Special Issue "Viral Reverse Transcriptases"
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 3575
Interests: HIV; reverse transcription; drug resistance; genetic variation; proteolytic processing; HIV protease
Special Issues, Collections and Topics in MDPI journals
Fifty years ago, the discovery of reverse transcriptases in retroviruses (then known as RNA tumor viruses) by David Baltimore and Howard Temin was a major breakthrough that revolutionized molecular biology and established the foundations of retrovirology and cancer biology while providing opportunity for the development of novel biotechnological methods with wide applications in life sciences. Reverse transcriptases are nucleic acid polymerases that synthesize DNA using RNA as a template. They play a pivotal role in the replication of several virus families, most notably Retroviridae and Hepadnaviridae. HIV-1 reverse transcriptase inhibitors acting on its polymerase activity constitute the backbone of currently prescribed antiretroviral therapies. Several nucleoside analogue inhibitors of the viral reverse transcriptase are also widely used in the treatment of chronic hepatitis B. Moreover, human endogenous retroviruses make up 8% of the human genome and encode reverse transcriptases, although their contribution to human health is poorly understood and understudied.
This Special Issue invites articles and reviews that focus on the structures of viral reverse transcriptases, their mechanisms of action, their interaction with viral and host factors and their contribution to viral evolution, as well as research in the design and development of antiviral agents targeting viral reverse transcriptases, and novel biotechnological methods and uses of those enzymes in basic and clinical virology.
Dr. Luis Menéndez-Arias
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- reverse transcription
- hepatitis B virus
- DNA polymerase
- ribonuclease H
- antiviral therapy
- virus evolution