Search Results (22)

The present paper addresses a comprehensive historical assessment of water consumption, demand, and supply in Saudi Arabia, along with future projections regarding water balance, in terms of demand and supply by source in various sectors. Being an arid region, Saudi Arabia experiences scorching heat, low precipitation, a high rate of potential evaporation, and the absence of permanent water bodies over the territory. Groundwater contributes almost 61% of total available water, while the recharge rate is negligible. However, few widyan (ephemeral streams) systems exists to satisfy water demand, which could contribute to approximately one year of domestic water consumption if managed efficiently. The study also predicts water consumption scenarios for the next three consecutive development plans, i.e., the 10th plan (2015–2019), 11th plan (2020–2024), and 12th plan (2025–2029). The analysis shows that water consumption may decline significantly in the future, if the present rate of decline continues. Scenario I, if the current rate is assumed, provides a decrease in consumption of 14.36, 12.66, and 11.15 BCM for 10th, 11th, and 12th plans, respectively. Moreover, the domestic and industrial sectors will consume more water in the future. In the same way, scenarios II and III represent a decline in total water consumption, along with that of agriculture, while domestic and industrial water usage would increase, thus improving environmental sustainability. Full article

Amidst the abundance of skincare options, the process of identifying the most fitting products is a daunting task. This challenge is further intensified when brands frequently lack transparency concerning their environment-friendly characteristics, fostering skepticism among consumers or potential adopters. As a result, to resolve the problem of consumers’ mixed emotions towards skincare brands, it is necessary to understand how greenwashing, green skepticism with two moderators (information quality and brand reputation) shape consumers’ intentions. Drawing on a theoretical conceptual model rooted in the consumer behavior literature, the present investigation tested the hypotheses through cross-sectional survey research. Using convenience sampling, 441 participants were recruited through social media platforms and skincare-related forums. This study establishes the mediating role of green skepticism and the direct impact of greenwashing on consumers’ purchase intentions. Consequently, the statistical significance of the path coefficients provide empirical support for the influence of greenwashing and green skepticism on consumers’ intentions. Our research contributes to the broader discourse on sustainable consumption, offering theoretical advancements and practical implications for the researchers, policymakers, and businesses involved in the Saudi Arabian skincare market. Full article

The soil microbiome is crucial for maintaining the sustainability of the agricultural environment. Concerning the role of diverse mycobiomes and their abundance toward the suppression of root-knot nematode (RKN) infection in vegetable crops, our understanding is unclear. To unveil this issue, we examined the fungal microbiome in tomato rhizosphere augmented with bioagents challenged against RKN at taxonomic and functional levels. Composition of the mycobiome in tomato rhizosphere treated with Bacillus velezensis VB7 and Trichoderma koningiopsis TK differed significantly from the infected tomato rhizosphere. The abundance and diversity of fungal species, however, were significantly higher in the combined treatments of bioagents than for individual treatments. Fungal microbiome diversity was negatively correlated in the RKN-associated soil. Network analysis of the fungal biome indicated a larger and complex network of fungal biome diversity in bioagent-treated soil than in nematode-associated tomato rhizosphere. The diversity index represented by that challenging the RKN by drenching with consortia of B. velezensis VB7 and T. koningiopsis TK, or applying them individually, constituted the maximum abundance and richness of the mycobiome compared to the untreated control. Thus, the increased diverse nature and relative abundance of the mycobiome in tomato rhizosphere was mediated through the application of either T. koningiopsis TK or B. velezensis VB7, individually or as a consortium comprising both fungal and bacterial antagonists, which facilitated engineering the community composition of fungal bioagents. This in turn inhibited the infestation of RKN in tomato. It would be interesting to explore further the possibility of combined applications of B. velezensis VB7 and T. koningiopsis TK to manage root-knot nematodes as an integrated approach for managing plant parasitic nematodes at the field level. Full article

