Application of Silicon Technology for Nanobiosensors

Dear Colleagues,

A nanobiosensor refers to a nanoscale device that transduces biochemical information, i.e. presence and/or concentration of a specific analyte, into an analytical signal. It can detect biomolecular interactions that are of paramount importance for environmental, pharmaceutical and biotechnological research and development. Therefore, a nanobiosensor holds great promises for a vast variety of applications including environmental control and early diagnosis of diseases as well as detection of charged species in electrolytes for chemical-biological-medical monitoring. Over the past two decades, there has been a growing interest in realizing nanobiosensors by exploiting the advanced nanofabrication capability of silicon technology. Silicon technology offers unmatched advantages for sensing applications: device miniaturization with controllability for signal enhancement, fast response, superior reliability, low energy consumption during operation, high-density integration for parallel analysis, and low-cost mass production of portable analytical systems.

A nanobiosensor normally consists of two basic components connected in series: a target recognition system at the sensor-sample interface where specific target-receptor interactions are generated and a nanoscale solid-state transducer that translates the interaction events to characteristic signals for scrutiny. For a nanobiosensor to achieve the ultimate capability of biochemical detection, increasing selectivity, enhancing signal, minimizing noise and shortening response time are essential. This Special Issue aims to present the latest developments in silicon technology based nanobiosensors as well as their applications. Submissions related to novel device concept, fabrication, sensing interface design, signal generation and noise mitigation, data analysis, modeling and simulation, packaging, as well as applications of nanobiosensors are welcome. Both reviews and original research articles are of equal value.

Prof. Dr. Shili Zhang
Prof. Dr. Zhen Zhang
Prof. Dr. Michel Calame
Guest Editors

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