The Application of Artificial Intelligence in Surgical Procedures

A special issue of Surgeries (ISSN 2673-4095).

Deadline for manuscript submissions: 30 September 2026 | Viewed by 3434

Special Issue Editors

Department of Osteopathic Manipulative Medicine, College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY 11568, USA
Interests: biomechanical engineering; computational mechanics; computational biomechanics; image processing; brain injuries; fetus injuries; impact biomechanics; cardiovascular fluid–structure interaction
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Co-Guest Editor
Entrepreneurship and Technology Innovation Center, College of Engineering and Computing Sciences, New York Institute of Technology, Old Westbury, NY 11568, USA
Interests: cybersecurity; software development; database design; data science; machine learning; quantum computing

Special Issue Information

Dear Colleagues,

We are pleased to announce a Special Issue of Surgeries dedicated to the transformative role of Artificial Intelligence (AI) in the field of surgery. The integration of AI technologies is rapidly reshaping surgical practice, from preoperative planning and intraoperative guidance to postoperative care and outcome prediction. This Special Issue aims to showcase cutting-edge research, innovative methodologies, and comprehensive reviews that highlight the current and future impact of AI across all surgical disciplines.

We invite submissions that explore the development and application of AI-driven tools for surgical decision support, robotic-assisted procedures, image analysis, and real-time intraoperative navigation. Topics may also include surgical simulation and training, predictive analytics for patient outcomes, digital twins, telemedicine, and the ethical, legal, and social implications of AI in surgical settings. Contributions addressing challenges such as data privacy, algorithm transparency, and the integration of AI into clinical workflows are particularly welcome.

By bringing together multidisciplinary perspectives, this Special Issue seeks to foster collaboration between surgeons, engineers, data scientists, and healthcare professionals. Our goal is to provide a comprehensive overview of how AI is advancing surgical care, improving patient safety, and shaping the future of operative medicine. We look forward to your valuable contributions to this rapidly evolving field.

Dr. Milan Toma
Dr. Michael Nizich
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Surgeries is an international peer-reviewed open access quarterly journal published by MDPI.

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Keywords

  • artificial intelligence in surgery
  • surgical robotics
  • medical imaging
  • surgical simulation
  • clinical decision support
  • digital health
  • predictive analytics
  • telemedicine
  • surgical data science
  • ethical and legal issues in AI

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Published Papers (4 papers)

