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Volume 17
Issue 6
10.3390/v17060762
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Comparative Analysis of Two Zika Virus Isolates in a Rhesus Macaque Pregnancy Model

by
Hannah K. Jaeger
1,
Jessica L. Smith
1,
Christopher J. Parkins
1,
Nicole N. Haese
1,
Craig N. Kreklywich
1,
Michael Denton
1,
Caralyn S. Labriola
1,2,
Michael K. Axthelm
1,3,
Aaron Barber-Axthelm
2,
Kim Chun
2,
Tonya Swanson
2,
Rahul J. D’Mello
3,4,
Terry K. Morgan
4,5,
Duncan R. Smith
6,
Jamie O. Lo
3,4,
Alec J. Hirsch
1,2,
Victoria H. J. Roberts
3 and
Daniel N. Streblow
1,2,*
1
The Vaccine & Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
2
Division of Pathobiology & Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
3
Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
4
Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, OR 97239, USA
5
Division of Pathology, Oregon Health & Science University, Portland, OR 97239, USA
6
Institute of Molecular Biosciences, Mahidol University, Salaya Campus, 25/25 Phuttamonthol Sai 4, Nakhon Pathom 73170, Thailand
*
Author to whom correspondence should be addressed.
Viruses 2025, 17(6), 762; https://doi.org/10.3390/v17060762 (registering DOI)
Submission received: 11 April 2025 / Revised: 18 May 2025 / Accepted: 21 May 2025 / Published: 27 May 2025
(This article belongs to the Special Issue Zika Virus and Congenital Zika Syndrome, 2nd Edition)
Versions Notes

Abstract

Zika virus (ZIKV) infection during pregnancy can cause a broad range of neurological birth defects, collectively named Congenital Zika Syndrome (CZS). We have previously shown that infection with the Puerto Rican isolate PRVABC59 (ZIKV-PR) results in abnormal oxygen transport in the placenta due to villous damage and uterine vasculitis in a nonhuman primate model. To investigate whether this type of damage occurs with endemically circulating strains in Thailand, we investigated a CZS case isolate, MU1-2017 (ZIKV-TH), in pregnant rhesus macaques. Pregnant animals (n = 3 per group) were infected subcutaneously with either ZIKV-PR or ZIKV-TH at ~50 days gestation (GD) and monitored for 40 days post-infection (GD90). Similar courses of viremia and immune activation were observed for both viruses when compared to uninfected controls. In addition, both viruses induced changes to the placental architecture, including spiral artery remodeling and the development of infarctions. Similar levels of viral RNA were detected at necropsy in maternal and fetal tissues. Overall, our results show that the ZIKV-TH strain MU1-2017 behaves similarly to the ZIKV-PR strain, and, importantly, provide evidence of in-utero infection with an additional contemporary strain of ZIKV.
Keywords: Zika virus; congenital Zika syndrome; non-human primate; placenta; immunology; Thailand Zika virus; congenital Zika syndrome; non-human primate; placenta; immunology; Thailand

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MDPI and ACS Style

Jaeger, H.K.; Smith, J.L.; Parkins, C.J.; Haese, N.N.; Kreklywich, C.N.; Denton, M.; Labriola, C.S.; Axthelm, M.K.; Barber-Axthelm, A.; Chun, K.; et al. Comparative Analysis of Two Zika Virus Isolates in a Rhesus Macaque Pregnancy Model. Viruses 2025, 17, 762. https://doi.org/10.3390/v17060762

AMA Style

Jaeger HK, Smith JL, Parkins CJ, Haese NN, Kreklywich CN, Denton M, Labriola CS, Axthelm MK, Barber-Axthelm A, Chun K, et al. Comparative Analysis of Two Zika Virus Isolates in a Rhesus Macaque Pregnancy Model. Viruses. 2025; 17(6):762. https://doi.org/10.3390/v17060762

Chicago/Turabian Style

Jaeger, Hannah K., Jessica L. Smith, Christopher J. Parkins, Nicole N. Haese, Craig N. Kreklywich, Michael Denton, Caralyn S. Labriola, Michael K. Axthelm, Aaron Barber-Axthelm, Kim Chun, and et al. 2025. "Comparative Analysis of Two Zika Virus Isolates in a Rhesus Macaque Pregnancy Model" Viruses 17, no. 6: 762. https://doi.org/10.3390/v17060762

APA Style

Jaeger, H. K., Smith, J. L., Parkins, C. J., Haese, N. N., Kreklywich, C. N., Denton, M., Labriola, C. S., Axthelm, M. K., Barber-Axthelm, A., Chun, K., Swanson, T., D’Mello, R. J., Morgan, T. K., Smith, D. R., Lo, J. O., Hirsch, A. J., Roberts, V. H. J., & Streblow, D. N. (2025). Comparative Analysis of Two Zika Virus Isolates in a Rhesus Macaque Pregnancy Model. Viruses, 17(6), 762. https://doi.org/10.3390/v17060762

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