Search Results (11)

In eutherian mammals, embryo implantation is a critical process for a successful pregnancy. In mice, the activation of the leukemia inhibitory factor (LIF) receptor–STAT3 signaling axis induces embryo adhesion and decidualization. The LIF receptor is believed to function as a heterodimer composed of LIFR (encoded by Lifr) and GP130 (encoded by Il6st); however, their distinct expression patterns in the uterine epithelium immediately prior to implantation suggest divergent functional roles. In this study, we generated uterine epithelium-specific Lifr knockout (Lifr eKO) mice and conducted a comprehensive gene expression analysis of the endometrium before implantation. We compared these results with those from uterine epithelium-specific Gp130 knockout (Gp130 eKO) mice. Similarly to Gp130 eKO mice, Lifr eKO mice were completely infertile. We identified 299 genes with expression changes greater than twofold following gene deletion; among these, 31 genes were downregulated and 57 genes were upregulated in both eKO models. Many of the downregulated genes were previously implicated in uterine function. Hub gene analysis identified Erbb2 and c-Fos as key regulators in both models. Further experiments using an ERBB2 inhibitor suggested that LIFR–ERBB2-mediated signaling plays a crucial role in embryo implantation. Full article

This study aims to investigate the suitability of earthen housing for refugees and establish a more efficient system for selecting and adjusting materials by quantitatively analyzing the influence of various factors affecting the mechanical performance of earthen housing. This paper examined the impact of dry unit weight, particle size distribution of soil solidification, clay minerals, and pH on the mechanical performance of soil solidification through compressive strength testing. Additionally, the tensile strength resulting from capillary forces between particles was estimated using a prediction equation, and the effects of capillary forces and cohesive forces due to clay minerals were quantitatively assessed by comparing them with the results of the compressive strength experiments. In an alkaline environment, conflicting results were obtained regarding the effect of the dispersion of particles on compressive strength, depending on the presence or absence of clay minerals in the soil. Based on these results, the implementation of earthen houses constructed in the target refugee camp was evaluated, and strategies for building houses more efficiently under given conditions were discussed. Full article

This study presents a novel approach to the design and assessment of slender reinforced concrete (RC) columns by integrating Brillouin Optical Time Domain Analysis (BOTDA) for real-time, distributed strain monitoring and introducing a “time-dependent deterioration factor” strain decay (η_decay). Experimental tests on 200 mm × 200 mm RC columns with lengths of 1800 mm and slenderness ratios of 29.4, reinforced with four 12 mm bars, captured strain variations up to 400 microstrain under an axial load of 1200 kN, demonstrate BOTDA’s sensitivity and precision. Unlike conventional strain gauges, BOTDA provided a continuous strain profile along the column height, accurately capturing strain decay with a resolution exceeding 95%, enabling the detection of localized strain reductions often missed by traditional methods. The integration of η_decay into ACI 318 and Eurocode 2 models conservatively improved predictions, particularly for specimens tested with long-term testing (720 days), with experimental-to-predicted (E/P) ratios of 1.42 and 1.29, respectively, compared to higher discrepancies in the original codes. The η_decay factor accounts for strain reduction along the column height caused by time-dependent effects such as creep, shrinkage, and material degradation, significantly improving the accuracy of axial load capacity predictions. Finite element analysis (FEA) validated these improvements, showing good agreement with experimental data up to the yield load. Post-yield, the modified equations effectively addressed underestimations caused by microcracking, highlighting the necessity of η_decay for reliable long-term performance predictions. This research combines advanced BOTDA technology with an innovative η_decay framework, addressing long-term structural deterioration and refining design codes. It establishes a robust foundation for integrating time-dependent effects into predictive models, enhancing the resilience, safety, and sustainability of RC structures under real-world conditions. Full article