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Research

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16 pages, 23623 KB  
Article
Deep Learning-Based Blood Segmentation and Temporal Characterization for the Robin Heart Surgical Robot
by Klaudia Senator, Dariusz Krawczyk and Zbigniew Nawrat
Surgeries 2026, 7(2), 70; https://doi.org/10.3390/surgeries7020070 (registering DOI) - 15 Jun 2026
Abstract
Background/Objectives: In laparoscopic and robot-assisted surgery, bleeding may rapidly impair operative-field readability and procedural safety. In the broader Robin Heart teleoperation framework, interpretation of such events is relevant not only for scene understanding but also as a potential prerequisite for future safety-oriented [...] Read more.
Background/Objectives: In laparoscopic and robot-assisted surgery, bleeding may rapidly impair operative-field readability and procedural safety. In the broader Robin Heart teleoperation framework, interpretation of such events is relevant not only for scene understanding but also as a potential prerequisite for future safety-oriented supervisory functions under communication-degraded conditions. The aim of this study was to assess whether a deep learning model for blood segmentation could provide outputs suitable for preliminary image-level temporal characterization of visible blood-region behavior in laparoscopic video. Methods: A U-Net-based binary blood-segmentation model was implemented in-house in PyTorch and evaluated on three paired image–mask datasets: a simulated bleeding dataset prepared under controlled laboratory conditions, an internal operative laparoscopic dataset, and an external-domain subset derived from the public GynSurg dataset. Segmentation performance was assessed using 5-fold cross-validation and reported using the Dice coefficient and Intersection over Union (IoU). Training dynamics were analyzed using training and validation loss and Dice curves. Additional baseline comparisons were performed on the internal operative dataset using U-Net++ and DeepLabV3+. Temporal analysis was performed on selected video fragments, including a low-motion reference sequence without active bleeding progression, internal bleeding-related sequences, and external-domain sequences, using mask-derived descriptors and auxiliary optical-flow-based motion descriptors computed after camera-motion compensation within the detected blood-related ROI. Results: In 5-fold cross-validation, the U-Net-based model achieved Dice coefficient and IoU values of 0.915 ± 0.012 and 0.851 ± 0.019 on the simulated dataset, 0.856 ± 0.013 and 0.756 ± 0.025 on the internal operative dataset, and 0.707 ± 0.053 and 0.570 ± 0.056 on the external-domain GynSurg subset, respectively. On the internal operative dataset, the proposed model performed comparably to U-Net++ and slightly above DeepLabV3+ under the same cross-validation protocol. The temporal descriptor set differentiated low-motion reference behavior, more spatially coherent progression, rapid coherent expansion, and dynamic or motion-active progression profiles. Peak dA/dt reflected abrupt visible blood-area expansion, temporal IoU described mask stability over time, and optical-flow-based descriptors provided additional information on local motion activity within the detected blood-related ROI. Conclusions: The results support the feasibility of combining deep-learning-based blood segmentation with temporal and optical-flow-based descriptors for exploratory image-level characterization of visible blood-region behavior in laparoscopic video. Within the Robin Heart development pathway, such descriptors may, in the future, serve as candidate components of image-analysis support modules for safety-oriented teleoperative scenarios. At this stage, they should be interpreted as exploratory image-derived indicators rather than clinically validated markers of bleeding severity. Full article
(This article belongs to the Special Issue The Application of Artificial Intelligence in Surgical Procedures)
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31 pages, 381 KB  
Article
Stratified Procedural Risk Assessment in Colorectal Surgery: A Comparative Analysis of Statistical and Machine Learning Approaches Using Combined Surgical Approach and Operative Duration Categories
by Dennis Elengickal, Michael Nizich and Milan Toma
Surgeries 2026, 7(2), 42; https://doi.org/10.3390/surgeries7020042 - 25 Mar 2026
Cited by 1 | Viewed by 818
Abstract
Background: Postoperative complications following colorectal surgery remain a persistent clinical challenge. Traditional risk stratification has focused on patient characteristics, while conventional modeling approaches treat procedural factors such as operative duration and surgical approach as independent predictors, potentially obscuring interaction effects. Methods: This study [...] Read more.
Background: Postoperative complications following colorectal surgery remain a persistent clinical challenge. Traditional risk stratification has focused on patient characteristics, while conventional modeling approaches treat procedural factors such as operative duration and surgical approach as independent predictors, potentially obscuring interaction effects. Methods: This study developed a machine learning model stratifying 7908 colorectal surgery patients into four distinct procedural risk categories based on combined surgical approach and operative duration (laparoscopic-short, laparoscopic-long, open-short, open-long), rather than treating these factors as separate variables. A gradient boosting ensemble classifier with RUSBoost resampling was trained on predictor variables including patient demographics, comorbidities, and intraoperative factors. Results: Feature importance analysis revealed that the open-long category emerged as the single most important predictor, substantially exceeding all other variables. Weight loss, body mass index, patient age, and electrolyte abnormalities ranked as the next most important predictors. Stratified complication rates demonstrated a critical interaction: prolonged duration more than doubled complication risk in open procedures (short-duration: 9.99%, long-duration: 20.46%), whereas laparoscopic procedures showed only a modest increase from short-duration (10.45%) to long-duration (14.08%) cases. Logistic regression benchmark analysis confirmed the duration-approach interaction (OR = 1.53, 95% CI: 0.97–2.39), achieving comparable discrimination (c-statistic 0.678 vs. 0.665 for the ensemble model). Decision curve analysis demonstrated logistic regression provided superior clinical utility across most threshold probabilities. Conclusions: The dual analytical framework (i.e., statistical inference for quantifying associations and machine learning for predictive feature ranking) offers complementary insights for clinical application. These findings demonstrate that stratified feature engineering can elucidate complex risk phenotypes that may be obscured when procedural factors are analyzed independently. Full article
(This article belongs to the Special Issue The Application of Artificial Intelligence in Surgical Procedures)
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Review

