Search Results (51)

The increasing demand for high-performance energy storage devices has stimulated interest in advanced electrolyte materials. Among them, ionic liquids ($\mathrm{I}\mathrm{L}\mathrm{s}$) stand out for their thermal stability, wide electrochemical windows, and good ionic conductivity. When doped into polymeric matrices, these ionic liquids form hybrid polymeric electrolytes that synergize the benefits of both liquid and solid electrolytes. This study explores a polymeric electrolyte based on polyethylene oxide ($\mathrm{P}\mathrm{E}\mathrm{O}$) doped with tributylmethylphosphonium iodide $\left(\mathrm{T}\mathrm{M}\mathrm{P}\mathrm{I}\right)$ and ammonium iodide ($\mathrm{N}{\mathrm{H}}_4\mathrm{I}$), focusing on its synthesis, structural and electrical properties, and performance in energy storage devices such as dye-sensitized solar cells and supercapacitors. Strategies to improve its ionic conductivity, mechanical and chemical stability, and electrode compatibility are also discussed, along with future directions in this field. Full article

Background: Head and neck cancer (HNC) remains a global health challenge with a poor 5-year survival rate among patients with relapsed or advanced-stage disease. Immune checkpoint blockade therapies have emerged as a promising approach to improve outcomes; however, their effectiveness is limited, with response rates of only 15–20% because of immune evasion mechanisms. MicroRNA (miRNA) dysregulation plays a key role in facilitating such immune evasion. In this study, we aim to identify specific miRNAs whose altered expression contributes to immune escape in HNC. Methods: We employed an integrated bioinformatics approach, incorporating differential expression analysis, survival analysis, target prediction, KEGG immune pathway analysis, a protein–protein interaction network, and the identification of hub genes using in silico tools. Results: Our analysis revealed that a high expression of miR-18a and miR-2355 was associated with reduced survival, with the median survival decreasing from 42.9 to 27.8 months, respectively, in advanced-stage patients. Conversely, a low expression of let-7c and miR-6510 was linked to poor prognosis, with survival decreasing from 40.1 to 19.2 months and from 50.1 to 26.8 months, respectively, across disease progression. Further pathway analysis revealed that these miRNAs are significantly involved in the regulation of key immune evasion signaling pathways, including T cell receptor, PD-L1/PD-1 checkpoint, JAK-STAT, TGF-beta, NF-kappa B, and TNF signaling pathways. Hub gene analysis identified AKT1, STAT3, NFKB1, CD4, IL2RB, TLR4, and CTLA-4 as potential dysregulated miRNA targets, with enrichment in immune-related signaling pathways. Conclusions: Taken together, these findings suggest that targeting these miRNAs could modulate immune evasion mechanisms and potentially enhance the efficacy of ICB therapies in HNC. Full article

The accurate prediction of river discharge is essential in water resource management, particularly under variability due to climate change. Traditional hydrological models commonly struggle to capture the complex, nonlinear relationships between climate variables and river discharge, leading to uncertainties in long-term projections. To mitigate these challenges, this research integrates machine learning (ML) and deep learning (DL) techniques to predict discharge in the Subernarekha River Basin (India) under future climate scenarios. Global climate models (GCMs) from the Coupled Model Intercomparison Project 6 (CMIP6) are assessed for their ability to reproduce historical discharge trends. The selected CNRM-M6-1 model is bias-corrected and downscaled before being used to simulate future discharge patterns under SSP585 (a high-emission scenario). Various AI-driven models, such as a temporal convolutional network (TCN), a gated recurrent unit (GRU), a support vector regressor (SVR), and a novel DL network named the Temporal Enhanced Attention Network (TeaNet), are implemented by integrating the maximum and minimum daily temperatures and precipitation as key input parameters. The performance of the models is evaluated using the mean absolute error (MAE), mean squared error (MSE), root mean squared error (RMSE), and coefficient of determination (R²). Among the evaluated models, TeaNet demonstrates the best performance, with the lowest error rates (RMSE: 2.34–3.04; MAE: 1.13–1.52 during training) and highest R² (0.87–0.95), outperforming the TCN (R²: 0.79–0.88), GRU (R²: 0.75–0.84), SVR (R²: 0.68–0.80), and RF (R²: 0.72–0.82) by 8–15% in accuracy across four gauge stations. The efficacy of the proposed model lies in its enhanced attention mechanism, which successfully identifies temporal relationships in hydrological information. In determining the most relevant predictors of river discharge, the feature importance is analyzed using the proposed TeaNet model. The findings of this research strengthen the role of DL architectures in improving long-term discharge prediction, providing valuable knowledge for climate adaptation and strategic planning in the Subernarekha region. Full article

