Molecular Insights into Drugs in Livestock: Oxidative Stress, Metabolism and Toxicity
A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Drugs Toxicity".
Deadline for manuscript submissions: 14 January 2026 | Viewed by 12
Special Issue Editor
Interests: natural antioxidants; antibiotic alternatives; drug absorption and metabolism; drug–drug interaction; drug toxicity; antimicrobial resistance; dissemination of resistance genes; mobile genetic element
Special Issue Information
Dear Colleagues,
Focus:
This Special Issue aims to explore the molecular mechanisms underlying the effects of veterinary drugs (including antibiotics, antiparasitics, growth promoters, and anti-inflammatory agents) on livestock, with a particular emphasis on (1) oxidative stress induction and cellular damage; (2) drug metabolism and bioactivation pathways; (3) and toxicity mechanisms and long-term health impacts. This Special Issue will integrate pharmacology, toxicology, and veterinary science to provide a comprehensive understanding of how drugs interact with biological systems in farm animals.
Scope:
Contributions should address, but are not limited to, the following themes:
(A) Drug-induced oxidative stress in livestock;
(B) Drug metabolism and species-specific differences;
(C) Molecular mechanisms of drug toxicity;
(D) Mitigation strategies and alternatives.
Positioning Within the Existing Literature:
Current knowledge gaps of veterinary drugs are that the long-term, low-dose exposure effects of veterinary drugs in livestock are limited; species-specific metabolic pathways (e.g., ruminants vs. monogastrics) are often overlooked; and few integrative studies combine omics technologies (e.g., metabolomics, proteomics) with traditional toxicology.
This Special Issue adds value in the following areas: (1) Livestock-centered research: prioritizes farm animals (cattle, poultry, swine, fish) over rodent models; (2) Translational applications: links molecular findings to practical solutions (e.g., antioxidant supplementation, drug withdrawal periods); (3) Interdisciplinary approach: merges veterinary medicine, pharmacology, and molecular biology to address One Health challenges.
Suggested Article Types:
- Original research articles;
- Reviews (systematic/mini-reviews);
- Methodological advances (e.g., novel biomarkers, in vitro models);
- Case studies with molecular insights.
Prof. Dr. Liping Wang
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- drug–drug interaction in livestock
- drug toxicity
- oxidative stress
- veterinary drugs and gut microbiome
- oxidative damage biomarkers
- ROS generation by veterinary drugs
- mitigation strategies and alternatives
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