Novel Areas for Prevention and Control of Leishmaniosis

Dear Colleagues,

Leishmaniasis is considered to be the most important parasitic disease affecting humans after malaria. It affects millions of people all over the world. Leishmania is a protozoan parasite transmitted by sand flies, which can cause severe disfiguring ulcers and systemic diseases that can be fatal when not treated. Until recently, the main form of treatment for leishmaniasis was pentavalent antimonials, which was first used over 80 years ago. More recently, new and effective therapies have been discovered. Recent work has further clarified mechanisms of pathogenesis and immunity to leishmaniasis. This includes the role of sand fly saliva on infection by the parasite. Generally, individuals who have once been infected are immune to subsequent re-infection. Consequently, prevention of this parasitic disease using a vaccine is a potentially viable approach and is an area of active research. As some disease causing Leishmania parasites have animal reservoirs, various control programs have been attempted, some more effective than others.

The Special Issue on “Leishmaniasis” may include the following topics:

The scope of Leishmaniasis in the world

Present and new therapies for Visceral Leishmaniasis

Present and new therapies for Cutaneous Leishmaniasis

Progress in the development of vaccines for Leishmaniasis

Control methods for the prevention of Leishmaniasis

Updates on host immune responses to Cutaneous, Muco-cutaneous and Visceral Leishmaniasis

Mechanisms of immune evasion by Leishmania parasites

The sand flies involved in the spread of Leishmaniasis

Effect of Sand fly Saliva on Leishmania Infection.

Prof. John David
Prof. Abhay Satoskar
Dr. Steve Oghumu
Guest Editors

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