Onion (Allium cepa L.) is a prominent spice and vegetable crop farmed commercially worldwide. Variability is viewed as a key signal for any red onion enhancement effort. The current study was, therefore, carried out to learn about genetic variability and diversity among selected genotypes of 20 red onions at the C Block Farm, Bidhan Chandra Krishi Viswavidyalaya, India, during the winter (rabi) season of 2021–2022, in Randomized Complete Block Design (RCBD) with three replications. The characters, viz., average weight of bulbs (kg), neck thickness (cm), total soluble solids (°Brix), total sugar (%), and reducing sugar (%) demonstrated high heritability (97.38–99.97%) coupled with high genetic gain. Such traits were the least influenced by environmental effects, and additive gene action played a pivotal role in the manifestation of such characters. Traits with high heritability values (51.37–67.94%) demonstrate that the observed variability was under genetic control and provide an enormous range of possibilities for accomplishing selection depending on their phenotypic performances. For traits with moderate heritability, viz., bolting (%) and doubling (%), selection would be less effective but can still be given great importance. Based on correlation analysis, the character’s neck thickness, equatorial diameter, and polar diameter unveiled highly positive genetic correlation with the average weight of bulbs (0.120, 0.112; 0.194, 0.210 and 0.120, 0.112 for phenotypic and genotypic correlation coefficient values, respectively), which indicates that the average weight of a bulb would be increased by an increase in such components. According to path coefficient analysis, the equatorial diameter exhibited the most positive direct effect on the average weight of bulbs (0.968), followed by polar diameter (0.687) and neck thickness (0.159). A wide range of variations for qualitative traits, including foliage colour, leaf width, foliage behaviour, the degree of leaf waxiness, the shape of the bulb, and bulb skin colour were observed. Based on Mahalanobish D² analysis, the genotypes were divided into four clusters. The highest number of genotypes was found in cluster I (eleven), followed by cluster IV (six genotypes) and cluster II (two genotypes). Cluster III had a single genotype and was monogenic. The study confirmed that a wide genetic variation prevailed in the onion genotypes taken under study, which could thereby be utilized in breeding programmes. Full article

This study effectively reports the influence of experimental incubation period on the sol-gel production of husk-like zinc oxide nanoparticles (ZNPs) and their anti-cancerous abilities. The surface morphology of ZNPs was studied with the help of SEM. With the use of TEM, the diameter range of the ZNPs was estimated to be ~86 and ~231 nm for ZNP^A and ZNP^B, prepared by incubating zinc oxide for 2 and 10 weeks, respectively. The X-ray diffraction (XRD) investigation showed that ZNPs had a pure wurtzite crystal structure. On prolonging the experimental incubation, a relative drop in aspect ratio was observed, displaying a distinct blue-shift in the UV-visible spectrum. Furthermore, RBC lysis assay results concluded that ZNP^A and ZNP^B both demonstrated innoxious nature. As indicated by MTT assay, reactive oxygen species (ROS) release, and chromatin condensation investigations against the human epidermoid carcinoma (HEC) A431 cells, ZNP^B demonstrated viable relevance to chemotherapy. Compared to ZNP^B, ZNP^A had a slightly lower IC₅₀ against A431 cells due to its small size. This study conclusively describes a simple, affordable method to produce ZNP nano-formulations that display significant cytotoxicity against the skin cancer cell line A431, suggesting that ZNPs may be useful in the treatment of cancer. Full article

(1) Background: Peste des petits ruminants (PPR) is a highly contagious animal disease affecting small ruminants, leading to significant economic losses. There has been little published data on PPR virus (PPRV) infection in the United Arab Emirates (UAE); (2) Methods: four outbreaks reported in goats and Dama gazelle in 2021 were investigated using pathological and molecular testing; (3) Results: The infected animals showed symptoms of dyspnea, oculo-nasal secretions, cough, and diarrhea. Necropsy findings were almost similar in all examined animals and compliant to the classical forms of the disease. Phylogenetic analysis based on N gene and F gene partial sequences revealed a circulation of PPRV Asian lineage IV in the UAE, and these sequences clustered close to the sequences of PPRV from United Arab Emirates, Pakistan, Tajikistan and Iran; (4) Conclusions: PPRV Asian lineage IV is currently circulating in the UAE. To the best of our knowledge, this is a first study describing PPRV in domestic small ruminant in the UAE. Full article

Salinity-induced ethylene production and reactive oxygen species (ROS) inhibit agricultural productivity. The plant synthesizes ethylene directly from aminocyclopropane-1-carboxylic acid (ACC). By using ACC as a nitrogen source, bacteria with ACC deaminase (ACCD) inhibit the overproduction of ethylene, thereby maintaining the ROS. The present study investigated the ACCD activity of previously identified rhizobacterial strains in Dworkin and Foster (DF) minimal salt media supplemented with 5 mM ACC (as N-source). Bacterial isolates GKP KS2_7 (Pseudomonas aeruginosa) and MBD 133 (Bacillus subtilis) could degrade ACC into α-ketobutyrate, exhibiting ACCD activity producing more than ~257 nmol of α-ketobutyrate mg protein⁻¹ h⁻¹, and were evaluated for other plant growth-promoting (PGP) traits including indole acetic acid production (>63 µg/mL), phosphate solubilization (>86 µg mL⁻¹), siderophore (>20%) ammonia and exopolysaccharide production. Furthermore, Fourier Transform Infrared analysis also demonstrated α-ketobutyrate liberation from ACC deamination in DF minimal salt media, thereby confirming the ACCD activity. These isolates also showed enhanced tolerance to salinity stress of 3% w/v NaCl in vitro, in addition to facilitating multifarious PGP activities. Seed bacterization by these ACCD-producing bacterial isolates (GKP KS2_7 and MBD 133) revealed a significant decline in stress-stimulated ethylene levels and its associated growth inhibition during seedling germination. They also mitigated the negative effects of salt stress and increased the root-shoot length, fresh and dry weight of root and shoot, root-shoot biomass, total sugar, protein, reducing sugar, chlorophyll content, and antioxidants enzymes in Pisum sativum. As a result, these strains (GKP KS2_7 and MBD 133) might be applied as biofertilizers to counteract the negative effects of soil salinity. Full article

