, along with the strength, microstructure, and hydration products of foamed concrete. The presence of NA effectively reduced the drainage volume and settlement distance of the foam. NA is distributed at the gas–liquid interface and within the liquid film to play a hindering role, increasing the thickness of the liquid film, delaying the liquid discharge rate from the liquid film, and hindering bubble aggregation, thereby enhancing foam stability. Additionally, due to the stabilizing effect of NA on the foam, the precast foam forms a fine and uniform pore structure in the hardened foamed concrete. At 28 d, the compressive strength of FC0 (0% NAs in foam) is 2.18 MPa, while that of FC3 (0.18% NAs in foam) is 3.90 MPa, increased by 79%. The reason for this is that NA promotes the formation of AFt, and its secondary hydration leads to the continuous consumption of Ca(OH)₂, resulting in a more complete hydration reaction. This study presents a novel method for significantly improving the performance of foamed concrete by incorporating NA. Full article

Beijing is a city on the North China Plain with severe land subsidence. In recent years, Beijing has implemented effective measures to control land subsidence. Since this implementation, the development of time-series land subsidence in Beijing has slowed and has shown nonlinearity. Most previous studies have focused on the linear evolution of land subsidence; the nonlinear evolutionary patterns of land subsidence require further discussion. Therefore, we aimed to identify the evolution of land subsidence in Beijing, based on Envisat ASAR and Radarsat-2 images from 2003 to 2020, using permanent scatterer interferometric synthetic aperture radar (PS-InSAR) and cubic curve polynomial fitting methods. The dates of the extreme and inflection points were identified from the polynomial coefficients. From 2003 to 2020, the subsidence rate reached 138.55 mm/year, and the area with a subsidence rate > 15 mm/year reached 1688.81 km². The cubic polynomials fit the time-series deformation well, with R² ranging from 0.86 to 0.99 and the RMSE ranging from 1.97 to 60.28 mm. Furthermore, the subsidence rate at 96.64% of permanent scatterer (PS) points first increased and then decreased. The subsidence rate at 86.58% of the PS points began to decrease from 2010 to 2015; whereas the subsidence rate at 30.51% of the PS point reached a maximum between 2015 and 2019 and then decreased. The cumulative settlement continued to increase at 69.49% of the PS points. These findings imply that groundwater levels are highly correlated with the temporal evolution of subsidence in areas with pattern D (Vs+-, S+), with increasing and then decelerating rates and increasing amounts. In regions with a thickness of compressible clay layer over 210 m, subsidence follows pattern E (Vs+, S+), with increasing rates and amounts. Fractures such as the Gaoliying and Sunhe fractures significantly influence the spatial distribution of subsidence patterns, showing distinct differences on either side. Near the Global Resort Station, pattern E (Vs+, S+) intensifies in subsidence, potentially due to factors like land use changes and construction activities. Full article

The “sol–gel method” was used to prepare spherical chitosan-modified bentonite (SCB) hydrogels in this study. The SCB hydrogels were characterized and used as sorbents to remove tetracycline (TC) from aqueous solutions. The adsorbents were characterized by SEM, XRD, FTIR, TG, and BET techniques. Various characterization results showed that the SCB adsorbent had fewer surface pores and a specific surface area that was 96.6% lower than the powder, but the layered mesoporous structure of bentonite remained unchanged. The adsorption process fit to both the Freundlich model and the pseudo-second-order kinetic model showed that it was a non-monolayer chemical adsorption process affected by intra-particle diffusion. The maximum monolayer adsorption capacity determined by the Langmuir model was 39.49 mg/g. Thermodynamic parameters indicated that adsorption was a spontaneous, endothermic, and entropy-increasing process. In addition, solid–liquid separation was easy with the SCB adsorbent, providing important reference information for the synthesis of SCB as a novel and promising adsorbent for the removal of antibiotics from wastewater at the industrial level. Full article

