Search Results (92)

Dichorhavirus is a recently accepted plant virus genus within the family Rhabdoviridae. Species assigned to the genus consist of bi-segmented, negative sense, single-stranded RNA viruses and are transmitted by Brevipalpus spp. Currently, there are five recognized species and two unclassified members in the genus Dichorhavirus. Four out of seven-orchid fleck virus (OFV), citrus leprosis virus N, citrus chlorotic spot virus, and citrus bright spot virus-can infect citrus and produce leprosis disease-like symptoms. The E-probe Diagnostic for Nucleic Acid Analysis (EDNA) was developed to reduce computational effort and then integrated within Microbe-Finder (MiFi^®) online platform to design and evaluate e-probes in raw High Throughput Sequencing (HTS) data. During this study, Dichorhavirus genomes were downloaded from public databases and e-probes were designed using the MiProbe incorporated into the MiFi^® platform. Three different sizes of e-probes, 40, 60, and 80 nucleotides, were developed and selected based on whole genome comparisons with near-neighbor genomes. For curation, each e-probe was searched in the NCBI nucleotide sequence database using BLASTn. All the e-probes that had hits with non-target species with ≥90% identities were removed. The sensitivity and specificity of Dichorhavirus genus, species, strain, and variant-specific e-probes were validated in vivo using HTS meta-transcriptomic libraries generated from Dichorhavirus-suspected citrus, orchid, and ornamentals. Through downstream analysis of HTS data, EDNA not only detected the known hosts of OFV but also discovered an unknown host leopard plant (Farfugium japonicum), and the possible existence of a new ornamental strain of OFV in nature. Full article

Background: Soft tissue sarcomas (STS) are aggressive cancers that show increasing response to novel targeted-therapies and immune-checkpoint-inhibitors. Despite anecdotal reports of cardiovascular adverse events (AEs) and major adverse cardiovascular events (MACE) potentially hindering their utility, the true cardiotoxic profile of these novel-therapies in STS has been largely understudied. Methods: We assessed the incidence and severity of AEs and MACE of contemporary FDA-approved targeted and immune-based therapies for STS, using data from landmark clinical trials supporting FDA-approval. We also analyzed data from the FDA adverse-event-reporting-system-(FAERS) for FDA-approved STS targeted and immune-based therapies for comparative real-world validation. Results: Overall, 12 clinical trials supporting FDA-approval of STS targeted-therapies and immune-checkpoint-inhibitors, incorporating 1249 patients, were identified. These clinical trials revealed 751 AEs including, hypertension (382, 50.87%), atrial fibrillation (3, 0.40%), myocardial infarction (2, 0.27%), cardiac failure (congestive included) (9, 1.20%), and cardiac failure (heart failure included) (7, 0.93%). Compared to placebo, those treated saw higher MACE (OR: 3.27, p < 0.001). The FAERS data showed 489 reported AEs including hypertension (275, 56.24%), atrial fibrillation (31, 6.34%), myocardial infarction (15, 3.07%), and cardiac failure (congestive included) (30, 6.13%). Programmed death-ligand 1 (PD-L1) inhibitors had the highest probability of AEs (0.65, 1.17), followed by tyrosine kinase inhibitors (0.66, 0.11), tropomyosin receptor kinase inhibitors (0.25, 0.13), mammalian target of rapamycin inhibitors (0.21, 0.09), and enhancer of zeste homologue 2 inhibitors (0.11, 0.06). Proportions were calculated from the samples in clinical trials supporting FDA-approval and FAERS, respectively. Conclusions: In this investigation, contemporary FDA-approved therapies for STS are associated with increased risk of AEs Full article