This article presents a novel buck–boost converter-based topology suitable for supercapacitors and grid-connected solar PV system applications. The proposed converter can handle a wide range of voltage variations at the input side, making it ideal for extracting most of the energy from supercapacitors or a solar PV system connected to the input side of the converter. The output voltage of the converter is non-inverting which makes the control easier. The design of passive components, continuous mode operation, and discontinuous mode operation are all thoroughly discussed. A low-power hardware prototype of three hundred watts is developed and tested in the laboratory to validate the theoretical aspects of the converter. Full article

Excessive nitrogenous fertilization in years resulted in larger nitrogen and profit losses. This problem can be reduced by using need-based and time-specific nitrogen management. Therefore, a field experiment was carried out during the Kharif season of 2019 and 2020 in order to evaluate the impact of precision nitrogen management on the phenology, yield and agrometeorological indices of hybrid maize genotypes at the Agronomy Research Farm, FoA Wadura, Sopore, SKUAST-Kashmir. The experiment was carried out in split-plot design consisting of maize hybrids (Shalimar Maize Hybrid-2 Vivek-45 and Kanchan-517) as main plot treatments and precision nitrogen management (T₁: Control, T₂: Recommended N, T₃: 25% N as basal ≤ LCC 3@20 kg N ha⁻¹, T₄: 25% N as basal ≤ LCC 3@30 kg N ha⁻¹, T₅: 25% N as basal ≤ LCC 4@20 kg N ha⁻¹, T₆: 25% N as basal ≤ LCC 4@30 kg N ha⁻¹, T₇: 25% N as basal ≤ LCC 5@20 kg N ha⁻¹ and T₈: 25% N as basal ≤ LCC 5@30 kg N ha⁻¹) as sub-plot treatments. Results demonstrated that maize hybrids showed a non-significant difference in attaining different phenophases during both years. However, Shalimar Maize Hybrid-2 demonstrated higher grain (62.35 and 60.65 q ha⁻¹) and biological yield (170.26 and 165.86 q ha⁻¹), a higher number of days to attain different phenological stages in comparison to Vivek-45 and Kanchan-517 thereby achieved higher heat units, PTUs, HTUs, PTI. The application of nitrogen through LCC ≤ 5@30 kg N ha⁻¹ noted higher grain yield (61.27 and 59.13 q ha⁻¹) and biological yield (171.30 and 166.13 q ha⁻¹) during 2019 and 2020 respectively. Higher values of Growing degree days (GDD), Heliothermal units (HTU), Photothermal units (PTU), Phenothermal index (PTI), heat use efficiency (HUE) and radiation use efficiency (RUE) were observed in the application of nitrogen through LCC ≤ 5@30 kg N ha⁻¹ and required the highest number of days to reach different phenophases than other treatments during crop growing seasons of 2019 and 2020. The results demonstrated that Nitrogen application based on LCC ≤ 5@30 proved effective and should be adopted in maize hybrids especially in Shalimar Maize Hybrid-2 to attain higher yield under the temperate climate of Kashmir Valley. Full article

Cancer cells change their glucose and glutamine (GLU) metabolism to obtain the energy required to continue growing. Glutaminase (GLS) plays a crucial role in promoting cell metabolism for cancer cell growth; targeting GLU metabolism by inhibiting GLS has attracted interest as a potential cancer management strategy. Herein, we employed a sequential screening of traditional Chinese medicine (TCM) database followed by drug-likeness and molecular dynamics simulations against the active site of GLS. We report 12 potent compounds after screening the TCM database against GLS, followed by a drug-likeness filter with Lipinski and Veber rule criteria. Among them, ZINC03978829 and ZINC32296657 were found to have higher binding energy (BE) values than the control compound 6-Diazo-5-Oxo-L-Norleucine, with BEs of −9.3 and −9.7 kcal/mol, respectively, compared to the BE of 6-Diazo-5-Oxo-L-Norleucine (−4.7 kcal/mol) with GLS. Molecular dynamics simulations were used to evaluate the results further, and a 100 ns MD simulation revealed that the hits form stable complexes with GLS and formed 2–5 hydrogen bond interactions. This study indicates that these hits might be employed as GLS inhibitors in the battle against cancer. However, more laboratory tests are a prerequisite to optimize them as GLS inhibitors. Full article