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13 pages, 354 KB  
Review
From Imaging to Implementation: Computed-Tomography-Based Surgical Artificial Intelligence Using DIEP Flap Reconstruction as a Model System
by Carlotta E. R. Keunecke, Nikolaus Watzinger, Gabriel Hundeshagen, Jochen-Frederick Hernekamp and Valentin F. M. Haug
Surgeries 2026, 7(2), 61; https://doi.org/10.3390/surgeries7020061 - 20 May 2026
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Abstract
Background/Objectives: Artificial intelligence (AI) is increasingly proposed to improve surgical planning, guidance, and postoperative surveillance. Yet many promising applications remain disconnected from the full surgical pathway and the feasible limitations of clinical deployment. In contrast to prior reviews that primarily catalog AI use [...] Read more.
Background/Objectives: Artificial intelligence (AI) is increasingly proposed to improve surgical planning, guidance, and postoperative surveillance. Yet many promising applications remain disconnected from the full surgical pathway and the feasible limitations of clinical deployment. In contrast to prior reviews that primarily catalog AI use cases, this review combines the literature to define the translational pathway—from label design through staged validation to workflow integration—required for clinically deployable computed tomography (CT)-based surgical AI. CT and particularly computed tomography angiography (CTA) are especially usable sources for surgical AI because they provide a standardized three-dimensional anatomic model that is already embedded in many clinical workflows. In autologous breast reconstruction, deep inferior epigastric perforator (DIEP) flap CTA offers an unusually strong model system: the anatomy is discrete, surgeon decisions are actionable, and downstream operative and postoperative outcomes are measurable. These characteristics make DIEP reconstruction suitable not only for technical model development, but also for exacting testing of how CT-based AI should be annotated, validated, displayed, and governed. Methods: This focused narrative review combines evidence across the surgical workflow, spanning preoperative planning and risk stratification, intraoperative support, and postoperative monitoring. Reporting standards, implementation frameworks, governance, and regulatory sources were also considered when directly relevant to clinical deployment. Results: Across the available literature on breast reconstruction with the DIEP flap, preoperative CTA has been associated with reductions in operative time of approximately 54–76 min in individual studies. Semi-automated perforator mapping can reduce review time from 2 to 3 h to approximately 30 min. Intraoperative extended-reality tools and surgeon-facing navigation systems illustrate the importance of the ‘last mile’ of translation, while postoperative monitoring models show how imaging-linked data can support a closed-loop learning system. Across these stages, recurring limits include target mismatch, weak external validation, protocol variability, inconsistent reporting, limited subgroup analysis, and inadequate integration of economic and governance considerations. Conclusions: We argue that the next important step is not a generic autonomous model, but a clinically deployable DIEP-CTA-AI program. The practical blueprint proposed here is staged: structured anatomical labels, separate imaging, surgeons’ decisions, and outcome reference standards, dense intermediate endpoints, retrospective and external validation, reader studies, prospective silent deployment, and workflow-impact assessment. If implemented in this way, DIEP flap CTA can serve as a practical blueprint for CT-based AI translation in surgery more broadly. Full article
(This article belongs to the Special Issue The Application of Artificial Intelligence in Surgical Procedures)
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24 pages, 2962 KB  
Review
Image-Guided Autonomous Robotic Surgery in the Context of Therapies Managed by Intelligent Digital Technologies: A Narrative Review
by Adel Razek
Surgeries 2026, 7(1), 26; https://doi.org/10.3390/surgeries7010026 - 16 Feb 2026
Viewed by 1403
Abstract
This narrative review aims to highlight and analyze the supervision of precision robotic surgical interventions. These are autonomous, closed-loop procedures, assisted by images and managed by intelligent digital tools. These administered procedures are designed to be safe and reliable, adhering to the principles [...] Read more.
This narrative review aims to highlight and analyze the supervision of precision robotic surgical interventions. These are autonomous, closed-loop procedures, assisted by images and managed by intelligent digital tools. These administered procedures are designed to be safe and reliable, adhering to the principles of minimal invasiveness, precise positioning, and non-toxicity. Thus, a precision intervention uses non-ionizing imaging-assisted robotics, controlled by a precise positioning device, forming an autonomous procedure augmented by artificial intelligence tools and supervised by digital twins. This intelligent digital management procedure allows staff to plan, train, predict, and execute interventions under human supervision. Patient safety and staff efficiency are linked to non-ionizing imaging, minimal invasiveness through image guidance, and strict delimitation of the intervention zone through precise positioning. This study includes, successively, sections covering an introduction, therapeutic and surgical interventions, imaging strategies integrating diagnostic and assistance functions, intelligent digital tools including digital twins and artificial intelligence, image-guided procedures including autonomous and precision robotic surgical interventions increased by machine learning, as well as augmented healthcare monitoring, and a discussion and conclusions of the review. All topics addressed in this analysis are supported by examples from the literature. Full article
(This article belongs to the Special Issue The Application of Artificial Intelligence in Surgical Procedures)
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