Search Results (9)

In this scholarly discourse, we present proof of the existence of unique fixed points in b-metric spaces for hybrid rational contractions. Moreover, we establish a common fixed point theorem for four self-mappings, assuming S-compatibility for two pairs of self-mappings within the framework of b-metric spaces. As a practical demonstration of the aforementioned results, we apply them to a type of integral equation and derive a theorem that guarantees the existence of solutions. Full article

Chronic liver disease (CLD) is a growing concern worldwide. The common etiological factors include infection, alcohol abuse, exposure to hepatotoxic drugs, autoimmune disorders, and metabolic diseases. The chronic liver disease progresses to liver cirrhosis and its consequent complications. It is routinely managed by a combination of various therapies in combination with lifestyle modifications. The current literature supports the growing importance of the usage of herbal medicines in the management of CLD due to their efficacy and very low incidence of adverse effects. Liv.52 is a known polyherbal formulation and has been used for over 50 years in India and other countries. The evidence collected from preclinical and clinical studies supports the use of Liv.52 in symptomatic improvement and supportive treatment due to hepatitis (including Hepatitis B), alcoholic liver disease, non-alcoholic fatty liver disease (NAFLD), and non-alcoholic steatohepatitis (NASH) and hepatotoxicity due to drugs used in the treatment of tuberculosis. Liv.52 has also shown some preliminary hepatoprotective effects in patients with liver cirrhosis due to its potential antioxidant and anti-inflammatory effects. Both the syrup and tablet formulations are well tolerated and have shown a good safety profile. Liv.52 may be a favorable herbal choice for the management of CLD due to various etiologies. Full article

Vogt-Koyanagi-Harada (VKH) disease is an auto-immune inflammatory disease of choroidal origin. During the acute stage, optical coherence tomography (OCT), however, may not be able to assess the entire choroid. The aims of the paper were to evaluate the role of retinal pigment epithelium (RPE) as a biomarker of inflammation in acute VKH. This was a retrospective observational study done in 55 eyes of 29 patients with acute VKH. RPE thickness, total choroidal thickness, and RPE reflectivity before and after resolution were analyzed using image J software. Correlations between several baseline and post-resolution parameters were performed, and factors affecting change in visual acuity were analyzed. A significant decrease in RPE thickness and a significant increase in RPE reflectivity were seen following resolution of the disease. Furthermore, there was a significant correlation between RPE and choroidal thickness during the acute stage of the disease. Baseline visual acuity and the presence of bacillary detachment at baseline were the only factors responsible for changes in visual acuity. We propose the utility of RPE layer as a surrogate biomarker of choroidal activity and inflammation in terms of RPE reflectivity and RPE thickness during the acute stage of VKH, especially when there is poor imaging of the choroid. Full article

To explore the quality rootstocks which impart better quality fruits in mango varieties, we studied the interactive effect of the scion and rootstock using five mango varieties (Mallika, Amrapali, Dashehari, Pusa Arunima, and Pusa Surya) grafted on three rootstocks (Olour, Kurukkan, and K-5). A total of 25 physico-chemical parameters were studied in the five grafted varieties viz., fruit weight, yield efficiency, fruit per plant, pulp percent, total soluble solids (TSS), acidity, physiological loss in weight (PLW), peel thickness, respiration rate, etc., and were found to be altered through scion–rootstock interaction. Among the five mango varieties, Olour rootstock proved best to improve the fruit quality and shelf life using the grafting approach. Physico-chemical-traits-based clustering was unable to precisely group scion varieties according to their grafting rootstock. A total of 35 shelf-life specific markers were designed from ripening genes, such as expansin, polygalactouranase, ethylene insensitive, ethylene sensitive, etc. Of these specific primers, 24 showed polymorphism among the studied genotypes. The gene diversity (GD), allele per locus (An), polymorphism information content (PIC), and major allele frequency (MAF) observed were 0.43, 2.00, 0.34, and 0.63, respectively. Cluster analysis clearly showed that scion grafted on Kurukkan and Olour rootstock, and scion varieties grafted on K-5 rootstock grouped together have more similarity. A total of eight simple sequence repeats loci (SSRs) markers were associated with eight physiological traits. Strong association of SSR loci NMSLC-12 and NMSLC-14 with yield efficiency and fruit weight were observed with a phenotypic variance of 85% and 70%, respectively. Full article

Alcoholic liver disease (ALD) has been a growing concern in developed and developing nations. Oxidative stress and lipid peroxidation are the most common cause of the development and progression of ALD. Due to paucity in the number and efficacy of hepatoprotective drugs currently available, and with the easy availability of natural therapy and herbal medicines, ALD is managed using a combination of pharmaceutical interventions and herbal medications. However, the effectiveness of these hepatoprotectives is controversial. Preclinical and clinical studies have demonstrated that Liv.52 modulates the lipotropic activity of hepatocytes, reduces inflammation, enhances alcohol and acetaldehyde metabolism, and protects the hepatic parenchyma by restoring the antioxidant levels of hepatocytes. Clinical studies further support that there is improvement in the subjective symptoms of patients as well as improvements in liver function test parameters. Studies suggest that Liv.52 is well tolerated and has no reported side effects. Full article