Natural products play a critical role in the discovery and development of numerous drugs for the treatment of various types of cancer. These phytochemicals have demonstrated anti-carcinogenic properties by interfering with the initiation, development, and progression of cancer through altering various mechanisms such as cellular proliferation, differentiation, apoptosis, angiogenesis, and metastasis. Treating multifactorial diseases, such as cancer with agents targeting a single target, might lead to limited success and, in many cases, unsatisfactory outcomes. Various epidemiological studies have shown that the steady consumption of fruits and vegetables is intensely associated with a reduced risk of cancer. Since ancient period, plants, herbs, and other natural products have been used as healing agents. Likewise, most of the medicinal ingredients accessible today are originated from the natural resources. Regardless of achievements, developing bioactive compounds and drugs from natural products has remained challenging, in part because of the problem associated with large-scale sequestration and mechanistic understanding. With significant progress in the landscape of cancer therapy and the rising use of cutting-edge technologies, we may have come to a crossroads to review approaches to identify the potential natural products and investigate their therapeutic efficacy. In the present review, we summarize the recent developments in natural products-based cancer research and its application in generating novel systemic strategies with a focus on underlying molecular mechanisms in solid cancer. Full article

Zinc is an essential nutrient for human health; it is involved in the catalytic, structural, and regulatory functions of the human cellular system. Different compositions of zinc, as well as its pharmaceutically acceptable salts, are available on the market. Recent studies have demonstrated the role of zinc in combating COVID-19. It has been determined that zinc prevents the entry of SARS-CoV-2 into cells by lowering the expression of ACE-2 receptors and inhibiting the RNA-dependent RNA polymerase of SARS-CoV-2. Zinc also prevents the cytokine storm that takes place after the entry of SARS-CoV-2 into the cell, via its anti-inflammatory activity. The authors believe that no study has yet been published that has reviewed the trends, inventions, and patent literature of zinc compositions to treat/prevent COVID-19. Accordingly, this review has been written in order to fill this gap in the literature. The information about the clinical studies and the published patents/patent applications was retrieved from different databases. This review covers patent literature on zinc compositions up to 31 January 2022. Many important patents/patent applications for zinc-based compositions filed by innovative universities and industries were identified. The patent literature revealed zinc compositions in combination with zinc ionophores, antioxidants, antivirals, antibiotics, hydroxychloroquine, heparin, ivermectin, and copper. Most of these studies were supported by clinical trials. The patent literature supports the potential of zinc and its pharmaceutical compositions as possible treatments for COVID-19. The authors believe that countless zinc-based compositions are still unexplored, and there is an immense opportunity to evaluate a considerable number of the zinc-based compositions for use against COVID-19. Full article

Cancer is, globally, one of the main causes of death. Even though various therapies are available, they are still painful because of their adverse side effects. Available treatments frequently fail due to unpromising responses, resistance to classical anticancer drugs, radiation therapy, chemotherapy, and low accessibility to tumor tissues. Developing novel strategies to minimize adverse side effects, improve chemotherapy sensitivity, and control cancer progression is needed. Many studies have suggested small dietary molecules as complementary treatments for cancer patients. Different components of herbal/edible plants, known as flavonoids, have recently garnered attention due to their broad biological properties (e.g., antioxidant, antiviral, antimicrobial, anti-inflammatory, anti-mutagenic, anticancer, hepatoprotective, and cardioprotective). These flavonoids have shown anticancer activity by affecting different signaling cascades. This article summarizes the key progress made in this area and discusses the role of flavonoids by specifically inhibiting the PI3K/Akt/mTOR pathway in various cancers. Full article

In the current scenario, sustainable power generation received greater attention due to the concerns of global warming and climate change. In the present paper, a Solar Photovoltaic/Diesel Generator/ Battery-based hybrid system has been considered to meet the electrical energy demand of a remote location of India. The cost of the energy of hybrid system is minimized using a Biogeography-based Optimization (BBO) algorithm under the constraints of power reliability, carbon emission and renewable energy fraction. Load following and cycle charging strategies have been considered in order to investigate the performance analysis of the proposed hybrid system. Further, different component combinations of specifications available on the market are presented for detail analysis. The minimum cost of energy of the proposed hybrid system is obtained as 0.225 $/kWh. Full article