Background and Objectives: Exercise-induced hypoalgesia (EIH) is a topic of interest in the scientific community. This umbrella review aimed to analyze EIH research and compare it with public dissemination on X. Materials and Methods: We selected relevant EIH reviews that included a healthy population or patients with pain and studied exercise interventions. A systematic literature search was carried out in PubMed, Web of Science, SciELO, PEDro, and Google Scholar, employing the Population, Intervention, Comparison, and Outcome strategy. Data were extracted and summarized, and methodological quality was assessed with the Quality Assessment Scale for Systematic Reviews, and risk of bias with the Risk of Bias in Systematic Reviews tool. The Physical Activity Guidelines Advisor Committee was employed for evidence synthesis. Simultaneously, advanced X website searches gathered EIH-related content for analysis. Information from posts on X was qualitatively analyzed and contrasted with evidence in the literature. Results: We included nine systematic reviews and 17 narrative reviews. Systematic reviews presented high methodological quality. However, half had low risk of bias, while the other half presented high risk of bias. The EIH in healthy participants was controversial for some exercise modalities, such as aerobic exercise, and the influence of psychological variables. Modalities, such as isotonic resistance exercise, showed favorable effects on hypoalgesia. However, in patients with musculoskeletal pain, different exercise modalities did not generate EIH. X analysis unveiled a considerable representation of science-related content, although with prevalent misinterpretations of scientific evidence. Conclusions: EIH has been extensively studied, yet the certainty of evidence remains limited. While some exercise modalities demonstrate hypoalgesic effects in asymptomatic individuals, these effects remain unverified in patients with musculoskeletal pain. Moreover, the analysis of social media content highlights frequent misinterpretations of scientific evidence, particularly conflating hypoalgesia with analgesia. This underscores the need for more precise, evidence-based communication on social media platforms. Full article

This study explores the potential of using underutilized materials from agricultural and forestry systems, such as rice husk, wheat straw, and wood strands, in developing corrugated core sandwich panels as a structural building material. By leveraging the unique properties of these biobased materials within a corrugated geometry, the research presents a novel approach to enhancing the structural performance of such underutilized biobased materials. These biobased materials were used in different lengths to consider the manufacturing feasibility of corrugated panels and the effect of fiber length on their structural performance. The average lengths for wood strands and wheat straws were 12–15 cm and 3–7.5 cm, respectively, while rice husks were like particles, about 7 mm long. Due to the high silica content in rice husk and wheat straw, which negatively impacts the bonding performance, polymeric diphenylmethane diisocyanate (pMDI), an effective adhesive for such materials, was used for the fabrication of corrugated panels. Wood strands and phenol formaldehyde (PF) adhesive were used to fabricate flat outer layers. Flat panels were bonded to both sides of the corrugated panels using a polyurethane adhesive to develop corrugated core sandwich panels. Four-point bending tests were conducted to evaluate the panel’s bending stiffness, load-carrying capacity, and failure modes. Results demonstrated that sandwich panels with wood strand corrugated cores exhibited the highest bending stiffness and load-bearing capacity, while those with wheat straw corrugated cores performed similarly. Rice husk corrugated core sandwich panels showed the lowest mechanical performance compared to other sandwich panels. Considering the applications of these sandwich panels as floor, wall, and roof sheathing, all these panels exhibited superior bending performance compared to 11.2 mm- and 17.42 mm-thick commercial OSB (oriented strand board) panels, which are commonly used as building materials. These sandwich structures supported a longer span than commercial OSB panels while satisfying the deflection limit of L/360. The findings suggest the transformative potential of converting renewable yet underutilized materials into an engineered concept, corrugated geometry, leading to the development of high-performance, carbon-negative building materials suitable for flooring and roof applications. Full article

This study introduces a novel seatbelt-integrated, non-invasive, beam-focusing metamaterial sensing system characterized by its thinness and flexibility. The system comprises a flexible transmitarray lens and an FMCW radar sensor, enabling the accurate detection and analysis of seatbelt usage and positioning through human tissue. The metasurface design remains effective even when subjected to different bending angles. Our system closely tracks heart rate and respiration, validated against standard reference methods, highlighting its potential for enhancing in-car healthcare monitoring. Experimental results demonstrate the system’s reliability in monitoring physiological signals within dynamic vehicular environments. Full article