All-solid-state Li-S batteries (use of solid electrolyte LiBH₄) were prepared using cathodes of a homogeneous mixture of graphene oxide (GO) and reduced graphene oxide (rGO) with sulfur (S) and solid electrolyte lithium borohydride (LiBH₄), and their electrochemical performance was reported. The use of LiBH₄ and its compatibility with Li metal permits the utilization of Li anode that improves the vitality of composite electrodes. The GO-S and rGO-S nanocomposites with different proportions have been synthesized. Their structural and morphological characterizations were performed by X-ray diffraction (XRD) and scanning electron microscopy (SEM), and the results are presented. The electrochemical performance was tested by galvanostatic charge-discharge measurements at a 0.1 C-rate. The results presented here demonstrate the successful implementation of GO-S composites in an all-solid-state battery. Full article

Fire is one of the mutable hazards that damage properties and destroy forests. Many researchers are involved in early warning systems, which considerably minimize the consequences of fire damage. However, many existing image-based fire detection systems can perform well in a particular field. A general framework is proposed in this paper which works on realistic conditions. This approach filters out image blocks based on thresholds of different temporal and spatial features, starting with dividing the image into blocks and extraction of flames blocks from image foreground and background, and candidates blocks are analyzed to identify local features of color, source immobility, and flame flickering. Each local feature filter resolves different false-positive fire cases. Filtered blocks are further analyzed by global analysis to extract flame texture and flame reflection in surrounding blocks. Sequences of successful detections are buffered by a decision alarm system to reduce errors due to external camera influences. Research algorithms have low computation time. Through a sequence of experiments, the result is consistent with the empirical evidence and shows that the detection rate of the proposed system exceeds previous studies and reduces false alarm rates under various environments. Full article

Chronic activation of B-cell receptor (BCR) signaling via Bruton tyrosine kinase (BTK) is largely considered to be one of the primary mechanisms driving disease progression in B–Cell lymphomas. Although the BTK-targeting agent ibrutinib has shown promising clinical responses, the presence of primary or acquired resistance is common and often leads to dismal clinical outcomes. Resistance to ibrutinib therapy can be mediated through genetic mutations, up-regulation of alternative survival pathways, or other unknown factors that are not targeted by ibrutinib therapy. Understanding the key determinants, including tumor heterogeneity and rewiring of the molecular networks during disease progression and therapy, will assist exploration of alternative therapeutic strategies. Towards the goal of overcoming ibrutinib resistance, multiple alternative therapeutic agents, including second- and third-generation BTK inhibitors and immunomodulatory drugs, have been discovered and tested in both pre-clinical and clinical settings. Although these agents have shown high response rates alone or in combination with ibrutinib in ibrutinib-treated relapsed/refractory(R/R) lymphoma patients, overall clinical outcomes have not been satisfactory due to drug-associated toxicities and incomplete remission. In this review, we discuss the mechanisms of ibrutinib resistance development in B-cell lymphoma including complexities associated with genomic alterations, non-genetic acquired resistance, cancer stem cells, and the tumor microenvironment. Furthermore, we focus our discussion on more comprehensive views of recent developments in therapeutic strategies to overcome ibrutinib resistance, including novel BTK inhibitors, clinical therapeutic agents, proteolysis-targeting chimeras and immunotherapy regimens. Full article

The texture evolution during hot compression of extruded ZK60A-T5 magnesium alloy plate loaded along the extrusion direction (ED) and the normal direction (ND) has been examined with the help of pole figures obtained on specimens deformed in the ranges of 200 °C to 500 °C and 0.0003 s⁻¹ to 10 s⁻¹. The results are interpreted in terms of the operating slip systems and mechanisms identified based on processing maps developed for the above two initial specimen orientations. The processing map for the initial ED orientation exhibited three domains. In Domains 1 and 3, first-order pyramidal slip {10 $\overline{1}$ l} <11 $\overline{2}$ 0> occurs, while in Domain 2, second-order pyramidal slip {11 $\overline{2}$ 2} <11 $\overline{2}$ 3> occurs. The pole figures obtained on specimens deformed in Domains 1 and 3 are strikingly similar, indicating that the operating slip system controls the texture evolution. Compression in Domains 1 and 3 nearly randomizes the intense basal texture in the as-received specimens, while a new texture is generated in Domain 2 with basal poles at 45° to ND or transverse direction (TD). This new texture will promote basal slip when loaded in a transverse direction. When loaded in the normal direction (ND), the processing map exhibited four domains. In Domains 1 and 4, {10 $\overline{1}$ l} <11 $\overline{2}$ 3> slip occurs, while {11 $\overline{2}$ 2} <11 $\overline{2}$ 3> slip occurs in Domains 2 and 3. The pole figures obtained from specimens deformed in Domains 1 and 4 have similar features, while those deformed in Domains 2 and 3 exhibited similar features to one another, confirming that the operating slip systems control the texture development since they are the same in each pair. The compression along ND produces strong basal textures with the basal planes normal to the ED. The texture gets intensified with increased temperature of deformation and causes strong anisotropy in mechanical properties. Full article