This study empirically examines the wealth effects of mergers and acquisitions (M&As) in the Indian capital market, focusing on cross-border M&As. This study considers a sample of 58 cross-border and 34 domestic M&As, comprising more than 50 percent of the shares acquired by the acquiring companies from 2004 to 2019. We analyzed the wealth effects of cross-border M&As by applying the event study methodology. The abnormal returns of domestic and cross-border mergers and acquisitions for various window periods were compared using an independent t-test. The wealth effects of the acquiring firm have been further investigated with the inclusion of top advisor services and without the inclusion of advisor services in mergers and acquisitions transactions. This result suggests that cross-border M&As do not create a significant positive return for shareholders. There is no considerable wealth gain for shareholders of acquiring companies in domestic and cross-border mergers and acquisitions. We also find that including top advisor services in the M&A process does not influence the acquiring firm’s wealth. The price-to-book value ratio of the acquiring firm is a significant determinant of its returns. Full article

The development of artificial skin that accurately mimics the mechanical properties of human skin is crucial for a wide range of applications, including surgical training for burn injuries, biomechanical testing, and research in sports injuries and ballistics. While traditional materials like gelatin, polydimethylsiloxane (PDMS), and animal skins (such as porcine and bovine skins) have been used for these purposes, they have inherent limitations in replicating the intricate properties of human skin. In this work, we conducted uniaxial tensile tests on freshly obtained cadaveric skin to analyze its mechanical properties under various loading conditions. The stress–strain data obtained from these tests were then replicated using advanced skin simulants. These skin simulants were specifically formulated using a cost-effective and moldable multi-part silicone-based polymer. This material was chosen for its ability to accurately replicate the mechanical behavior of human skin while also addressing ethical considerations and biosafety concerns. In addition, the non-linear mechanical behavior of the developed skin simulants was characterized using three different hyperelastic curve-fit models (i.e., Neo-Hookean, Mooney–Rivlin, and Yeoh models). Moreover, these innovative simulants offer an ethical and practical alternative to cadaveric skin for use in laboratory and clinical settings. Full article

New forms of interaction made possible by developments in special educational technologies can now help students with dyscalculia. Artificial intelligence (AI) has emerged as a promising tool in recent decades, particularly between 2001 and 2010, offering avenues to enhance the quality of education for individuals with dyscalculia. Therefore, the implementation of AI becomes crucial in addressing the needs of students with dyscalculia. Content analysis techniques were used to examine the literature covering the influence of AI on dyscalculia and its potential to assist instructors in promoting education for individuals with dyscalculia. The study sought to create a foundation for a more inclusive dyscalculia education in the future through in-depth studies. AI integration has had a big impact on educational institutions as well as people who struggle with dyscalculia. This paper highlights the importance of AI in improving the educational outcomes of students affected by dyscalculia. Full article

The increasing commercial, industrial, and medical applications of plastics cannot be halted during the coming years. Microplastics are a new class of plastic pollutants which have emerged as escalating environmental threats. The persistence, effects, and removal of MPs present in soil, water, and numerous organisms have become an important research field. However, atmospheric microplastics (AMPs), which are subcategorized into deposited and suspended, remain largely unexplored. This review presents the recent developments and challenges involved in fully understanding suspended and deposited AMPs. The evaluation of indoor suspended MP fibers needs to be critically investigated to understand their implications for human health. Furthermore, the transportation of AMPs to isolated locations, such as cryospheric regions, requires immediate attention. The major challenges associated with AMPs, which have hindered advancement in this field, are inconsistency in the available data, limited knowledge, and the lack of standardized methodologies for the sampling and characterization techniques of AMPs. Full article

