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Surfaces
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Biointerfaces and Interfacial Phenomena in Biology and Nanomedicine
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Biointerfaces and Interfacial Phenomena in Biology and Nanomedicine

A special issue of Surfaces (ISSN 2571-9637).

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 6422

Special Issue Editor

Dr. Vladimir Lucian Ene

E-Mail Website
Guest Editor
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 060042 Bucharest, Romania
Interests: thin films; interfaces; nanomaterials; biomaterials; advanced ceramics; characterization methods (X-ray diffraction and electron microscopy)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our Special Issue on Biointerfaces and Interfacial Phenomena in Biology and Nanomedicine Metal Nanostructures. The latest developments in technology allow researchers to access the intracellular environment and give new perspectives on studying cell–surface interactions. The conventional cell–material interfaces (consisting of a buffer protein layer that affects the intracellular processes) can now be substituted with direct interfaces between the material and the intracellular media. Hence, new methods to control cellular activities and offer access to information about intracellular processes will arise.

This collection aims to highlight recent developments in the synthesis and advanced characterization of nanobiomaterials for prospective medical applications, focusing on the surface properties and cell–surface interactions. Based on the area's great potential, we expect to see several thrilling developments soon that will speed up the integration of synthetic materials with cells significantly and open up a series of new applications.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: cell–surface interactions, interfaces between biomaterials and tissue, chemistry/biochemistry of the nanostructured biointerfaces, biocompatible thin-film synthesis and characterization, medical applications of nanostructured biointerfaces (protein immobilization, gene delivery, biosensors, cancer therapy), and piezoelectric materials for cell stimulation.

We look forward to receiving your contributions.

Dr. Vladimir Lucian Ene
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Surfaces is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cellular biology
  • biochemistry
  • biointerfaces
  • stimuli-responsive biointerfaces
  • surface functionalization
  • nanoparticles and nanocomposites
  • thin-films
  • biomimetic surfaces
  • surfaces of 3D materials
  • regenerative medicine

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Published Papers (2 papers)

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19 pages, 10746 KiB  
Article
Electrostatic Assembly of Anti-Listeria Bacteriophages on a Self-Assembled Monolayer of Aminoundecanethiol: Film Morphology, Charge Transfer Studies, and Infectivity Assays
by Paula M. V. Fernandes, Cláudia Maciel, Paula Teixeira, Carlos M. Pereira and José M. Campiña
Surfaces 2023, 6(2), 114-132; https://doi.org/10.3390/surfaces6020009 - 7 Apr 2023
Viewed by 2150
Abstract
The integration of bacteriophages, a particular class of viruses that specifically infect bacteria and archaea, in biosensors for the monitoring of pathogens in foods and beverages is highly desirable. To this end, an increasing focus has been set on the exploration of covalent [...] Read more.
The integration of bacteriophages, a particular class of viruses that specifically infect bacteria and archaea, in biosensors for the monitoring of pathogens in foods and beverages is highly desirable. To this end, an increasing focus has been set on the exploration of covalent and physical methods for the immobilization of phages on solid surfaces. This work investigates the electrostatic assembly of tailed phages, specifically anti-Listeria monocytogenes P100 phages, on an ultrathin self-assembled monolayer (SAM) of 11-amino-1-undecanethiol (AUT). The cationic properties of AUT may allow for the electrostatic capture of P100 in a capsid-down fashion, thereby exposing the specific receptor-binding proteins on their tails to the corresponding pathogens in the analytical samples. The morphology and charge transfer behavior of the assembled films were studied with atomic force microscopy, scanning electron microscopy and electrochemical techniques. These methods provided valuable insights into the orientation of the phages and the relevant role of the pH. Biological plaque assays revealed that the immobilized phages remain active towards the target bacterium. Overall, this research portrays SAMs of amino-akylthiols as a valid platform for the oriented immobilization of bacteriophages on surfaces for electroanalytical purposes. Full article
(This article belongs to the Special Issue Biointerfaces and Interfacial Phenomena in Biology and Nanomedicine)
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18 pages, 3429 KiB  
Article
Cell Adhesion Strength Indicates the Antithrombogenicity of Poly(2-methoxyethyl acrylate) (PMEA): Potential Candidate for Artificial Small-Diameter Blood Vessel
by Md Azizul Haque, Daiki Murakami and Masaru Tanaka
Surfaces 2022, 5(3), 365-382; https://doi.org/10.3390/surfaces5030027 - 27 Jul 2022
Viewed by 3357
Abstract
Poly(2-methoxyethyl acrylate) (PMEA) is a US FDA-approved biocompatible polymer, although there is insufficient work on human umbilical vein endothelial cells (HUVECs) and platelet interaction analysis on PMEA-analogous polymers. In this study, we extensively investigated HUVEC–polymer and platelet–polymer interaction behavior by measuring the adhesion [...] Read more.
Poly(2-methoxyethyl acrylate) (PMEA) is a US FDA-approved biocompatible polymer, although there is insufficient work on human umbilical vein endothelial cells (HUVECs) and platelet interaction analysis on PMEA-analogous polymers. In this study, we extensively investigated HUVEC–polymer and platelet–polymer interaction behavior by measuring the adhesion strength using single-cell force spectroscopy. Furthermore, the hydration layer of the polymer interface was observed using frequency-modulation atomic force microscopy. We found that endothelial cells can attach and spread on the PMEA surface with strong adhesion strength compared to other analogous polymers. We found that the hydration layers on the PMEA-analogous polymers were closely related to their weak platelet adhesion behavior. Based on our results, it can be concluded that PMEA is a promising candidate for the construction of artificial small-diameter blood vessels owing to the presence of IW and a hydration layer on the interface. Full article
(This article belongs to the Special Issue Biointerfaces and Interfacial Phenomena in Biology and Nanomedicine)
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