Special Issue "Varicella Zoster Virus"
Deadline for manuscript submissions: closed (28 February 2019)
Prof. Dr. Randall J. Cohrs
Department of Neurology, School of Medicine, University of Colorado, Aurora, CO 80045, USA
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Interests: molecular biology of alphaherpesvirus latency, especially epigenetic control of latent virus transcription; novel application of next-generation sequencing to questions in virology; reactivation of alphaherpesviruses in extreme environments
With recent advances in vaccine development, disease modeling and global analysis of nucleic acids, proteins, and metabolites, our understanding of the molecular biology of varicella zoster virus (VZV) has expanded. In addition, application of novel diagnostic tools has expanded the spectrum of disease caused by this virus. While disease caused by primary infection is still a concern, the larger problem is disease caused when latent VZV reactivates. Consequently, a great deal of current research is directed towards understanding the molecular biology of latency, including host innate and adaptive control of virus reactivation. This Special Issue is designed to provide a firm base of understanding concerning VZV latency, the mechanism of virus reactivation including the spectrum of disease caused upon reactivation, especially in the expanding elderly and immunocompromised population. In addition, current treatments including vaccines will be reviewed.
The goal of this Special Issue is to assemble comprehensive reviews of VZV latency including the latent state, mechanism of reactivation, in vitro and in vivo models, immunology, vaccines, clinical aspects of virus reactivation, and therapy. It is our hope that this up-to-date review will aid in directing future studies of this enigmatic human alphaherpesvirus.
Prof. Dr. Randall J. Cohrs
Manuscript Submission Information
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- varicella zoster virus
- human herpesvirus type 3