Background/Objectives: The impacts of the coronavirus disease 2019 (COVID-19) pandemic on patients using helicopter emergency medical services (HEMS) regarding tracheal intubation and patient management remain unclear. Thus, we aimed to investigate this matter in Japan. Methods: In this retrospective, observational study, we analyzed 2277 patients who utilized HEMS in Tochigi Prefecture during 2018–2022. We included only patients who required tracheal intubation. We categorized patients from February 2020 to January 2022 in the pandemic group and those from February 2018 to January 2020 in the control group. We compared the interval from arrival at the scene to leaving the scene (on-scene time) and secondary variables between the two groups. Results: A total of 278 eligible patients were divided into the pandemic group (n = 127) and the control group (n = 151). The on-scene time was lower during the pandemic than that before (25.64 ± 9.19 vs. 27.83 ± 8.74 min, p = 0.043). The percentage of patients using midazolam was lower (11.8% vs. 22.5%, p = 0.02) and that of patients using rocuronium bromide was higher (29.1% vs. 6.0%, p < 0.001) during the pandemic. In contrast, the type of intervention other than tracheal intubation and the type of transportation to the hospital did not differ between the groups. Conclusions: The COVID-19 pandemic was associated with changes in the mission time of and the frequency of certain drugs administered by the HEMS. However, the type of intervention and the type of transportation did not differ. Further research is needed on changes in patient prognosis and condition due to the effects of the COVID-19 pandemic. Full article

This paper aims to determine the effects of local corrosion at three different corrosion areas, the (1) entire area, (2) the constant moment area, and (3) the constant shear area, on the flexural performance of RC beams. To analyze this, an experimental study was carried out to prepare two series of RC beams (200 × 300 × 2800 mm) created with three different degrees of corrosion, inducing local rebar corrosion. Furthermore, two series of experimental tests were conducted under different loading types: monotonic and cyclic loading. It was observed that the strength capacity reduction grew in the RC specimens with induced corrosion in the order of the (1) entire area > (2) the constant moment area > (3) the constant shear area, as the average corrosion rate increased. Our test results further showed that the yield and ultimate strength were kept nearly equivalent to the uncorroded RC specimen, with average corrosion rates of 10% and 15%, respectively. Over these corrosion rates, the yield strength and ultimate strength dropped significantly. Compared to the test results under a monotonic loading condition, the structural capacity under a cyclic loading condition decreased, with a more pronounced tendency for each corrosion case as the corrosion rate increased. Longitudinal cracks developed throughout and adjacent to the corrosion areas as the corrosion rate increased. Thus, we can infer that strength reductions may be strongly influenced by these longitudinal cracks. Full article

Lack of exercise, which increases the risk of many serious physical and mental illness, has been a common health issue in Japan. Recent studies confirm that financial literacy discourages irrational behavior like gambling and smoking. We therefore investigate how financial literacy, as a rational decision-making instrument, relates to peoples’ exercise behavior in Japan. We hypothesize that financial literacy encourages people to exercise regularly. Using Osaka University’s Preference Parameters Study (PPS) for 2010, we categorized respondents into two groups: those who exercise regularly or at least once a week and those who do not. Our probit estimation results show that financial literacy is positively related with exercise behavior, meaning that financially literate people are more likely to exercise regularly. As the COVID-19 health pandemic seems to exacerbate peoples’ physical inactivity, the results of our study show an alternative approach to encourage exercise. We therefore recommend that governments implement a financial literacy improvement policy to alleviate the lack of exercise. Full article

Since biogenic volatile organic compounds (BVOCs) are important precursors of ozone, the monitoring of the BVOC concentration distributions is needed. In general, forest BVOC concentrations increase in summer as well as in other seasons. This study aims to detect temporally sporadic increases in BVOC concentrations in the non-summer months and to analyze the occurring climatic conditions. Using a uniform sampling system and shared gas chromatography–mass spectrometry, the concentrations of isoprene and monoterpenes in six Japanese forests were observed approximately once a month for 3 years. Using the observed data, the relations between the BVOC concentration increases and meteorological factors were evaluated. Twenty instances of temporal increases in BVOC concentrations were observed. These mainly occurred in spring for isoprene and in autumn for monoterpenes. Most of the increases in the non-summer months were observed after a rainfall event, when the daily temperature range was large, suggesting that wind, rain, and a rapid diurnal temperature rise could be factors in the non-summer months. Thus, the network monitoring of BVOC concentrations might be effective for understanding the effects of factors other than temperature, and the mechanisms and frequency of the temporal increases, on the BVOC concentrations in various forests. Full article