Background/Objectives: The recent discovery of BRAF mutation in papillary craniopharyngiomas opened new avenues for targeted therapies to control tumour growth, decreasing the need for invasive treatments and relative complications. The aim of this systematic review was to summarize the recent scientific data dealing with the use of targeted therapies in papillary craniopharyngiomas, as adjuvant and neoadjuvant treatments. Methods: The PRISMA guidelines were followed with searches performed in Scopus, MEDLINE, and Embase, following a dedicated PICO approach. Results: We included 21 pertinent studies encompassing 53 patients: 26 patients received BRAF inhibitors (BRAFi) as adjuvant treatment, while 25 received them as neoadjuvant treatment. In the adjuvant setting, BRAFi were used to treat recurrent tumours after surgery or adjuvant radiation therapy. The most common regimen combined dabrafenib (BRAFi) with trametinib (MEK1 and 2 inhibitor) in 81% of cases. The mean treatment length was 8.8 months (range 1.6 to 28 months) and 32% were continuing BRAFi. A reduction of tumour volume variable from 24% to 100% was observed at cerebral MRI during treatment and volumetric reduction ≥80% was described in 64% of cases. Once the treatment was stopped, adjuvant treatments were performed to stabilize patients in remission in 11 cases (65%) or when a progression was detected in three cases (12%). In four cases no further therapies were administered (16%). Mean follow-up after the end of targeted therapy was 17.1 months. As neoadjuvant regimen, 36% of patients were treated with dabrafenib and trametinib with a near complete radiological response in all the cases with a mean treatment of 5.7 months. The neoadjuvant use of verumafenib (BRAFi) and cometinib (MEK1 inhibitor) induced a near complete response in 15 patients (94%), with a median volumetric reduction between 85% and 91%. Ten patients did not receive further treatments. Side effects varied among studies. The optimal timing, sequencing, and duration of treatment of these new therapies should be established. Moreover, questions remain about the choice of specific BRAF/MEK inhibitors, the optimal protocol of treatment, and the strategies for managing adverse events. Conclusions: Treatment is shifting to a wider multidisciplinary management, where a key role is played by targeted therapies, to improve outcomes and quality of life for patients with BRAF-mutated craniopharyngiomas. Future, larger comparative trials will optimize their protocol of use and integration into multimodal strategies of treatment. Full article

This study reports two cases of Global Rostral Midbrain Syndrome (GRMS) and corpus callosum infarction in the context of shunt overdrainage caused by obstructive hydrocephalus due to aqueductal stenosis. We detail how thorough clinical evaluation and appropriate investigation helped avoid a coma misdiagnosis and describe the excellent response to pharmacological treatment and successful neurorehabilitation in both cases. We analyze the cognitive profile of patients with GRMS, a rare condition that mimics disorders such as coma and progressive supranuclear palsy at various stages. In conscious cases, GRMS typically presents with parkinsonian syndrome, Parinaud syndrome, and cognitive issues. The awareness of this rare complication of shunt overdrainage facilitates more accurate diagnosis and better management. Full article

The present study, carried out in Gujarat (India) between 2005 and 2021, aims to prepare dew and rain maps of Gujarat over a long period (17 years, from 2005 to 2021) in order to evaluate the evolution of the potential for dew and rain in the state. The ratio of dew to precipitation is also determined, which is an important metric that quantifies the contribution of dew to the overall water resources. Global warming leads, in general, to a reduction in precipitation and non-rainfall water contributions such as dew. The study shows, however, a rare increase in the rainfall and dew condensation, with the latter related to an increase in relative humidity and a decrease in wind amplitudes. Rain primarily occurs during the monsoon months, while dew forms during the dry season. Although dew alone cannot resolve water scarcity, it nonetheless may provide an exigent and unignorable contribution to the water balance in time to come. According to the site, the dew–rain ratios, which are also, in general, well correlated with dew yields, can represent between 4.6% (Ahmedabad) and 37.2% (Jamnagar). The positive trend, observed since 2015–2017, is expected to continue into the future. Full article

