Special Issue "Application of GC or LC Methods Coupled with QqQ or HRMS in the Analysis of Organic Contaminants and Their Metabolites or Transformation Products"

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Environmental Chemistry".

Deadline for manuscript submissions: 15 August 2022 | Viewed by 496

Special Issue Editor

Prof. Dr. Renata Raina-Fulton
E-Mail Website
Guest Editor
Department of Chemistry and Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada
Interests: analytical chemistry; environmental chemistry; separation techniques-mass spectrometry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Analytical methods for organic contaminant analyses range from focus on several compounds or specific chemical classes to multi-residue analysis methods capable of analyzing hundreds of compounds by either gas or liquid chromatography coupled most frequently with low-resolution triple quadrupole mass spectrometry (GC or LC-QqQ) to meet regulatory and research requirements. These methods unambiguously provide confirmation utilizing reference standards. Database developments have also recently been made for advancing metabolite or transformation product analysis in tandem mass spectrometry. Recently, target methods with suspect lists and nontarget screening methods with computer molecular identification have also been developed using GC and LC coupled to quadrupole time-of-flight (Q/TOF). These high-resolution (GC or LC-HRMS) methods are aimed at streamlining the detection of GC-Q/TOF and LC-Q/TOF amenable compounds to over several hundred target suspect compounds and enhanced capability for nontargeted analysis (NTA). GC and LC-HRMS NTA has high potential to aid in the identification of new metabolite or transformation products of organic contaminants, particularly where no current available analytical standards are commercially available. In addition, there is growing interest in examining the occurrence of organic contaminants in new matrices that are a repository for the accumulation of target analytes or metabolites such as biological samples, dust or particles, household or worker exposure materials, nutrition and food products, sediment and wastewater matrices. Organic contaminants may include perfluorinated chemicals, pesticides, pharmaceuticals, polycyclic aromatic hydrocarbons, polychlorinated biphenyls, and other organic contaminants from a broad range of emerging or endrocrine disrupting chemicals in these sample matrices. The special issues focuses on applications involving analysis with GC or LC coupled with low or high-resolution mass spectrometry detection.

Prof. Dr. Renata Raina-Fulton
Guest Editor

Manuscript Submission Information

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  • GC mass spectrometry
  • LC mass spectrometry
  • nontarget analysis (NTA)
  • target methods of analysis
  • multi-residue analysis
  • pesticides
  • metabolites
  • transformation products

Published Papers (1 paper)

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Dissipation and Distribution of Prochloraz in Bananas and a Risk Assessment of Its Dietary Intake
Toxics 2022, 10(8), 435; https://doi.org/10.3390/toxics10080435 - 29 Jul 2022
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Background: As a systematic fungicide, prochloraz is often used to control banana freckle disease, and it is significant to assess the safety and risk of prochloraz. Methods: The dissipation kinetics and distribution of prochloraz in bananas were measured by high-performance liquid chromatography (HPLC). [...] Read more.
Background: As a systematic fungicide, prochloraz is often used to control banana freckle disease, and it is significant to assess the safety and risk of prochloraz. Methods: The dissipation kinetics and distribution of prochloraz in bananas were measured by high-performance liquid chromatography (HPLC). Results: The results showed that the fortified recoveries in bananas were 83.01–99.12%, and the relative standard deviations (RSDs) were 2.45–7.84%. The half-life of prochloraz in banana peel (3.93–5.60 d) was significantly lower than it was in whole banana (8.25–10.80 d) and banana pulp (10.35–12.84 d). The terminal residue of prochloraz in banana fruits was below the maximum residue level (MRL, China) at pre-harvest intervals (PHI) of 21 d. Moreover, the residue of prochloraz in banana peel was always 1.06–7.71 times greater than it was in banana pulp. The dietary risk assessment results indicated that the prochloraz residue in bananas at PHI of 21 d was safe for representative populations. (4) Conclusions: We found that a 26.7% prochloraz emulsion oil in water (EW) diluted 1000-fold and sprayed three times under field conditions was safe and reliable, providing a reference for the safe application of prochloraz in bananas. Full article
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