Bacillus strains have long been recognized for their beneficial interactions with plants, enhancing growth, nutrient uptake, and stress resistance. Understanding their molecular mechanisms and plant-microbe interactions is crucial for harnessing their potential in sustainable agriculture. Here we used ten strains from the 5 Bacillus species namely Bacillus velezensis, Bacillus subtilis, Bacillus atrophaeus, Bacillus altitudinis and Bacillus amylofaciens, which are previously reported for PGPR activity. A comparative analysis of these strains was performed to determine their evolutionary relationships, which revealed that Bacillus velezensis and Bacillus amyloliquefaciens are closely related based on underlying genetic and proteomic similarities. Bacillus altitudinis strain LZP02 was the most distantly related to all the other selected strains. On the other hand, Bacillus atrophaeus strains GQJK17 and CNY01 are shown to be closely related to each other. Mauve alignment was performed to determine the genetic relationships between these strains. The LZP02 strain exhibited several unique inversions harboring important genes, such as betB, ftsW, and rodA, which are important for bacterial survival. Proteomic analysis highlighted important pathways that were conserved across these strains, including xenobiotic biodegradation and metabolism, biosynthesis of polyketides and nonribosomal pathways, and biosynthesis of secondary metabolites, all of which have been shown to be involved in plant growth promotion. Full article

Molecular chaperones are highly conserved across evolution and play a crucial role in preserving protein homeostasis. The 60 kDa heat shock protein (HSP60), also referred to as chaperonin 60 (Cpn60), resides within mitochondria and is involved in maintaining the organelle’s proteome integrity and homeostasis. The HSP60 family, encompassing Cpn60, plays diverse roles in cellular processes, including protein folding, cell signaling, and managing high-temperature stress. In prokaryotes, HSP60 is well understood as a GroEL/GroES complex, which forms a double-ring cavity and aids in protein folding. In eukaryotes, HSP60 is implicated in numerous biological functions, like facilitating the folding of native proteins and influencing disease and development processes. Notably, research highlights its critical involvement in sustaining oxidative stress and preserving mitochondrial integrity. HSP60 perturbation results in the loss of the mitochondria integrity and activates apoptosis. Currently, numerous clinical investigations are in progress to explore targeting HSP60 both in vivo and in vitro across various disease models. These studies aim to enhance our comprehension of disease mechanisms and potentially harness HSP60 as a therapeutic target for various conditions, including cancer, inflammatory disorders, and neurodegenerative diseases. This review delves into the diverse functions of HSP60 in regulating proteo-homeostasis, oxidative stress, ROS, apoptosis, and its implications in diseases like cancer and neurodegeneration. Full article

Transcranial direct current stimulation (tDCS) is a non-invasive and painless technique of brain neuromodulation that applies a low-intensity galvanic current to the scalp with the aim of stimulating specific areas of the brain. Preliminary investigations have indicated the potential therapeutic efficacy of multisession tDCS applied to the auditory cortex (AC) in the treatment of chronic tinnitus. The aim of this study was to explore the therapeutic effects of repeated sessions of bilateral tDCS targeting the AC on chronic tinnitus. A double-blinded randomized placebo-controlled trial was conducted on patients (n = 48) with chronic intractable tinnitus (>2 years duration). Participants were randomly allocated to two groups: one receiving tDCS (n = 26), with the anode/cathode placed over the left/right AC, and the other receiving a placebo treatment (n = 22). A 20 min daily session of 2 mA current was administered for five consecutive days per week over two consecutive weeks, employing 35 cm² electrodes. Tinnitus handicap inventory (THI) scores, tinnitus loudness, and tinnitus distress were measured using a visual analogue scale (VAS), and were assessed before intervention, immediately after, and at one-month follow-up. Anodal tDCS significantly reduced THI from 72.93 ± 10.11 score to 46.40 ± 15.36 after the last session and 49.68 ± 14.49 at one-month follow-up in 18 out of 25 participants (p < 0.001). The risk ratio (RR) of presenting an improvement of ≥20 points in the THI after the last session was 10.8 in patients treated with tDCS. Statistically significant reductions were observed in distress VAS and loudness VAS (p < 0.001). No statistically significant differences in the control group were observed. Variables such as age, gender, duration of tinnitus, laterality of tinnitus, baseline THI scores, and baseline distress and loudness VAS scores did not demonstrate significant correlations with treatment response. Repeated sessions of bilateral AC tDCS may potentially serve as a therapeutic modality for chronic tinnitus. Full article