This manuscript describes the synthesis of green long afterglow nanophosphors SrAl₂O₄:Eu²⁺, Nd³⁺ using the combustion process. The study encompassed the photoluminescence behavior, elemental composition, chemical valence, morphology, and phase purity of SrAl₂O₄:Eu²⁺, Nd³⁺ nanoparticles. The results demonstrate that after introducing Eu²⁺ into the matrix lattice, it exhibits an emission band centered at 508 nm when excited by 365 nm ultraviolet light, which is induced by the 4f⁶5d¹→4f⁷ transition of Eu²⁺ ions. The optimal doping concentrations of Eu²⁺ and Nd³⁺ were determined to be 2% and 1%, respectively. Based on X-ray diffraction (XRD) analysis, we have found that the physical phase was not altered by the doping of Eu²⁺ and Nd³⁺. Then, we analyzed and compared the quantum yield, fluorescence lifetime, and afterglow decay time of the samples; the co-doped ion Nd³⁺ itself does not emit light, but it can serve as an electron trap center to collect a portion of the electrons produced by the excitation of Eu²⁺, which gradually returns to the ground state after the excitation stops, generating an afterglow luminescence of about 15 s. The quantum yields of SrAl₂O₄:Eu²⁺ and SrAl₂O₄:Eu²⁺, Nd³⁺ phosphors were 41.59% and 10.10% and the fluorescence lifetimes were 404 ns and 76 ns, respectively. In addition, the E_g value of 4.98 eV was determined based on the diffuse reflectance spectra of the material, which closely matches the calculated bandgap value of SrAl₂O₄. The material can be combined with polyacrylic acid to create optical anti-counterfeiting ink, and the butterfly and ladybug patterns were effectively printed through screen printing; this demonstrates the potential use of phosphor in the realm of anti-counterfeiting printing. Full article

Against the backdrop of swiftly changing industrial environments, this study aims to investigate the influence of technology convergence on the sustainable innovation of manufacturing enterprises. The purpose of this research is to determine the future competitiveness and expansion potential of industries by evaluating the impact of technological convergence on innovation performance, which serves as a significant metric for assessing the sustainability of corporate innovation practices. Specifically, the relationships among three characteristics of technological convergence and enterprise innovation performance—betweenness, closeness, and clustering—are analyzed. Using the financial, property, and patent data of listed companies in China’s automotive manufacturing industry, an empirical study is conducted using a negative binomial regression model. Enhancing all three technology convergence characteristics is found to be conducive to enhancing sustainable innovation. Meanwhile, the corporate knowledge base plays a mediating role in which the effect of knowledge base width on clustering technology integration is more strongly mediated by the effect of knowledge base depth on approaching technology integration. The results of this study are useful for policymakers, corporate strategists, and innovation managers who are looking to enhance sustainable innovation practices within their organizations. By understanding the critical roles of betweenness, closeness, and clustering in technological convergence, stakeholders can better position their firms to leverage these attributes for improved innovation performance and competitive advantage. Full article

In this study, seven Engineering Geopolymer Composite (EGC) groups with varying proportions were prepared. Rheological, compressive, flexural, and axial tensile tests of the EGC were conducted to study the effects of the water/binder ratio, the cement/sand ratio, and fiber type on its properties. Additionally, a uniaxial tension constitutive model was established. The results indicate that the EGC exhibits early strength characteristics, with the 7-day compressive strength reaching 80% to 92% of the 28-day compressive strength. The EGC demonstrates high compressive strength and tensile ductility, achieving up to 70 MPa and 4%, respectively. The mechanical properties of the EGC improved with an increase in the sand/binder ratio and decreased with an increase in the water/binder ratio. The stress–strain curve of the EGC resembles that of the ECC, displaying a strain-hardening state that can be divided into two stages: before cracking, the matrix primarily bears the stress; after cracking, the slope decreases, and the fiber predominantly bears the stress. Full article