Few studies have reported on the increase in cervical cancer incidence in Japan. We aimed to determine the relevant trends in the metropolitan regions of Japan and to identify the population with the highest risk, based on histological subtype, cancer stage, and diagnostic processes. Using population-based data (2009–2013), we identified 2110 women, aged ≥20 years, with cervical cancer. We estimated the age-standardized and age-specific incidence rates of cervical cancer for the study period based on the 1985 national model population. The average annual percent change (AAPC) and 95% confidence interval (CI) were calculated using the joinpoint regression analysis. We stratified the analyses based on histological subtypes, stage, and diagnostic process via cancer screening. The increase in the overall age-standardized incidence was not significant. However, the increase was significant for women aged 30–39 years (AAPC 20.0%/year, 95% CI: 9.9–31.1), which was attributable to the increase in the incidence of the squamous cell carcinoma (SCC) subtype (AAPC 23.1%/year, 95% CI: 10.7–36.8). Among younger women, aged <50 years, further stratification showed an increase in the undiagnosed early-stage SCC subtype via cancer screening. In Japan, the incidence of HPV-related cervical cancer has been increasing in undiagnosed younger women. Full article

Ocean thermal energy conversion (OTEC) harvests the power from the thermal energy in the ocean, which is reserved in the ocean as the temperature difference between warm surface and cold deep seawaters. In the energy conversion, the heat exchangers transfer the thermal energy to the heat engine, which converts it into power. The pressure drops yielded by piping, valve and heat exchangers cause pump loads, which show significant negative power with respect to net power in OTEC. The heat transfer performance and the pressure drop in heat exchanger depend on the types and shapes of each heat transfer area. Generally, heat exchangers with higher friction factors yield higher heat transfer performance and vice versa. However, heat transfer performance and pressure drop are separately evaluated and there is no comprehensive performance evaluation index for OTEC power take-off. Therefore, this research proposes a new simplified overall performance evaluation method for heat exchangers, which can be comprehensively and easily applied and takes into consideration the heat transfer performance and the pressure drop. The evaluation results on plate-type heat exchangers show that the overall performance in each heat exchanger are elucidated and are quantitatively compared. Full article

Using ground granulated blast-furnace slag (GGBS) under different alkaline conditions, we studied the mechanisms and extents of Cr(VI) reduction and sorption and compared them to reactions with Portland cement (PC). We also investigated the effects of mixing PC/GGBS ratios on Cr(VI) dissolution after carbonating the substrates. We observed a complete sorption and reduction of Cr(VI) to Cr(III) in a GGBS-in-Ca(OH)₂ solution (pH > ~12.5) after 10 h, whereas in distilled water (pH = ~11.5) GGBS exhibited only marginal sorption and reduction (20%). Cr reactions with dissolved ions in supernatants derived from GGBS indicated that the anions dissolved from GGBS act as a reducing agent for Cr(VI) in a Ca(OH)₂ solution. Soft X-ray absorption microscopy identified a partial reduction of Cr(VI) to Cr(III) on the GGBS surface. The carbonation of pure PC paste substantially increased the amount of dissolved Cr(VI) in a solution phase whereas a 5 wt % replacement of PC with GGBS significantly reduced the amount of dissolved Cr(VI). We concluded that in the mixed paste during the early curing stage GGBS reduced a significant fraction of Cr(VI) to Cr(III) and that the Cr(III) adsorbed in the GGBS-PC mixture’s hydration products does not readily dissolve, even under carbonation conditions. Full article

Efficient maintenance and upgrading of a building during its lifecycle are difficult because a cementitious finish uses materials and parts with low disassembly properties. Additionally, the reuse and recycling processes during building demolition also present numerous problems from the perspective of environmental technology. In this study, an induction heating (IH) method was used to disassemble cementitious finish joints, which are widely used to join building members and materials. The IH rapidly and selectively heated and weakened these joints. The temperature elevation characteristics of the cementitious joint materials were measured as a function of several resistor types, including wire meshes and punching metals, which are usually used for cementitious finishing. The disassembly properties were evaluated through various tests using conductive resistors in cementitious joints such as mortar. When steel fiber, punching metal, and wire mesh were used as conductive resistors, the cementitious modifiers could be weakened within 30 s. Cementitious joints with conductive resistors also showed complete disassembly with little residual bond strength. Full article