The influences of legume diversification on soil carbon (C) pools and sequestration, particularly in Himalayan pastureland, remain poorly understood. Moreover, the impact of legume diversification activities and the stoichiometry of soil enzymes in C biogeochemistry at the ecosystem level remains largely overlooked. The purpose of this study is to investigate the influences of legume diversification on activities and the stoichiometry of soil enzymes and their control of C sequestration in pasturelands. Four experimental fertilized species combinations, namely, SG (50% Festuca arundinacea + 50% Dactylis glomerata), SGL1 (25% Festuca arundinacea + 25% Dactylis glomerata + 50% Onobrychis viciifolia), SGL2 (25% Festuca arundinacea + 25% Dactylis glomerata + 50% Trifolium pratense), SGL12 (25% Festuca arundinacea + 25% Dactylis glomerata + 25% Onobrychis viciifolia + 25% Trifolium pratense), and natural pasture (NG) were compared. Soils under SGL1, SGL2, and SG12 had ~18, 36, and 22% greater soil C than SG, respectively. Among the pastures with fertilization, the C mineralization was suppressed by legume diversification. C sequestration under SGL1, SGL2, and SG12 was ~27, 22, and 38% higher than SG, respectively, at the 0–30 cm soil layer. The ratios of DHA are as follows: for PhOX and DHA, PerOX significantly decreased with an increasing grass–legume mixture, suggesting greater C sequestration. PCA analysis revealed that C sequestration under legume diversification and enzymatic stoichiometry had an indirect but substantial impact on C sequestration. The increasing C sequestration under SGL12 was complemented by higher productivity. Data suggested that increasing legumes in pastureland might greatly enhance ecosystem functions such as soil C storage, productivity, ecorestoration efficiency, and biological activity in Indian Himalayan pastureland. Full article

In this study, the impacts of long-term soil and crop management practices on crop productivity and soil health in oilseed brassica-based production systems were examined. Different tillage, crop residue recycling and cropping systems (fallow–mustard, cluster bean–mustard, green gram–mustard, maize–mustard, pearl millet–mustard and sesame–mustard) were studied for 5 years at two soil depths (0–15 and 15–30 cm) in a split-plot design with three replications. No-till permanent beds with crop residue (PB + R) noticeably improved soil organic carbon (SOC), microbial biomass carbon (MBC), enzymes (dehydrogenase (DHA) and alkaline phosphatase (AlP)), nitrogen fractions (available and total nitrate) and available phosphorus and potassium content in both soil layers compared to conventional tillage without crop residues. However, the plough soil layer (0–15 cm) showed higher concentrations of soil carbon, enzymes, N fractions and available P than in the subsoil (15–30 cm). The dynamic soil biological and chemical properties also varied with the crop stage, and higher MBC at 30 days, SOC and enzymatic activities at 60 days, and N fractions and available P and K during the harvesting of mustard crop were recorded. Green gram–mustard rotation showed higher values in terms of biological and chemical parameters. Thus, the legume-based mustard crop rotation following no-till permanent beds and residue recycling was found to be holistic in terms of improving soil health and nutrient cycling. Full article