The proliferation of digital technologies is substantially transforming inspection methodologies for construction activities. Although the implementation of a three-dimensional (3D) model has emerged as an advantageous, feasible inspection application, the selection of the most suitable 3D models is challenging due to multiple technology options. The primary objectives of this study were to investigate current trends and identify future technologies for 3D models in the construction industry. This study utilized systematic reviews by identifying and selecting quality journals, analyzing selected articles, and conducting content analysis and meta-analysis to identify dominant themes in 3D models. Results showed that the top technologies used to model construction projects are building information models, remote sensing, stereo vision system/photo processing programs, and augmented reality/virtual reality. The main benefits and challenges of these technologies for modeling were also determined. This study identified three areas with significant knowledge gaps for future research: (1) the amalgamation of two or more technologies to overcome project obstacles; (2) solution optimization for inspections in remote areas; and (3) the development of algorithm-based technologies. This research contributes to the body of knowledge by exploring current trends and future directions of 3D model technologies in the construction industry. Full article

Utility as-built plans, which typically provide information about underground utilities’ position and spatial locations, are known to comprise inaccuracies. Over the years, the reliance on utility investigations using an array of sensing equipment has increased in an attempt to resolve utility as-built inaccuracies and mitigate the high rate of accidental underground utility strikes during excavation activities. Adapting data fusion into utility engineering and investigation practices has been shown to be effective in generating information with improved accuracy. However, the complexities in data interpretation and associated prohibitive costs, especially for large-scale projects, are limiting factors. This paper addresses the problem of data interpretation, costs, and large-scale utility mapping with a novel framework that generates probabilistic inferences by fusing data from an automatically generated initial map with as-built data. The probabilistic inferences expose regions of high uncertainty, highlighting them as prime targets for further investigations. The proposed model is a collection of three main processes. First, the automatic initial map creation is a novel contribution supporting rapid utility mapping by subjecting identified utility appurtenances to utility inference rules. The second and third processes encompass the fusion of the created initial utility map with available knowledge from utility as-builts or historical satellite imagery data and then evaluating the uncertainties using confidence value estimators. The proposed framework transcends the point estimation of buried utility locations in previous works by producing a final probabilistic utility map, revealing a confidence level attributed to each segment linking aboveground features. In this approach, the utility infrastructure is rapidly mapped at a low cost, limiting the extent of more detailed utility investigations to low-confidence regions. In resisting obsolescence, another unique advantage of this framework is the dynamic nature of the mapping to automatically update information upon the arrival of new knowledge. This ultimately minimizes the problem of utility as-built accuracies dwindling over time. Full article

We introduce a hybrid quantum-classical vision transformer architecture, notable for its integration of variational quantum circuits within both the attention mechanism and the multi-layer perceptrons. The research addresses the critical challenge of computational efficiency and resource constraints in analyzing data from the upcoming High Luminosity Large Hadron Collider, presenting the architecture as a potential solution. In particular, we evaluate our method by applying the model to multi-detector jet images from CMS Open Data. The goal is to distinguish quark-initiated from gluon-initiated jets. We successfully train the quantum model and evaluate it via numerical simulations. Using this approach, we achieve classification performance almost on par with the one obtained with the completely classical architecture, considering a similar number of parameters. Full article