The discovery of new natural products has become more challenging because of the re-isolation of compounds and the lack of new sources. Microbes dwelling in extreme conditions of high salinity and temperature are huge prospects for interesting natural metabolites. In this study, the endophytic bacteria Bacillus velezensis 7NPB-3B isolated from the halophyte Salicornia brachiata was screened for its biofilm inhibition against methicillin-resistant Staphylococcus aureus (MRSA). The fractionation of the crude extract was guided by bioassay and LC-HRMS-based metabolomics using multivariate analysis. The 37 fractions obtained by high-throughput chromatography were dereplicated using an in-house MS-Excel macro coupled with the Dictionary of Natural Products database. Successive bioactivity-guided separation yielded one novel compound (1), a diketopiperazine (m/z 469.258 [M − H]⁻) with an attached saturated decanoic acid chain, and four known compounds (2–5). The compounds were identified based on 1D- and 2D-NMR and mass spectrometry. Compounds 1 and 5 exhibited excellent biofilm inhibition properties of >90% against the MRSA pathogen at minimum inhibition concentrations of 25 and 35 µg/mL, respectively. The investigation resulted in the isolation of a novel diketopiperazine from a bacterial endophyte of an untapped plant using an omics approach. Full article

Pomegranate (Punica granatum L.) is a fruit tree that is globally distributed, especially in warm areas with low annual rainfall and limited water availability. This species exemplifies the critical role of water in agriculture and the need for efficient irrigation practices due to its characteristics, cultivation requirements, and geographic diffusion. In this study, we investigated the effects of drip irrigation and mulching on the vegetative growth, yield, and fruit quality attributes of pomegranate. The experiment involved three irrigation regimes (100% of evapotranspiration, 80%, and 60%) and three mulching treatments (no mulch, plastic mulch, and organic mulch) in a factorial combination. Both irrigation and mulching had significant positive influences on the yield and fruit quality attributes. Specifically, deficit irrigation strategies showed a negative impact on the fruit yield per tree, with a greater effect observed as the severity of the irrigation deficit increased. Mulching, on the other hand, led to a significant increase in the fruit yield, primarily attributed to an increase in fruit size. Furthermore, the analysis indicated that irrigation and mulching treatments had distinct effects on fruit traits such as the fruit length, width, volume, and rind thickness. Interestingly, the study highlighted that the effects of irrigation and mulching on fruit quality attributes were mostly independent of each other, suggesting an additive influence rather than an interaction between the two factors. These findings underscore the importance of considering irrigation and mulching practices for optimizing fruit quality in pomegranate cultivation, particularly in semi-arid regions. The results contribute valuable insights for farmers and researchers seeking to enhance fruit production and quality. Full article

This work provides an overview of the importance of recycling PET waste to reduce the environmental impact of plastic waste, conserve natural resources and energy, and create jobs in the recycling industry. Many countries have implemented regulations and initiatives to promote the recycling of PET waste and reduce plastic pollution, such as extended producer responsibility (EPR) systems, bans on certain single-use plastics, and deposit–return systems for plastic bottles. The article further underscores the versatility of recycled PET, as it can be transformed into various products such as fibers, sheets, film, and strapping. These recycled materials find applications in numerous sectors including clothing, carpets, upholstery, and industrial fibers. Recognizing the importance of collaboration among governments, industries, and individuals, we emphasize the need for sustainable PET waste management practices and the promotion of recycled materials. The article also provides information on India’s experiences with PET waste management and regulations in other countries. It is important to note that the global production and consumption of PET have increased significantly in recent years, with the packaging industry being the largest consumer of PET. This has resulted in a significant increase in the generation of PET waste, which poses a significant environmental and health hazard if not managed properly. PET waste can end up in landfills, where it can take hundreds of years to decompose, or it can end up in the oceans, where it can harm marine life and the environment. Therefore, the proper management and recycling of PET waste are essential to mitigate these negative impacts. In terms of India’s experiences with PET waste management, several initiatives have been implemented to promote the recycling of PET waste. For example, the government has launched the Swachh Bharat Abhiyan campaign, which aims to promote cleanliness and sanitation in the country to promote waste segregation and recycling. Full article