Background: Awake craniotomy (AC) is recommended for the resection of tumors in eloquent areas. It is traditionally performed under monitored anesthesia care (MAC), which relies on hypnotics and opioids. Hypnosis-assisted AC (HAAC) is an emerging technique that aims to provide psychological support while reducing the need for pharmacological sedation and analgesia. We aimed to compare the characteristics and outcomes of patients who underwent AC under HAAC or MAC. Methods: We retrospectively analyzed the clinical, anesthetic, surgical, and neuropsychological data of patients who underwent awake surgical resection of eloquent brain tumors under HAAC or MAC. We used Mann–Whitney U tests, Wilcoxon signed-rank tests, and repeated-measures analyses of variance to identify statistically significant differences at the 0.05 level. Results: A total of 22 patients were analyzed, 14 in the HAAC group and 8 in the MAC group. Demographic, radiological, and surgical characteristics as well as postoperative outcomes were similar. Patients in the HAAC group received less remifentanil (p = 0.047) and propofol (p = 0.002), but more dexmedetomidine (p = 0.025). None of them received ketamine as a rescue analgesic. Although patients in the HAAC group experienced higher levels of perioperative pain (p < 0.05), they reported decreasing stress levels (p = 0.04) and greater levels of satisfaction (p = 0.02). Conclusion: HAAC is a safe alternative to MAC as it reduces perioperative stress and increases overall satisfaction. Further research is necessary to assess whether hypnosis is clinically beneficial. Full article

Inferior frontal sulcal hyperintensities (IFSHs) on fluid-attenuated inversion recovery (FLAIR) sequences have been proposed to be indicative of glymphatic dysfunction. Replication studies in large and diverse samples are nonetheless needed to confirm them as an imaging biomarker. We investigated whether IFSHs were tied to Alzheimer’s disease (AD) pathology and cognitive performance. We used data from 361 participants along the AD continuum, who were enrolled in the multicentre DELCODE study. The IFSHs were rated visually based on FLAIR magnetic resonance imaging. We performed ordinal regression to examine the relationship between the IFSHs and cerebrospinal fluid-derived amyloid positivity and tau positivity (Aβ42/40 ratio ≤ 0.08; pTau181 ≥ 73.65 pg/mL) and linear regression to examine the relationship between cognitive performance (i.e., Mini-Mental State Examination and global cognitive and domain-specific performance) and the IFSHs. We controlled the models for age, sex, years of education, and history of hypertension. The IFSH scores were higher in those participants with amyloid positivity (OR: 1.95, 95% CI: 1.05–3.59) but not tau positivity (OR: 1.12, 95% CI: 0.57–2.18). The IFSH scores were higher in older participants (OR: 1.05, 95% CI: 1.00–1.10) and lower in males compared to females (OR: 0.44, 95% CI: 0.26–0.76). We did not find sufficient evidence linking the IFSH scores with cognitive performance after correcting for demographics and AD biomarker positivity. IFSHs may reflect the aberrant accumulation of amyloid β beyond age. Full article

There are scarce data regarding the rate of the occurrence of primary open-angle glaucoma (POAG) and visible lamina cribrosa pores (LCPs) in the eyes of individuals with African ancestry; the potential impact of these features on disease burden remains unknown. We recruited subjects with POAG to the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study. Through regression models, we evaluated the association between the presence of LCPs and various phenotypic features. In a multivariable analysis of 1187 glaucomatous eyes, LCPs were found to be more likely to be present in eyes with cup-to-disc ratios (CDR) of ≥0.9 (adjusted risk ratio (aRR) 1.11, 95%CI: 1.04–1.19, p = 0.005), eyes with cylindrical-shaped (aRR 1.22, 95%CI: 1.11–1.33) and bean pot (aRR 1.24, 95%CI: 1.13–1.36) cups versus conical cups (p < 0.0001), moderate cup depth (aRR 1.24, 95%CI: 1.06–1.46) and deep cups (aRR 1.27, 95%CI: 1.07–1.50) compared to shallow cups (p = 0.01), and the nasalization of central retinal vessels (aRR 1.33, 95%CI: 1.23–1.44), p < 0.0001). Eyes with LCPs were more likely to have a higher degree of African ancestry (q0), determined by means of SNP analysis (aRR 0.96, 95%CI: 0.93–0.99, p = 0.005 for per 0.1 increase in q0). Our large cohort of POAG cases of people with African ancestry showed that LCPs may be an important risk factor in identifying severe disease, potentially warranting closer monitoring by physicians. Full article